Detailed information for compound 1245315

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 7955.24 | Formula: C235H303N71O145P24S24
  • H donors: 67 H acceptors: 80 LogP: -17.2 Rotable bonds: 142
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(OC[C@H]1O[C@H](C[C@@H]1OP(=S)(O)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C235H303N71O145P24S24/c1-80-37-288(223(343)270-182(80)319)135-24-93(106(50-307)404-135)429-459(364,483)393-63-119-165(154(308)201(417-119)283-19-14-130(236)253-218(283)338)441-471(376,495)399-69-125-174(163(317)210(423-125)305-78-251-152-180(305)262-216(245)268-199(152)336)450-469(374,493)391-61-117-104(35-146(415-117)299-48-91(12)193(330)281-234(299)354)439-462(367,486)396-66-122-168(157(311)204(420-122)286-22-17-133(239)256-221(286)341)444-475(380,499)402-72-128-173(162(316)209(426-128)304-77-250-151-179(304)261-215(244)267-198(151)335)449-468(373,492)389-59-115-102(33-144(413-115)297-46-89(10)191(328)279-232(297)352)435-458(363,482)384-54-110-97(28-139(408-110)292-41-84(5)186(323)274-227(292)347)432-455(360,479)385-55-111-98(29-140(409-111)293-42-85(6)187(324)275-228(293)348)436-460(365,484)394-64-120-166(155(309)202(418-120)284-20-15-131(237)254-219(284)339)442-472(377,496)403-73-129-175(164(318)211(427-129)306-79-252-153-181(306)263-217(246)269-200(153)337)451-470(375,494)392-62-118-105(36-147(416-118)300-49-92(13)194(331)282-235(300)355)440-463(368,487)397-67-123-169(158(312)205(421-123)287-23-18-134(240)257-222(287)342)445-474(379,498)401-71-127-172(161(315)208(425-127)303-76-249-150-178(303)260-214(243)266-197(150)334)448-467(372,491)388-58-114-101(32-143(412-114)296-45-88(9)190(327)278-231(296)351)434-457(362,481)383-53-109-96(27-138(407-109)291-40-83(4)185(322)273-226(291)346)430-454(359,478)382-52-108-95(26-137(406-108)290-39-82(3)184(321)272-225(290)345)431-456(361,480)386-56-112-99(30-141(410-112)294-43-86(7)188(325)276-229(294)349)437-464(369,488)398-68-124-170(159(313)206(422-124)301-74-247-148-176(301)258-212(241)264-195(148)332)446-465(370,489)390-60-116-103(34-145(414-116)298-47-90(11)192(329)280-233(298)353)438-461(366,485)395-65-121-167(156(310)203(419-121)285-21-16-132(238)255-220(285)340)443-473(378,497)400-70-126-171(160(314)207(424-126)302-75-248-149-177(302)259-213(242)265-196(149)333)447-466(371,490)387-57-113-100(31-142(411-113)295-44-87(8)189(326)277-230(295)350)433-453(358,477)381-51-107-94(428-452(356,357)476)25-136(405-107)289-38-81(2)183(320)271-224(289)344/h14-23,37-49,74-79,93-129,135-147,154-175,201-211,307-318H,24-36,50-73H2,1-13H3,(H,358,477)(H,359,478)(H,360,479)(H,361,480)(H,362,481)(H,363,482)(H,364,483)(H,365,484)(H,366,485)(H,367,486)(H,368,487)(H,369,488)(H,370,489)(H,371,490)(H,372,491)(H,373,492)(H,374,493)(H,375,494)(H,376,495)(H,377,496)(H,378,497)(H,379,498)(H,380,499)(H2,236,253,338)(H2,237,254,339)(H2,238,255,340)(H2,239,256,341)(H2,240,257,342)(H,270,319,343)(H,271,320,344)(H,272,321,345)(H,273,322,346)(H,274,323,347)(H,275,324,348)(H,276,325,349)(H,277,326,350)(H,278,327,351)(H,279,328,352)(H,280,329,353)(H,281,330,354)(H,282,331,355)(H2,356,357,476)(H3,241,258,264,332)(H3,242,259,265,333)(H3,243,260,266,334)(H3,244,261,267,335)(H3,245,262,268,336)(H3,246,263,269,337)/t93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,154+,155+,156+,157+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174+,175+,201+,202+,203+,204+,205+,206+,207+,208+,209+,210+,211+,453?,454?,455?,456?,457?,458?,459?,460?,461?,462?,463?,464?,465?,466?,467?,468?,469?,470?,471?,472?,473?,474?,475?/m0/s1
  • InChiKey: QQOZXRUMSXYQAG-UOJSNSPOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0122 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0122 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.1698 0.1772
Leishmania major DNA polymerase eta, putative 0.0019 0.0122 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Trypanosoma cruzi cAMP response protein 1 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Echinococcus granulosus g protein coupled receptor 0.0066 0.1698 0.1772
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0245 0.7734 0.8475
Loa Loa (eye worm) voltage-gated potassium channel 0.0019 0.0098 0.0107
Schistosoma mansoni biogenic amine receptor 0.0066 0.1698 0.1615
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.1698 0.1772
Mycobacterium ulcerans transmembrane transport protein 0.0041 0.0863 0.1398
Schistosoma mansoni DNA polymerase eta 0.0019 0.0122 0.0024
Plasmodium falciparum cGMP-dependent protein kinase 0.0041 0.0863 0.1398
Leishmania major hypothetical protein, unknown function 0.0041 0.0863 0.1409
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0026 0.0346 0.0287
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0286 0.9126 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus multilocularis fmrfamide receptor 0.0066 0.1698 0.1772
Echinococcus granulosus g protein coupled receptor 0.0066 0.1698 0.1772
Brugia malayi GnHR receptor homolog 0.0066 0.1698 0.186
Echinococcus multilocularis hyperpolarization activated cyclic 0.006 0.149 0.1542
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Brugia malayi neuropeptide F receptor 0.0066 0.1698 0.186
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0041 0.0863 0.1409
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.1698 0.1772
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0863 0.0773
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0019 0.0098 0.0107
Brugia malayi Egg laying defective protein 4 0.0041 0.0863 0.0946
Schistosoma mansoni neuropeptide receptor 0.0066 0.1698 0.1615
Onchocerca volvulus 0.0066 0.1698 0.2329
Leishmania major protein kinase, putative 0.0041 0.0863 0.1409
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0346 0.0287
