Detailed information for compound 1196825

Basic information

Technical information
  • TDR Targets ID: 1196825
  • Name: STK096729
  • MW: 255.355 | Formula: C17H21NO
  • H donors: 0 H acceptors: 1 LogP: 4.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1ccc(nc1)c1ccc(cc1)OC
  • InChi: 1S/C17H21NO/c1-3-4-5-6-14-7-12-17(18-13-14)15-8-10-16(19-2)11-9-15/h7-13H,3-6H2,1-2H3
  • InChiKey: HVCJMCBYJRJDTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-Methoxy-phenyl)-5-pentyl-pyridine
  • BAS 01123654
  • MLS000711784
  • SMR000281551
  • ZINC02495203

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 7 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K08596 sentrin-specific protease 7, putative Get druggable targets OG5_131076 All targets in OG5_131076
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_131076 All targets in OG5_131076
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0705 0.0992
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0444 0.1127
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0469 0.404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0469 0.404
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.116 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.116 1
Toxoplasma gondii hypothetical protein 0.0031 0.0456 0.0695
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0087 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Onchocerca volvulus 0.0016 0.0087 0.0191
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0565 0.4866
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0256 0.1378
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.186 0.2833
Toxoplasma gondii sugar transporter ST2 0.0014 0.0059 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0472 0.0664
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2138 0.3256
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0256 0.1378
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Leishmania major glucose transporter, lmgt1 0.0032 0.0469 0.3723
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0472 0.0472
Loa Loa (eye worm) sugar transporter 0.0014 0.0059 0.0083
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0258 0.1389
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0705 0.1787
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Plasmodium vivax sentrin-specific protease 1, putative 0.0016 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0705 0.0992
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0705 0.1084
Brugia malayi Sugar transporter family protein 0.0014 0.0059 0.0083
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0016 0.0087 0.0753
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0705 0.0992
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0444 0.0625
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0256 0.065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Brugia malayi beta-lactamase family protein 0.0042 0.0705 0.0992
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1027 0.2604
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0059 0.0083
Trichomonas vaginalis Sentrin-specific protease, putative 0.0016 0.0087 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0705 0.1787
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0472 0.0719
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0565 0.4592
Mycobacterium tuberculosis Conserved protein 0.0042 0.0705 0.1084
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.116 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0456 0.2453
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0469 0.066
Plasmodium falciparum sentrin-specific protease 1 0.0016 0.0087 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0469 0.066
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0258 0.0364
Echinococcus multilocularis solute carrier family 22 0.0014 0.0059 0.0149
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0178 0.3943 1
Schistosoma mansoni glucose transport protein 0.0102 0.2138 0.5422
Leishmania major hypothetical protein, conserved 0.0042 0.0705 0.5863
Loa Loa (eye worm) Ulp1 protease 0.0016 0.0087 0.0123
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Brugia malayi Cam kinase protein 1 0.0032 0.0472 0.0664
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0472 0.1197
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0444 0.1127
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) hypothetical protein 0.009 0.186 0.2619
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0222
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0472 0.0472
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0016 0.0087 0.047
Schistosoma mansoni ap endonuclease 0.0023 0.0256 0.065
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0059 0.0089
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0256 0.0256
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0469 0.066
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0258 0.1389
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0705 0.1084
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.186 0.186
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0258 0.0656
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0256 0.2209
Onchocerca volvulus 0.0042 0.0705 0.1544
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0123
Onchocerca volvulus 0.0014 0.0059 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0705 0.6072
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0087 0.0123
Echinococcus granulosus sentrin specific protease 1 0.0016 0.0087 0.0222
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0258 0.2228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0444 0.0625
Loa Loa (eye worm) sugar transporter 0.0102 0.2138 0.3009
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0258 0.1814
Mycobacterium ulcerans lipase LipD 0.0042 0.0705 0.3787
Plasmodium falciparum hexose transporter 0.0102 0.2138 0.2138
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Leishmania major glucose transporter, lmgt2 0.0032 0.0469 0.3723
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0123
Toxoplasma gondii exonuclease III APE 0.0023 0.0256 0.039
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0025 0.0308 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0705 0.6072
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.116 0.1633
Leishmania major glucose transporter, lmgt3 0.0032 0.0469 0.3723
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.186 0.4719
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0016 0.0087 0.047
Plasmodium vivax hexose transporter 0.0102 0.2138 0.2138
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0472 0.0472
Onchocerca volvulus 0.0014 0.0059 0.0128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0456 0.0456
Trypanosoma brucei glucose transporter 2A 0.0032 0.0469 0.404
Echinococcus granulosus solute carrier family 22 0.0014 0.0059 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Loa Loa (eye worm) beta-lactamase 0.0042 0.0705 0.0992
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0087 0.0133
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.116 0.1633
Echinococcus multilocularis solute carrier family 22 0.0014 0.0059 0.0149
Echinococcus multilocularis sentrin specific protease 7 0.0178 0.3943 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.1122 0.1785
Giardia lamblia Sugar-proton symporter 0.0014 0.0059 0.0505
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.116 0.2943
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1027 0.2604
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0059 0.0505
Toxoplasma gondii ABC1 family protein 0.0042 0.0705 0.1073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2604
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.186 0.186
Echinococcus granulosus expressed conserved protein 0.0163 0.3574 0.9064
Mycobacterium ulcerans beta-lactamase 0.0042 0.0705 0.3787
Plasmodium vivax sugar transporter, putative 0.0014 0.0059 0.0059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1027 0.1445
