Detailed information for compound 1247659

Basic information

Technical information
  • TDR Targets ID: 1247659
  • Name: 3-methyl-5-(phenylamino)-1,3-thiazolidine-2,4 -dione
  • MW: 222.264 | Formula: C10H10N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C(=O)SC(C1=O)Nc1ccccc1
  • InChi: 1S/C10H10N2O2S/c1-12-9(13)8(15-10(12)14)11-7-5-3-2-4-6-7/h2-6,8,11H,1H3
  • InChiKey: NYONKYOVBVHEOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-5-(phenylamino)thiazolidine-2,4-dione
  • 3-methyl-5-(phenylamino)thiazolidine-2,4-quinone
  • MLS000528370
  • STK215703
  • SMR000120945
  • 3-Methyl-5-phenylamino-thiazolidine-2,4-dione
  • BAS 07297786

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi CCR4 0.0008 0.0053 0.0145
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0053 0.0163
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0276 0.3188 0.8456
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0053 0.0071
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.4294
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0438 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0071 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0438 0.1372
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0219 0.4705
Leishmania major hypothetical protein, conserved 0.0008 0.0053 0.072
Loa Loa (eye worm) hypothetical protein 0.003 0.0313 0.0813
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0053 0.0125
Echinococcus multilocularis cpg binding protein 0.0034 0.0352 0.0345
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.4987
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.3188 0.7476
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0438 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0041 0.0123
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0245 0.0766
Schistosoma mansoni smad1 5 8 and 0.001 0.0071 0.0166
Echinococcus multilocularis geminin 0.0368 0.4264 0.426
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0071 0.0064
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0053 0.072
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0438 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0053 0.0163
Plasmodium falciparum DNase I-like protein, putative 0.0008 0.0053 0.1215
Brugia malayi phosphoinositide-dependent protein kinase I 0.0276 0.3188 1
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0008 0.0053 0.072
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0053 0.0046
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0053 0.0071
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0053 0.072
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0072 0.0099
Trypanosoma brucei RNA editing exonuclease 2 0.0008 0.0053 0.072
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Echinococcus granulosus translational activator gcn1 0.0006 0.0023 0.0025
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0219 0.0212
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0438 0.1356
Schistosoma mansoni smad1 5 8 and 0.001 0.0071 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.075 0.1759
Plasmodium falciparum transportin 0.0006 0.0023 0.0533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Brugia malayi MH2 domain containing protein 0.0144 0.1646 0.5152
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1646 0.4356
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0072 0.0064
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0438 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0049 0.0115
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.4705
Trichomonas vaginalis AGC family protein kinase 0.0276 0.3188 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0053 0.1215
Echinococcus multilocularis importin 5 0.0006 0.0023 0.0016
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0219 0.0325
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0276 0.3188 0.8456
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0071 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0053 0.0071
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0053 0.0122
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0053 0.0046
Plasmodium falciparum importin beta, putative 0.003 0.0313 0.7138
Leishmania major endonuclease/exonuclease protein-like protein 0.0008 0.0053 0.072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0053 0.072
Schistosoma mansoni Smad4 0.001 0.0071 0.0166
Trichomonas vaginalis helicase, putative 0.0007 0.0041 0.0123
Trichomonas vaginalis ran, putative 0.0022 0.0219 0.0682
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0071 0.0169
Schistosoma mansoni hypothetical protein 0.0368 0.4264 1
Leishmania major RNA-editing complex protein MP100, putative 0.0008 0.0053 0.072
Brugia malayi MH1 domain containing protein 0.0005 0.002 0.0038
Loa Loa (eye worm) nuclear factor I 0.0005 0.002 0.0032
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0023 0.0043
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Echinococcus granulosus importin 5 0.0006 0.0023 0.0025
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0053 0.0122
Echinococcus granulosus smad 0.001 0.0071 0.0098
Schistosoma mansoni smad 0.001 0.0071 0.0166
Schistosoma mansoni smad1 5 8 and 0.001 0.0071 0.0166
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0245 0.0766
Onchocerca volvulus 0.0008 0.0053 0.1423
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Echinococcus granulosus snurportin 1 0.0325 0.3769 0.5791
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0053 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0438 0.1372
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1646 0.4356
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0053 0.0163
Leishmania major importin beta-1 subunit, putative 0.0025 0.0245 0.535
Brugia malayi MH2 domain containing protein 0.001 0.0071 0.02
Brugia malayi kap beta 3 protein 0.0006 0.0023 0.0051
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0053 0.0125
Plasmodium vivax importin-beta 2, putative 0.003 0.0313 0.6977
Schistosoma mansoni hypothetical protein 0.0368 0.4264 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0054 0.0737
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0122
Schistosoma mansoni hypothetical protein 0.0325 0.3769 0.8838
Echinococcus multilocularis Smad4 0.001 0.0071 0.0064
Brugia malayi CXXC zinc finger family protein 0.0032 0.033 0.1015
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0313 0.6977
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0053 0.072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0245 0.4989
Schistosoma mansoni importin-beta 2 0.0006 0.0023 0.0055
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0053 0.0046
Echinococcus granulosus geminin 0.0368 0.4264 0.6554
Brugia malayi Importin beta-1 subunit 0.003 0.0313 0.0961
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0008 0.0053 0.1215
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0053 0.0046
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0053 0.1215
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0053 0.072
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0438 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Schistosoma mansoni cript-related 0.0008 0.0053 0.0125
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0438 1
Loa Loa (eye worm) Smad1 0.001 0.0071 0.0169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0665 1
Leishmania major GTP-binding protein, putative 0.0022 0.0219 0.4705
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0245 0.0766