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0863 0.0848
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) ryanodine receptor 0.0019 0.0098 0.0107
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0086 0.2364 0.2591
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trypanosoma brucei protein kinase A regulatory subunit 0.0041 0.0863 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.251 0.2435
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.1698 0.1772
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.1698 0.1615
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.006 0.149 0.1406
Echinococcus multilocularis lamin 0.0029 0.0458 0.0399
Trichomonas vaginalis adenylate cyclase type III, putative 0.0026 0.0346 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0105 0.0008
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0179 0.553 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.1698 0.1772
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0105 0.0013
Echinococcus granulosus fmrfamide receptor 0.0066 0.1698 0.1772
Brugia malayi Zinc finger, C2H2 type family protein 0.007 0.1837 0.2013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.1698 0.1772
Leishmania major protein kinase, putative 0.0041 0.0863 0.1409
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0122 0.0031
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Schistosoma mansoni hypothetical protein 0.0066 0.1698 0.1615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.251 0.2435
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.1698 0.1615
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0041 0.0863 0.1398
Brugia malayi Melatonin receptor type 1A 0.0066 0.1698 0.186
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0122 0.0134
Brugia malayi RE15519p 0.0066 0.1698 0.186
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.1698 0.186
Brugia malayi bZIP transcription factor family protein 0.0091 0.2542 0.2786
Echinococcus granulosus lamin dm0 0.0029 0.0458 0.0399
Schistosoma mansoni 60S ribosomal protein L21 0.0044 0.0973 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.006 0.149 0.1542
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.1698 0.1615
Echinococcus granulosus orexin receptor type 2 0.0066 0.1698 0.1772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Mycobacterium tuberculosis Conserved protein 0.0041 0.0863 0.1398
Mycobacterium ulcerans regulatory protein 0.0041 0.0863 0.1398
Brugia malayi Serotonin receptor 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Echinococcus multilocularis serotonin receptor 0.0066 0.1698 0.1772
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0041 0.0863 0.1398
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.1698 0.186
Brugia malayi cation channel family protein 0.0019 0.0098 0.0107
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.1698 0.1772
Brugia malayi ORL1-like opioid receptor 0.0066 0.1698 0.186
Onchocerca volvulus 0.0071 0.1883 0.2598
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0041 0.0863 0.0946
Leishmania major cyclic nucleotide-binding protein-like protein 0.0041 0.0863 0.1409
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.1698 0.1772
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.251 0.275
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.1698 0.1772
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.1698 0.1615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.251 0.2435
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.044 0.0482
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0041 0.0863 0.0848
Onchocerca volvulus 0.0066 0.1698 0.2329
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.1837 0.1927
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0026 0.0346 0.0457
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.1698 0.1615
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Brugia malayi N-terminal motif family protein 0.0222 0.6967 0.7635
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Treponema pallidum catabolite gene activator (Crp) 0.0041 0.0863 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0041 0.0863 0.0773
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0041 0.0863 0.0848
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.1698 0.1772
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.1698 0.1772
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.006 0.149 0.1406
Brugia malayi Dopamine receptor protein 2 0.0066 0.1698 0.186
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0041 0.0863 0.1398
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0041 0.0863 0.1398
Brugia malayi intermediate filament protein 0.0029 0.0458 0.0502
Brugia malayi hypothetical protein 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Leishmania major protein kinase A regulatory subunit, putative 0.0041 0.0863 0.1409
Echinococcus multilocularis neuropeptide receptor 0.0066 0.1698 0.1772
Brugia malayi ion channel NompC 0.0019 0.0098 0.0107
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0086 0.2364 0.251
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0973 0.0883
Schistosoma mansoni hypothetical protein 0.0066 0.1698 0.1615
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0134
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.1698 0.1772
Echinococcus multilocularis g protein coupled receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni ap endonuclease 0.0019 0.0105 0.0007
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.1698 0.2329
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0105 0.0013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0267 0.8499 1
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0222 0.6967 0.7635