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.116 0.2943
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Echinococcus multilocularis sentrin specific protease 1 0.0016 0.0087 0.0222
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0258 0.0394
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Toxoplasma gondii sugar transporter ST3 0.0014 0.0059 0.0089
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0177 0.0952
Onchocerca volvulus 0.0014 0.0059 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1027 0.2604
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0059 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2138 0.3009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0258 0.0364
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0222
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0129 0.1108
Plasmodium vivax sentrin-specific protease 2, putative 0.0016 0.0087 0.0087
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.4564 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0472 0.1197
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0705 0.1084
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0705 0.3787
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0705 0.0992
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0256 0.0361
Brugia malayi hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0256 0.0361
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0472 0.0664
Echinococcus multilocularis solute carrier family 22 0.0014 0.0059 0.0149
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0059 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis esterase, putative 0.0042 0.0705 0.0992
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0705 0.1084
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0469 0.3723
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0444 0.1127
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.116 0.1633
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1027 0.2604
Brugia malayi major facilitator superfamily protein 0.0014 0.0059 0.0083
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.186 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0565 0.4592
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0256 0.2209
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.116 0.2943
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.4825 0.6792
Echinococcus multilocularis General substrate transporter 0.0088 0.1798 0.456
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0087 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma brucei sugar transporter, putative 0.0014 0.0059 0.0505
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0565 0.0565
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0469 0.404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0087 0.0261
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0705 0.6072
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0565 0.0565
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0413 0.1049
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0444 0.0625
Onchocerca volvulus 0.0014 0.0059 0.0128
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0256 0.1794
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0059 0.0505
Loa Loa (eye worm) Ulp1 protease 0.0016 0.0087 0.0123
Schistosoma mansoni glucose transport protein 0.0102 0.2138 0.5422
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0472 0.0719
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0256 0.0361
Echinococcus granulosus General substrate transporter 0.0088 0.1798 0.456
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Echinococcus granulosus sentrin specific protease 8 0.0016 0.0087 0.0222
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Brugia malayi major facilitator superfamily protein 0.0014 0.0059 0.0083
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.186 0.2833
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0087 0.0133
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Brugia malayi Sugar transporter family protein 0.0014 0.0059 0.0083
Brugia malayi Sugar transporter family protein 0.0102 0.2138 0.3009
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0258 0.2228
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0705 0.0992
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.4825 0.6792
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0059 0.0315
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0256 0.2209
Schistosoma mansoni protein kinase 0.0032 0.0472 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0444 0.1127
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0256 0.065
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0016 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0705 0.0992
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0444 0.2388
Trypanosoma brucei glucose transporter 1E 0.0032 0.0469 0.404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0469 0.404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Brugia malayi MAP kinase sur-1 0.0061 0.116 0.1633
Onchocerca volvulus 0.0042 0.0705 0.1544
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.1122 0.6033
Onchocerca volvulus 0.0042 0.0705 0.1544
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0016 0.0087 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Giardia lamblia Hexose transporter 0.0014 0.0059 0.0505
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0059 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0705 0.3787
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0059 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0472 0.1197
Mycobacterium ulcerans hypothetical protein 0.0042 0.0705 0.3787
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0456 0.0456
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0469 0.404
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Onchocerca volvulus 0.0014 0.0059 0.0128
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.186 0.4719
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Brugia malayi beta-lactamase family protein 0.0042 0.0705 0.0992
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Schistosoma mansoni hypothetical protein 0.0102 0.2138 0.5422
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0469 0.066
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3641 0.3641
Schistosoma mansoni sugar transporter 0.0014 0.0059 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 0.0083
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0059 0.0149
Schistosoma mansoni protein kinase 0.0032 0.0472 0.1197
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.1122 0.1785
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3641 0.5544
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0177 0.0199
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0258 0.0656
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0256 0.0256
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0472 0.0472
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0472 0.0472
Brugia malayi hypothetical protein 0.0014 0.0059 0.0083
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.116 1
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0472 0.0664
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.1122 0.2847
Trypanosoma brucei protein kinase, putative 0.0061 0.116 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0705 0.0705
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0469 0.404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1027 0.1445
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0413 0.1049
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Onchocerca volvulus 0.0014 0.0059 0.0128
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.186 0.4719
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0256 0.0332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2604
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0256 0.2209
Onchocerca volvulus 0.0014 0.0059 0.0128
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.116 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0123
