TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.441 | Formula: C18H21N3O5S
H donors: 3 H acceptors: 1 LogP: 2.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)/C(=N/NC(=S)N)/c1ccc(c(c1)O)OC
InChi: 1S/C18H21N3O5S/c1-23-13-6-5-10(7-12(13)22)16(20-21-18(19)27)11-8-14(24-2)17(26-4)15(9-11)25-3/h5-9,22H,1-4H3,(H3,19,21,27)/b20-16+
InChiKey: AJHVVOQAFZABFE-CAPFRKAQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.005	0.2398	0.2361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0478	0.1438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.3037	0.3003
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0031	0.1226	0.5014
Echinococcus multilocularis	multidrug resistance protein 1	0.005	0.2398	0.2361
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0478	0.1829
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0031	0.1226	0.3942
Loa Loa (eye worm)	multidrug resistance protein 3	0.005	0.2398	0.2295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0738	0.1322
Onchocerca volvulus		0.0032	0.1297	0.3366
Plasmodium vivax	ABC transporter B family member 6, putative	0.0018	0.0436	0.1652
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Echinococcus multilocularis	ATP binding cassette sub family B	0.0018	0.0436	0.039
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0738	0.0613
Echinococcus granulosus	multidrug resistance protein 1	0.0032	0.1305	0.1263
Echinococcus granulosus	cysteine protease	0.0019	0.0478	0.0432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Plasmodium falciparum	multidrug resistance protein 2	0.0018	0.0436	0.1652
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0031	0.1226	0.3942
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.005	0.2398	0.7861
Onchocerca volvulus		0.0032	0.1297	0.3366
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0018	0.0436	0.1652
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.3037	1
Entamoeba histolytica	P-glycoprotein-2	0.005	0.2398	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0031	0.1226	0.1184
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.005	0.2398	0.7587
Trichomonas vaginalis	ABC transporter, putative	0.005	0.2398	0.7587
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0018	0.0436	0.1652
Echinococcus granulosus	cathepsin b	0.0171	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0478	0.0093
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.005	0.2398	0.2361
Echinococcus granulosus	multidrug resistance protein 1	0.005	0.2398	0.2361
Plasmodium vivax	vivapain-3	0.0019	0.0478	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0738	0.0613
Echinococcus granulosus	multidrug resistance protein 1	0.0032	0.1305	0.1263
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0018	0.0436	0.1299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Entamoeba histolytica	P-glyco protein 6, putative	0.005	0.2398	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0031	0.1226	0.4037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Giardia lamblia	Multidrug resistance-associated protein 1	0.003	0.1178	0.3879
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0018	0.0436	0.1299
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0018	0.0436	0.1652
Onchocerca volvulus		0.0032	0.1297	0.3366
Entamoeba histolytica	P-glycoprotein-2	0.005	0.2398	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0478	0.0432
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Trichomonas vaginalis	taga, putative	0.005	0.2398	0.7587
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1297	0.1179
Schistosoma mansoni	multidrug resistance protein	0.0031	0.1226	0.1184
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0018	0.0436	1
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.1297	0.1255
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0478	0.0432
Plasmodium vivax	ABC transporter B family member 5, putative	0.0018	0.0436	0.1652
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0018	0.0436	1
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0018	0.0436	0.039
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0738	0.0613
Trichomonas vaginalis	abcb9, putative	0.005	0.2398	0.7587
Entamoeba histolytica	hypothetical protein	0.0031	0.1226	0.5014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Echinococcus granulosus	cathepsin b	0.0171	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Echinococcus granulosus	ATP binding cassette sub family B	0.0018	0.0436	0.039
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.1297	0.4179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0738	0.1322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1297	0.3431
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0478	0.1829
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0738	0.0694
Echinococcus multilocularis		0.0018	0.0436	0.039
Plasmodium falciparum	multidrug resistance protein 1	0.005	0.2398	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0031	0.1226	0.4037
Giardia lamblia	Cathepsin B precursor	0.006	0.3037	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.1297	0.5315
Leishmania major	pentamidine resistance protein 1	0.0031	0.1226	0.3942
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.005	0.2398	0.2361
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.005	0.2398	0.7587