Echinococcus granulosus patatin phospholipase domain containing protein 0.0041 0.0863 0.0848
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.1698 0.1772
Echinococcus granulosus sex peptide receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0041 0.0863 0.0848
Echinococcus multilocularis fmrfamide receptor 0.0066 0.1698 0.1772
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.006 0.149 0.1406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0134
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis adenylate cyclase type III, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.2364 0.2289
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0122 0.0044
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0041 0.0863 0.1409
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.1698 0.1615
Brugia malayi larval opioid receptor 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Mycobacterium ulcerans hypothetical protein 0.0041 0.0863 0.1398
Schistosoma mansoni neuropeptide receptor 0.0066 0.1698 0.1615
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0041 0.0863 0.1398
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0134
Leishmania major DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0863 0.0773
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.1698 0.1615
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.1698 0.1772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0026 0.0346 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Schistosoma mansoni jun-related protein 0.0074 0.1967 0.1888
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0863 0.1409
Echinococcus granulosus neuropeptide receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis sex peptide receptor 0.0066 0.1698 0.1772
Onchocerca volvulus 0.0029 0.0458 0.0524
Brugia malayi follicle stimulating hormone receptor 0.0066 0.1698 0.186
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0086 0.2364 0.2591
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.006 0.149 0.1542
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.1698 0.1772
Brugia malayi hypothetical protein 0.0071 0.1883 0.2063
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0346 0.0287
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0122 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus granulosus somatostatin receptor 0.0066 0.1698 0.1772
Onchocerca volvulus 0.0066 0.1698 0.2329
Plasmodium falciparum dihydroorotate dehydrogenase 0.0179 0.553 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0122 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Mycobacterium ulcerans hypothetical protein 0.0041 0.0863 0.1398
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0041 0.0863 0.0848
Brugia malayi cation channel family protein 0.0019 0.0098 0.0107
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0179 0.553 1
Loa Loa (eye worm) hypothetical protein 0.006 0.149 0.1633
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0019 0.0098 0.0107
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Schistosoma mansoni adenoreceptor 0.0066 0.1698 0.1615
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.2542 0.2708
Onchocerca volvulus 0.0029 0.0458 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0863 0.0773
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.007 0.1837 1
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.1698 0.186
Schistosoma mansoni intermediate filament proteins 0.0029 0.0458 0.0363
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.1837 0.2063
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0863 0.0998
Onchocerca volvulus 0.0066 0.1698 0.2329
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0031
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.1698 0.1772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0041 0.0863 0.0848
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.1837 0.1927
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0179 0.553 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0286 0.9126 1
Trichomonas vaginalis hypothetical protein 0.0026 0.0346 0.0287
Schistosoma mansoni hypothetical protein 0.0074 0.1967 0.1888
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0105 0.0013
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0041 0.0863 0.0848
Trichomonas vaginalis adenylate cyclase type, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) AGC/PKG protein kinase 0.0041 0.0863 0.0946
Schistosoma mansoni biogenic amine receptor 0.0066 0.1698 0.1615
Echinococcus granulosus cGMP dependent protein kinase 0.0041 0.0863 0.0848
Echinococcus granulosus allatostatin A receptor 0.0066 0.1698 0.1772
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0066 0.1698 0.1772
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0863 0.1398
Toxoplasma gondii exonuclease III APE 0.0019 0.0105 0.0013
Loa Loa (eye worm) calcium channel 0.0019 0.0098 0.0107
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0267 0.8499 1
Brugia malayi Transient-receptor-potential like protein 0.0019 0.0098 0.0107
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0863 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0122 0.002
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0041 0.0863 0.1409
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0041 0.0863 0.0848
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.1698 0.1772
Trypanosoma cruzi Flagellar Member 6 0.0041 0.0863 0.1409
Loa Loa (eye worm) ion channel NompC 0.0019 0.0098 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Onchocerca volvulus 0.0066 0.1698 0.2329
Giardia lamblia DINP protein human, muc B family 0.0019 0.0122 0.0219
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0041 0.0863 0.0848
