TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.655 | Formula: C25H34N8OS
H donors: 4 H acceptors: 4 LogP: 3.56 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCNc1nc(cc(n1)c1cnc(s1)NC(C)C)c1ccccc1CNC(=O)NC1CC1)C
InChi: 1S/C25H34N8OS/c1-16(2)29-25-28-15-22(35-25)21-13-20(31-23(32-21)26-11-12-33(3)4)19-8-6-5-7-17(19)14-27-24(34)30-18-9-10-18/h5-8,13,15-16,18H,9-12,14H2,1-4H3,(H,28,29)(H,26,31,32)(H2,27,30,34)
InChiKey: FXBBSUNCFKSBRC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0022	0.0142	0.0239
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.039	0.0657
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0178	0.2345	0.3944
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0587	0.4334
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1983	0.1907
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Schistosoma mansoni	protein kinase	0.0019	0.0095	0.0159
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0587	0.4334
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0173	0.0224
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0226	0.1004
Toxoplasma gondii	hypothetical protein	0.004	0.039	0.3225
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0178	0.2345	0.2345
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1144	0.1925
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.039	0.0657
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0037	0.035	0.0588
Echinococcus granulosus	serotonin transporter	0.0234	0.315	0.5299
Schistosoma mansoni	sodium/chloride dependent transporter	0.0234	0.315	0.5299
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Echinococcus granulosus	glutamate receptor 2	0.0056	0.0618	0.104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.039	0.0657
Onchocerca volvulus		0.0022	0.0142	0.0239
Echinococcus granulosus	neuroligin	0.0022	0.0142	0.0239
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0173	0.0079
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.002	0.0106	0.0179
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0141	0.0047
Echinococcus multilocularis	glycine receptor subunit beta	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Echinococcus granulosus	nAChR subunit	0.0027	0.0203	0.0342
Brugia malayi	metabotropic glutamate receptor type 2	0.0019	0.0095	0.0095
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Echinococcus granulosus	nmda type glutamate receptor	0.0132	0.1692	0.2847
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0027	0.0203	0.0203
Onchocerca volvulus		0.004	0.039	0.0657
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0027	0.0203	0.0342
Giardia lamblia	Flap structure-specific endonuclease	0.0027	0.0213	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0207	0.0339
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.1983	0.1907
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.009	0.1109	0.1866
Echinococcus granulosus	nAChR subunit	0.0014	0.0029	0.0049
Echinococcus granulosus	receptor type guanylyl cyclase	0.0019	0.0095	0.0159
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0095	0.1169	0.3224
Brugia malayi	Glutamate receptor 1 precursor	0.0037	0.035	0.035
Brugia malayi	P38 map kinase family protein 2	0.0152	0.1983	0.1983
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0019	0.0095	0.0159
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0787	0.1324
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0787	0.0787
Brugia malayi	hypothetical protein	0.0019	0.0095	0.0095
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0142	0.012
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0056	0.0618	0.104
Loa Loa (eye worm)	GABA receptor subunit	0.0014	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0135	0.174	0.174
Toxoplasma gondii	hypothetical protein	0.004	0.039	0.3225
Onchocerca volvulus		0.004	0.039	0.0657
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.002	0.0106	0.0179
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.039	0.0657
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0027	0.0203	0.0342
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.039	0.0657
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0223	0.0375
Schistosoma mansoni	vesicular acetylcholine transporter	0.0431	0.5944	1
Loa Loa (eye worm)	hypothetical protein	0.0234	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Brugia malayi	Receptor family ligand binding region containing protein	0.0019	0.0095	0.0095
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0019	0.0095	0.0095
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.039	0.0657
Brugia malayi	Pre-SET motif family protein	0.0202	0.2697	0.2697
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0141	0.0396
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.1144	0.1144
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.002	0.0106	0.0012
Schistosoma mansoni	glutamate receptor kainate	0.0037	0.035	0.0588
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.1983	0.1869
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0056	0.0618	0.104
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0027	0.0203	0.0342
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.039	0.0657
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0142	0.0239
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Entamoeba histolytica	Flap nuclease, putative	0.0027	0.0213	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0142	0.0239
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.0987	1
Trichomonas vaginalis	ran, putative	0.0022	0.0141	0.0117
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0178	0.2345	0.3944
Loa Loa (eye worm)	carboxylesterase	0.0132	0.1697	0.1697
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0365	0.0614
Brugia malayi	Guanylyl cyclase protein 23	0.0019	0.0095	0.0095
