Detailed information for compound 1259046

Basic information

Technical information
  • TDR Targets ID: 1259046
  • Name: 4-[[4-(5-chloro-2-methylphenyl)piperazin-1-yl ]-(1-cyclopentyltetrazol-5-yl)methyl]benzonit rile
  • MW: 461.99 | Formula: C25H28ClN7
  • H donors: 0 H acceptors: 4 LogP: 4.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(c1nnnn1C1CCCC1)N1CCN(CC1)c1cc(Cl)ccc1C
  • InChi: 1S/C25H28ClN7/c1-18-6-11-21(26)16-23(18)31-12-14-32(15-13-31)24(20-9-7-19(17-27)8-10-20)25-28-29-30-33(25)22-4-2-3-5-22/h6-11,16,22,24H,2-5,12-15H2,1H3
  • InChiKey: NNBHCZXOHFSMTR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[[4-(5-chloro-2-methyl-phenyl)piperazin-1-yl]-(1-cyclopentyltetrazol-5-yl)methyl]benzonitrile
  • 4-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-(1-cyclopentyl-5-tetrazolyl)methyl]benzonitrile
  • 4-[[4-(5-chloro-2-methyl-phenyl)piperazin-1-yl]-(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)methyl]benzonitrile
  • ASN 07881641
  • 4-[[4-(5-Chloro-2-methyl-phenyl)-piperazin-1-yl]-(1-cyclopentyl-1H-tetrazol-5-yl)-methyl]-benzonitrile
  • MLS000030314
  • SMR000008242

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.067 0.242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2943 0.4753
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1792 0.1693
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.7929 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0695 0.1123
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0137 0.0444
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2476 0.8171
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0917 0.3021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0137 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0917 0.0917
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.006 0.1826 0.6023
Brugia malayi MH2 domain containing protein 0.0144 0.4968 0.4968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Onchocerca volvulus 0.002 0.0367 0.0308
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.1274 0.2055
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0137 0.0444
Onchocerca volvulus 0.0035 0.0917 0.0991
Mycobacterium tuberculosis Conserved protein 0.0035 0.0917 0.1001
Mycobacterium tuberculosis Conserved protein 0.0035 0.0917 0.1001
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2476 0.8171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0137 0.0137
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.1274 0.1555
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0367 0.5457
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0917 0.3021
Trypanosoma brucei prolyl oligopeptidase, putative 0.0014 0.0137 0.0444
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0917 0.1119
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.1274 0.4199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2943 0.4756
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.1274 0.1555
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0367 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Echinococcus multilocularis peregrin 0.0028 0.067 0.1078
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0367 0.0251
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2476 0.8171
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2338 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0367 0.5457
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0137 0.0221
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.1274 0.393
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Echinococcus multilocularis prolyl endopeptidase 0.0014 0.0137 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0137 0.0164
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.303 0.4893
Loa Loa (eye worm) hypothetical protein 0.0029 0.0695 0.0583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Plasmodium vivax hypothetical protein, conserved 0.0028 0.067 0.7293
Onchocerca volvulus Cathepsin L homolog 0.002 0.0367 0.0308
Onchocerca volvulus 0.002 0.0367 0.0308
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2943 0.2859
Giardia lamblia PHD finger protein 15 0.0028 0.067 0.1841
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0695 0.1123
Brugia malayi Pre-SET motif family protein 0.0029 0.0695 0.0695
Brugia malayi Cathepsin L-like precursor 0.0014 0.0118 0.0118
Brugia malayi beta-lactamase 0.0035 0.0917 0.0917
Giardia lamblia Kinase, PLK 0.0092 0.303 1
Trypanosoma brucei prolyl endopeptidase 0.0014 0.0137 0.0444
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0695 0.2534
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0367 0.0588
Onchocerca volvulus Alhambra homolog 0.0028 0.067 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.303 0.3613
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0137 0.0019
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0177 0.6189 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0137 0.0164
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4968 0.4908
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0367 0.0588
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.006 0.1826 0.6023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0917 0.1001
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.0137 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0891 0.0782
Loa Loa (eye worm) beta-lactamase 0.0035 0.0917 0.0808
Leishmania major cathepsin L-like protease 0.002 0.0367 0.0427
Loa Loa (eye worm) ctsf protein 0.002 0.0367 0.0251
Leishmania major hypothetical protein, unknown function 0.0159 0.5513 1
Brugia malayi PHD-finger family protein 0.0028 0.067 0.067
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0118 0.0191
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0891 0.144
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0003 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0367 0.0588
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0367 0.1202
Onchocerca volvulus Prolyl endopeptidase homolog 0.0014 0.0137 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0917 0.1001
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.1274 0.2055
Trypanosoma cruzi prolyl endopeptidase 0.0014 0.0137 0.0444
Echinococcus multilocularis Dipeptidyl peptidase 9 0.006 0.1826 0.2947
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0917 0.1001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Mycobacterium ulcerans lipase LipD 0.0035 0.0917 0.3545
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1306 0.1594
Echinococcus granulosus cathepsin l1 0.002 0.0367 0.0588
Toxoplasma gondii ABC1 family protein 0.0035 0.0917 0.3545
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2338 0.3778
