Detailed information for compound 1192553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 374.459 | Formula: C21H18N4OS
  • H donors: 2 H acceptors: 3 LogP: 4 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CNc2c(C(=O)N1)sc1c2c2ccc(nc2cc1)c1ccc(nc1)C
  • InChi: 1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1
  • InChiKey: CMWRPDHVGMHLSZ-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Brugia malayi ABC transporter transmembrane region family protein ATP-binding cassette, sub-family B (MDR/TAP), member 11 1321 aa 1106 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0316 0.0179
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.9702 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2461 0.2457
Plasmodium falciparum thioredoxin reductase 0.0055 0.1168 1
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0432 0.0299
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0153 0.0016
Schistosoma mansoni hypothetical protein 0.0364 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0432 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.1021 0.0918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0794 0.0788
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2461 0.2457
Loa Loa (eye worm) hypothetical protein 0.0025 0.0316 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.4381 0.4434
Schistosoma mansoni hypothetical protein 0.0029 0.0415 0.041
Onchocerca volvulus 0.0045 0.0898 0.0695
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0794 0.0666
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0775 0.0517
Schistosoma mansoni smad1 5 8 and 0.0019 0.0137 0.0131
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.1168 0.1045
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0354 0.9702 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0792 0.0664
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1117 0.0993
Mycobacterium tuberculosis Conserved protein 0.0042 0.0794 0.0918
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.2268 0.216
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0794 0.0704
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.1168 0.1071
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.3573 0.4845
Loa Loa (eye worm) hypothetical protein 0.0028 0.0387 0.0342
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.2461 0.2357
Mycobacterium ulcerans hypothetical protein 0.0042 0.0794 0.136
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0206 0.0065
Trypanosoma brucei polo-like protein kinase 0.0093 0.2255 0.2208
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0206 0.0065
Brugia malayi MH2 domain containing protein 0.0019 0.0137 0.0184
Entamoeba histolytica hypothetical protein 0.0029 0.0432 0.0303
Echinococcus granulosus intermediate filament protein 0.0059 0.1294 0.1173
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0418 0.0285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1117 0.1337
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.3175 0.6646
Onchocerca volvulus 0.0272 0.7364 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0206 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0794 0.1064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0692 0.0398
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0144 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Loa Loa (eye worm) transcription factor SMAD2 0.0275 0.7465 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.1021 0.0918
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0432 0.1735
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1547 0.1519
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0794 0.0704
Brugia malayi MH2 domain containing protein 0.0275 0.7465 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.2268 0.216
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0794 0.0918
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1117 0.0993
Echinococcus multilocularis lamin dm0 0.0059 0.1294 0.1173
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0587 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0432 0.0312
Mycobacterium ulcerans lipase LipD 0.0042 0.0794 0.136
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.2255 0.2147
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.7222 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0794 0.0918
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.3175 0.4282
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0206 0.0815
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0508 0.0681
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.1168 0.1045
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.3175 0.4282
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0415 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1117 0.1111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0387 0.0342
Toxoplasma gondii ABC1 family protein 0.0042 0.0794 0.3209
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0206 0.0065
Echinococcus multilocularis geminin 0.0364 1 1
Onchocerca volvulus 0.003 0.0456 0.0059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.1294 0.1579
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0153 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Leishmania major trypanothione reductase 0.0055 0.1168 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi Thioredoxin reductase 0.0055 0.1168 0.1564
Schistosoma mansoni Smad4 0.0019 0.0137 0.0131
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0734 0.0605
Toxoplasma gondii melibiase subfamily protein 0.01 0.2461 1
Schistosoma mansoni ap endonuclease 0.0019 0.0153 0.0147
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.4381 0.4434
Onchocerca volvulus 0.0059 0.1294 0.1265
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0508 0.0506
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0794 0.068
Brugia malayi PHD-finger family protein 0.0029 0.0415 0.0556
Echinococcus granulosus lamin dm0 0.0059 0.1294 0.1173
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0794 0.136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0415 0.265
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0153 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi jmjC domain containing protein 0.0093 0.2268 0.3038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.058 0.0449
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0794 0.0704
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0218 0.5819 0.7753
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.5819 0.5816
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0794 0.0666
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0415 0.1667
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.6422 0.8576
Entamoeba histolytica hypothetical protein 0.0042 0.0792 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0923 0.0844
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1117 0.1111
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0153 0.0087
Mycobacterium ulcerans beta-lactamase 0.0042 0.0794 0.136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.4921 0.675
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Mycobacterium ulcerans hypothetical protein 0.0186 0.4921 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0153 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0692 0.0593
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1547 0.1924