Trypanosoma cruzi hypothetical protein 0.0016 0.0087 0.0753
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.116 0.2943
Loa Loa (eye worm) hypothetical protein 0.0032 0.0472 0.0664
Loa Loa (eye worm) hypothetical protein 0.0042 0.0705 0.0992
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0444 0.0625
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.7104 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Echinococcus granulosus solute carrier family 22 0.0014 0.0059 0.0149
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0472 0.0664
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Echinococcus multilocularis sentrin specific protease 8 0.0016 0.0087 0.0222
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0565 0.086
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0469 0.066
Echinococcus granulosus solute carrier family 22 0.0014 0.0059 0.0149
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0472 0.4067
Onchocerca volvulus 0.0014 0.0059 0.0128
Schistosoma mansoni sugar transporter 0.0014 0.0059 0.0149
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0456 0.2453
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0059 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0705 0.1787
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0705 0.1084
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0258 0.1389
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0258 0.0656
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0258 0.0364
Onchocerca volvulus 0.0014 0.0059 0.0128
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0258 0.1389
Brugia malayi hypothetical protein 0.0014 0.0059 0.0083
Plasmodium falciparum protein kinase 7 0.0289 0.6567 0.6567
Onchocerca volvulus Putative transporter 0.0014 0.0059 0.0128
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Echinococcus granulosus sentrin specific protease 7 0.0178 0.3943 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 1 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3641 0.3641
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0472 0.0472
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0059 0.0083
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0472 0.0472
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0444 0.1127
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0059 0.0083
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0256 0.0361
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.6019 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Schistosoma mansoni sugar transporter 0.0014 0.0059 0.0149
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.1122 0.2847
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0177 0.0199
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0258 0.0656
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0472 0.0472
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0469 0.066
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 0.0083
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Schistosoma mansoni glucose transport protein 0.0102 0.2138 0.5422
Brugia malayi Probable ClpP-like protease 0.009 0.186 0.2619
Mycobacterium tuberculosis Conserved protein 0.0042 0.0705 0.1084
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0087 0.0222
Mycobacterium tuberculosis Conserved protein 0.0042 0.0705 0.1084
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0705 0.3787
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0059 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma brucei SUMO1/Ulp2, putative 0.0016 0.0087 0.0753
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0192 0.027
Entamoeba histolytica hypothetical protein 0.0023 0.0258 0.0656
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0059 0.0505
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0059 0.0315
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.116 0.1767
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0444 0.3829
Schistosoma mansoni ap endonuclease 0.0023 0.0256 0.065
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0059 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0059 0.0315
Brugia malayi beta-lactamase 0.0042 0.0705 0.0992
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2138 0.5422
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.186 1
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.116 0.1633
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0472 0.0719
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0258 0.2228
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0705 0.1084
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0472 0.1197
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.116 1
Toxoplasma gondii sugar transporter ST1 0.0014 0.0059 0.0089
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0256 0.1378
Entamoeba histolytica protein kinase, putative 0.0032 0.0472 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.116 1
Mycobacterium ulcerans sugar transporter 0.0014 0.0059 0.0315
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0087 0.0222
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0059 0.0315
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0059 0.0505
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.116 0.2943
Onchocerca volvulus 0.0014 0.0059 0.0128
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.7104 1
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0059 0.0083
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2138 0.5422
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0083
Schistosoma mansoni protein kinase 0.0032 0.0472 0.1197
Mycobacterium leprae Probable lipase LipE 0.0042 0.0705 0.3787
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0258 0.0258
Schistosoma mansoni sugar transporter 0.0014 0.0059 0.0149
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0178 0.3943 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0469 0.066
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0087 0.0123
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0565 0.4866
Trypanosoma cruzi hexose transporter 0.0032 0.0469 0.404
Toxoplasma gondii protein kinase, putative 0.0289 0.6567 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1027 0.2604
Echinococcus multilocularis expressed conserved protein 0.0163 0.3574 0.9064
Giardia lamblia Sentrin specific protease, putative 0.0016 0.0087 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.7104 1
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.116 0.1633
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0256 0.065
Leishmania major protein kinase, putative 0.0032 0.0472 0.3751
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.4564 0.6425
Echinococcus multilocularis solute carrier family 22 0.0014 0.0059 0.0149
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0472 0.0472
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0705 0.0992
Schistosoma mansoni glucose transporter 0.0014 0.0059 0.0149
Onchocerca volvulus 0.0014 0.0059 0.0128
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0444 0.0625
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0087 0.0753
Echinococcus granulosus solute carrier family 22 0.0014 0.0059 0.0149
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0565 0.4866
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0705 0.1084
Trypanosoma brucei glucose transporter, putative 0.0032 0.0469 0.404
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0705 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0059 0.0083
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0087 0.0222

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.32 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 37.2 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (functional) = 41.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2575, AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 80.5 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575, AID2582, AID434986] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.