Detailed information for compound 1187114

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 238.283 | Formula: C12H18N2O3
  • H donors: 2 H acceptors: 4 LogP: -0.86 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(CCO)CCC(=O)c1ccncc1
  • InChi: 1S/C12H18N2O3/c15-9-7-14(8-10-16)6-3-12(17)11-1-4-13-5-2-11/h1-2,4-5,15-16H,3,6-10H2
  • InChiKey: FQVASFUIUJNSIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0092 0.5371
Trichomonas vaginalis set domain proteins, putative 0.0255 0.0356 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0011 0.0581
Echinococcus granulosus Smad4 0.0018 0.0003 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0497 0.0715 0.2057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0094 0.0093
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0001 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0932
Echinococcus granulosus lamin 0.0029 0.002 0.0019
Echinococcus multilocularis lamin dm0 0.0029 0.002 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0044 0.1742
Echinococcus multilocularis GPCR, family 2 0.0034 0.0028 0.0027
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0092 0.0091
Brugia malayi intermediate filament protein 0.0029 0.002 0.0545
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0045 0.0044 0.0115
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0092 0.2513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0038 0.105
Schistosoma mansoni tar DNA-binding protein 0.0069 0.008 0.0079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0028 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Loa Loa (eye worm) hypothetical protein 0.0074 0.0087 0.2368
Brugia malayi MH2 domain containing protein 0.0018 0.0003 0.0091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Brugia malayi Pre-SET motif family protein 0.0032 0.0025 0.067
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0092 0.2576
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.002 0.0545
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0092 0.0255
Brugia malayi beta-lactamase family protein 0.0078 0.0092 0.2513
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.0365 0.9932
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0025 0.0024
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 1
Plasmodium falciparum thioredoxin reductase 0.0045 0.0044 0.1227
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 0.0662
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2351 0.3467 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0932
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0057 0.1539
Loa Loa (eye worm) hypothetical protein 0.0109 0.0138 0.3754
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0092 0.0255
Mycobacterium leprae Probable lipase LipE 0.0078 0.0092 0.0255
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0045 0.0044 0.1227
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0044 0.1742
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0173 0.0233 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0368 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0092 0.0255
Toxoplasma gondii ABC1 family protein 0.0078 0.0092 0.3463
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0092 0.0255
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0045 0.0044 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Plasmodium falciparum glutathione reductase 0.0045 0.0044 0.1227
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0173 0.0233 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0028 0.0027
Brugia malayi hypothetical protein 0.0018 0.0003 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0018 0.0985
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0138 0.3754
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0049 0.2808
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0049 0.0048
Leishmania major hypothetical protein, conserved 0.0078 0.0092 0.5371
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0044 0.254
Mycobacterium tuberculosis Conserved protein 0.0078 0.0092 0.0255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0094 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0299 0.042 0.1201
Mycobacterium tuberculosis Probable oxidoreductase 0.0332 0.047 0.1347
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0028 0.0758
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0044 0.254
Schistosoma mansoni tar DNA-binding protein 0.0069 0.008 0.0079
Schistosoma mansoni smad 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0092 0.0255
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.2808
Brugia malayi hypothetical protein 0.0263 0.0368 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0131 0.0171 0.0483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0045 0.0044 0.1227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0025 0.068
Schistosoma mansoni tar DNA-binding protein 0.0069 0.008 0.0079
Loa Loa (eye worm) glutathione reductase 0.0131 0.0171 0.4656
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0173 0.0233 0.0232
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0113 0.0145 0.0407
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0028 0.0027
Onchocerca volvulus 0.0078 0.0092 0.2156
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0045 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Echinococcus granulosus GPCR family 2 0.0034 0.0028 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0049 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0003 0.0002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Toxoplasma gondii thioredoxin reductase 0.0131 0.0171 0.7117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0092 0.0255
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Schistosoma mansoni peptidase Clp (S14 family) 0.0173 0.0233 0.0232
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0025 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0092 0.2576
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0091
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0299 0.042 0.1204
Schistosoma mansoni hypothetical protein 0.0074 0.0087 0.0086
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0023 0.0022
Echinococcus granulosus thioredoxin glutathione reductase 0.0132 0.0173 0.0172