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0738	0.0694
Schistosoma mansoni	multidrug resistance protein	0.005	0.2398	0.2361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.2398	0.7587
Onchocerca volvulus		0.0032	0.1297	0.3366
Schistosoma mansoni	multidrug resistance protein	0.0031	0.1226	0.1184
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0018	0.0436	0.1299
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1297	0.1255
Plasmodium vivax	ABC transporter B family member 3, putative	0.0018	0.0436	0.1652
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Schistosoma mansoni	multidrug resistance protein	0.0018	0.0436	0.039
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0017	0.0388	0.1448
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0018	0.0436	0.1652
Plasmodium vivax	ABC transporter B family member 4, putative	0.0018	0.0436	0.1652
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.1297	0.1255
Echinococcus multilocularis	multidrug resistance protein 1	0.005	0.2398	0.2361
Leishmania major	ABC-thiol transporter	0.0031	0.1226	0.3942
Echinococcus granulosus	ATP binding cassette sub family B	0.0017	0.0388	0.0342
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0478	0.0432
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0478	0.0432
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0018	0.0436	0.1652
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1297	0.1255
Brugia malayi	ABC transporter family protein	0.0018	0.0436	0.005
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0478	0.0432
Loa Loa (eye worm)	hypothetical protein	0.005	0.2398	0.2295
Entamoeba histolytica	P-glycoprotein 6, putative	0.0018	0.0436	0.1652
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0738	0.0364
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1297	0.5315
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0388	0.0258
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.005	0.2398	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0738	0.0364
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.1297	0.1179
Loa Loa (eye worm)	ABC transporter	0.0018	0.0436	0.0307
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1297	0.1255
Leishmania major	p-glycoprotein e	0.0031	0.1226	0.3942
Echinococcus granulosus	multidrug resistance associated protein 4	0.0013	0.0086	0.0038
Schistosoma mansoni	multidrug resistance protein	0.005	0.2398	0.2361
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Schistosoma mansoni	multidrug resistance protein	0.0031	0.1226	0.1184
Loa Loa (eye worm)	hypothetical protein	0.005	0.2398	0.2295
Entamoeba histolytica	cysteine protease, putative	0.0032	0.1297	0.5315
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.1297	0.1255
Trichomonas vaginalis	abcb9, putative	0.005	0.2398	0.7587
Schistosoma mansoni	multidrug resistance protein	0.005	0.2398	0.2361
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Plasmodium vivax	multidrug resistance protein 1, putative	0.005	0.2398	1
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0478	0.1829
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Echinococcus multilocularis	ATP binding cassette sub family B	0.0049	0.235	0.2313
Trypanosoma brucei	p-glycoprotein	0.0031	0.1226	0.3942
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0031	0.1226	0.5014
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0031	0.1226	0.1184
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Entamoeba histolytica	P-glycoprotein 5, putative	0.0017	0.0388	0.1448
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0049	0.235	0.2313
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0018	0.0436	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1297	0.1255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.3037	1
Leishmania major	p-glycoprotein	0.005	0.2398	0.7861
Echinococcus multilocularis	multidrug resistance protein 1	0.0032	0.1305	0.1263
Giardia lamblia	MRP-like ABC transporter	0.0031	0.1226	0.4037
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1297	0.3366
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.2398	0.7587
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1226	0.1107
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Brugia malayi	cathepsin L-like precursor	0.0023	0.0738	0.0364
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0031	0.1226	0.3942
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.005	0.2398	0.2361
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.005	0.2398	0.2361
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0018	0.0436	0.1652
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0018	0.0436	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0018	0.0436	0.018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.1297	0.1255
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0478	0.1438
Loa Loa (eye worm)	fibroinase	0.0032	0.1297	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Echinococcus granulosus	cathepsin l1	0.0023	0.0738	0.0694
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.1297	0.3431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Brugia malayi	ABC transporter transmembrane region family protein	0.0031	0.1226	0.0872
Toxoplasma gondii	cathepsin B	0.006	0.3037	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.005	0.2398	0.2361