Brugia malayi	chromobox protein homolog 3	0.0038	0.0365	0.0365
Brugia malayi	Carboxylesterase family protein	0.0022	0.0142	0.0142
Schistosoma mansoni	glutamate receptor kainate	0.0037	0.035	0.0588
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0056	0.0618	0.104
Loa Loa (eye worm)	hypothetical protein	0.0234	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.1697	0.2855
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.004	0.0395	0.0665
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.039	0.0657
Leishmania major	GTP-binding protein, putative	0.0022	0.0141	0.0047
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Plasmodium falciparum	amino acid transporter, putative	0.004	0.039	0.2946
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0365	0.0865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1144	0.1925
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Echinococcus granulosus	glycine receptor subunit beta	0.0027	0.0203	0.0342
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0135	0.174	0.2927
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0019	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.039	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2345	0.2345
Loa Loa (eye worm)	hypothetical protein	0.009	0.1109	0.1109
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0322	0.4396	0.4396
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Echinococcus granulosus	chromobox protein 1	0.0068	0.0787	0.1324
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0234	0.315	0.315
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0365	0.0865
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0142	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0234	0.315	0.315
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.1697	0.2855
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.039	0.0657
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.0987	1
Echinococcus multilocularis	NMDA receptor	0.0037	0.035	0.0588
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0142	0.0239
Echinococcus multilocularis	glutamate receptor 2	0.0056	0.0618	0.104
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0027	0.0203	0.0203
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.039	0.0657
Echinococcus multilocularis	nmda type glutamate receptor	0.0132	0.1692	0.2847
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0095	0.0095
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Onchocerca volvulus		0.003	0.0248	0.0418
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0056	0.0618	0.104
Loa Loa (eye worm)	LGC-31 protein	0.0027	0.0203	0.0203
Echinococcus multilocularis	nAChR subunit	0.0014	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1697	0.1697
Echinococcus multilocularis	serotonin receptor	0.0135	0.174	0.2927
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0027	0.0203	0.0342
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0238	0.04
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0987	1
Echinococcus granulosus	nmda type glutamate receptor	0.0019	0.0095	0.0159
Onchocerca volvulus		0.0027	0.0203	0.0342
Schistosoma mansoni	chromobox protein	0.0068	0.0787	0.1324
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.3225
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1144	0.1925
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.1983	0.3337
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Echinococcus granulosus	biogenic amine 5HT receptor	0.0135	0.174	0.2927
Onchocerca volvulus		0.023	0.3093	0.5204
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.1144	0.1144
Brugia malayi	Carboxylesterase family protein	0.0022	0.0142	0.0142
Onchocerca volvulus		0.004	0.0395	0.0665
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.0987	0.1661
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0142	0.0239
Brugia malayi	Cation transporter family protein	0.0027	0.0203	0.0203
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0095	0.1169	1
Brugia malayi	hypothetical protein	0.004	0.039	0.039
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.7668
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0173	0.0224
Schistosoma mansoni	hypothetical protein	0.0177	0.2342	0.394
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0987	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0226	0.1004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0406	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0132	0.1697	0.1697
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0027	0.0203	0.0342
Brugia malayi	RNA, U transporter 1	0.0086	0.1043	0.1043
Onchocerca volvulus		0.0019	0.0095	0.0159
Echinococcus granulosus	glutamate receptor 2	0.0019	0.0095	0.0159
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1144	0.1925
Echinococcus multilocularis	glutamate receptor 2	0.0019	0.0095	0.0159
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0095	0.1169	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0176	0.0295
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.039
Onchocerca volvulus		0.0027	0.0203	0.0342
Echinococcus multilocularis	flap endonuclease 1	0.0027	0.0213	0.0358
Echinococcus granulosus	acetylcholinesterase	0.0132	0.1697	0.2855
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0238	0.04
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1144	0.1925
Plasmodium vivax	importin-beta 2, putative	0.003	0.0254	0.1336
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0027	0.0203	0.0203
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0027	0.0203	0.0342
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0027	0.0203	0.0203
Schistosoma mansoni	importin beta-1	0.003	0.0254	0.0428
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0056	0.0618	0.104
Entamoeba histolytica	hypothetical protein	0.0024	0.0173	0.7847