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0794 0.0704
Echinococcus multilocularis lamin 0.0059 0.1294 0.1173
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0794 0.0918
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.2255 0.2279
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0206 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1547 0.1519
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi MH2 domain containing protein 0.0019 0.0137 0.0184
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0153 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.058 0.0574
Schistosoma mansoni smad1 5 8 and 0.0019 0.0137 0.0131
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2461 0.2457
Giardia lamblia GTOR 0.0021 0.0206 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Entamoeba histolytica hypothetical protein 0.0042 0.0792 0.0693
Onchocerca volvulus 0.0155 0.4034 0.5208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0794 0.0897
Trichomonas vaginalis set domain proteins, putative 0.0272 0.7364 0.7821
Loa Loa (eye worm) hypothetical protein 0.0038 0.0692 0.0757
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0206 0.0058
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.3573 0.4845
Schistosoma mansoni hypothetical protein 0.0042 0.0792 0.0786
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0587 0.0614
Toxoplasma gondii hypothetical protein 0.0057 0.123 0.4986
Echinococcus granulosus peregrin 0.0029 0.0415 0.0282
Loa Loa (eye worm) glutathione reductase 0.0055 0.1168 0.1406
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2255 0.2208
Echinococcus multilocularis musashi 0.0059 0.1294 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Brugia malayi Smad1 0.0019 0.0137 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1117 0.0993
Brugia malayi Heterochromatin protein 1 0.0068 0.1547 0.2072
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0218 0.5819 0.5761
Loa Loa (eye worm) hypothetical protein 0.0029 0.0415 0.038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0153 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0207 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.058 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Echinococcus granulosus chromobox protein 1 0.0068 0.1547 0.1429
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0144 0.0562
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.2255 0.2647
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0206 0.007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.058 0.2335
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0153 0.0205
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.1294 0.1734
Brugia malayi Bromodomain containing protein 0.0029 0.0415 0.0556
Onchocerca volvulus 0.0042 0.0794 0.0545
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0206 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0206 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0206 0.0276
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0206 0.02
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0144 0.0562
Schistosoma mansoni smad1 5 8 and 0.0019 0.0137 0.0131
Plasmodium falciparum glutathione reductase 0.0055 0.1168 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0206 0.0065
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0587 0.0581
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0206 0.0065
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0206 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.4376 0.8858
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0207 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0775 0.0683
Onchocerca volvulus 0.0059 0.1294 0.1265
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.2255 0.3021
Echinococcus granulosus lamin 0.0059 0.1294 0.1173
Loa Loa (eye worm) hypothetical protein 0.0029 0.0418 0.0384
Brugia malayi Melibiase family protein 0.0067 0.1509 0.2021
Loa Loa (eye worm) hypothetical protein 0.0155 0.4034 0.5318
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.1332 0.1243
Brugia malayi Pre-SET motif family protein 0.0239 0.6422 0.8602
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0206 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.2255 0.2208
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0137 0.0131
Brugia malayi beta-lactamase family protein 0.0042 0.0794 0.1064
Schistosoma mansoni kinase 0.0048 0.0958 0.0952
Loa Loa (eye worm) MH2 domain-containing protein 0.0275 0.7465 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.1547 0.1429
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0153 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.1021 0.0918
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0898 0.0892
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0153 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.058 0.0574
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0792 0.0664
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1117 0.0993
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.9702 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1117 0.1496
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.2461 0.2357
Brugia malayi intermediate filament protein 0.0059 0.1294 0.1734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0794 0.068
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0794 0.0704
Loa Loa (eye worm) beta-lactamase 0.0042 0.0794 0.0897
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.3573 0.7759
Plasmodium vivax SET domain protein, putative 0.0034 0.058 0.4254
Schistosoma mansoni lamin 0.0059 0.1294 0.1289
Loa Loa (eye worm) intermediate filament protein 0.0059 0.1294 0.1579
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.1168 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0794 0.0918
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.4376 0.5979
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.058 0.0449
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0206 0.0276
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0153 0.0009
Schistosoma mansoni intermediate filament proteins 0.0059 0.1294 0.1289
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0153 0.001
Echinococcus multilocularis chromobox protein 1 0.0068 0.1547 0.1429
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0167 0.4376 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1509 0.1872
Onchocerca volvulus 0.0042 0.0794 0.0545
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1282 0.1563
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0432 0.0301
Brugia malayi glutathione reductase 0.0055 0.1168 0.1564
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0794 0.6349
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0544 0.0412
Giardia lamblia PHD finger protein 15 0.0029 0.0415 0.0294
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0794 0.0918
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0144 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi hypothetical protein 0.0042 0.0792 0.1061
Brugia malayi map kinase activated protein kinase protein 2 0.0218 0.5819 0.7795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0415 0.0282
Schistosoma mansoni jumonji domain containing protein 0.0074 0.172 0.1715
Brugia malayi hypothetical protein 0.0155 0.4034 0.5404
Schistosoma mansoni lamin 0.0059 0.1294 0.1289
Entamoeba histolytica hypothetical protein 0.0042 0.0792 0.0693