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0041 0.0863 0.0903
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0041 0.0863 0.1409
Schistosoma mansoni hypothetical protein 0.0066 0.1698 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Schistosoma mansoni neuropeptide receptor 0.0066 0.1698 0.1615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0863 0.1398
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0286 0.9126 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0105 0.0115
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.006 0.149 0.1633
Schistosoma mansoni opsin-like receptor 0.0066 0.1698 0.1615
Echinococcus multilocularis lamin dm0 0.0029 0.0458 0.0399
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.1698 0.1772
Schistosoma mansoni hypothetical protein 0.0066 0.1698 0.1615
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Mycobacterium ulcerans transcriptional regulatory protein 0.0041 0.0863 0.1398
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0041 0.0863 0.0848
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0346 0.0287
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.1698 0.186
Echinococcus multilocularis g protein coupled receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.251 0.2671
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0041 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0179 0.553 1
Brugia malayi Dopamine receptor protein 1 0.0066 0.1698 0.186
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0179 0.553 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.1698 0.186
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0041 0.0863 0.0848
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis voltage gated potassium channel 0.0086 0.2364 0.251
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.1698 0.1772
Schistosoma mansoni amine GPCR 0.0066 0.1698 0.1615
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0041 0.0863 0.0946
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.1698 0.186
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0041 0.0863 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.1698 0.1772
Trypanosoma brucei unspecified product 0.0019 0.0122 0.0044
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Brugia malayi Dopamine receptor 0.0066 0.1698 0.186
Brugia malayi olfactory channel protein osm-9 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.1698 0.1772
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.1698 0.1772
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.007 0.1837 0.1927
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0179 0.553 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0346 0.0287
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0041 0.0863 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0863 0.0773
Echinococcus granulosus serotonin receptor 0.0066 0.1698 0.1772
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0179 0.553 0.606
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0179 0.553 1
Trypanosoma brucei cAMP binding protein, putative 0.0041 0.0863 0.1409
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.1698 0.1615
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0041 0.0863 0.0848
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Trichomonas vaginalis adenylate cyclase type, putative 0.0026 0.0346 0.0287
Schistosoma mansoni lamin 0.0029 0.0458 0.0363
Brugia malayi neuropeptide F receptor 0.0066 0.1698 0.186
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.1698 0.186
Echinococcus granulosus jun protein 0.0091 0.2542 0.2708
Echinococcus granulosus g protein coupled receptor 0.0066 0.1698 0.1772
Onchocerca volvulus 0.0066 0.1698 0.2329
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0105 0.0008
Brugia malayi G-protein coupled receptor 0.0066 0.1698 0.186
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.1698 0.1772
Schistosoma mansoni amine GPCR 0.0066 0.1698 0.1615
Leishmania major regulatory subunit of protein kinase a-like protein 0.0041 0.0863 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0863 0.0903
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0122 0.0096
Onchocerca volvulus 0.0041 0.0863 0.1114
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.1698 0.1772
Onchocerca volvulus 0.0066 0.1698 0.2329
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0041 0.0863 0.0773
Onchocerca volvulus 0.0041 0.0863 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Loa Loa (eye worm) hypothetical protein 0.0088 0.2458 0.2694
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0863 0.0773
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Mycobacterium ulcerans hypothetical protein 0.0041 0.0863 0.1398
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.1698 0.1615
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.007 0.1837 0.1927
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.1698 0.1772
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0041 0.0863 0.1409
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0458 0.0502
Schistosoma mansoni myosin xvIII 0.0066 0.1698 0.1615
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.1698 0.1772
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.1698 0.186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.1698 0.1772
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0086 0.2364 0.251
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0026 0.0346 0.0379
Schistosoma mansoni histamine h1 receptor 0.0066 0.1698 0.1615
Brugia malayi hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0041 0.0863 0.0773
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus neuropeptide s receptor 0.0066 0.1698 0.1772
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0863 0.1409