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0027	0.0203	0.0203
Onchocerca volvulus		0.0014	0.0029	0.0049
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0095	0.1169	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0095	0.0095
Brugia malayi	Heterochromatin protein 1	0.0068	0.0787	0.0787
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Schistosoma mansoni	glutamate receptor kainate	0.0037	0.035	0.0588
Brugia malayi	hypothetical protein	0.0022	0.0142	0.0142
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.002	0.0106	0.4196
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0173	0.0079
Schistosoma mansoni	tyrosine kinase	0.0019	0.0095	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0717	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0238	0.04
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Onchocerca volvulus		0.0022	0.0142	0.0239
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.039	0.0657
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0142	0.0239
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0238	0.1494
Plasmodium vivax	SET domain protein, putative	0.0029	0.0238	0.1143
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0207	0.0339
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0254	0.0115
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.1983	0.1983
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Schistosoma mansoni	glutamate receptor AMPA	0.0037	0.035	0.0588
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.039	0.0657
Echinococcus granulosus	importin subunit beta 1	0.003	0.0254	0.0428
Brugia malayi	Carboxylesterase family protein	0.0132	0.1697	0.1697
Brugia malayi	Serine protease Z688.6 precursor	0.002	0.0106	0.0106
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0717	1	1
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.002	0.0106	0.0012
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0014	0.0029	0.0029
Onchocerca volvulus		0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.7668
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0019	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Onchocerca volvulus		0.0234	0.315	0.5299
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.039	0.0657
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0027	0.0203	0.0342
Onchocerca volvulus	Putative nachr subunit	0.0178	0.2345	0.3944
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0234	0.315	0.5299
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.3279
Loa Loa (eye worm)	hypothetical protein	0.009	0.1109	0.1109
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0142	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0254	0.0115
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0178	0.2345	0.3944
Treponema pallidum	sodium- and chloride- dependent transporter	0.0234	0.315	1
Brugia malayi	Carboxylesterase family protein	0.0022	0.0142	0.0142
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0014	0.0029	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.009	0.1109	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Brugia malayi	Probable ClpP-like protease	0.0082	0.0987	0.0987
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0019	0.0095	0.0095
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0431	0.5944	0.5944
Brugia malayi	Flap endonuclease-1	0.0027	0.0213	0.0213
Echinococcus granulosus	geminin	0.0177	0.2342	0.394
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0587	0.0988
Brugia malayi	Cation transporter family protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	serotonin transporter b	0.0234	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0135	0.174	0.174
Brugia malayi	Importin beta-1 subunit	0.003	0.0254	0.0254
Loa Loa (eye worm)	norepinephrine transporter	0.0234	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.0141
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0431	0.5944	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0095	0.3561
Schistosoma mansoni	glutamate receptor NMDA	0.0037	0.035	0.0588
Trichomonas vaginalis	set domain proteins, putative	0.023	0.3093	1
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0027	0.0203	0.0203
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0027	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Brugia malayi	Glutamate receptor 2 precursor	0.0037	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Plasmodium falciparum	transporter, putative	0.004	0.039	0.2946
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0431	0.5944	0.5944
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0367	0.5026	0.5026
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1983	0.1907
Plasmodium falciparum	importin beta, putative	0.003	0.0254	0.1336
Plasmodium vivax	flap endonuclease 1, putative	0.0027	0.0213	0.0846
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0027	0.0203	0.0203
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0178	0.2345	0.3944
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.1983	0.3337
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0142	0.012
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Echinococcus multilocularis	glycine receptor subunit beta	0.0027	0.0203	0.0342
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0027	0.0213	0.0119
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1983	0.3337
Echinococcus multilocularis	nAChR subunit	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.0987	0.1661
Leishmania major	C-8 sterol isomerase-like protein	0.0717	1	1
Echinococcus multilocularis	glutamate receptor 2	0.0037	0.035	0.0588
Echinococcus granulosus	carboxylesterase 5A	0.0132	0.1697	0.2855
Loa Loa (eye worm)	flap endonuclease-1	0.0027	0.0213	0.0213
Onchocerca volvulus		0.0019	0.0095	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Plasmodium falciparum	flap endonuclease 1	0.0027	0.0213	0.0846
