Detailed information for compound 1208059

Basic information

Technical information
  • TDR Targets ID: 1208059
  • Name: N-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]met hyl]-2-[(2-methoxy-5,6,7,8-tetrahydronaphthal en-1-yl)oxy]ethanamine
  • MW: 369.454 | Formula: C22H27NO4
  • H donors: 1 H acceptors: 0 LogP: 4.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1OCCNC[C@@H]1COc3c(O1)cccc3)CCCC2
  • InChi: 1S/C22H27NO4/c1-24-21-11-10-16-6-2-3-7-18(16)22(21)25-13-12-23-14-17-15-26-19-8-4-5-9-20(19)27-17/h4-5,8-11,17,23H,2-3,6-7,12-15H2,1H3/t17-/m1/s1
  • InChiKey: QQNWVORTUJAROO-QGZVFWFLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-(6-methoxytetralin-5-yl)oxy-ethanamine
  • N-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-2-[(6-methoxy-5-tetralinyl)oxy]ethanamine
  • [(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-[2-(6-methoxytetralin-5-yl)oxyethyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0051 0.009 0.0115
Brugia malayi Pre-SET motif family protein 0.0087 0.0204 0.0255
Mycobacterium leprae PROBABLE TRANSFERASE 0.008 0.018 0.0209
Entamoeba histolytica ankyrin, putative 0.0083 0.019 0.0222
Schistosoma mansoni bromodomain containing protein 0.006 0.0119 0.0152
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0054 0.007
Echinococcus multilocularis carbonic anhydrase II 0.2511 0.7785 1
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0011 0.0014
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0011 0.0014
Brugia malayi jmjC domain containing protein 0.0098 0.0238 0.0299
Mycobacterium ulcerans integral membrane transporter 0.0038 0.0051 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0053 0.0053
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0085 0.0238
Brugia malayi hypothetical protein 0.0032 0.003 0.0033
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.1014 0.3104 0.3979
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0053 0.0054
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0038 0.0048
Brugia malayi MH2 domain containing protein 0.0116 0.0293 0.037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0108 0.0139
Brugia malayi PHD-finger family protein 0.0028 0.0019 0.0019
Brugia malayi hypothetical protein 0.0249 0.071 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.3219 1 1
Brugia malayi Pre-SET motif family protein 0.0608 0.1832 0.2348
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0019 0.0027
Echinococcus multilocularis translocator protein 0.1182 0.3628 0.4661
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.008 0.0088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0011
Mycobacterium leprae Probable transmembrane transport protein 0.0278 0.0801 0.1006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0085 0.0095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0136 0.0174
Mycobacterium ulcerans hypothetical protein 0.0039 0.0053 0.0035
Leishmania major hypothetical protein, conserved 0.0048 0.008 0.0088
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0257 0.0329
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0608 0.1832 0.2342
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.008 0.0088
Loa Loa (eye worm) hypothetical protein 0.0067 0.0141 0.0167
Onchocerca volvulus 0.1182 0.3628 1
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0019 0.0427
Schistosoma mansoni carbonic anhydrase 0.2516 0.7802 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.2516 0.7802 1
Brugia malayi hypothetical protein 0.0049 0.0085 0.0103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Echinococcus granulosus histone lysine methyltransferase setb 0.0103 0.0254 0.0327
Onchocerca volvulus 0.0692 0.2094 0.5751
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0019 0.0025
Schistosoma mansoni carbonic anhydrase 0.1014 0.3104 0.3979
Loa Loa (eye worm) hypothetical protein 0.0104 0.0257 0.0316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Onchocerca volvulus 0.1182 0.3628 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0019 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0085 0.011
Mycobacterium ulcerans lipase LipD 0.0039 0.0053 0.0035
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0011 0.0014
Echinococcus granulosus GPCR family 2 0.0065 0.0136 0.0174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Brugia malayi Bromodomain containing protein 0.0031 0.0027 0.0028
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0017 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0038 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0045 0.0043
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0373 0.0473
Echinococcus multilocularis GPCR, family 2 0.0065 0.0136 0.0174
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.0708 0.1065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.009 0.0109
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1014 0.3104 0.3984
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0053 0.0053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0136 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0293 0.0363
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0053 0.0067
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0194 0.0249
Loa Loa (eye worm) beta-lactamase 0.0039 0.0053 0.0053
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0038 0.0051 0.0129
Brugia malayi glutaminase DH11.1 0.0311 0.0903 0.1155
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2511 0.7785 1
Schistosoma mansoni hypothetical protein 0.0028 0.0019 0.0025
Plasmodium falciparum phd finger protein, putative 0.0028 0.0019 0.0027
Echinococcus granulosus translocator protein 0.1182 0.3628 0.4661
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0011 0.0014
