TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 311.416 | Formula: C17H29NO4
H donors: 2 H acceptors: 3 LogP: 3.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCC/C(=C\1/C(=O)N[C@H](C1=O)CCO)/OC
InChi: 1S/C17H29NO4/c1-3-4-5-6-7-8-9-10-14(22-2)15-16(20)13(11-12-19)18-17(15)21/h13,19H,3-12H2,1-2H3,(H,18,21)/b15-14-/t13-/m0/s1
InChiKey: XLJNLIUYLCHZLK-YCPJBFQXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0187	0.0311	0.0311
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0069	0.0066
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0045	0.0018
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0024	0.0569
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0054	0.0054
Loa Loa (eye worm)	beta-lactamase	0.011	0.0174	0.0668
Echinococcus multilocularis	cysteine protease	0.0035	0.0042	0.0042
Leishmania major	acetyl-CoA synthetase, putative	0.0036	0.0045	0.108
Loa Loa (eye worm)	ctsf protein	0.0035	0.0042	0.0159
Entamoeba histolytica	hypothetical protein	0.0187	0.0311	1
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0042	0.0999
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.011	0.0174	0.0174
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0151	0.0151
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0042	0.0042
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2872	0.5044	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0037	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Schistosoma mansoni	hypothetical protein	0.0128	0.0207	0.0207
Mycobacterium ulcerans	acyl-CoA synthetase	0.0124	0.0198	0.0308
Trypanosoma brucei	hypothetical protein, conserved	0.011	0.0174	0.7973
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0035	0.0042	0.2279
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0115	0.0115
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0143	0.0549
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0045	0.0018
Schistosoma mansoni	survival motor neuron protein	0.0302	0.0514	0.0514
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0124	0.0198	0.0308
Onchocerca volvulus		0.0252	0.0426	0.8207
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0151	0.4632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0036	0.0045	0.0045
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0224	0.0224
Onchocerca volvulus		0.0035	0.0042	0.0414
Brugia malayi	AMP-binding enzyme family protein	0.0124	0.0198	0.0761
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0124	0.0198	0.0325
Onchocerca volvulus		0.0035	0.0042	0.0414
Trichomonas vaginalis	D-aminoacylase, putative	0.011	0.0174	0.3915
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Brugia malayi	Probable ClpP-like protease	0.0076	0.0115	0.0439
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Schistosoma mansoni	hypothetical protein	0.0187	0.0311	0.0311
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Echinococcus granulosus	cathepsin L	0.0018	0.0012	0.0012
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0012	0.0012
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Trichomonas vaginalis	antibiotic synthetase, putative	0.0036	0.0045	0.078
Trichomonas vaginalis	antibiotic synthetase, putative	0.0036	0.0045	0.078
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0045	0.2034
Leishmania major	cysteine peptidase A (CPA)	0.0035	0.0042	0.0957
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0037	0.0037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0045	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0174	0.8081
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0115	0.0141
Mycobacterium ulcerans	hypothetical protein	0.011	0.0174	0.0259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Toxoplasma gondii	cathepsin CPL	0.0035	0.0042	0.1219
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0042	0.0414
Brugia malayi	Pre-SET motif family protein	0.0032	0.0037	0.0138
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0045	0.0018
Mycobacterium ulcerans	transcriptional regulator	0.2872	0.5044	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0042	0.0042
Brugia malayi	AMP-binding enzyme family protein	0.0124	0.0198	0.0761
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1585	0.2775	0.2775
Leishmania major	cathepsin L-like protease	0.0035	0.0042	0.0957
Schistosoma mansoni	microtubule-associated protein tau	0.5682	1	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0115	0.0175
Schistosoma mansoni	hypothetical protein	0.0302	0.0514	0.0514
Plasmodium vivax	vivapain-2	0.0035	0.0042	0.2381
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.008
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0042	0.1924
Echinococcus multilocularis	survival motor neuron protein 1	0.1483	0.2595	0.2595
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.011	0.0174	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0042	0.0159
Brugia malayi	beta-lactamase family protein	0.011	0.0174	0.0668
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0036	0.0045	0.1376
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0022	0.0022
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0122	0.0195	0.905
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0215	1
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2872	0.5044	1
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.0225	0.0225