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.3175 0.4282
Giardia lamblia Kinase, PLK 0.0093 0.2255 0.2286
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0206 0.0065
Toxoplasma gondii exonuclease III APE 0.0019 0.0153 0.0598
Leishmania major mitochondrial DNA polymerase beta 0.0354 0.9702 1
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.2255 0.225
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.058 0.0449
Echinococcus granulosus chromobox protein 1 0.0068 0.1547 0.1429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0794 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Brugia malayi MH1 domain containing protein 0.0019 0.0137 0.0184
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0432 0.0301
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.2255 0.2147
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0373 0.0248
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0418 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0456 0.0436
Onchocerca volvulus 0.0042 0.0794 0.0545
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.1168 0.1406
Echinococcus granulosus jumonji domain containing protein 0.004 0.0734 0.0605
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0415 0.041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.3175 0.4282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.058 0.0574
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2461 0.2457
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.2255 0.289
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.1509 0.1478
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0794 0.136
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0153 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0153 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi jmjC domain containing protein 0.0035 0.0587 0.0786
Plasmodium falciparum phd finger protein, putative 0.0029 0.0415 0.265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.4381 0.4434
Leishmania major hypothetical protein, conserved 0.0042 0.0794 0.068
Schistosoma mansoni ap endonuclease 0.0019 0.0153 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.3573 0.4845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1117 0.1111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0794 0.0918
Toxoplasma gondii thioredoxin reductase 0.0055 0.1168 0.4731
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.3175 0.4282
Schistosoma mansoni chromobox protein 0.0068 0.1547 0.1542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0144 0.5
Brugia malayi beta-lactamase 0.0042 0.0794 0.1064
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0218 0.5819 0.5761
Schistosoma mansoni chromobox protein 0.0068 0.1547 0.1542
Echinococcus multilocularis peregrin 0.0029 0.0415 0.0282
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0415 0.1667
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0153 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0587 0.0456
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0206 0.0058
Treponema pallidum fructose-bisphosphate aldolase 0.0342 0.9376 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0144 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0692 0.0593
Brugia malayi MH1 domain containing protein 0.0019 0.0137 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0206 0.0065
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0342 0.9376 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0432 0.0579
Mycobacterium tuberculosis Conserved protein 0.0042 0.0794 0.0918
Loa Loa (eye worm) hypothetical protein 0.0058 0.1263 0.1537
Schistosoma mansoni smad 0.0019 0.0137 0.0131
Plasmodium vivax glutathione reductase, putative 0.0055 0.1168 1
Trichomonas vaginalis esterase, putative 0.0042 0.0794 0.0704
Brugia malayi beta-lactamase family protein 0.0042 0.0794 0.1064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0794 0.0788
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.2255 0.2208
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0206 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Mycobacterium tuberculosis Conserved protein 0.0042 0.0794 0.0918
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0206 0.02
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1509 0.1503
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0144 0.0193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0153 0.0009
Giardia lamblia Fructose-bisphosphate aldolase 0.0342 0.9376 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0794 0.0897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0587 0.0581
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0775 0.0683
Loa Loa (eye worm) hypothetical protein 0.0059 0.1294 0.1579
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0153 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0792 0.0786
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0206 0.007
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0206 0.0065
Brugia malayi chromobox protein homolog 3 0.0038 0.0692 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0997 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0342 0.9376 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.2255 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0432 0.0426
Trypanosoma brucei trypanothione reductase 0.0055 0.1168 0.1071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1509 0.1503
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0206 0.0065
Brugia malayi Pre-SET motif family protein 0.0034 0.058 0.0776
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0206 0.0065
Entamoeba histolytica hypothetical protein 0.0042 0.0792 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0206 0.007
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0206 0.0065
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.1021 0.0918
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.2461 0.2357
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0415 0.038
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0794 0.068
Mycobacterium tuberculosis Probable reductase 0.0125 0.3175 0.4282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0206 0.0067
Schistosoma mansoni hypothetical protein 0.0364 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0373 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0923 0.0844
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.1168 0.1446

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 201 nM Inhibition of MK2 in human U937 cells assessed as reduction in LPS-stimulated HSP27 phosphorylation at Ser82 preincubated for 1 hr followed by LPS addition measured after 30 mins by Western blot analysis ChEMBL. 26502061
IC50 (binding) = 0.005 uM Binding affinity to recombinant MAPKAP-K2 using KKKALSRQLSVAA as substrate after 4 mins by surface plasmon resonance spectroscopic analysis ChEMBL. 22746295
IC50 (binding) = 7 uM Inhibition of human BSEP expressed in recombinant baculovirus infected insect Sf9 cell membrane vesicles assessed as [3H]-taurocholate transport preincubated for 5 mins followed by ATP or AMP addition measured after 5 mins by scintillation counting method ChEMBL. 26502061
Ki (binding) = 5 nM Inhibition of recombinant MK2 (45 to 400 residues) (unknown origin) using fluorescein isothiocyanate-KKKALSRQLSVAA as substrate LITERATURE. 28280261

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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