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0095	0.1169	0.3224
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.003	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	ACC-1 protein	0.0027	0.0203	0.0203
Schistosoma mansoni	tyrosine kinase	0.0019	0.0095	0.0159
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0027	0.0203	0.0203
Brugia malayi	Carboxylesterase family protein	0.0022	0.0142	0.0142
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0037	0.035	0.0588
Schistosoma mansoni	ran	0.0022	0.0141	0.0237
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0787	0.2279
Toxoplasma gondii	hypothetical protein	0.0028	0.0226	0.1361
Plasmodium vivax	amine transporter, putative	0.004	0.039	0.2946
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0019	0.0095	0.0159
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0037	0.035	0.0588
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.039	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Brugia malayi	excitatory GABA receptor EXP-1A	0.0027	0.0203	0.0203
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0142	0.0142
Loa Loa (eye worm)	glutamate receptor	0.0019	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Schistosoma mansoni	glutamate receptor AMPA	0.0037	0.035	0.0588
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0037	0.035	0.0588
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0019	0.0095	0.0159
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0019	0.0095	0.0095
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0037	0.035	0.0588
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2697	0.2697
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0027	0.0203	0.0342
Brugia malayi	Pre-SET motif family protein	0.0029	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.003	0.0254	0.0254
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0142	0.0239
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0141	0.0237
Echinococcus granulosus	acetylcholinesterase	0.0132	0.1697	0.2855
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.1697	0.2855
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0203
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.3225
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0037	0.035	0.0588
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.039	0.0657
Echinococcus multilocularis	nmda type glutamate receptor	0.0019	0.0095	0.0159
Schistosoma mansoni	hypothetical protein	0.0322	0.4396	0.7396
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0027	0.0203	0.0342
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0406	0.1002
Schistosoma mansoni	glutamate receptor NMDA	0.0056	0.0618	0.104
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.039	0.0657
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0027	0.0213	0.0073
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.8231
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0173	0.0224
Echinococcus granulosus	glycine receptor subunit beta	0.0027	0.0203	0.0342
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0787	0.2279
Brugia malayi	Receptor family ligand binding region containing protein	0.0019	0.0095	0.0095
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1144	0.1925
Onchocerca volvulus		0.002	0.0106	0.0179
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0014	0.0029	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0029	0.0029
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0142	0.0239
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0142	0.0239
Schistosoma mansoni	ran	0.0022	0.0141	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0987	0.0987
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0027	0.0213	0.1209
Echinococcus granulosus	tyrosine kinase	0.0019	0.0095	0.0159
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0238	0.04
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0027	0.0203	0.0203
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0027	0.0203	0.0342
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0056	0.0618	0.104
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0027	0.0203	0.0203
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.0987	0.1661
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.039	0.0657
Onchocerca volvulus		0.0022	0.0142	0.0239
Onchocerca volvulus		0.0027	0.0203	0.0342
Schistosoma mansoni	metabotropic glutamate receptor	0.0019	0.0095	0.0159
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.009	0.1109	0.1866
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.0141
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	1
Entamoeba histolytica	Ran family GTPase	0.0022	0.0141	0.6099
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0254	0.1679
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.039
Schistosoma mansoni	neurotransmitter gated ion channel	0.0014	0.0029	0.0049
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.039	0.039
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0587	0.4744
Schistosoma mansoni	chromobox protein	0.0068	0.0787	0.1324
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0037	0.035	0.0588
Echinococcus granulosus	flap endonuclease 1	0.0027	0.0213	0.0358
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0014	0.0029	0.0049
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.039	0.0657
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0142	0.0142
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0142	0.0239
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0027	0.0203	0.0203
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0431	0.5944	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1983	0.3337
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0037	0.035	0.0588