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.008 0.018 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1014 0.3104 0.3984
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0136 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0293 0.0363
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0578 0.0729
Echinococcus granulosus dynactin 5 p25 0.0083 0.019 0.0245
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.0415 0.0532
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.071 0.0912
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0085 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0053 0.0053
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0011 0.0014
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.1395 0.4295 0.6605
Brugia malayi beta-lactamase family protein 0.0039 0.0053 0.0061
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2511 0.7785 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0087 0.0204 0.0622
Schistosoma mansoni hypothetical protein 0.072 0.2184 0.2799
Mycobacterium ulcerans transferase 0.008 0.018 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0204 0.0261
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0114 0.0132
Echinococcus granulosus peregrin 0.0031 0.0027 0.0034
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.072 0.2184 0.2799
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0053 0.0045
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0083 0.019 0.0266
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1014 0.3104 0.3979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0085 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0085 0.0238
Echinococcus granulosus phd:f box containing protein 0.0026 0.0011 0.0014
Onchocerca volvulus 0.008 0.018 0.0451
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0108 0.0139
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0095
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0011 0.0014
Plasmodium falciparum carbonic anhydrase 0.1014 0.3104 1
Chlamydia trachomatis sulfate transporter 0.0038 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0054 0.007
Mycobacterium ulcerans glutaminase 0.0311 0.0903 0.0887
Mycobacterium ulcerans hypothetical protein 0.0048 0.008 0.0062
Toxoplasma gondii ABC1 family protein 0.0039 0.0053 0.0134
Onchocerca volvulus 0.0104 0.0257 0.0662
Loa Loa (eye worm) hypothetical protein 0.004 0.0058 0.006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0017 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.008 0.018 0.0129
Loa Loa (eye worm) hypothetical protein 0.0065 0.0136 0.016
Onchocerca volvulus 0.0051 0.009 0.02
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.071 0.0912
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0048 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0355 0.0455
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1399 0.4308 0.6625
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Schistosoma mansoni hypothetical protein 0.1014 0.3104 0.3979
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.2098 0.6493 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.0103 0.0254 0.0313
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0085 0.3821
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2511 0.7785 1
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Entamoeba histolytica carbonic anhydrase, putative 0.2516 0.7802 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0019 0.0005
Plasmodium vivax sulfate transporter, putative 0.0038 0.0051 0.2066
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0053 0.0035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0136 0.0168
Brugia malayi beta-lactamase 0.0039 0.0053 0.0061
Onchocerca volvulus 0.0087 0.0204 0.0515
Echinococcus granulosus carbonic anhydrase 0.1014 0.3104 0.3988
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0053 0.0035
Loa Loa (eye worm) glutaminase 2 0.0311 0.0903 0.1148
Echinococcus granulosus geminin 0.072 0.2184 0.2805
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0053 0.0054
Schistosoma mansoni survival motor neuron protein 0.0051 0.009 0.0115
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1014 0.3104 0.3984
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Giardia lamblia PHD finger protein 15 0.0028 0.0019 0.5
Mycobacterium ulcerans tryptophan-rich sensory protein 0.1182 0.3628 0.3617
Plasmodium vivax SET domain protein, putative 0.0087 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Schistosoma mansoni carbonic anhydrase-related 0.1014 0.3104 0.3979
Mycobacterium ulcerans beta-lactamase 0.0039 0.0053 0.0035
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Onchocerca volvulus Putative sulfate transporter 0.0241 0.0684 0.1846
Echinococcus multilocularis peregrin 0.0031 0.0027 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0018 0.0008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0238 0.0305
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0011 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0085 0.0095
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.3219 1 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0578 0.0729
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.0415 0.0532
Loa Loa (eye worm) glutaminase 0.0311 0.0903 0.1148
Schistosoma mansoni glutaminase 0.0311 0.0903 0.1158
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0019 0.0011
Leishmania major carbonic anhydrase-like protein 0.2511 0.7785 0.9978
Echinococcus granulosus tumor protein p63 0.0712 0.2158 0.2772
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0136 0.0168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0578 0.0736
Echinococcus granulosus lysine specific demethylase 5A 0.0098 0.0238 0.0305
