TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.835 | Formula: C18H19ClN6O2
H donors: 2 H acceptors: 6 LogP: 3.35 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nc(O)c2c(n1)n(nn2)Cc1ccccc1Cl)NC1CCCCC1
InChi: 1S/C18H19ClN6O2/c19-13-9-5-4-6-11(13)10-25-16-14(23-24-25)17(26)22-15(21-16)18(27)20-12-7-2-1-3-8-12/h4-6,9,12H,1-3,7-8,10H2,(H,20,27)(H,21,22,26)
InChiKey: NQLORFPQWFZXIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0042	0.0227	0.0174
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.011	0.0131
Loa Loa (eye worm)	hypothetical protein	0.018	0.1256	0.1209
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0292	0.0548
Schistosoma mansoni	hypothetical protein	0.0079	0.0502	0.1032
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0248	0.1767	0.1723
Schistosoma mansoni	zinc finger protein	0.003	0.0141	0.0202
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.066	0.4833	0.4806
Trypanosoma brucei	protein kinase, putative	0.005	0.0292	0.8643
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0042	0.0227	0.0174
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0186	0.0305
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0292	0.8643
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0329	0.0632
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0042	0.0227	0.0174
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0132	0.0079
Echinococcus granulosus	geminin	0.0172	0.1199	0.2631
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0227	0.7264
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.0125	0.0847	0.0798
Schistosoma mansoni	bromodomain containing protein	0.0125	0.0845	0.1819
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0167	0.0261
Schistosoma mansoni	hypothetical protein	0.0172	0.1199	0.2631
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0292	0.0548
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0167	0.0261
Echinococcus granulosus	importin subunit beta 1	0.0056	0.0338	0.0653
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.1706	0.3796
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0186	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0847	0.0798
Brugia malayi	Importin beta-1 subunit	0.0056	0.0338	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0543	0.0492
Echinococcus granulosus	tar DNA binding protein	0.0191	0.1339	0.2953
Loa Loa (eye worm)	RNA binding protein	0.0191	0.1339	0.1293
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0042	0.0227	0.7264
Entamoeba histolytica	hypothetical protein	0.0046	0.0258	0.0206
Brugia malayi	PHD-finger family protein	0.0049	0.0282	0.023
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0258	0.0206
Brugia malayi	latrophilin 2 splice variant baaae	0.017	0.1182	0.1134
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0079	0.0502	0.1032
Schistosoma mansoni	hypothetical protein	0.0079	0.0502	0.1032
Schistosoma mansoni	importin beta-1	0.0056	0.0338	0.0653
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0329	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0053	0.031	0.0258
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0046	0.0258	0.0206
Brugia malayi	hypothetical protein	0.024	0.1706	0.1661
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.1256	1
Brugia malayi	intermediate filament protein	0.0054	0.0318	0.0266
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0329	0.0632
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0329	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0076	0.048	0.0429
Schistosoma mansoni	hypothetical protein	0.0172	0.1199	0.2631
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0292	1
Loa Loa (eye worm)	PHD-finger family protein	0.0041	0.022	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.1353	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1339	0.2953
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0167	0.0261
Schistosoma mansoni	lamin	0.0054	0.0318	0.0607
Brugia malayi	RNA, U transporter 1	0.0161	0.1113	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0167	0.0114
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0118	0.0793	0.1698
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0042	0.0227	0.0174
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0318	0.0607
Loa Loa (eye worm)	TAR-binding protein	0.0191	0.1339	0.1293
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0118	0.0793	0.1698
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0954	0.0906
Brugia malayi	hypothetical protein	0.0148	0.1019	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0847	0.0798
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.1353	1	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0053	0.1583
Schistosoma mansoni	ran	0.0042	0.0227	0.0398
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0034	0.0167	0.0261
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0042	0.0227	0.0174
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0053	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0292	0.024
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0186	0.0305
