Detailed information for compound 1171228

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.416 | Formula: C17H29NO4
  • H donors: 2 H acceptors: 3 LogP: 3.66 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCC/C(=C\1/C(=O)N[C@H](C1=O)CCO)/OC
  • InChi: 1S/C17H29NO4/c1-3-4-5-6-7-8-9-10-14(22-2)15-16(20)13(11-12-19)18-17(15)21/h13,19H,3-12H2,1-2H3,(H,18,21)/b15-14-/t13-/m0/s1
  • InChiKey: XLJNLIUYLCHZLK-YCPJBFQXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.011 0.0174 0.0259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0092 0.0143 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0174 0.3915
Onchocerca volvulus 0.011 0.0174 0.3096
Mycobacterium leprae conserved hypothetical protein 0.011 0.0174 0.0294
Loa Loa (eye worm) hypothetical protein 0.1483 0.2595 1
Entamoeba histolytica hypothetical protein 0.0187 0.0311 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0133 0.0215 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0037 0.0852
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0124 0.0198 0.0308
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0174 0.0174
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.0198 0.0308
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0174 0.3915
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0045 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0174 0.3915
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0042 0.0414
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0045 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0045 0.0045
Plasmodium vivax acetyl-CoA synthetase, putative 0.0036 0.0045 0.2517
Onchocerca volvulus 0.0035 0.0042 0.0414
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0042 0.0723
Schistosoma mansoni thyroid hormone receptor 0.0139 0.0225 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0207 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0042 0.0414
Brugia malayi Cathepsin L-like precursor 0.0023 0.0022 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium ulcerans TetR family transcriptional regulator 0.2872 0.5044 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0045 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.0311 0.0311
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.1069
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0012 0.0044
Leishmania major cathepsin L-like protease 0.0035 0.0042 0.0957
Leishmania major cathepsin L-like protease 0.0133 0.0215 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0051
Mycobacterium tuberculosis Conserved protein 0.011 0.0174 0.0277
Onchocerca volvulus 0.0302 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0042 0.0159
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.0215 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0701 0.1217 0.2359
Loa Loa (eye worm) hypothetical protein 0.0097 0.0151 0.0577
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0174 0.0174
Brugia malayi beta-lactamase family protein 0.011 0.0174 0.0668
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0174 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.1069
Plasmodium vivax vivapain-3 0.0018 0.0012 0.0656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0037 0.0037
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0128 0.0207 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium ulcerans hypothetical protein 0.0124 0.0198 0.0308
Leishmania major cathepsin L-like protease 0.0035 0.0042 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Plasmodium vivax vivapain-1 0.0018 0.0012 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Schistosoma mansoni microtubule-associated protein tau 0.5682 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0124 0.0198 0.0342
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0051
Onchocerca volvulus 0.0036 0.0045 0.0462
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0174 0.3915
Toxoplasma gondii propionate-CoA ligase 0.0036 0.0045 0.1376
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.008
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2872 0.5044 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0037 0.0037
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0022 0.008
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0045 0.0018
Echinococcus multilocularis protein dispatched 1 0.0047 0.0064 0.0064
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0115 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0045 0.0018
Echinococcus granulosus tumor protein p63 0.1379 0.2412 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Toxoplasma gondii ABC1 family protein 0.011 0.0174 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0069 0.0066
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0045 0.078
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0174 0.3915
Entamoeba histolytica acyl-coA synthetase, putative 0.0124 0.0198 0.6228
Echinococcus multilocularis survival motor neuron protein 1 0.1483 0.2595 0.2595
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0302 0.0514 0.1977
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.0198 0.9119
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0174 0.8081
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0054 0.0999
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0054 0.0054
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0224 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0036 0.0045 0.0035
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0045 0.2034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0037 0.0037
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0054 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Trichomonas vaginalis set domain proteins, putative 0.0252 0.0426 1
Brugia malayi hypothetical protein 0.0016 0.0009 0.0029
Plasmodium vivax unspecified product 0.0018 0.0012 0.0656
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0174 0.0277
Toxoplasma gondii hypothetical protein 0.0026 0.0027 0.0198
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0115 0.0175
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0045 0.0168
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0012 0.053
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0069 0.0066
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0174 0.0277
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0069 0.0069
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0045 0.2034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0124 0.0198 0.0342
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0151 0.4632
Trypanosoma cruzi cruzipain precursor, putative 0.0133 0.0215 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0124 0.0198 0.0308