Brugia malayi MH1 domain containing protein 0.001 0.0071 0.02
Echinococcus granulosus transportin 1 0.0006 0.0023 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0276 0.3188 1
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0008 0.0053 0.0167
Trichomonas vaginalis hypothetical protein 0.0006 0.0023 0.0069
Echinococcus granulosus importin subunit beta 1 0.003 0.0313 0.0471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.4294
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0053 0.0167
Toxoplasma gondii exonuclease III APE 0.0041 0.0438 0.6467
Leishmania major hypothetical protein, conserved 0.0008 0.0053 0.072
Trichomonas vaginalis AGC family protein kinase 0.0276 0.3188 1
Schistosoma mansoni hypothetical protein 0.0008 0.0053 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0313 0.6977
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0023 0.0073
Echinococcus multilocularis transportin 1 0.0006 0.0023 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0562
Schistosoma mansoni synaptojanin 0.0008 0.0053 0.0125
Brugia malayi MH1 domain containing protein 0.0005 0.002 0.0038
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0053 0.0046
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0071 0.0169
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Entamoeba histolytica hypothetical protein 0.0025 0.0245 0.077
Echinococcus multilocularis smad 0.001 0.0071 0.0064
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Brugia malayi MH1 domain containing protein 0.001 0.0071 0.02
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0122
Schistosoma mansoni ap endonuclease 0.0041 0.0438 0.1028
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0053 0.0071
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0053 0.072
Schistosoma mansoni cpg binding protein 0.0034 0.0352 0.0825
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0041 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0438 1
Echinococcus multilocularis synaptojanin 1 0.0008 0.0053 0.0046
Brugia malayi Smad1 0.001 0.0071 0.02
Echinococcus granulosus cpg binding protein 0.0034 0.0352 0.053
Onchocerca volvulus 0.0008 0.0053 0.1423
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6502 0.6499
Echinococcus multilocularis snurportin 1 0.0325 0.3769 0.3764
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0008 0.0053 0.072
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0053 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0053 0.072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0438 0.0664
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0053 0.0163
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0665
Onchocerca volvulus Putative neutral sphingomyelinase 0.0008 0.0053 0.1423
Schistosoma mansoni ran 0.0022 0.0219 0.0513
Echinococcus multilocularis importin subunit beta 1 0.003 0.0313 0.0306
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0219 0.3043
Brugia malayi Protein kinase domain containing protein 0.0276 0.3188 1
Brugia malayi RNA, U transporter 1 0.0087 0.0971 0.3032
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0053 0.072
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0313 0.4512
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0122
Schistosoma mansoni ap endonuclease 0.0041 0.0438 0.1028
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0167
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0008 0.0053 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0049 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6502 1
Echinococcus granulosus synaptojanin 1 0.0008 0.0053 0.0071
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0438 0.0432
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0438 0.1146
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.007 0.0198
Schistosoma mansoni ran 0.0022 0.0219 0.0513
Schistosoma mansoni Smad4 0.0004 0.0007 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0438 1
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0053 0.0071
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0008 0.0053 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Onchocerca volvulus 0.0032 0.033 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.033 0.0859
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0053 0.0163
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0053 0.0163
Schistosoma mansoni cpg binding protein 0.0034 0.0352 0.0825
Loa Loa (eye worm) hypothetical protein 0.0005 0.002 0.0032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0071 0.0166
Loa Loa (eye worm) hypothetical protein 0.0008 0.0053 0.0122
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0008 0.0053 0.072
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0042
Brugia malayi MH2 domain containing protein 0.001 0.0071 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0053 0.0163
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0053 0.0122
Schistosoma mansoni importin beta-1 0.003 0.0313 0.0734
Schistosoma mansoni smad 0.0004 0.0007 0.0017
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0053 0.0466
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0053 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0438 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0438 0.5
Echinococcus granulosus Smad4 0.001 0.0071 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6502 1
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0008 0.0053 0.072
Schistosoma mansoni cpg binding protein 0.0032 0.033 0.0775
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6502 0.6499
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0053 0.0046
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0053 0.072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.4294
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0276 0.3188 0.3183
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0123
Loa Loa (eye worm) histone methyltransferase 0.001 0.0072 0.0171
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0053 0.0122
Entamoeba histolytica Ran family GTPase 0.0022 0.0219 0.0686
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0053 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.001 0.0022
Leishmania major hypothetical protein, conserved 0.0008 0.0053 0.072
Echinococcus multilocularis translational activator gcn1 0.0006 0.0023 0.0016
Schistosoma mansoni synaptojanin 0.0008 0.0053 0.0125
Entamoeba histolytica protein kinase, putative 0.0276 0.3188 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0064
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0053 0.0122
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0023 0.0043
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.3769 1
Schistosoma mansoni nocturnin 0.0008 0.0053 0.0125
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0053 0.0167
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0438 0.5
Schistosoma mansoni Smad4 0.0004 0.0007 0.0017
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0276 0.3188 0.4897
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0123
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0071 0.0098
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0008 0.0053 0.0167
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0053 0.0145
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0049 0.0064
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0438 0.1375
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0053 0.0122

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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