Leishmania major	cathepsin L-like protease	0.0133	0.0215	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0037	0.0037
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2872	0.5044	1
Schistosoma mansoni	cellular tumor antigen P53	0.0202	0.0337	0.0337
Entamoeba histolytica	hypothetical protein	0.0187	0.0311	1
Entamoeba histolytica	hypothetical protein	0.0187	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0115	0.0439
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0036	0.0045	0.0168
Loa Loa (eye worm)	fibroinase	0.0035	0.0042	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0054	0.0999
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0036	0.0045	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0143	0.0549
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0012	0.053
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0092	0.0143	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0035	0.0042	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0198	0.0761
Onchocerca volvulus		0.011	0.0174	0.3096
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0036	0.0045	0.2459
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0024	0.1323
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0037	0.0037
Brugia malayi	beta-lactamase family protein	0.011	0.0174	0.0668
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Trichomonas vaginalis	penicillin-binding protein, putative	0.011	0.0174	0.3915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0124	0.0198	0.0325
Onchocerca volvulus		0.0124	0.0198	0.3589
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0022	0.008
Trichomonas vaginalis	D-aminoacylase, putative	0.011	0.0174	0.3915
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0036	0.0045	0.2034
Mycobacterium tuberculosis	Conserved protein	0.011	0.0174	0.0277
Brugia malayi	cathepsin L-like precursor	0.0023	0.0022	0.008
Onchocerca volvulus		0.0035	0.0042	0.0414
Echinococcus granulosus	cathepsin l1	0.0023	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Onchocerca volvulus		0.0036	0.0045	0.0462
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0012	0.053
Brugia malayi	hypothetical protein	0.0187	0.0311	0.1196
Leishmania major	4-coumarate:coa ligase-like protein	0.0124	0.0198	0.9119
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.008
Leishmania major	4-coumarate:coa ligase-like protein	0.0124	0.0198	0.9119
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0036	0.0045	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0143	0.0549
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0092	0.0143	0.0198
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0024	0.1069
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0224	0.0224
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0035	0.0042	0.2279
Trichomonas vaginalis	D-aminoacylase, putative	0.011	0.0174	0.3915
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0092	0.0143	0.0215
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0022	0.0318
Onchocerca volvulus		0.0035	0.0042	0.0414
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.011	0.0174	0.0668
Leishmania major	4-coumarate:coa ligase-like protein	0.0124	0.0198	0.9119
Schistosoma mansoni	cathepsin s	0.0012	0.0001	0.0001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0054	0.0203
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0036	0.0045	0.1588
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0036	0.0045	0.2517
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0036	0.0045	0.0035
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0012	0.053
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2872	0.5044	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0302	0.0514	0.1977
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0036	0.0045	0.1078
Leishmania major	cathepsin L-like protease	0.0133	0.0215	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0124	0.0198	0.0308
Leishmania major	cathepsin L-like protease	0.0035	0.0042	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0151	0.0577
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0187	0.0311	0.0311
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0036	0.0045	0.2034
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0143	0.0549
Schistosoma mansoni	hypothetical protein	0.004	0.0051	0.0051
Echinococcus granulosus	cathepsin L cysteine protease	0.0018	0.0012	0.0012
Plasmodium vivax	vivapain-3	0.0018	0.0012	0.0656
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0701	0.1217	0.2359
Mycobacterium tuberculosis	Probable hydrolase	0.011	0.0174	0.0277
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.0225	0.0225
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0027	0.1495
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0174	0.0294
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0151	0.0151
Schistosoma mansoni	patched 1	0.0041	0.0054	0.0054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0018	0.0012	0.053
Leishmania major	cathepsin L-like protease	0.0035	0.0042	0.0957
Onchocerca volvulus		0.011	0.0174	0.3096
Mycobacterium ulcerans	hypothetical protein	0.0124	0.0198	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0198	0.0761
Mycobacterium tuberculosis	Conserved protein	0.011	0.0174	0.0277
Toxoplasma gondii	propionate-CoA ligase	0.0036	0.0045	0.1376