Giardia lamblia	Macrophage migration inhibitory factor	0.1353	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0318	0.0266
Schistosoma mansoni	hypothetical protein	0.0079	0.0502	0.1032
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0044	0.0248	0.0446
Onchocerca volvulus		0.0125	0.0847	0.5805
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0034	0.0167	0.0261
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0186	0.0134
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0158	0.5
Trichomonas vaginalis	importin beta-1, putative	0.0046	0.0258	0.0206
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0318	0.0266
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0079	0.0502	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0103	0.005
Schistosoma mansoni	hypothetical protein	0.0049	0.0282	0.0525
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0292	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0079	0.0502	0.0451
Brugia malayi	RNA binding protein	0.0191	0.1339	0.1293
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1339	0.2953
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0847	0.0798
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0292	0.024
Echinococcus multilocularis	lamin dm0	0.0054	0.0318	0.0607
Brugia malayi	MAP kinase sur-1	0.005	0.0292	0.024
Entamoeba histolytica	Ran family GTPase	0.0042	0.0227	0.0174
Echinococcus granulosus	intermediate filament protein	0.0054	0.0318	0.0607
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1019	0.7569
Echinococcus multilocularis	musashi	0.0054	0.0318	0.0607
Schistosoma mansoni	hypothetical protein	0.017	0.1182	0.2592
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0186	0.5518
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0186	1
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1339	0.2953
Brugia malayi	RNA recognition motif domain containing protein	0.0191	0.1339	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0318	0.0266
Onchocerca volvulus		0.0125	0.0847	0.5805
Loa Loa (eye worm)	inositol-1	0.0036	0.0186	0.0134
Echinococcus granulosus	lamin dm0	0.0054	0.0318	0.0607
Plasmodium falciparum	importin beta, putative	0.0056	0.0338	0.0286
Schistosoma mansoni	zinc finger protein	0.0039	0.0204	0.0346
Echinococcus multilocularis	lamin	0.0054	0.0318	0.0607
Schistosoma mansoni	ran	0.0042	0.0227	0.0398
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0167	0.0261
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.1353	1	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.1706	0.1661
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0186	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0603	0.4407	0.4377
Trypanosoma brucei	importin beta-1 subunit, putative	0.0056	0.0338	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0186	0.0134
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0186	0.5573
Schistosoma mansoni	lamin	0.0054	0.0318	0.0607
Echinococcus multilocularis	importin subunit beta 1	0.0056	0.0338	0.0653
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0042	0.0227	0.0398
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0034	0.0167	0.0261
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1339	0.2953
Onchocerca volvulus		0.0054	0.0318	0.0366
Echinococcus multilocularis	zinc finger protein	0.0039	0.0204	0.0346
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0292	0.024
Loa Loa (eye worm)	hypothetical protein	0.0026	0.011	0.0057
Loa Loa (eye worm)	thyroglobulin type-1 repeat family protein	0.0125	0.0847	0.0798
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0329	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1019	0.0971
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0329	0.0632
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0186	0.0134
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0186	0.5573
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0186	0.0305
Brugia malayi	TAR-binding protein	0.0191	0.1339	0.1293
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0282	0.023
Leishmania major	macrophage migration inhibitory factor-like protein	0.1353	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.2001	0.1958
Leishmania major	importin beta-1 subunit, putative	0.0046	0.0258	0.0206
Onchocerca volvulus		0.0125	0.0847	0.5805
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.1706	0.3796
Plasmodium falciparum	macrophage migration inhibitory factor	0.1353	1	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0158	1
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0282	0.0525
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.1353	1	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0186	0.0305
Schistosoma mansoni	hypothetical protein	0.0079	0.0502	0.1032
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0079	0.0502	0.1032
Trypanosoma cruzi	ISWI complex protein	0.003	0.0141	0.3693
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0071	0.0444	0.0897
Trichomonas vaginalis	ran, putative	0.0042	0.0227	0.0174
Loa Loa (eye worm)	hypothetical protein	0.017	0.1182	0.1134