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.1274 0.2055
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0917 0.1119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2943 0.4756
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0891 0.1436
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.303 0.2946
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Onchocerca volvulus 0.002 0.0367 0.0308
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0137 0.0221
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.1274 0.2058
Schistosoma mansoni jumonji domain containing protein 0.0074 0.2358 0.3809
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0137 0.0221
Onchocerca volvulus 0.002 0.0367 0.0308
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0118 0.0383
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0917 0.1001
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.303 0.4896
Schistosoma mansoni hypothetical protein 0.0028 0.067 0.1082
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0159 0.5513 0.8908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Leishmania major cysteine peptidase A (CPA) 0.002 0.0367 0.0427
Leishmania major cathepsin L-like protease 0.002 0.0367 0.0427
Leishmania major cathepsin L-like protease 0.002 0.0367 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1306 0.1594
Loa Loa (eye worm) hypothetical protein 0.0014 0.0137 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.2338 0.2825
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.303 0.303
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0367 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Leishmania major cathepsin L-like protease 0.0077 0.2476 0.4351
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0695 0.1119
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2338 0.3778
Leishmania major cathepsin L-like protease 0.0077 0.2476 0.4351
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0049 0.1422 0.132
Leishmania major hypothetical protein, unknown function 0.0159 0.5513 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0118 0.0142
Loa Loa (eye worm) cysteine protease 0.002 0.0367 0.0251
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0367 0.0588
Toxoplasma gondii cathepsin CPL 0.002 0.0367 0.1044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Brugia malayi cathepsin L-like precursor 0.0014 0.0118 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0137 0.0444
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.7138 0.7103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0917 0.1001
Onchocerca volvulus 0.002 0.0367 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Mycobacterium ulcerans hypothetical protein 0.0035 0.0917 0.3545
Trypanosoma brucei polo-like protein kinase 0.0092 0.303 1
Brugia malayi Bromodomain containing protein 0.0028 0.067 0.067
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0695 0.1119
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0014 0.0137 0.0444
Leishmania major hypothetical protein, conserved 0.0035 0.0917 0.1451
Mycobacterium leprae Probable lipase LipE 0.0035 0.0917 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0014 0.0137 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Onchocerca volvulus Cathepsin F homolog 0.002 0.0367 0.0308
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0917 0.1119
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0367 0.1202
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0917 0.0808
Onchocerca volvulus 0.0231 0.8177 1
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0891 0.1436
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Onchocerca volvulus 0.002 0.0367 0.0308
Mycobacterium ulcerans beta-lactamase 0.0035 0.0917 0.3545
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0917 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0695 0.1123
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0367 0.1202
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.303 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0367 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2338 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.2338 0.4095
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0159 0.5513 0.8908
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.3067 0.4953
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.067 0.1078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1864 0.6149
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0917 0.1119
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0917 0.3545
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0137 0.0137
Leishmania major cathepsin L-like protease 0.002 0.0367 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2943 0.4753
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0917 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.006 0.1826 0.7672
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0177 0.6189 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2943 0.4756
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0917 0.3545
Trichomonas vaginalis set domain proteins, putative 0.0231 0.8177 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Brugia malayi Pre-SET motif family protein 0.0203 0.7138 0.7138
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.1274 0.1274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0137 0.0217
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2228 0.7351
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.1274 0.2055
Onchocerca volvulus 0.0029 0.0695 0.0715
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0367 0.0445
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Echinococcus multilocularis cysteine protease 0.002 0.0367 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.1274 0.2055
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0917 0.1478
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1274 0.4199
Onchocerca volvulus 0.002 0.0367 0.0308
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0367 0.0588
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0137 0.0444
Echinococcus multilocularis cysteine protease 0.002 0.0367 0.0588
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0367 0.0588
Trypanosoma cruzi oligopeptidase b 0.0014 0.0137 0.0444
Plasmodium vivax vivapain-2 0.002 0.0367 0.398
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0917 0.1119
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0137 0.1468
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0003 0.0004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0917 0.1001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.303 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.067 0.1082