Onchocerca volvulus		0.0027	0.0203	0.0342
Onchocerca volvulus		0.0022	0.0142	0.0239
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0027	0.0203	0.0342
Schistosoma mansoni	nAChR subunit	0.0027	0.0203	0.0342
Echinococcus multilocularis	serotonin transporter	0.0234	0.315	0.5299
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0365	0.0365
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1983	0.3337
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0019	0.0095	0.0095
Plasmodium vivax	hypothetical protein, conserved	0.004	0.039	0.2946
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0141	0.0047
Chlamydia trachomatis	glutamine binding protein	0.0095	0.1169	1
Brugia malayi	Carboxylesterase family protein	0.0132	0.1697	0.1697
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0238	0.04
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.002	0.0106	0.0012
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0019	0.0095	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0238	0.0238
Brugia malayi	Serine protease Z688.6 precursor	0.002	0.0106	0.0106
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.002	0.0106	0.4196
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0019	0.0095	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0029	0.0029
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0027	0.0213	0.0119
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0027	0.0203	0.0342
Loa Loa (eye worm)	hypothetical protein	0.004	0.039	0.039
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0178	0.2345	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0029	0.0029
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0019	0.0095	0.0159
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0234	0.315	0.315
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.009	0.1109	0.1866
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0132	0.1692	0.2847
Onchocerca volvulus		0.004	0.039	0.0657
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0587	0.0988
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0178	0.2345	0.3944
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.2603
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0037	0.035	0.0588
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0787	0.1324
Trichomonas vaginalis	flap endonuclease-1, putative	0.0027	0.0213	0.0356
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0238	0.04
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0027	0.0203	0.0203
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0142	0.0239
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.002	0.0106	0.4196
Echinococcus multilocularis	neuroligin	0.0022	0.0142	0.0239
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0056	0.0618	0.104
Echinococcus granulosus	vesicular acetylcholine transporter	0.0431	0.5944	1
Echinococcus multilocularis	snurportin 1	0.0322	0.4396	0.7396
Schistosoma mansoni	hypothetical protein	0.0037	0.035	0.0588
Brugia malayi	Serine carboxypeptidase S28 family protein	0.009	0.1109	0.1109
Loa Loa (eye worm)	acetylcholinesterase 1	0.0132	0.1697	0.1697
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0398	0.067
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.3225
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.039	0.039
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0027	0.0203	0.0203
Echinococcus multilocularis	carboxylesterase 5A	0.0132	0.1697	0.2855
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0406	0.1002
Loa Loa (eye worm)	glutamate receptor 1	0.0037	0.035	0.035
Loa Loa (eye worm)	glutamate receptor 2	0.0037	0.035	0.035
Echinococcus granulosus	snurportin 1	0.0322	0.4396	0.7396
Loa Loa (eye worm)	ACC-1 protein	0.0027	0.0203	0.0203
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0019	0.0095	0.0159
Onchocerca volvulus		0.0014	0.0029	0.0049
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0987	0.8231
Schistosoma mansoni	hypothetical protein	0.0177	0.2342	0.394
Echinococcus granulosus	chromobox protein 1	0.0068	0.0787	0.1324
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0027	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0095	0.0095
Schistosoma mansoni	ATP-binding cassette transporter	0.0037	0.035	0.0588
Echinococcus multilocularis	tyrosine kinase	0.0019	0.0095	0.0159
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1144	0.1925
Brugia malayi	Cation transporter family protein	0.0027	0.0203	0.0203
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0717	1	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0019	0.0095	0.0159
Echinococcus multilocularis	serotonin receptor	0.0135	0.174	0.2927
Schistosoma mansoni	gliotactin	0.0022	0.0142	0.0239
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.002	0.0106	0.0179
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.039	0.0657
Echinococcus multilocularis	geminin	0.0177	0.2342	0.394
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0254	0.0428
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0019	0.0095	0.0159
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0056	0.0618	0.104
Onchocerca volvulus		0.0027	0.0203	0.0342
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.039	0.0657
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1983	0.3337
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0141	0.0237
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0178	0.2345	0.3944

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 11 nM	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA	ChEMBL.	20732813
IC50 (binding)	= 16 nM	Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting	ChEMBL.	20732813

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	20732813

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1257366

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1257588