Schistosoma mansoni hypothetical protein 0.0026 0.0346 0.0251
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.1698 0.1772
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0222 0.6967 1
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.1698 0.1772
Echinococcus multilocularis somatostatin receptor 0.0066 0.1698 0.1772
Brugia malayi Cyclic-nucleotide gated cation channel 0.006 0.149 0.1633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0041 0.0863 0.1398
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0105 0.0013
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.007 0.1837 0.2063
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0286 0.9126 1
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0863 0.0773
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Trypanosoma cruzi cAMP response protein 1, putative 0.0041 0.0863 0.1409
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.251 0.2671
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Echinococcus granulosus intermediate filament protein 0.0029 0.0458 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.251 0.2671
Echinococcus granulosus voltage gated potassium channel 0.0086 0.2364 0.251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.1698 0.1772
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0122 0.0044
Echinococcus granulosus g-protein coupled receptor 0.0066 0.1698 0.1772
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.1698 0.186
Echinococcus multilocularis expressed conserved protein 0.0041 0.0863 0.0848
Leishmania major dihydroorotate dehydrogenase 0.0179 0.553 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0019 0.0098 0.0107
Echinococcus multilocularis hyperpolarization activated cyclic 0.006 0.149 0.1542
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.006 0.149 0.1649
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0179 0.553 1
Leishmania major hypothetical protein, conserved 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.1698 0.1615
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.1698 0.1615
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni voltage-gated potassium channel 0.0312 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.006 0.149 0.1633
Onchocerca volvulus 0.0066 0.1698 0.2329
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0458 0.0502
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0041 0.0863 0.0773
Schistosoma mansoni amine GPCR 0.0066 0.1698 0.1615
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0863 0.0903
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus granulosus cyclic nucleotide gated cation channel 0.006 0.149 0.1542
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.1837 0.2063
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0019 0.0098 0.0107
Echinococcus multilocularis allatostatin A receptor 0.0066 0.1698 0.1772
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0019 0.0098 0.0107
Echinococcus multilocularis serotonin receptor 0.0066 0.1698 0.1772
Trichomonas vaginalis adenylate cyclase type, putative 0.0026 0.0346 0.0287
Brugia malayi G-protein coupled receptor 0.0066 0.1698 0.186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Treponema pallidum catabolite gene activator 0.0041 0.0863 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.006 0.149 0.1406
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.1698 0.186
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.1698 0.1772
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.006 0.149 0.1406
Brugia malayi putative neuropeptide receptor 0.0066 0.1698 0.186
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus dna polymerase eta 0.0019 0.0122 0.0026
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.2542 0.2708
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.1837 0.2063
Echinococcus granulosus hypothetical protein 0.0066 0.1698 0.1772
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus hyperpolarization activated cyclic 0.006 0.149 0.1542
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Mycobacterium ulcerans hypothetical protein 0.0041 0.0863 0.1398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.1698 0.1772
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0458 0.0502
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.1698 0.1772
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.1698 0.186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.251 0.275
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0026
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0863 0.1409
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0863 0.0903
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.1698 0.1772
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0041 0.0863 0.0946
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0019 0.0098 0.0107
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0041 0.0863 0.0773
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.1698 0.2329
Schistosoma mansoni neuropeptide receptor 0.0066 0.1698 0.1615
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0043 0.0937 0.0847
Schistosoma mansoni voltage-gated potassium channel 0.006 0.149 0.1406
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0026 0.0346 0.0287
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0019 0.0098 0.0107
Brugia malayi G protein-coupled receptor 0.0066 0.1698 0.186
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0019 0.0098 0.0107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.1698 0.1772
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus granulosus dna polymerase kappa 0.0019 0.0122 0.0026
Schistosoma mansoni opsin-like receptor 0.0066 0.1698 0.1615