Echinococcus granulosus carbonic anhydrase II 0.2511 0.7785 1
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0083 0.019 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0053 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0254 0.0326
Leishmania major hypothetical protein, conserved 0.0049 0.0085 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0018 0.0017
Onchocerca volvulus 0.1182 0.3628 1
Brugia malayi Bromodomain containing protein 0.0036 0.0045 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0085 0.011
Onchocerca volvulus 0.0241 0.0684 0.1846
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2511 0.7785 0.9978
Onchocerca volvulus 0.1182 0.3628 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0278 0.0801 0.1209
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988
Echinococcus granulosus microtubule associated protein 2 0.2015 0.6233 0.8007
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0038 0.0051 0.0129
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0053 0.0054
Leishmania major carbonic anhydrase family protein, putative 0.2516 0.7802 1
Brugia malayi TspO/MBR family protein 0.1182 0.3628 0.4657
Loa Loa (eye worm) hypothetical protein 0.0065 0.0134 0.0158
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0053 0.2148
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0238 0.0305
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0136 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0254 0.0326
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0011 0.0014
Brugia malayi jmjC domain containing protein 0.0155 0.0415 0.0526
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0087 0.0204 0.0262
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0053 0.0068
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.0232 0.0298
Loa Loa (eye worm) carbonic anhydrase 3 0.2511 0.7785 1
Onchocerca volvulus 0.0039 0.0053 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0085 0.011
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Mycobacterium leprae Probable lipase LipE 0.0039 0.0053 0.0045
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0048 0.008 0.0096
Schistosoma mansoni hypothetical protein 0.0141 0.0373 0.0478
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0053 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0098 0.0238 0.0291
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0053 0.0054
Echinococcus multilocularis geminin 0.072 0.2184 0.2805
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0038 0.0051 0.0033
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0174
Onchocerca volvulus 0.0039 0.0053 0.0096
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2511 0.7785 0.9978
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0019 0.0027
Brugia malayi Bromodomain containing protein 0.0071 0.0154 0.0191
Loa Loa (eye worm) hypothetical protein 0.1182 0.3628 0.4653
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0019 0.0025
Schistosoma mansoni microtubule-associated protein tau 0.2015 0.6233 0.7989
Loa Loa (eye worm) hypothetical protein 0.0141 0.0373 0.0466
Brugia malayi hypothetical protein 0.0477 0.1424 0.1824
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0103 0.0254 0.0327
Brugia malayi beta-lactamase family protein 0.0039 0.0053 0.0061
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2511 0.7785 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0053 0.0054
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0085 0.0238
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.008 0.0088
Loa Loa (eye worm) hypothetical protein 0.1014 0.3104 0.3979
Leishmania major hypothetical protein, conserved 0.0039 0.0053 0.0053
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.1182 0.3628 0.4651
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0053 0.0068
Trichomonas vaginalis set domain proteins, putative 0.0692 0.2094 0.2052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0053 0.0053
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0085 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0085 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.1712 0.5285 0.6785
Loa Loa (eye worm) hypothetical protein 0.0249 0.071 0.0899
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0052
Onchocerca volvulus 0.0039 0.0053 0.0096
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0038 0.0051 0.0033
Entamoeba histolytica acetyltransferase, putative 0.0083 0.019 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0204 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0085 0.0103
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0083 0.019 1
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0011 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.2015 0.6233 0.8007
Toxoplasma gondii hypothetical protein 0.1014 0.3104 1
Echinococcus multilocularis tumor protein p63 0.0712 0.2158 0.2772
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2511 0.7785 1
Trichomonas vaginalis glutaminase, putative 0.0311 0.0903 0.0855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0136 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0578 0.0736
Brugia malayi jmjC domain containing protein 0.0026 0.0011 0.0008
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0038 0.0051 0.0051
Mycobacterium ulcerans carbonic anhydrase 0.2516 0.7802 0.7798
Mycobacterium tuberculosis Conserved protein 0.0039 0.0053 0.0054
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0011 0.0014
Trypanosoma brucei carbonic anhydrase-like protein 0.2511 0.7785 1
Echinococcus multilocularis carbonic anhydrase 0.1014 0.3104 0.3988

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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