Echinococcus multilocularis cysteine protease 0.0035 0.0042 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Plasmodium vivax vivapain-2 0.0035 0.0042 0.2381
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0045 0.0035
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0027 0.1109
Loa Loa (eye worm) hypothetical protein 0.0092 0.0143 0.0549
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0174 0.0259
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0042 0.0159
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0012 0.053
Onchocerca volvulus 0.0252 0.0426 0.8207
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0124 0.0198 0.0308
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0115 0.0141
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0036 0.0045 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0042 0.1924
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.011 0.0174 0.7851
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0022 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0036 0.0045 0.1078
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0045 0.0018
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Entamoeba histolytica cysteine protease, putative 0.0035 0.0042 0.0999
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0045 0.078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1585 0.2775 0.2775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0122 0.0195 0.905
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0045 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0882
Leishmania major cathepsin L-like protease 0.0035 0.0042 0.0957
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0042 0.0042
Trypanosoma cruzi major cysteine proteinase, putative 0.0105 0.0165 0.7656
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0187 0.0311 0.0311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Echinococcus multilocularis microtubule associated protein 2 0.5682 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0115 0.0439
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0045 0.108
Loa Loa (eye worm) hypothetical protein 0.0124 0.0198 0.0761
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0174 0.0259
Schistosoma mansoni patched 1 0.0041 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0174 0.7973
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0012 0.053
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.0215 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0045 0.108
Plasmodium vivax vivapain-2 0.0035 0.0042 0.2381
Onchocerca volvulus 0.0035 0.0042 0.0414
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0174 0.0277
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0174 0.0668
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0174 0.0277
Leishmania major cathepsin L-like protease 0.0035 0.0042 0.0957
Schistosoma mansoni cellular tumor antigen P53 0.0202 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0092 0.0143 0.0549
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0045 0.0168
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0045 0.0018
Leishmania major cathepsin L-like protease 0.0035 0.0042 0.0957
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0168
Brugia malayi Probable ClpP-like protease 0.0076 0.0115 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Echinococcus multilocularis cathepsin L 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0092 0.0143 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Brugia malayi AMP-binding enzyme family protein 0.0124 0.0198 0.0761
Plasmodium vivax hypothetical protein, conserved 0.011 0.0174 1
Onchocerca volvulus 0.0036 0.0045 0.0462
Loa Loa (eye worm) beta-lactamase 0.011 0.0174 0.0668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Onchocerca volvulus 0.011 0.0174 0.3096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.0197
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0027 0.1495
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0115 0.6578
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0115 0.6056
Echinococcus multilocularis expressed conserved protein 0.0091 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Echinococcus granulosus cysteine protease 0.0018 0.0012 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.0311 0.0311
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0012 0.053
Entamoeba histolytica hypothetical protein 0.0187 0.0311 1
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0115 0.7826
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0115 0.6056
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0051
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2872 0.5044 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.0198 0.9119
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0069 0.0069
Brugia malayi hypothetical protein 0.0025 0.0024 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0174 0.8081
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0042 0.2279
Loa Loa (eye worm) hypothetical protein 0.0032 0.0037 0.0138
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0045 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0151 0.0577
Echinococcus multilocularis tumor protein p63 0.1379 0.2412 0.2412
Loa Loa (eye worm) cysteine protease 0.0035 0.0042 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.0197
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0054 0.0054
Brugia malayi CHE-14 protein 0.0041 0.0054 0.0203
Onchocerca volvulus 0.0035 0.0042 0.0414
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0036 0.0045 0.1376
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0012 0.0012
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0045 0.2034
Onchocerca volvulus 0.0035 0.0042 0.0414
Loa Loa (eye worm) ctsf protein 0.0035 0.0042 0.0159
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0037 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0174 0.0277
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0042 0.0414
Mycobacterium ulcerans lipase LipD 0.011 0.0174 0.0259
Plasmodium vivax SET domain protein, putative 0.0032 0.0037 0.2062
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0115 0.5
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0045 0.2034
Loa Loa (eye worm) oxidoreductase 0.0036 0.0045 0.0168
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Echinococcus multilocularis protein patched 0.0041 0.0054 0.0054
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0115 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0198 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0022 0.0318
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0124 0.0198 0.6228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.008
