Detailed information for compound 1248958

Basic information

Technical information
  • TDR Targets ID: 1248958
  • Name: 1-(4-methylcyclohexyl)-4-propylsulfonylpipera zine; oxalic acid
  • MW: 378.484 | Formula: C16H30N2O6S
  • H donors: 2 H acceptors: 6 LogP: -0.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CCCS(=O)(=O)N1CCN(CC1)C1CCC(CC1)C
  • InChi: 1S/C14H28N2O2S.C2H2O4/c1-3-12-19(17,18)16-10-8-15(9-11-16)14-6-4-13(2)5-7-14;3-1(4)2(5)6/h13-14H,3-12H2,1-2H3;(H,3,4)(H,5,6)
  • InChiKey: JQHTVBSIYFLQPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methylcyclohexyl)-4-propylsulfonyl-piperazine; oxalic acid
  • ethanedioic acid; 1-(4-methylcyclohexyl)-4-propylsulfonyl-piperazine
  • MLS000714530
  • SMR000274509

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.02 0.1489
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.026
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0066 0.0208
Schistosoma mansoni hypothetical protein 0.0035 0.0392 0.0577
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0392 0.0392
Echinococcus multilocularis GPCR, family 2 0.0035 0.0392 0.0392
Mycobacterium ulcerans L-lysine aminotransferase 0.0024 0.0158 0.0493
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.2 0.2022
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.5141 0.5254
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0264
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0624 0.0624
Mycobacterium ulcerans acetylornithine aminotransferase 0.0024 0.0158 0.0493
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0857 0.0846
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.02 0.0241
Schistosoma mansoni transient receptor potential channel 0.0133 0.2396 0.3523
Echinococcus granulosus Aminotransferase class III 0.0024 0.0158 0.0158
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0391 0.0391
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0158 0.0493
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0712 0.0698
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0392 0.0368
Echinococcus multilocularis muscleblind protein 1 0.018 0.3369 0.3369
Echinococcus multilocularis peregrin 0.0035 0.0391 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Leishmania major importin beta-1 subunit, putative 0.0026 0.0211 0.1567
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0948 0.094
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0171 0.3173 0.3173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0712 0.0712
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0712 0.1048
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.3173 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6908 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0512 0.0512
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0291 0.0264
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0066 0.0208
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0391 0.1233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0291 0.0264
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1173 0.366
Echinococcus granulosus peptidase Clp S14 family 0.0112 0.1966 0.1966
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.209 0.6339
Echinococcus granulosus muscleblind protein 0.018 0.3369 0.3369
Schistosoma mansoni jumonji domain containing protein 0.0163 0.3005 0.4419
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0034 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.0138
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0075 0.1202 0.1202
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0712 0.5296
Echinococcus multilocularis snurportin 1 0.0348 0.68 0.68
Brugia malayi jmjC domain containing protein 0.003 0.0291 0.0298
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0211 0.0305
Schistosoma mansoni hypothetical protein 0.0076 0.1231 0.1811
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1345 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0255
Brugia malayi hypothetical protein 0.0041 0.0512 0.0525
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0082 0.1345 0.1345
Schistosoma mansoni phd/f-box containing protein 0.003 0.0291 0.0428
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0712 0.2245
Toxoplasma gondii thioredoxin reductase 0.0047 0.0624 0.1966
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1847 0.5761
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.02 0.0241
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.02 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0171 0.0251
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0712 0.2245
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0033
Plasmodium vivax glutathione reductase, putative 0.0047 0.0624 0.1966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.076 0.076
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0024 0.0158 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0624 0.4638
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1345 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1847 0.5761
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.1345 0.1379
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0042 0.0008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0042 0.0042
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0948 0.0948
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0082 0.1345 0.1345
Brugia malayi MH2 domain containing protein 0.0018 0.0042 0.0043
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0291 0.0291
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.1345 0.1947
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0624 0.1946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0272 0.2026
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0624 0.1966
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.1345 0.1947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Brugia malayi MH2 domain containing protein 0.0267 0.5141 0.5271
Echinococcus multilocularis short transient receptor potential channel 6 0.0133 0.2396 0.2396
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0034 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.0138
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1847 0.5761
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0272 0.2026
Echinococcus multilocularis transient receptor potential gamma protein 0.0201 0.3792 0.3792
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0211 0.0305
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0291 0.0291
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0337 0.1062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0211 0.0305
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.68 0.696
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1173 0.1725
Brugia malayi PHD-finger family protein 0.0035 0.0391 0.0401
Echinococcus granulosus tar DNA binding protein 0.0062 0.0948 0.0948
Trypanosoma brucei trypanothione reductase 0.0047 0.0624 0.4638
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.02 0.1489
Schistosoma mansoni smad 0.0018 0.0042 0.0062
