Detailed information for compound 1231806

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 235.345 | Formula: C13H17NOS
  • H donors: 1 H acceptors: 1 LogP: 2.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=S)c1ccc(cc1)O
  • InChi: 1S/C13H17NOS/c1-10-6-8-14(9-7-10)13(16)11-2-4-12(15)5-3-11/h2-5,10,15H,6-9H2,1H3
  • InChiKey: UKAFKKJTWPITNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0035 0.0282 0.0701
Loa Loa (eye worm) histone deacetylase 7A 0.0068 0.0678 0.1245
Brugia malayi hypothetical protein 0.005 0.0466 0.0849
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0578 0.7196
Echinococcus granulosus histone deacetylase 7 0.0068 0.0678 0.0668
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Brugia malayi beta-lactamase family protein 0.0035 0.0282 0.0506
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0282 0.0887
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0061 0.005
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.08 0.079
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0803 1
Schistosoma mansoni smad 0.0017 0.0061 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0038
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0239
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0299 0.0923
Schistosoma mansoni histone deacetylase 0.0072 0.0723 0.0723
Schistosoma mansoni alpha-glucosidase 0.0142 0.1586 0.1586
Entamoeba histolytica histone deacetylase, putative 0.0072 0.0723 0.5826
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Brugia malayi glutaminase DH11.1 0.0269 0.3122 0.5809
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Trichomonas vaginalis hypothetical protein 0.0024 0.0139 0.0411
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0061 0.0093
Echinococcus granulosus histone deacetylase 8 0.002 0.01 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.08 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Brugia malayi histone deacetylase 3 (HD3) 0.0072 0.0723 0.1328
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0299 0.0923
Toxoplasma gondii ABC1 family protein 0.0035 0.0282 0.3514
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0165
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0239
Schistosoma mansoni histone deacetylase 0.0072 0.0723 0.0723
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Schistosoma mansoni hypothetical protein 0.0175 0.1978 0.1978
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Toxoplasma gondii histone deacetylase HDAC4 0.002 0.01 0.1245
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.0246
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.1779
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0299 0.2295
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0299 0.0536
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0143 0.0246
Trypanosoma brucei polo-like protein kinase 0.0114 0.1241 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0701 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0578 0.0567
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0282 0.0701
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1241 0.2296
Trypanosoma brucei histone deacetylase 1 0.0072 0.0723 0.5764
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0058 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Trypanosoma brucei histone deacetylase, putative 0.0068 0.0678 0.54
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.0038
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0143 0.1152
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.0246
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0282 0.0887
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0282 0.2161
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0139 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Mycobacterium ulcerans hypothetical protein 0.0035 0.0282 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0803 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0282 0.0282
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Schistosoma mansoni histone deacetylase 4 5 0.0068 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0453 0.5366 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0183 0.2079 0.3861
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Onchocerca volvulus 0.0096 0.1017 0.8172
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0803 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0142 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0965 0.0954
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0061 0.0061
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0078 0.0803 0.1479
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Trichomonas vaginalis esterase, putative 0.0035 0.0282 0.0871
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0143 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.08 0.6451
Plasmodium vivax histone deacetylase 1, putative 0.0072 0.0723 0.8999
Loa Loa (eye worm) hypothetical protein 0.0041 0.035 0.0632
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0282 0.0271
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1867 0.1858
Mycobacterium leprae Probable lipase LipE 0.0035 0.0282 0.2516
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.0038
Trypanosoma brucei histone deacetylase 2 0.002 0.01 0.0671
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0068 0.0046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0018 0.0145
Mycobacterium ulcerans glutaminase 0.0269 0.3122 1
Schistosoma mansoni hypothetical protein 0.0175 0.1978 0.1978
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0143 0.0132
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0139 0.0239
Brugia malayi Smad1 0.0017 0.0061 0.0093
Loa Loa (eye worm) Smad1 0.0017 0.0061 0.0093
Echinococcus multilocularis histone deacetylase 7 0.0068 0.0678 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0803 0.6421
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0139 0.0992
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0803 1
Leishmania major histone deacetylase, putative 0.0068 0.0678 0.54
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Trypanosoma brucei histone deacetylase 3 0.0068 0.0678 0.54
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0139 0.0992
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1241 0.1231
Trypanosoma cruzi histone deacetylase, putative 0.002 0.01 0.0671
Schistosoma mansoni DNA helicase recq1 0.0024 0.0143 0.0143
Brugia malayi Cytochrome P450 family protein 0.0032 0.0236 0.042
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0139 0.0967
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.08 0.2397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Echinococcus granulosus histone deacetylase 0.0068 0.0678 0.0668
Toxoplasma gondii histone deacetylase HDAC2 0.0072 0.0723 0.8999
Onchocerca volvulus 0.0035 0.0282 0.2161
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0142 0.024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.2407
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0139 0.0967
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Brugia malayi beta-lactamase 0.0035 0.0282 0.0506
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0142 0.0334
Schistosoma mansoni inositol monophosphatase 0.0078 0.08 0.08
Echinococcus multilocularis histone deacetylase 8 0.002 0.01 0.0089
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0068 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1867 0.3465
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0058 0.0046
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0143 0.0423
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Schistosoma mansoni histone deacetylase hda2 0.0068 0.0678 0.0678