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.2338 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.5513 0.5459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0917 0.1482
Plasmodium falciparum peptidase, putative 0.0014 0.0137 0.2013
Brugia malayi jmjC domain containing protein 0.0093 0.3067 0.3067
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.3067 0.4953
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.1274 0.2055
Trypanosoma brucei oligopeptidase b 0.0014 0.0137 0.0444
Trypanosoma cruzi oligopeptidase b 0.0014 0.0137 0.0444
Echinococcus granulosus Dipeptidyl peptidase 9 0.006 0.1826 0.2947
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0367 0.5457
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2338 1
Onchocerca volvulus 0.0159 0.5513 0.6694
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1274 0.4199
Brugia malayi prolyl oligopeptidase family protein 0.0177 0.6189 0.6189
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2476 0.8171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1274 0.4199
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0177 0.6189 0.7533
Brugia malayi beta-lactamase family protein 0.0035 0.0917 0.0917
Brugia malayi hypothetical protein 0.0045 0.1305 0.1305
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0891 0.144
Leishmania major cathepsin L-like protease 0.0077 0.2476 0.4351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2943 0.4753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Onchocerca volvulus 0.0035 0.0917 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0137 0.0444
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0137 0.0137
Plasmodium vivax vivapain-2 0.002 0.0367 0.398
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4968 0.4908
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0917 0.1001
Loa Loa (eye worm) hypothetical protein 0.0045 0.1274 0.1169
Leishmania major cathepsin L-like protease 0.002 0.0367 0.0427
Brugia malayi jmjC domain containing protein 0.0034 0.0891 0.0891
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0177 0.6189 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0118 0.0118
Trichomonas vaginalis esterase, putative 0.0035 0.0917 0.1119
Loa Loa (eye worm) hypothetical protein 0.0045 0.1305 0.1201
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.006 0.1826 0.6023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0917 0.1482
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.303 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Echinococcus multilocularis ng dimethylarginine dimethylaminohydrolase 0.0159 0.5513 0.8908
Echinococcus granulosus prolyl endopeptidase 0.0014 0.0137 0.0217
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0137 0.0164
Loa Loa (eye worm) prolyl oligopeptidase 0.0177 0.6189 0.6143
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0917 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0014 0.0137 0.0444
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.006 0.1826 0.6023
Entamoeba histolytica cysteine protease, putative 0.002 0.0367 0.1202
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2943 0.2943
Loa Loa (eye worm) hypothetical protein 0.0028 0.067 0.0558
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.006 0.1826 0.3142
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0137 0.0444
Plasmodium vivax SET domain protein, putative 0.0029 0.0695 0.7569
Plasmodium falciparum phd finger protein, putative 0.0028 0.067 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0367 0.0445
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.1274 0.2058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2943 0.4753
Brugia malayi prolyl oligopeptidase family protein 0.006 0.1826 0.1826
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.1082 0.1745
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0655 0.1055
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.2338 0.3775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2476 0.8171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0367 0.0445
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0137 0.0221
Echinococcus granulosus jumonji domain containing protein 0.0039 0.1082 0.1745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0118 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0695 0.1123
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0003 0.0004
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0137 0.0019
Echinococcus granulosus ng dimethylarginine dimethylaminohydrolase 0.0159 0.5513 0.8908
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0003 0.0003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.303 0.4893
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.006 0.1826 0.295
Loa Loa (eye worm) fibroinase 0.002 0.0367 0.0251
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.303 0.5381
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.2338 0.3775
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0137 0.0217
Onchocerca volvulus Cathepsin L homolog 0.002 0.0367 0.0308
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Brugia malayi Cathepsin L-like precursor 0.002 0.0367 0.0367
Schistosoma mansoni kinase 0.0047 0.1351 0.2183
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.067 0.1078
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0367 0.0367
Onchocerca volvulus 0.0035 0.0917 0.0991
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0137 0.0444
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0367 0.0251
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0014 0.0137 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0367 0.0445
Brugia malayi beta-lactamase family protein 0.0035 0.0917 0.0917
Echinococcus granulosus cathepsin l1 0.0014 0.0118 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0695 0.1119
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.067 0.0558
Echinococcus granulosus peregrin 0.0028 0.067 0.1078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0917 0.0808
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.303 0.3703
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0917 0.1001
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.1274 0.2115
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.1274 0.1555
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.067 0.242
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0917 0.3021
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0003 0.0003
Brugia malayi NG,NG-dimethylarginine dimethylaminohydrolase 1, putative 0.0159 0.5513 0.5513

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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