Entamoeba histolytica hypothetical protein 0.0024 0.0171 0.0198
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0168 0.3108 0.9679
Giardia lamblia GTOR 0.0018 0.0034 0.005
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.0255
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.02 0.0625
Loa Loa (eye worm) glutathione reductase 0.0047 0.0624 0.0606
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0059 0.0877 0.2358
Loa Loa (eye worm) hypothetical protein 0.0082 0.1345 0.1348
Plasmodium vivax importin-beta 2, putative 0.0033 0.0337 0.1062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1954 0.2003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0026 0.02 0.0205
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1173 0.3697
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0712 0.0712
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0082 0.1345 0.1907
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0024 0.0158 0.0493
Loa Loa (eye worm) hypothetical protein 0.0026 0.02 0.0171
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0042 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0948 0.1394
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.6908 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Plasmodium falciparum importin beta, putative 0.0033 0.0337 0.1062
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0034 0.0034
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0168 0.3108 0.9694
Loa Loa (eye worm) hypothetical protein 0.0126 0.2258 0.2288
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.209 0.6519
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0171 0.0171
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0042 0.0042
Echinococcus multilocularis neuropeptide s receptor 0.0504 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0171 0.1269
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1954 0.1975
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0255
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0112 0.1966 0.6134
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.1345 0.1947
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0942 0.0942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.076 0.076
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0291 0.0428
Plasmodium vivax ornithine aminotransferase, putative 0.0024 0.0158 0.0498
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.02 0.0241
Echinococcus multilocularis phd:f box containing protein 0.003 0.0291 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Brugia malayi follicle stimulating hormone receptor 0.0492 0.9755 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0942 0.294
Brugia malayi Thioredoxin reductase 0.0047 0.0624 0.0639
Echinococcus granulosus ornithine aminotransferase 0.0024 0.0158 0.0158
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.3491 0.3491
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0291 0.0916
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0024 0.0158 0.0493
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0392 0.0402
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0512 0.0512
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.5141 0.5254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0392 0.0392
Echinococcus multilocularis transient receptor potential ion channel A 0.0194 0.3654 0.3654
Loa Loa (eye worm) hypothetical protein 0.0026 0.02 0.0171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2 0.2941
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0171 0.3173 0.9895
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6908 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0062
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0877 0.2762
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0112 0.1966 0.6134
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0171 0.1269
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0024 0.0158 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.02 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0391 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus granulosus flap endonuclease 1 0.0029 0.0272 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Mycobacterium ulcerans hypothetical protein 0.0026 0.02 0.0625
Loa Loa (eye worm) hypothetical protein 0.018 0.3369 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Brugia malayi Flap endonuclease-1 0.0029 0.0272 0.0279
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.02 0.0625
Giardia lamblia PHD finger protein 15 0.0035 0.0391 0.0566
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0272 0.2026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0035
Echinococcus granulosus transient receptor potential gamma protein 0.0201 0.3792 0.3792
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0082 0.1345 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0042 0.0008
Leishmania major trypanothione reductase 0.0047 0.0624 0.4638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.076 0.1118
Schistosoma mansoni hypothetical protein 0.0348 0.68 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0255
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0024 0.0158 0.0493
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0158 0.0158
Echinococcus multilocularis Smad4 0.0018 0.0042 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.02 0.0625
Mycobacterium tuberculosis Probable aminotransferase 0.0168 0.3108 0.9694
Brugia malayi Probable ClpP-like protease 0.0171 0.3173 0.3253
Loa Loa (eye worm) hypothetical protein 0.0201 0.3792 0.3865
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1847 0.5761
Leishmania major hypothetical protein, conserved 0.003 0.0291 0.2162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0942 0.294
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0291 0.2162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0391 0.0367
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.2 0.2
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0712 0.073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0033
Echinococcus multilocularis peptidase Clp (S14 family) 0.0112 0.1966 0.1966
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0066 0.0206
Schistosoma mansoni hypothetical protein 0.0035 0.0392 0.0577
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 0.99
Echinococcus granulosus transient receptor potential ion channel A 0.0194 0.3654 0.3654
Plasmodium vivax JmjC domain containing protein 0.003 0.0291 0.0916
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0712 0.0712
Schistosoma mansoni Smad4 0.0018 0.0042 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0082 0.1345 0.1947
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.02 0.0625
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0291 0.0428
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0337 0.0337
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.02 0.1489
Schistosoma mansoni transient receptor potential channel 4 0.0201 0.3792 0.5576