Brugia malayi AMP-binding enzyme family protein 0.0124 0.0198 0.0761
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0042 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0042 0.0999
Brugia malayi beta-lactamase 0.011 0.0174 0.0668
Brugia malayi hypothetical protein 0.1483 0.2595 1
Entamoeba histolytica hypothetical protein 0.0187 0.0311 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0024 0.1323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Trichomonas vaginalis esterase, putative 0.011 0.0174 0.3915
Brugia malayi Pre-SET motif family protein 0.0222 0.0372 0.1429
Entamoeba histolytica acyl-CoA synthetase, putative 0.0124 0.0198 0.6228
Loa Loa (eye worm) hypothetical protein 0.0124 0.0198 0.0761
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Schistosoma mansoni thyroid hormone receptor 0.0139 0.0225 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0045 0.0018
Mycobacterium tuberculosis Conserved protein 0.011 0.0174 0.0277
Onchocerca volvulus 0.0035 0.0042 0.0414
Mycobacterium tuberculosis Conserved protein 0.011 0.0174 0.0277
Onchocerca volvulus 0.0032 0.0037 0.0302
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0012 0.053
Onchocerca volvulus 0.0036 0.0045 0.0462
Leishmania major cathepsin L-like protease 0.0133 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0198 0.0761
Onchocerca volvulus 0.0124 0.0198 0.3589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0042 0.0723
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0042 0.0999
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0045 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0124 0.0198 0.9119
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0092 0.0143 1
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0042 0.0957
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0069 0.0083
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Brugia malayi Pre-SET motif family protein 0.0032 0.0037 0.0138
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0174 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0042 0.0159
Echinococcus granulosus cathepsin l1 0.0035 0.0042 0.0042
Onchocerca volvulus 0.0035 0.0042 0.0414
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.0215 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0092 0.0143 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0092 0.0143 0.0198
Toxoplasma gondii cathepsin CPL 0.0035 0.0042 0.1219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0012 0.0012
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.0198 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0037 0.0037
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0045 0.0045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0045 0.0168
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0042 0.0042
Loa Loa (eye worm) fibroinase 0.0035 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0092 0.0143 0.0549
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0045 0.108
Plasmodium vivax acyl-CoA synthetase, putative 0.0092 0.0143 0.8222
Brugia malayi beta-lactamase family protein 0.011 0.0174 0.0668
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0115 0.0115
Schistosoma mansoni cathepsin s 0.0012 0.0001 0.0001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0045 0.1376
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0124 0.0198 0.0325
Echinococcus multilocularis cysteine protease 0.0035 0.0042 0.0042
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0036 0.0045 0.2459
Schistosoma mansoni hypothetical protein 0.0302 0.0514 0.0514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.0197
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0124 0.0198 0.0308
Brugia malayi hypothetical protein 0.0187 0.0311 0.1196
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0042 0.2279
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0042 0.0042
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0042 0.2279
Onchocerca volvulus 0.0202 0.0337 0.6395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Mycobacterium ulcerans acyl-CoA synthetase 0.0124 0.0198 0.0308
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0151 0.0151
Plasmodium falciparum acyl-CoA synthetase 0.0092 0.0143 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0042 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0012 0.0012
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.011 0.0174 0.0668
Schistosoma mansoni survival motor neuron protein 0.0302 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723
Brugia malayi AMP-binding enzyme family protein 0.0124 0.0198 0.0761
Onchocerca volvulus 0.0036 0.0045 0.0462
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0042 0.0042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0174 0.0668
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0372 0.1429
Mycobacterium leprae Probable lipase LipE 0.011 0.0174 0.0294
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0045 0.0018
Loa Loa (eye worm) hypothetical protein 0.0202 0.0337 0.1293
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.0266
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0134 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0882
Brugia malayi Cathepsin L-like precursor 0.0035 0.0042 0.0159
Brugia malayi cathepsin L-like precursor 0.0023 0.0022 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0042 0.0723
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0022 0.0022
Echinococcus granulosus cathepsin l1 0.0023 0.0022 0.0022
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0159
Onchocerca volvulus 0.0035 0.0042 0.0414
Onchocerca volvulus 0.011 0.0174 0.3096
Mycobacterium ulcerans beta-lactamase 0.011 0.0174 0.0259
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0022 0.023
Echinococcus granulosus survival motor neuron protein 1 0.1483 0.2595 0.2595
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0023 0.0022 0.008
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2872 0.5044 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0036 0.0045 0.1588
Mycobacterium ulcerans transcriptional regulator 0.2872 0.5044 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0045 0.1588
Entamoeba histolytica hypothetical protein 0.0187 0.0311 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0133 0.0215 1
Echinococcus granulosus cathepsin L 0.0018 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0037 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0174 0.0174
Echinococcus granulosus expressed conserved protein 0.0091 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0042 0.0723

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.