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1867 0.3465
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0143 0.0423
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0143 0.0423
Echinococcus multilocularis histone deacetylase 0.0068 0.0678 0.0668
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0142 0.1141
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0143 0.0132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0038
Echinococcus granulosus geminin 0.0175 0.1978 0.1969
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0278 0.0267
Plasmodium vivax histone deacetylase, putative 0.002 0.01 0.1245
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.2161
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0278 0.0267
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.08 0.2536
Mycobacterium tuberculosis Conserved protein 0.0035 0.0282 0.0887
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0038
Schistosoma mansoni histone deacetylase hda2 0.002 0.01 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0142 0.0334
Plasmodium vivax histone deacetylase 2, putative 0.0068 0.0678 0.8445
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.024
Schistosoma mansoni glutaminase 0.0269 0.3122 0.3122
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0139 0.0411
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Echinococcus granulosus histone deacetylase 6 0.0068 0.0678 0.0668
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0282 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0965 0.0954
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0803 0.6421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0578 0.0578
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0071
Loa Loa (eye worm) glutaminase 2 0.0269 0.3122 0.5809
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Schistosoma mansoni hypothetical protein 0.0035 0.0279 0.0279
Loa Loa (eye worm) histone deacetylase 11 0.002 0.01 0.0165
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0578 0.2048
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.3719
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Toxoplasma gondii hypothetical protein 0.0024 0.0139 0.1734
Echinococcus granulosus bloom syndrome protein 0.0024 0.0143 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0139 0.0128
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0061 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0282 0.0282
Echinococcus multilocularis histone deacetylase 3 0.0072 0.0723 0.0712
Loa Loa (eye worm) hypothetical protein 0.0072 0.0723 0.1328
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0142 0.1141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0299 0.0923
Loa Loa (eye worm) histone deacetylase 1 0.0072 0.0723 0.1328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1241 0.1231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0038
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Giardia lamblia Kinase, PLK 0.0114 0.1241 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0142 0.1141
Leishmania major histone deacetylase, putative 0.0068 0.0678 0.54
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0143 0.0246
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Loa Loa (eye worm) histone deacetylase 3 0.0072 0.0723 0.1328
Brugia malayi hypothetical protein 0.0078 0.0803 0.1479
Leishmania major histone deacetylase, putative 0.0072 0.0723 0.5764
Onchocerca volvulus Histone deacetylase 10 homolog 0.002 0.01 0.0671
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0143 0.1022
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.0093
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0068 0.0849
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0058 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0087
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.08 0.6398
Schistosoma mansoni smad1 5 8 and 0.0017 0.0061 0.0061
Loa Loa (eye worm) histone deacetylase 0.0068 0.0678 0.1245
Echinococcus multilocularis histone deacetylase 1 0.0072 0.0723 0.0712
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1241 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0282 0.3514
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0282 0.0871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0477 0.087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.0093
Brugia malayi MH1 domain containing protein 0.0017 0.0061 0.0093
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0477 0.087
Schistosoma mansoni inositol monophosphatase 0.0078 0.08 0.08
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1241 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0282 0.0506
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2604 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0282 0.0701
Toxoplasma gondii histone deacetylase HDAC5 0.002 0.01 0.1245
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0416 0.0756
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0139 0.1734
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Echinococcus granulosus histone deacetylase 3 0.0072 0.0723 0.0712
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.1985 0.6346
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Brugia malayi Histone deacetylase family protein 0.0068 0.0678 0.1245
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Toxoplasma gondii histone deacetylase HDAC1 0.0068 0.0678 0.8445
Plasmodium vivax histone deacetylase, putative 0.0068 0.0678 0.8445
Plasmodium falciparum histone deacetylase 2 0.0068 0.0678 0.8301
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0011 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0282 0.0871
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0282 0.0887
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0072 0.0723 0.2287
Leishmania major histone deacetylase, putative 0.0072 0.0723 0.5764
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Plasmodium falciparum histone deacetylase 1 0.0072 0.0723 0.8906
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0803 0.6421
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0236 0.042
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0299 0.0923
Brugia malayi histone deacetylase 1 (HD1) 0.0072 0.0723 0.1328
Schistosoma mansoni DNA helicase recq5 0.0024 0.0143 0.0143
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0143 0.1017
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0282 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0142 0.0243
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0143 0.1017
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0323 0.1002
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0139 0.0992
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0701 0.253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0965 0.0954
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Schistosoma mansoni alpha-glucosidase 0.0142 0.1586 0.1586
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Echinococcus granulosus histone deacetylase 1 0.0072 0.0723 0.0712
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0139 0.1734
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0058 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0539 0.1697
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0143 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Echinococcus multilocularis smad 0.0017 0.0061 0.005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0282 0.0887
Loa Loa (eye worm) RecQ helicase 0.0024 0.0143 0.0246
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0018 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Leishmania major hypothetical protein, conserved 0.0078 0.0803 0.6421
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0282 0.0871