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0186	0.0134
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0292	0.024
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0847	0.0798
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.0125	0.0847	0.0798
Echinococcus multilocularis	geminin	0.0172	0.1199	0.2631
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0044	0.0248	0.0446
Trypanosoma cruzi	ISWI complex protein	0.003	0.0141	0.3693
Loa Loa (eye worm)	hypothetical protein	0.008	0.0515	0.0464
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1019	0.7569
Echinococcus granulosus	snurportin 1	0.0603	0.4407	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0079	0.0502	0.1032
Schistosoma mansoni	hypothetical protein	0.0041	0.022	0.0382
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0248	0.1767	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0103	0.005
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.1353	1	1
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.1353	1	1
Loa Loa (eye worm)	bromodomain containing protein	0.0035	0.0176	0.0123
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0292	0.0548
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0292	0.024
Onchocerca volvulus		0.0125	0.0847	0.5805
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0042	0.0227	0.6711
Leishmania major	GTP-binding protein, putative	0.0042	0.0227	0.0174
Brugia malayi	Bromodomain containing protein	0.0075	0.0479	0.0428
Brugia malayi	N-terminal motif family protein	0.018	0.1256	0.1209
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.0125	0.0847	0.0798
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0042	0.0227	0.0174
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.011	0.0131
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0186	0.0134
Brugia malayi	Latrophilin receptor protein 2	0.0079	0.0502	0.0451
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0191	0.1339	0.1293
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0292	0.024
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1019	0.0971
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0292	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1767	0.1723
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0329	0.0277
Echinococcus granulosus	fetal alzheimer antigen falz	0.0044	0.0248	0.0446
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0329	0.0632
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0248	0.1767	0.1723
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0292	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0329	0.0632
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0034	0.0167	0.0261
Echinococcus granulosus	GPCR family 2	0.0079	0.0502	0.1032
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0292	0.024
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0502	0.0451
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0132	0.0079
Leishmania major	hypothetical protein, conserved	0.003	0.0141	0.0089
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0292	0.024
Echinococcus multilocularis	GPCR, family 2	0.0079	0.0502	0.1032
Echinococcus multilocularis	tar DNA binding protein	0.0191	0.1339	0.2953
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0079	0.0502	0.1032
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0292	0.0548
Brugia malayi	Bromodomain containing protein	0.0148	0.1017	0.0969
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0292	0.0548
Schistosoma mansoni	hypothetical protein	0.0603	0.4407	1
Plasmodium vivax	importin-beta 2, putative	0.0056	0.0338	0.0286
Schistosoma mansoni	hypothetical protein	0.003	0.0141	0.0202
Onchocerca volvulus		0.0054	0.0318	0.0366
Trypanosoma brucei	ISWI complex protein	0.003	0.0141	0.419
Toxoplasma gondii	HEAT repeat-containing protein	0.0056	0.0338	0.0286
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0046	0.0258	0.8585
Echinococcus granulosus	lamin	0.0054	0.0318	0.0607
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0042	0.0227	0.0398
Loa Loa (eye worm)	thyroglobulin type-1 repeat family protein	0.0125	0.0847	0.0798
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.066	0.4833	0.4806
Brugia malayi	Inositol-1	0.0036	0.0186	0.0134
Brugia malayi	secreted modular calcium-binding protein 1	0.0125	0.0847	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0338	0.0286
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0318	0.0266
Leishmania major	macrophage migration inhibitory factor-like protein	0.1353	1	1
Brugia malayi	follicle stimulating hormone receptor	0.028	0.2001	0.1958
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1339	0.2953
Echinococcus multilocularis	snurportin 1	0.0603	0.4407	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0071	0.0444	0.0897
Trypanosoma brucei	importin beta-1 subunit, putative	0.0056	0.0338	1
Echinococcus granulosus	zinc finger protein	0.0039	0.0204	0.0346
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0292	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1346311

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1227631