Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0008 | 0.0008 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0437 | 0.0425 | 0.0399 |
Echinococcus multilocularis | geminin | 0.0169 | 0.0133 | 0.0132 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.1468 | 0.1548 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | TRE-1 protein | 0.0136 | 0.0097 | 0.0097 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.005 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Onchocerca volvulus | 0.0136 | 0.0097 | 0.0093 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0111 | 0.0111 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0094 | 0.009 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Onchocerca volvulus | 0.0136 | 0.0097 | 0.0093 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0796 | 0.0816 | 0.0791 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0315 | 0.0293 | 0.0267 |
Schistosoma mansoni | alpha glucosidase | 0.1468 | 0.1548 | 0.1657 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.1468 | 0.1548 | 0.1525 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0796 | 0.0816 | 0.0791 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0796 | 0.0816 | 0.5004 |
Onchocerca volvulus | Trehalase homolog | 0.0136 | 0.0097 | 0.0093 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0123 | 0.0083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0023 | 0.0022 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Brugia malayi | Trehalase family protein | 0.0136 | 0.0097 | 0.0097 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0094 | 0.009 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1468 | 0.1548 | 0.1547 |
Schistosoma mansoni | alpha-amylase | 0.0123 | 0.0083 | 0.0078 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.7545 | 0.8162 | 0.8788 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.7545 | 0.8162 | 0.8788 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0796 | 0.0816 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.5093 | 0.5493 | 0.5493 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.1468 | 0.1548 | 0.1525 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.8174 | 0.8847 | 0.8847 |
Schistosoma mansoni | beta-mannosidase | 0.0102 | 0.0061 | 0.0054 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1468 | 0.1548 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.005 | 0.0043 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0796 | 0.0816 | 0.0791 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.7545 | 0.8162 | 0.8788 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.1468 | 0.1548 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0796 | 0.0816 | 0.0791 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.8174 | 0.8847 | 0.9526 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.8578 | 0.9287 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6384 | 0.6899 | 0.6891 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0123 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0094 | 0.0094 |
Leishmania major | alpha glucosidase II subunit, putative | 0.1468 | 0.1548 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.0202 | 0.0207 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.7545 | 0.8162 | 0.8788 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0186 | 0.0152 | 0.0126 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.001 | 0.001 |
Brugia malayi | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.005 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Echinococcus granulosus | smoothened | 0.0173 | 0.0137 | 0.0137 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0001 | 0.0001 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.7545 | 0.8162 | 0.8788 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0058 | 0.0058 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.01 | 0.0058 | 0.0032 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.1468 | 0.1548 | 0.1657 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.8174 | 0.8847 | 0.9526 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.8578 | 0.9287 | 1 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0112 | 0.011 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.0136 | 0.0097 | 0.0093 | |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0102 | 0.0061 | 0.0034 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0796 | 0.0816 | 0.0791 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.005 | 0.0043 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.9233 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.8578 | 0.9287 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1468 | 0.1548 | 0.1548 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0186 | 0.0152 | 0.0126 |
Echinococcus granulosus | bile acid beta glucosidase | 0.7545 | 0.8162 | 0.8788 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0207 | 0.0175 | 0.0628 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.005 | 0.005 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.1468 | 0.1548 | 0.1525 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0796 | 0.0816 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0008 | 0.0008 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0207 | 0.0175 | 0.0178 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.6058 | 0.6544 | 0.7043 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.1468 | 0.1548 | 0.1525 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.1468 | 0.1548 | 0.1657 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0123 | 0.0083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.001 | 0.001 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0071 | 0.0027 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.0438 | 0.0437 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.001 | 0.001 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0008 | 0.0008 |
Schistosoma mansoni | alpha-amylase | 0.0123 | 0.0083 | 0.0078 |