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0181 0.018
Trichomonas vaginalis mercuric reductase, putative 0.0045 0.0044 0.1218
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Mycobacterium tuberculosis Probable reductase 0.0299 0.042 0.1204
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0092 0.5371
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0045 0.0044 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0932
Leishmania major hypothetical protein, conserved 0.0028 0.0018 0.0985
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.2808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Mycobacterium tuberculosis Probable dehydrogenase 0.0299 0.042 0.1204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0092 0.0091
Echinococcus multilocularis tumor protein p63 0.1472 0.2163 0.2162
Echinococcus multilocularis smad 0.0018 0.0003 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0198 0.0197
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2351 0.3467 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0113 0.0145 0.0407
Toxoplasma gondii NADPH-glutathione reductase 0.0045 0.0044 0.1227
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0044 0.254
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.002 0.0545
Leishmania major trypanothione reductase 0.0131 0.0171 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0018 0.0985
Plasmodium falciparum thioredoxin reductase 0.0131 0.0171 0.7117
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0003 0.0002
Loa Loa (eye worm) beta-lactamase 0.0078 0.0092 0.2513
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0045 0.0044 0.254
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0332 0.047 0.1347
Onchocerca volvulus 0.0216 0.0297 0.8238
Loa Loa (eye worm) hypothetical protein 0.0173 0.0233 0.6346
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0003 0.0091
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0131 0.0171 0.7117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0932
Mycobacterium ulcerans hypothetical protein 0.0078 0.0092 0.0255
Brugia malayi RNA binding protein 0.0069 0.008 0.2165
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0092 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0092 0.2576
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0092 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0131 0.0171 0.4656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0019 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0029 0.002 0.0545
Schistosoma mansoni intermediate filament proteins 0.0029 0.002 0.0019
Treponema pallidum NADH oxidase 0.0045 0.0044 0.1742
Mycobacterium ulcerans transcriptional regulator 0.2351 0.3467 1
Schistosoma mansoni cellular tumor antigen P53 0.0216 0.0297 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0003 0.0002
Echinococcus granulosus lamin dm0 0.0029 0.002 0.0019
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0173 0.0233 0.0232
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0034 0.1947
Trichomonas vaginalis esterase, putative 0.0078 0.0092 0.2576
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0018 0.0985
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0034 0.1947
Echinococcus multilocularis ferritin 0.0018 0.0004 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0045 0.0044 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0092 0.0255
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 1
Brugia malayi Smad1 0.0018 0.0003 0.0091
Echinococcus granulosus ferritin 0.0018 0.0004 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0045 0.0044 0.1203
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.0065 0.266
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0025 0.0024
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.0091
Plasmodium vivax glutathione reductase, putative 0.0131 0.0171 0.7117
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0045 0.0044 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0019 0.0519
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0092 0.2576
Onchocerca volvulus 0.0078 0.0092 0.2156
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.0368 0.0367
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Brugia malayi MH2 domain containing protein 0.0262 0.0365 0.9932
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0049 0.2808
Schistosoma mansoni tar DNA-binding protein 0.0069 0.008 0.0079
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0026 0.0717
Brugia malayi Thioredoxin reductase 0.0131 0.0171 0.4656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0092 0.2576
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0299 0.042 0.1204
Brugia malayi glutathione reductase 0.0131 0.0171 0.4656
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0002
Toxoplasma gondii hypothetical protein 0.006 0.0065 0.2202
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0523
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0173 0.0233 0.0662
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0034 0.1947
Echinococcus multilocularis Smad4 0.0018 0.0003 0.0002
Echinococcus granulosus tumor protein p63 0.1472 0.2163 0.2162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0034 0.0932
Mycobacterium ulcerans TetR family transcriptional regulator 0.2351 0.3467 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0332 0.047 0.1344
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.008 0.2165
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0094 0.0093
Schistosoma mansoni survival motor neuron protein 0.0054 0.0057 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Plasmodium falciparum glutathione reductase 0.0131 0.0171 0.7117
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0045 0.0044 0.254
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0045 0.0044 0.254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.003 0.0584
Onchocerca volvulus 0.0032 0.0025 0.0137
Brugia malayi TAR-binding protein 0.0069 0.008 0.2165
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0003 0.0002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 0.0662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.031 0.8426