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0863 0.0946
Echinococcus granulosus hyperpolarization activated cyclic 0.006 0.149 0.1542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.1698 0.1615
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.006 0.149 0.1542
Echinococcus granulosus lamin 0.0029 0.0458 0.0399
Schistosoma mansoni hypothetical protein 0.0041 0.0863 0.0773
Echinococcus multilocularis musashi 0.0029 0.0458 0.0399
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0041 0.0863 0.1398
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.1698 0.186
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.006 0.149 0.1542
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.006 0.149 0.1649
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Schistosoma mansoni amine GPCR 0.0066 0.1698 0.1615
Brugia malayi Serotonin receptor 0.0066 0.1698 0.186
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0863 0.0848
Echinococcus multilocularis dna polymerase eta 0.0019 0.0122 0.0026
Onchocerca volvulus 0.0066 0.1698 0.2329
Schistosoma mansoni dihydroorotate dehydrogenase 0.0179 0.553 0.5486
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0041 0.0863 0.0946
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0019 0.0098 0.0107
Brugia malayi sulfakinin receptor protein 0.0066 0.1698 0.186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Leishmania major hypothetical protein, conserved 0.0041 0.0863 0.1409
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.1698 0.1772
Onchocerca volvulus 0.0066 0.1698 0.2329
Echinococcus granulosus cyclic nucleotide gated cation channel 0.006 0.149 0.1542
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.1698 0.186
Onchocerca volvulus 0.0066 0.1698 0.2329
Schistosoma mansoni lamin 0.0029 0.0458 0.0363
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.2364 0.2289
Onchocerca volvulus 0.0066 0.1698 0.2329
Brugia malayi voltage-dependent calcium channel 0.0019 0.0098 0.0107
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0863 0.0773
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.1698 0.186
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0026 0.0346 0.0287
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0105 0.0115
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0041 0.0863 0.1409
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.1837 0.2063
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0122 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.006 0.149 0.1542
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.007 0.1837 0.2063
Echinococcus multilocularis neuropeptide receptor 0.0066 0.1698 0.1772
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0179 0.553 0.606
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0041 0.0863 0.0848
Loa Loa (eye worm) voltage-gated potassium channel 0.0019 0.0098 0.0107
Trypanosoma cruzi cAMP binding protein, putative 0.0041 0.0863 0.1409
Echinococcus granulosus single minded 2 0.0026 0.0346 0.0275
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0179 0.553 1
Trypanosoma brucei Flagellar Member 6 0.0041 0.0863 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Brugia malayi AKH receptor 0.0066 0.1698 0.186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0346 0.0287
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Leishmania major hypothetical protein, conserved 0.0041 0.0863 0.1409
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.007 0.1837 0.3202
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.1698 0.186
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0041 0.0863 0.0773
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.251 0.2671
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0122 0.0044
Echinococcus multilocularis jun protein 0.0091 0.2542 0.2708
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.1698 0.186
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.1698 0.1615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.1698 0.1772
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0019 0.0098 0.0107
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0458 0.0502
Schistosoma mansoni ap endonuclease 0.0019 0.0105 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.1698 0.1772
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0346 0.0287
Trypanosoma brucei cAMP response protein 1, putative 0.0041 0.0863 0.1409
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0041 0.0863 0.0903
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0863 1
Trypanosoma cruzi protein kinase A regulatory subunit 0.0041 0.0863 0.1409
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0107
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0026 0.0346 0.0287
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.1698 0.1772
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0019 0.0098 0.0107
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) voltage-gated calcium channel 0.0019 0.0098 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0346 0.0287
Schistosoma mansoni amine GPCR 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0179 0.553 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.1698 0.1615
Schistosoma mansoni opsin-like receptor 0.0066 0.1698 0.1615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.1698 0.1615
Echinococcus multilocularis orexin receptor type 2 0.0066 0.1698 0.1772
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0044
Echinococcus granulosus neuropeptide receptor 0.0066 0.1698 0.1772
Schistosoma mansoni biogenic amine receptor 0.0066 0.1698 0.1615
Loa Loa (eye worm) hypothetical protein 0.0066 0.1698 0.186

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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