Onchocerca volvulus | 0.0136 | 0.0097 | 0.0093 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.1468 | 0.1548 | 0.1525 |
Brugia malayi | Ceramide glucosyltransferase | 0.8578 | 0.9287 | 0.9287 |
Echinococcus multilocularis | smoothened | 0.0173 | 0.0137 | 0.0137 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0207 | 0.0175 | 0.0175 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0207 | 0.0175 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0046 | 0.0045 |
Loa Loa (eye worm) | TRE-2 protein | 0.0136 | 0.0097 | 0.0097 |
Echinococcus granulosus | geminin | 0.0169 | 0.0133 | 0.0132 |
Schistosoma mansoni | alpha-glucosidase | 0.7501 | 0.8115 | 0.8737 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.8578 | 0.9287 | 0.9287 |
Brugia malayi | Beta-glucuronidase precursor | 0.017 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | trehalase | 0.0136 | 0.0097 | 0.0097 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.1468 | 0.1548 | 0.1525 |
Loa Loa (eye worm) | beta-glucuronidase | 0.017 | 0.0134 | 0.0134 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.005 | 0.0043 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0071 | 0.0027 | 0.0018 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.8578 | 0.9287 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0136 | 0.0097 | 0.007 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0008 | 0.0008 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0207 | 0.0175 | 0.0178 |
Brugia malayi | Trehalase family protein | 0.0136 | 0.0097 | 0.0097 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0123 | 0.0083 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.7501 | 0.8115 | 0.8737 |
Schistosoma mansoni | hypothetical protein | 0.0267 | 0.024 | 0.0247 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.01 | 0.0058 | 0.0052 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0207 | 0.0175 | 0.0149 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.1468 | 0.1548 | 0.1525 |
Onchocerca volvulus | 0.533 | 0.5751 | 0.6188 | |
Brugia malayi | Trehalase family protein | 0.0136 | 0.0097 | 0.0097 |
Schistosoma mansoni | alpha-amylase | 0.0123 | 0.0083 | 0.0078 |
Onchocerca volvulus | 0.0136 | 0.0097 | 0.0093 | |
Brugia malayi | manba-prov protein | 0.0102 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0101 | 0.0059 | 0.0059 |
Brugia malayi | Trehalase family protein | 0.0136 | 0.0097 | 0.0097 |
Echinococcus multilocularis | beta galactosidase | 0.0149 | 0.0111 | 0.0109 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.8578 | 0.9287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | alpha amylase | 0.0123 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0178 | 0.0143 | 0.0143 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.01 | 0.0058 | 0.0052 |
Schistosoma mansoni | beta-galactosidase | 0.0149 | 0.0111 | 0.0109 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0213 | 0.0181 | 0.067 |
Echinococcus multilocularis | alpha glucosidase | 0.0123 | 0.0083 | 0.0078 |
Giardia lamblia | Ceramide glucosyltransferase | 0.3889 | 0.4182 | 1 |
Treponema pallidum | hypothetical protein | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0796 | 0.0816 | 0.0816 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1468 | 0.1548 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.1468 | 0.1548 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0796 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0097 | 0.0097 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0123 | 0.0083 | 0.5 |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0207 | 0.0175 | 0.0783 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0065 | 0.0038 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Loa Loa (eye worm) | alpha amylase | 0.0123 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.001 | 0.001 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.1468 | 0.1548 | 0.1525 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.9233 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0133 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0133 | 0.0132 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.8174 | 0.8847 | 0.8847 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.005 | 0.0043 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6384 | 0.6899 | 0.6891 |
Trichomonas vaginalis | trehalase, putative | 0.0136 | 0.0097 | 0.007 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.8174 | 0.8847 | 0.9526 |
Schistosoma mansoni | alpha-amylase | 0.0123 | 0.0083 | 0.0078 |
Trypanosoma brucei | glucosidase, putative | 0.1468 | 0.1548 | 1 |
Loa Loa (eye worm) | trehalase | 0.0136 | 0.0097 | 0.0097 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0796 | 0.0816 | 0.0868 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.005 | 0.0049 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.1468 | 0.1548 | 0.1525 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0123 | 0.0083 | 0.0083 |
Schistosoma mansoni | alpha-amylase | 0.0123 | 0.0083 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0009 | 0.0009 |
Echinococcus granulosus | beta galactosidase | 0.0149 | 0.0111 | 0.0109 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0315 | 0.0293 | 0.0267 |
Loa Loa (eye worm) | trehalase | 0.0136 | 0.0097 | 0.0097 |
Echinococcus granulosus | alpha glucosidase | 0.0123 | 0.0083 | 0.0078 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0796 | 0.0816 | 0.0791 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6058 | 0.6544 | 0.6535 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.005 | 0.0043 |
Brugia malayi | Melibiase family protein | 0.01 | 0.0058 | 0.0058 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0178 | 0.0143 | 0.0143 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 29 uM | Inhibition of electric eel AChE by Ellman's method | ChEMBL. | 20850311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.