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0034 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.02 0.0625
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0942 0.0966
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 0.4594
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0624 0.0606
Mycobacterium ulcerans hypothetical protein 0.0168 0.3108 0.9694
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0674 0.0674
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0082 0.1345 0.1345
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0171 0.3173 1
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0158 0.0158
Echinococcus multilocularis short transient receptor potential channel 6 0.0133 0.2396 0.2396
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0624 0.0624
Echinococcus granulosus GPCR family 2 0.0035 0.0392 0.0392
Echinococcus granulosus importin subunit beta 1 0.0033 0.0337 0.0337
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0712 0.5296
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.116 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0291 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1173 0.366
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0158 0.0493
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0034 0.0255
Brugia malayi RNA binding protein 0.0062 0.0948 0.0972
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1202 0.1202
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.02 0.0139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.076 0.0747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Plasmodium falciparum ornithine aminotransferase 0.0024 0.0158 0.0498
Brugia malayi glutathione reductase 0.0047 0.0624 0.0639
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0024 0.0158 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Loa Loa (eye worm) RNA binding protein 0.0062 0.0948 0.094
Onchocerca volvulus Alhambra homolog 0.0035 0.0391 1
Echinococcus multilocularis smad 0.0018 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.01 0.0747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Entamoeba histolytica hypothetical protein 0.0041 0.0512 0.0695
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0168 0.3108 0.9694
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0066 0.0208
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0171 0.3173 0.3173
Echinococcus multilocularis ubiquitin specific protease 41 0.0082 0.1345 0.1345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0712 0.0712
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0171 0.0171
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0168 0.3108 0.4498
Loa Loa (eye worm) hypothetical protein 0.0076 0.1231 0.1231
Echinococcus granulosus snurportin 1 0.0348 0.68 0.68
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1173 0.1173
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0024 0.0158 0.0498
Schistosoma mansoni transient receptor potential channel 0.0201 0.3792 0.5576
Echinococcus granulosus phd:f box containing protein 0.003 0.0291 0.0291
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0942 0.0942
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0337 0.2507
Brugia malayi jmjC domain containing protein 0.003 0.0291 0.0298
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1173 0.1725
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0033
Entamoeba histolytica hypothetical protein 0.0026 0.0211 0.0257
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0082 0.1345 0.1345
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0512 0.0753
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0712 0.0712
Brugia malayi MH1 domain containing protein 0.0018 0.0042 0.0043
Echinococcus granulosus smad 0.0018 0.0042 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.209 0.6519
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3206 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0712 0.2245
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0291 0.0291
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0392 0.0392
Brugia malayi jmjC domain containing protein 0.003 0.0291 0.0298
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0942 0.294
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0034 0.0255
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.076 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1231 0.1262
Brugia malayi RNA, U transporter 1 0.0093 0.1569 0.1608
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0712 0.5296
Loa Loa (eye worm) hypothetical protein 0.0068 0.1065 0.106
Loa Loa (eye worm) Smad1 0.0018 0.0042 0.0008
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0674 0.0674
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0171 0.3173 0.4667
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0391 0.0391
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0291 0.0916
Brugia malayi jmjC domain containing protein 0.0186 0.3491 0.3579
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0948 0.094
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0112 0.1966 0.5933
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0211 0.1567
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1173 0.8722
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0034 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0942 0.1386
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0062
Schistosoma mansoni hypothetical protein 0.0035 0.0392 0.0577
Brugia malayi Bromodomain containing protein 0.0035 0.0391 0.0401
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0272 0.0245
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1847 0.5541
Schistosoma mansoni hypothetical protein 0.0035 0.0391 0.0575
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0272 0.0859
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0291 0.0291
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.076 0.076
Plasmodium falciparum thioredoxin reductase 0.0047 0.0624 0.1966
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2 0.2941
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0272 0.0346
Brugia malayi AMP-binding enzyme family protein 0.0026 0.02 0.0205
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0111 0.1954 0.1975
Mycobacterium tuberculosis Probable reductase 0.0106 0.1847 0.5761
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0948 0.1394
Brugia malayi Transient-receptor-potential like protein 0.0075 0.1202 0.1233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1954 0.2003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.0138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0171 0.0175
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.02 0.0625
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0034 0.0255
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 0.99
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0272 0.0859
Loa Loa (eye worm) hypothetical protein 0.0171 0.3173 0.3229
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0291 0.0916