Echinococcus multilocularis	beta LACTamase domain containing family member	0.011	0.0174	0.0174
Onchocerca volvulus		0.0035	0.0042	0.0414
Brugia malayi	AMP-binding enzyme family protein	0.0124	0.0198	0.0761
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0036	0.0045	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Leishmania major	cathepsin L-like protease	0.0133	0.0215	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0037	0.0037
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0036	0.0045	0.0018
Onchocerca volvulus		0.0036	0.0045	0.0462
Echinococcus granulosus	cysteine protease	0.0018	0.0012	0.0012
Leishmania major	hypothetical protein, conserved	0.011	0.0174	0.7851
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0174	0.8081
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.0197
Schistosoma mansoni	acetyl-CoA synthetase	0.0036	0.0045	0.0045
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0124	0.0198	0.0342
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0124	0.0198	0.6228
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0036	0.0045	0.0168
Mycobacterium tuberculosis	Probable esterase LipL	0.011	0.0174	0.0277
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0035	0.0042	0.0042
Onchocerca volvulus	Cathepsin F homolog	0.0035	0.0042	0.0414
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0035	0.0042	0.2279
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0064	0.0064
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.0197
Mycobacterium ulcerans	beta-lactamase	0.011	0.0174	0.0259
Trichomonas vaginalis	esterase, putative	0.011	0.0174	0.3915
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0036	0.0045	0.0035
Mycobacterium ulcerans	acyl-CoA synthetase	0.0124	0.0198	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium ulcerans	acyl-CoA synthetase	0.0124	0.0198	0.0308
Trypanosoma cruzi	cysteine peptidase, putative	0.0133	0.0215	1
Brugia malayi	Pre-SET motif family protein	0.0222	0.0372	0.1429
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0022	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0036	0.0045	0.0018
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.0372	0.1429
Echinococcus granulosus	cathepsin l1	0.0035	0.0042	0.0042
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0045	0.1588
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0087	0.0134	0.0197
Echinococcus multilocularis	microtubule associated protein 2	0.5682	1	1
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Onchocerca volvulus		0.0032	0.0037	0.0302
Mycobacterium tuberculosis	Probable lipase LipD	0.011	0.0174	0.0277
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0027	0.1109
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0035	0.0042	0.0042
Trichomonas vaginalis	set domain proteins, putative	0.0252	0.0426	1
Onchocerca volvulus		0.0302	0.0514	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0045	0.2034
Echinococcus granulosus	survival motor neuron protein 1	0.1483	0.2595	0.2595
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.0165	0.7656
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0036	0.0045	0.0045
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0024	0.1069
Mycobacterium ulcerans	esterase/lipase LipP	0.011	0.0174	0.0259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0337	0.1293
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.004	0.0051	0.0051
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0115	0.7826
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0115	0.5
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0054	0.0203
Loa Loa (eye worm)	oxidoreductase	0.0036	0.0045	0.0168
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0036	0.0045	0.108
Echinococcus granulosus	expressed conserved protein	0.0091	0.014	0.014
Mycobacterium tuberculosis	Conserved protein	0.011	0.0174	0.0277
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0042	0.0999
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.0159
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0036	0.0045	0.1376
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0115	0.6578
Trypanosoma cruzi	cysteine protease, putative	0.0018	0.0012	0.053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0036	0.0045	0.0018
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0012	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0022	0.023
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.011	0.0174	0.0277
Brugia malayi	hypothetical protein	0.0016	0.0009	0.0029
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0124	0.0198	0.0308
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0054	0.0054
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0012	0.0044
Echinococcus multilocularis	cathepsin L	0.0018	0.0012	0.0012
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0024	0.0882
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0042	0.0159
Trichomonas vaginalis	penicillin-binding protein, putative	0.011	0.0174	0.3915
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0115	1
Plasmodium vivax	vivapain-1	0.0018	0.0012	0.0656
Entamoeba histolytica	acyl-coA synthetase, putative	0.0124	0.0198	0.6228
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.0207	0.0207
Onchocerca volvulus		0.0035	0.0042	0.0414
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0022	0.008
Schistosoma mansoni	hypothetical protein	0.004	0.0051	0.0051