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.005	0.2398	0.7861
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1226	0.1107
Echinococcus granulosus	ATP binding cassette sub family B	0.0018	0.0436	0.039
Trichomonas vaginalis	ABC transporter, putative	0.005	0.2398	0.7587
Schistosoma mansoni	multidrug resistance protein	0.0031	0.1226	0.1184
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0018	0.0436	0.1299
Toxoplasma gondii	cathepsin CPL	0.0032	0.1297	0.4179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0478	0.0093
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0018	0.0436	0.1299
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1297	0.1255
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0031	0.1226	0.5014
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Plasmodium vivax	vivapain-2	0.0032	0.1297	0.5315
Plasmodium vivax	ABC transporter B family member 7, putative	0.0018	0.0436	0.1652
Echinococcus multilocularis	cysteine protease	0.0032	0.1297	0.1255
Brugia malayi	ABC transporter transmembrane region family protein	0.0018	0.0436	0.005
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.3037	1
Onchocerca volvulus		0.0032	0.1297	0.3366
Onchocerca volvulus		0.005	0.2398	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0031	0.1226	0.5014
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.2398	0.7587
Giardia lamblia	Cathepsin B precursor	0.006	0.3037	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0478	0.0432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Plasmodium vivax	unspecified product	0.0019	0.0478	0.1829
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.2398	0.7587
Entamoeba histolytica	P-glycoprotein-2, putative	0.005	0.2398	1
Onchocerca volvulus		0.0032	0.1297	0.3366
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.005	0.2398	0.2361
Trichomonas vaginalis	ABC transporter, putative	0.005	0.2398	0.7587
Plasmodium vivax	multidrug resistance protein 2, putative	0.0018	0.0436	0.1652
Trypanosoma cruzi	hypothetical protein	0.0013	0.0086	0.0038
Brugia malayi	hypothetical protein	0.0018	0.0436	0.005
Echinococcus multilocularis	ATP binding cassette sub family B	0.0018	0.0436	0.039
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0017	0.0388	0.0342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0031	0.1226	0.3942
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.1297	0.1255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Giardia lamblia	Hypothetical protein	0.0017	0.0388	0.1278
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.005	0.2398	0.2361
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0013	0.0086	0.0038
Loa Loa (eye worm)	ABC transporter	0.0018	0.0436	0.0307
Brugia malayi	multidrug resistance related protein 1	0.0031	0.1226	0.0872
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.005	0.2398	0.2295
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0018	0.0436	0.1299
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Trichomonas vaginalis	abcb9, putative	0.005	0.2398	0.7587
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Giardia lamblia	Multidrug resistance-associated protein Mrp2	0.0017	0.0388	0.1278
Brugia malayi	ABC transporter family protein	0.0018	0.0436	0.005
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0018	0.0436	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Entamoeba histolytica	P-glycoprotein 6, putative	0.0018	0.0436	0.1652
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0018	0.0436	0.039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trypanosoma brucei	multidrug resistance protein E	0.0031	0.1226	0.3942
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.1297	0.3366
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.005	0.2398	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.1297	0.3366
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0018	0.0436	1
Schistosoma mansoni	smdr1	0.0018	0.0436	0.039
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.1297	0.1179
Schistosoma mansoni	smdr2	0.005	0.2398	0.2361
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Loa Loa (eye worm)	ABC transporter	0.0018	0.0436	0.0307
Echinococcus granulosus	cathepsin L	0.0019	0.0478	0.0432
Echinococcus granulosus	multidrug resistance protein 1	0.005	0.2398	0.2361
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0018	0.0436	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0478	0.0432
Echinococcus granulosus	multidrug resistance associated protein 7	0.0031	0.1226	0.1184
Entamoeba histolytica	ABC transporter, putative	0.0031	0.1226	0.5014
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0478	0.0432
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0478	0.0432
Echinococcus multilocularis	ATP binding cassette sub family B	0.0018	0.0436	0.039
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0031	0.1226	0.1184
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0478	0.1829
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0031	0.1226	0.3942
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0436	0.0307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Trichomonas vaginalis	ABC transporter, putative	0.005	0.2398	0.7587
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0018	0.0436	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0738	0.2938