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0282 0.2516
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0339 0.0339
Brugia malayi MH2 domain containing protein 0.0253 0.293 0.5451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0965 0.0965
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0139 0.0411
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0011 0.0011
Mycobacterium ulcerans lipase LipD 0.0035 0.0282 0.0701
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0299 0.2295
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0142 0.024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0416 0.0405
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0463 0.0463
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0012
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1241 1
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0463 0.0463
Schistosoma mansoni Smad4 0.0017 0.0061 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0282 0.0506
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0239
Brugia malayi Inositol-1 0.0078 0.08 0.1473
Echinococcus multilocularis histone deacetylase 6 0.0068 0.0678 0.0668
Plasmodium falciparum histone deacetylase, putative 0.0068 0.0678 0.8301
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0299 0.2295
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0142 0.101
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.3122 1
Loa Loa (eye worm) inositol-1 0.0078 0.08 0.1473
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0143 0.1779
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0139 0.0992
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0021
Loa Loa (eye worm) beta-lactamase 0.0035 0.0282 0.0506
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1241 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0058 0.0046
Schistosoma mansoni hypothetical protein 0.004 0.0339 0.0339
Schistosoma mansoni histone deacetylase 4 5 0.0068 0.0678 0.0678
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0018 0.0021
Onchocerca volvulus 0.0035 0.0282 0.2161
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Schistosoma mansoni alpha glucosidase 0.0037 0.0299 0.0299
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0142 0.024
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0139 0.0128
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0416 0.0405
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1241 0.2296
Trypanosoma cruzi histone deacetylase, putative 0.0068 0.0678 0.54
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0282 0.0887
Leishmania major hypothetical protein, conserved 0.0035 0.0282 0.2161
Schistosoma mansoni histone deacetylase 1 2 3 0.002 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0323 0.1002
Brugia malayi Histone deacetylase 1 0.0072 0.0723 0.1328
Toxoplasma gondii histone deacetylase HDAC3 0.0072 0.0723 0.8999
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0781
Loa Loa (eye worm) hypothetical protein 0.0183 0.2079 0.3861
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.2161
Echinococcus multilocularis Smad4 0.0017 0.0061 0.005
Brugia malayi Histone deacetylase family protein 0.0068 0.0678 0.1245
Brugia malayi histone deacetylase 11 0.002 0.01 0.0165
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0781
Brugia malayi beta-lactamase family protein 0.0035 0.0282 0.0506
Loa Loa (eye worm) hypothetical protein 0.0051 0.0477 0.087
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0139 0.1122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0965 0.178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0416 0.0756
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1241 0.1241
Echinococcus granulosus Smad4 0.0017 0.0061 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0282 0.0271
Onchocerca volvulus 0.0035 0.0282 0.2161
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Echinococcus granulosus smad 0.0017 0.0061 0.005
Giardia lamblia Histone deacetylase 0.0072 0.0723 0.5282
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.08 0.9965
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0011 0.0011
Trypanosoma cruzi histone deacetylase 1, putative 0.0072 0.0723 0.5764
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0061 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.08 0.2536
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.293 0.5451
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0142 0.024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1867 0.1858
Schistosoma mansoni hypothetical protein 0.0035 0.0278 0.0278
Trypanosoma brucei histone deacetylase 4 0.0068 0.0678 0.54
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0106
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0299 0.0288
Onchocerca volvulus 0.0024 0.0142 0.101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0578 0.458
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0578 0.1669
Trypanosoma cruzi histone deacetylase 1, putative 0.0072 0.0723 0.5764
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1241 0.3952
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0578 0.0578
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0339 0.0328
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0578 0.0567
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.08 0.2536
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0049
Loa Loa (eye worm) glutaminase 0.0269 0.3122 0.5809
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0139 0.0139
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0299 0.0288
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0061 0.005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0143 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0539 0.1697
Trypanosoma cruzi histone deacetylase, putative 0.002 0.01 0.0671
Trypanosoma brucei glucosidase, putative 0.0037 0.0299 0.2295
Loa Loa (eye worm) hypothetical protein 0.0035 0.0279 0.05
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0143 0.0132
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0299 0.2407
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0139 0.0239
Loa Loa (eye worm) hypothetical protein 0.0453 0.5366 1
Brugia malayi hypothetical protein 0.004 0.0339 0.0612
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.08 0.079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0142 0.0243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0965 0.178
Schistosoma mansoni kinase 0.0058 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0506
Entamoeba histolytica hypothetical protein 0.0024 0.0139 0.1122
Trichomonas vaginalis histone deacetylase, putative 0.0072 0.0723 0.2287
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.293 0.5451
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0058 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0339 0.0328
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0299 0.0923
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0058 0.0058
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0011 0.0011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0061 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0477 0.087
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0139 0.0967
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0279 0.05
Brugia malayi MH2 domain containing protein 0.0017 0.0061 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0071
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0299 0.0536
Echinococcus multilocularis geminin 0.0175 0.1978 0.1969
Entamoeba histolytica hypothetical protein 0.004 0.0339 0.2734
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1867 0.1858

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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