Echinococcus granulosus tar DNA binding protein 0.0069 0.008 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0198 0.0197
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0545
Echinococcus multilocularis tar DNA binding protein 0.0069 0.008 0.0079
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0181 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0131 0.0171 1
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0087 0.2368
Loa Loa (eye worm) RNA binding protein 0.0069 0.008 0.2165
Echinococcus granulosus peptidase Clp S14 family 0.0113 0.0145 0.0144
Onchocerca volvulus 0.0255 0.0356 1
Echinococcus multilocularis musashi 0.0029 0.002 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0028 0.0758
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0483
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.0365 0.9932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0045 0.0044 0.1227
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0025 0.0319
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0065 0.2202
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0299 0.042 0.1204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0138 0.3754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0024 0.0636
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0045 0.0044 0.254
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0054 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0028 0.0758
Mycobacterium tuberculosis Conserved protein 0.0078 0.0092 0.0255
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0045 0.0044 0.1227
Entamoeba histolytica hypothetical protein 0.0079 0.0094 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0049 0.2808
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0026 0.0717
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0025 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0092 0.3463
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0003 0.0091
Trichomonas vaginalis ferritin, putative 0.0018 0.0004 0.0094
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0092 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Onchocerca volvulus 0.0054 0.0057 0.1089
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0044 0.254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0007 0.0338
Entamoeba histolytica hypothetical protein 0.0079 0.0094 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.008 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0028 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.067
Echinococcus multilocularis expressed protein 0.0018 0.0004 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0092 0.2513
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.0198 0.0197
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0002
Brugia malayi beta-lactamase family protein 0.0078 0.0092 0.2513
Loa Loa (eye worm) Smad1 0.0018 0.0003 0.0091
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0044 0.254
Brugia malayi hypothetical protein 0.0079 0.0094 0.2554
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0173 0.0233 1
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Entamoeba histolytica hypothetical protein 0.0079 0.0094 1
Schistosoma mansoni hypothetical protein 0.0034 0.0028 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.0368 0.0367
Mycobacterium ulcerans lipase LipD 0.0078 0.0092 0.0255
Schistosoma mansoni hypothetical protein 0.0079 0.0094 0.0093
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0113 0.0145 0.0406
Onchocerca volvulus 0.0078 0.0092 0.2156
Brugia malayi Probable ClpP-like protease 0.0173 0.0233 0.6346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0092 0.5371
Schistosoma mansoni Smad4 0.0018 0.0003 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0138 0.3754
Echinococcus multilocularis peptidase Clp (S14 family) 0.0113 0.0145 0.0144
Echinococcus multilocularis lamin 0.0029 0.002 0.0019
Echinococcus granulosus intermediate filament protein 0.0029 0.002 0.0019
Mycobacterium ulcerans beta-lactamase 0.0078 0.0092 0.0255
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0173 0.0233 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0332 0.047 0.1347
Schistosoma mansoni hypothetical protein 0.0138 0.0181 0.018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.006 0.0065 0.0176
Brugia malayi hypothetical protein 0.0028 0.0018 0.0483
Brugia malayi Pre-SET motif family protein 0.0224 0.031 0.8426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0044 0.254
Loa Loa (eye worm) hypothetical protein 0.0078 0.0092 0.2513
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0003 0.0002
Brugia malayi beta-lactamase 0.0078 0.0092 0.2513
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0065 0.2202
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0132 0.0173 0.0172
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.008 0.2165
Trypanosoma brucei trypanothione reductase 0.0131 0.0171 1
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0092 0.0255
Giardia lamblia GTOR 0.0048 0.0049 1
Echinococcus granulosus expressed protein 0.0018 0.0004 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0069 0.008 0.2165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0299 0.042 0.1204
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Brugia malayi MH2 domain containing protein 0.0018 0.0003 0.0091
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0045 0.0044 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0028 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0045 0.0044 0.1227
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2346 0.346 1
Echinococcus granulosus smad 0.0018 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0079 0.0094 1
Trichomonas vaginalis glutathione reductase, putative 0.0045 0.0044 0.1218
Plasmodium vivax SET domain protein, putative 0.0032 0.0025 0.0319
Mycobacterium tuberculosis Conserved protein 0.0078 0.0092 0.0255
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0216 0.0297 0.8068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.003 0.0827
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0049 0.2808
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0049 0.1327

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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