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0478	0.1829
Brugia malayi	P-glycoprotein-like protein	0.0018	0.0436	0.005
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0738	0.0364
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0031	0.1226	0.3942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1297	0.1255
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0032	0.1305	0.3462
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0018	0.0436	1
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0018	0.0436	0.1299
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.1297	0.3431
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0031	0.1226	0.1107
Toxoplasma gondii	ABC transporter, putative	0.0018	0.0436	0.1299
Entamoeba histolytica	P-glycoprotein-5	0.005	0.2398	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0031	0.1226	0.3942
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.3037	0.3003
Brugia malayi	ABC transporter family protein	0.0018	0.0436	0.005
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.1297	0.5315
Echinococcus granulosus	multidrug resistance associated protein 1	0.0031	0.1226	0.1184
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.1297	0.1255
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0018	0.0436	0.1652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0478	0.0338
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.005	0.2398	0.7587
Entamoeba histolytica	P-glycoprotein 5, putative	0.005	0.2398	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.1178	0.1059
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0018	0.0436	0.1299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.1297	0.4179
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.005	0.2398	0.7861
Brugia malayi	ABC transporter	0.0018	0.0436	0.005
Giardia lamblia	Cathepsin B precursor	0.006	0.3037	1
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0018	0.0436	0.005
Loa Loa (eye worm)	cysteine protease	0.0032	0.1297	0.1179
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0031	0.1226	0.1184
Entamoeba histolytica	multidrug resistance protein, putative	0.0031	0.1226	0.5014
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0478	0.1829
Giardia lamblia	ABC transporter, putative	0.0031	0.1226	0.4037
Loa Loa (eye worm)	ctsf protein	0.0032	0.1297	0.1179
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.005	0.2398	0.7587
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0031	0.1226	0.1184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0478	0.0338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Toxoplasma gondii	ABC transporter family protein	0.0018	0.0436	0.1299
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Brugia malayi	ABC transporter family protein	0.005	0.2398	0.2091
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.005	0.2398	0.2361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.1297	0.3431
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0478	0.1829
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Onchocerca volvulus		0.0032	0.1297	0.3366
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0018	0.0436	0.1299
Loa Loa (eye worm)	cathepsin B	0.006	0.3037	0.2943
Echinococcus multilocularis	cysteine protease	0.0032	0.1297	0.1255
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0018	0.0436	0.1299
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0018	0.0436	0.1652
Loa Loa (eye worm)	hypothetical protein	0.0049	0.235	0.2246
Echinococcus multilocularis	cathepsin L	0.0019	0.0478	0.0432
Echinococcus granulosus	multidrug resistance protein 1	0.005	0.2398	0.2361
Entamoeba histolytica	P-glycoprotein-1	0.005	0.2398	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.1297	0.5315
Leishmania major	cathepsin L-like protease	0.0032	0.1297	0.4179
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Brugia malayi	Cathepsin L-like precursor	0.0032	0.1297	0.0945
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.1297	0.5315
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0018	0.0436	0.1299
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0018	0.0436	0.039
Echinococcus granulosus	cathepsin l1	0.0032	0.1297	0.1255
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0018	0.0436	0.1652
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0478	0.1829
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.005	0.2398	0.7587
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.1297	0.1255
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.1297	0.0945
Schistosoma mansoni	multidrug resistance protein	0.0017	0.0388	0.0342
Brugia malayi	multidrug resistance protein 3	0.005	0.2398	0.2091
Plasmodium vivax	vivapain-1	0.0019	0.0478	0.1829
Plasmodium vivax	vivapain-2	0.0032	0.1297	0.5315
Echinococcus multilocularis	ATP binding cassette sub family B	0.0018	0.0436	0.039

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1424 nM	Inhibition of human liver cathepsin B after 5 mins by microplate reader analysis	ChEMBL.	20933415
IC50 (binding)	= 3600 nM	Inhibition of human liver cathepsin L after 5 mins by microplate reader analysis	ChEMBL.	20933415

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1271602

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1253783