Detailed information for compound 1267101

Basic information

Technical information
  • TDR Targets ID: 1267101
  • Name: 3-(2-bromophenyl)-6-(2,3-dihydro-1,4-benzodio xin-7-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadi azole
  • MW: 415.264 | Formula: C17H11BrN4O2S
  • H donors: 0 H acceptors: 3 LogP: 3.99 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccccc1c1nnc2n1nc(s2)c1ccc2c(c1)OCCO2
  • InChi: 1S/C17H11BrN4O2S/c18-12-4-2-1-3-11(12)15-19-20-17-22(15)21-16(25-17)10-5-6-13-14(9-10)24-8-7-23-13/h1-6,9H,7-8H2
  • InChiKey: ZYVOGSJKUFUMPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-bromophenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
  • MLS000052350
  • SMR000081678
  • STK228938
  • AO-365/43113775
  • ZINC02236350

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Echinococcus granulosus growth factor receptor bound protein 2 0.0106 0.3139 0.3074
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0136 0.4279 0.4224
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0115 0.0103
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.003 0.022 0.0106
Echinococcus granulosus fibroblast growth factor receptor 4 0.003 0.022 0.0127
Onchocerca volvulus 0.0106 0.3139 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0106 0.3139 0.4471
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.022 0.0127
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.003 0.022 0.0127
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Brugia malayi MH2 domain containing protein 0.0102 0.2969 0.296
Echinococcus granulosus tyrosine kinase 0.0136 0.4279 0.4224
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Plasmodium falciparum protein kinase, putative 0.003 0.022 0.1258
Echinococcus multilocularis GPCR, family 2 0.0027 0.0115 0.0021
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0106 0.3139 0.3074
Echinococcus multilocularis tensin 0.0106 0.3139 0.3074
Loa Loa (eye worm) hypothetical protein 0.0058 0.1316 0.1215
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.022 0.0184
Echinococcus granulosus tyrosine protein kinase pr2 0.003 0.022 0.0127
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0788 0.07
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Brugia malayi Tensin 0.0106 0.3139 0.3131
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase shark 0.0136 0.4279 0.4224
Schistosoma mansoni growth factor receptor-bound protein 0.0106 0.3139 0.4471
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.4365 0.4358
Brugia malayi Protein kinase domain containing protein 0.0136 0.4279 0.4272
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0136 0.4279 0.6144
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Toxoplasma gondii ABC1 family protein 0.0035 0.0428 0.2444
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0428 0.3652
Onchocerca volvulus 0.0106 0.3139 0.5
Echinococcus multilocularis tyrosine kinase 0.0136 0.4279 0.4224
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0086 0.2351 0.2341
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus multilocularis activin receptor type 0.003 0.022 0.0127
Echinococcus multilocularis ephrin type A receptor 4 A 0.003 0.022 0.0127
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Echinococcus multilocularis activated cdc42 kinase 1 0.003 0.022 0.0127
Schistosoma mansoni suppressor of cytokine signaling 0.0106 0.3139 0.4471
Echinococcus granulosus SH2 motif 0.0106 0.3139 0.3074
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase Blk 0.0136 0.4279 0.4224
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.022 0.0127
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0106 0.3139 0.3074
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.022 0.1258
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Schistosoma mansoni tensin 0.0106 0.3139 0.4471
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Schistosoma mansoni src-type protein tyrosine kinase-related 0.003 0.022 0.0184
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.022 0.0106
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0136 0.4279 0.4224
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0136 0.4279 0.4224
Echinococcus granulosus expressed conserved protein 0.0106 0.3139 0.3074
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Brugia malayi tRNA modification GTPase TrmE family protein 0.0106 0.3139 0.3131
Schistosoma mansoni bromodomain containing protein 0.0062 0.1448 0.1987
Echinococcus granulosus protein tyrosine kinase 0.003 0.022 0.0127
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.003 0.022 0.0127
Trichomonas vaginalis esterase, putative 0.0035 0.0428 0.3652
Echinococcus multilocularis integrin linked protein kinase 0.003 0.022 0.0127
Schistosoma mansoni tensin-related 0.0106 0.3139 0.4471
Echinococcus multilocularis SH2 motif 0.0106 0.3139 0.3074
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.003 0.022 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0428 0.2444
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.022 0.0127
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0106 0.3139 0.3074
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni hypothetical protein 0.0027 0.0115 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0115 0.0103
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) TK/DDR protein kinase 0.003 0.022 0.0106
Loa Loa (eye worm) TK/RYK protein kinase 0.003 0.022 0.0106
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.022 0.0106
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.022 0.1258
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0106 0.3139 0.3059
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.022 0.0184
Brugia malayi hypothetical protein 0.0182 0.6058 0.6053
Loa Loa (eye worm) STAT protein 0.0106 0.3139 0.3059
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.003 0.022 0.1258
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Loa Loa (eye worm) serine/threonine protein kinase 0.003 0.022 0.0106
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.003 0.022 0.0127
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0106 0.3139 0.3074
Echinococcus granulosus tyrosine protein kinase Src64B 0.0136 0.4279 0.4224