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.011	0.0174	0.0668
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.0723
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0042	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0069	0.0069
Brugia malayi	CHE-14 protein	0.0041	0.0054	0.0203
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0036	0.0045	0.0018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0042	0.0042
Toxoplasma gondii	ABC1 family protein	0.011	0.0174	1
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0042	0.0414
Echinococcus granulosus	tumor protein p63	0.1379	0.2412	0.2412
Echinococcus granulosus	beta LACTamase domain containing family member	0.011	0.0174	0.0174
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0042	0.0042
Onchocerca volvulus		0.0202	0.0337	0.6395
Entamoeba histolytica	hypothetical protein	0.0187	0.0311	1
Onchocerca volvulus		0.011	0.0174	0.3096
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0037	0.0852
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0037	0.0037
Leishmania major	cathepsin L-like protease	0.0035	0.0042	0.0957
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.0207	0.0207
Brugia malayi	hypothetical protein	0.1483	0.2595	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0069	0.0066
Onchocerca volvulus		0.0036	0.0045	0.0462
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0022	0.023
Plasmodium vivax	unspecified product	0.0018	0.0012	0.0656
Onchocerca volvulus		0.0035	0.0042	0.0414
Toxoplasma gondii	hypothetical protein	0.0026	0.0027	0.0198
Mycobacterium tuberculosis	Probable lipase LipE	0.011	0.0174	0.0277
Trypanosoma cruzi	cruzipain precursor, putative	0.0133	0.0215	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0115	0.6056
Mycobacterium ulcerans	lipase LipD	0.011	0.0174	0.0259
Echinococcus multilocularis	tumor protein p63	0.1379	0.2412	0.2412
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0069	0.0069
Loa Loa (eye worm)	cysteine protease	0.0035	0.0042	0.0159
Echinococcus multilocularis	protein patched	0.0041	0.0054	0.0054
Echinococcus multilocularis	cysteine protease	0.0035	0.0042	0.0042
Echinococcus multilocularis	expressed conserved protein	0.0091	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.1483	0.2595	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.011	0.0174	0.0259
Leishmania major	cathepsin L-like protease	0.0035	0.0042	0.0957
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0054	0.0054
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.011	0.0174	0.0277
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0115	0.0115
Plasmodium vivax	acyl-CoA synthetase, putative	0.0092	0.0143	0.8222
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Brugia malayi	beta-lactamase	0.011	0.0174	0.0668
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0139	0.0225	0.0225
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0151	0.0577
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0124	0.0198	0.0342
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.004	0.0051	0.0051
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0115	0.6056
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.008
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0024	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0143	0.0549
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Brugia malayi	hypothetical protein	0.0025	0.0024	0.0088
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0042	0.0999
Plasmodium vivax	hypothetical protein, conserved	0.011	0.0174	1
Brugia malayi	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Onchocerca volvulus		0.0036	0.0045	0.0462
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Plasmodium falciparum	acyl-CoA synthetase	0.0092	0.0143	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0036	0.0045	0.0018
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0036	0.0045	0.0168
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0124	0.0198	0.6228
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0024	0.0882
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0124	0.0198	0.0308
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.007	0.0266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0115	0.0141
Schistosoma mansoni	transcription factor LCR-F1	0.0187	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0042	0.0723
Mycobacterium leprae	Probable lipase LipE	0.011	0.0174	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0133	0.0215	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.011	0.0174	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0037	0.0138
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0115	0.0115
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0069	0.0083
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0042	0.0042
Plasmodium vivax	SET domain protein, putative	0.0032	0.0037	0.2062
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0198	0.0761
Plasmodium vivax	vivapain-2	0.0035	0.0042	0.2381
Loa Loa (eye worm)	hypothetical protein	0.011	0.0174	0.0668
Leishmania major	acetyl-CoA synthetase, putative	0.0036	0.0045	0.108
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0153	0.0153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1213024

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1171228