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1173 0.366
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0291 0.2162
Schistosoma mansoni protein phosphatase 2C 0.003 0.0291 0.0428
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.3491 0.3491
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0391 0.1233
Brugia malayi AMP-binding enzyme family protein 0.0026 0.02 0.0205
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.6908 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.02 0.0139
Plasmodium falciparum phd finger protein, putative 0.0035 0.0391 0.1233
Schistosoma mansoni hypothetical protein 0.0041 0.0512 0.0753
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3206 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.209 0.6519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0368
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Schistosoma mansoni transient receptor potential channel 0.0133 0.2396 0.3523
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0948 0.1394
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0877 0.2762
Loa Loa (eye worm) hypothetical protein 0.0021 0.01 0.0068
Echinococcus granulosus neuropeptide receptor A26 0.0504 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0082 0.1345 0.1978
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0171 0.3173 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0392 0.0392
Schistosoma mansoni importin beta-1 0.0033 0.0337 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0171 0.0538
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0024 0.0158 0.0493
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0492 0.9755 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0024 0.0158 0.0498
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0034 0.005
Loa Loa (eye worm) hypothetical protein 0.018 0.3369 0.3431
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3206 1
Brugia malayi isocitrate dehydrogenase 0.0051 0.0712 0.073
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1173 0.1173
Echinococcus granulosus short transient receptor potential channel 6 0.0133 0.2396 0.2396
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0391 0.0367
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0034 0.0255
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0712 0.2245
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0024 0.0158 0.0493
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0066 0.0206
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0082 0.1345 0.1978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.076 0.076
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0272 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0948 0.1394
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0712 0.5296
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0034 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.076 0.1118
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0948 0.1394
Schistosoma mansoni jumonji domain containing protein 0.003 0.0291 0.0428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Plasmodium falciparum flap endonuclease 1 0.0029 0.0272 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0171 0.0247
Plasmodium falciparum glutathione reductase 0.0047 0.0624 0.1966
Brugia malayi MH2 domain containing protein 0.0018 0.0042 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.076 0.1118
Entamoeba histolytica hypothetical protein 0.0041 0.0512 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus multilocularis Aminotransferase class III 0.0024 0.0158 0.0158
Toxoplasma gondii hypothetical protein 0.0059 0.0877 0.2762
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0337 0.2507
Brugia malayi Importin beta-1 subunit 0.0033 0.0337 0.0346
Brugia malayi Muscleblind-like protein 0.018 0.3369 0.3454
Loa Loa (eye worm) hypothetical protein 0.0033 0.0337 0.0312
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.1345 1
Schistosoma mansoni hypothetical protein 0.0035 0.0392 0.0577
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0291 0.0291
Entamoeba histolytica hypothetical protein 0.0041 0.0512 0.0695
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0877 0.1269
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0272 0.0394
Echinococcus granulosus peregrin 0.0035 0.0391 0.0391
Brugia malayi jmjC domain containing protein 0.003 0.0291 0.0298
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0291 0.0264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6908 1
Echinococcus granulosus ubiquitin specific protease 41 0.0082 0.1345 0.1345
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0712 0.5296
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0948 0.0972
Echinococcus granulosus TRP transient receptor potential channel 0.0075 0.1202 0.1202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1173 0.366
Schistosoma mansoni flap endonuclease-1 0.0027 0.0215 0.0315
Loa Loa (eye worm) hypothetical protein 0.0079 0.1296 0.1298
Brugia malayi TAR-binding protein 0.0062 0.0948 0.0972
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0024 0.0158 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.0138
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0034 0.0255
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0034 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.2 0.2
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0033
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0291 0.2162
Brugia malayi MH1 domain containing protein 0.0018 0.0042 0.0043
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0272 0.0394
Echinococcus multilocularis muscleblind protein 0.018 0.3369 0.3369
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0391 0.0575
Brugia malayi Smad1 0.0018 0.0042 0.0043
Echinococcus granulosus Smad4 0.0018 0.0042 0.0042
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0291 0.0291
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0712 0.2222
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0034 0.0035
Brugia malayi jmjC domain containing protein 0.0114 0.2 0.205
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0291 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0034 0.005
Echinococcus granulosus short transient receptor potential channel 6 0.0133 0.2396 0.2396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.02 0.0625
Echinococcus multilocularis neuropeptide receptor A26 0.0504 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0392 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.02 0.0625
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0942 0.7006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1847 0.5761
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0264
Entamoeba histolytica hypothetical protein 0.0041 0.0512 0.0695
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0171 0.3173 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 232.23 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 1.2589 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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