Onchocerca volvulus 0.0136 0.4279 0.6952
Plasmodium falciparum protein kinase, putative 0.003 0.022 0.1258
Echinococcus multilocularis tyrosine protein kinase Srms 0.0136 0.4279 0.4224
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0788 1
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Schistosoma mansoni serine/threonine protein kinase 0.003 0.022 0.0184
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.7686 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0428 0.2444
Echinococcus multilocularis tyrosine kinase 0.003 0.022 0.0127
Echinococcus multilocularis protein tyrosine kinase 0.003 0.022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0086 0.2351 0.2261
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Schistosoma mansoni hypothetical protein 0.0027 0.0115 0.003
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0106 0.3139 0.4471
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2006 0.2806
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0106 0.3139 0.3074
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2006 0.1913
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.007 0.1749 1
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Schistosoma mansoni nck2/grb4 0.0106 0.3139 0.4471
Brugia malayi beta-lactamase family protein 0.0035 0.0428 0.0416
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0106 0.3139 0.3074
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0106 0.3139 0.3074
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0136 0.4279 0.4224
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0788 0.0777
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Schistosoma mansoni GTPase activating protein 0.0106 0.3139 0.4471
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2006 0.2806
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2006 0.1913
Brugia malayi hypothetical protein 0.003 0.022 0.0208
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Brugia malayi cytokine inducible SH2-containing protein 5 0.0106 0.3139 0.3131
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0788 0.07
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.003 0.022 0.0127
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.003 0.022 0.03
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.003 0.022 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Brugia malayi SH2 domain containing protein 0.0136 0.4279 0.4272
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) TK/ACK protein kinase 0.003 0.022 0.0106
Echinococcus granulosus SH2 domain containing protein 7 0.0106 0.3139 0.3074
Onchocerca volvulus 0.0058 0.1308 0.1863
Brugia malayi TAR-binding protein 0.0076 0.2006 0.1996
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Loa Loa (eye worm) SH2 domain-containing protein 0.0106 0.3139 0.3059
Schistosoma mansoni hypothetical protein 0.0027 0.0115 0.003
Echinococcus granulosus natriuretic peptide receptor 1 0.003 0.022 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0086 0.2351 0.2341
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Loa Loa (eye worm) hypothetical protein 0.004 0.0605 0.0495
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.022 0.0127
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.022 0.1258
Loa Loa (eye worm) TK/FAK protein kinase 0.003 0.022 0.0106
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0428 0.3652
Echinococcus multilocularis FL cytokine receptor 0.003 0.022 0.0127
Loa Loa (eye worm) transcription factor SMAD2 0.0102 0.2969 0.2887
Onchocerca volvulus 0.0106 0.3139 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Brugia malayi bone morphogenetic protein type 1 receptor 0.003 0.022 0.0208
Entamoeba histolytica hypothetical protein, conserved 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.4365 0.4311
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0788 1
Brugia malayi Variant SH3 domain containing protein 0.0106 0.3139 0.3131
Entamoeba histolytica ankyrin repeat protein 0.003 0.022 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Schistosoma mansoni vav2 0.0106 0.3139 0.4471
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.003 0.022 0.1258
Echinococcus granulosus protein kinase 0.003 0.022 0.0127
Entamoeba histolytica SH2 domain containing protein 0.0106 0.3139 0.7277
Loa Loa (eye worm) hypothetical protein 0.0069 0.1726 0.163
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.4365 0.627
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.022 0.0127
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0136 0.4279 0.4224
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.022 0.0127
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.4279 0.4272
Onchocerca volvulus 0.0182 0.6058 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0106 0.3139 0.7277
Brugia malayi beta-lactamase 0.0035 0.0428 0.0416
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Echinococcus granulosus activin receptor type 0.003 0.022 0.0127
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.022 0.1258
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Brugia malayi Bromodomain containing protein 0.0037 0.0513 0.0502
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.022 0.0127
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.022 0.0127
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0106 0.3139 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni serine/threonine protein kinase 0.003 0.022 0.0184
Echinococcus multilocularis fibroblast growth factor receptor 4 0.003 0.022 0.0127
Brugia malayi Variant SH3 domain containing protein 0.0106 0.3139 0.3131
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Echinococcus granulosus integrin linked protein kinase 0.003 0.022 0.0127
Schistosoma mansoni hypothetical protein 0.0205 0.6905 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.003 0.022 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis protein kinase 0.003 0.022 0.0127
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0428 0.3652
Echinococcus granulosus tyrosine protein kinase shark 0.0136 0.4279 0.4224
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Echinococcus multilocularis tyrosine protein kinase 0.003 0.022 0.0127
Onchocerca volvulus 0.0106 0.3139 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Onchocerca volvulus 0.0136 0.4279 0.6952
Echinococcus granulosus geminin 0.0205 0.6905 0.6876
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.022 0.0127
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Echinococcus granulosus tyrosine protein kinase Src42A 0.0106 0.3139 0.3074
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.022 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0425 0.0333
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0136 0.4279 0.4224
Brugia malayi integrin-linked kinase 0.003 0.022 0.0208
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.022 0.0208
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.003 0.022 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus multilocularis geminin 0.0205 0.6905 0.6876
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0788 0.1018
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Echinococcus multilocularis natriuretic peptide receptor 1 0.003 0.022 0.0127
Echinococcus granulosus kinase suppressor of Ras 1 0.003 0.022 0.0127
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis growth factor receptor bound protein 2 0.0106 0.3139 0.3074
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Plasmodium falciparum protein kinase, putative 0.003 0.022 0.1258
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.022 0.0127
Loa Loa (eye worm) TK protein kinase 0.0136 0.4279 0.4212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0428 0.0489
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis transfer RNA-Thr 0.003 0.022 0.0127
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Brugia malayi C-terminal src kinase protein 1 0.003 0.022 0.0208
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0788 0.07
Brugia malayi hypothetical protein 0.0136 0.4279 0.4272
Loa Loa (eye worm) TK/ABL protein kinase 0.0136 0.4279 0.4212
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.003 0.022 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0788 0.1658
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.003 0.022 0.0127
Schistosoma mansoni hypothetical protein 0.0058 0.1308 0.1781
Brugia malayi Furin-like cysteine rich region family protein 0.003 0.022 0.0208
Entamoeba histolytica tyrosin kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0106 0.3139 0.3059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2006 0.2806
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Schistosoma mansoni peptidase Clp (S14 family) 0.007 0.1749 0.243
Echinococcus granulosus tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Echinococcus multilocularis retinal guanylyl cyclase 2 0.003 0.022 0.0127
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.022 0.0127
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.022 0.0127
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.022 0.1258
Onchocerca volvulus 0.0106 0.3139 0.5
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Brugia malayi Protein kinase domain containing protein 0.0136 0.4279 0.4272
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.022 0.0127
Echinococcus multilocularis heat shock protein 70 0.003 0.022 0.0127
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 0.5
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus granulosus ephrin type A receptor 4 A 0.003 0.022 0.0127
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0115 0.0021
Echinococcus granulosus tar DNA binding protein 0.0076 0.2006 0.1929
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Schistosoma mansoni suppressor of cytokine signaling 0.0106 0.3139 0.4471
Loa Loa (eye worm) hypothetical protein 0.0042 0.0676 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Brugia malayi hypothetical protein 0.0027 0.0094 0.0082
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0106 0.3139 0.3074
Entamoeba histolytica ankyrin repeat protein 0.003 0.022 0.03
Schistosoma mansoni tensin 0.0106 0.3139 0.4471
Schistosoma mansoni ephrin receptor 0.003 0.022 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.4365 0.627
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus granulosus SH2 domain containing adapter protein F 0.0106 0.3139 0.3074
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.022 0.0106
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Brugia malayi Sex muscle abnormal protein 5 0.0106 0.3139 0.3131
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Echinococcus multilocularis NCK adaptor protein 0.0106 0.3139 0.3074
Entamoeba histolytica tyrosin kinase, putative 0.003 0.022 0.03
Brugia malayi Guanylyl cyclase protein 23 0.003 0.022 0.0208
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.022 0.0127
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis SH2 motif 0.0106 0.3139 0.3074
Brugia malayi Probable ClpP-like protease 0.007 0.1749 0.1739
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.022 0.1258
Schistosoma mansoni serine/threonine protein kinase 0.003 0.022 0.0184
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.022 0.0127
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0136 0.4279 0.4224
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Schistosoma mansoni growth factor receptor-bound protein 0.0106 0.3139 0.4471
Echinococcus granulosus suppressor of cytokine signaling 7 0.0106 0.3139 0.3074
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0106 0.3139 0.4471
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus granulosus tyrosine protein kinase 0.003 0.022 0.0127
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0136 0.4279 0.4224
Loa Loa (eye worm) hypothetical protein 0.0182 0.6058 0.6012
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.003 0.022 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0428 0.3652
Loa Loa (eye worm) hypothetical protein 0.0045 0.0788 0.0681
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.022 0.0127
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0788 0.1018
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.003 0.022 0.0106
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Onchocerca volvulus 0.0035 0.0428 0.0355
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.022 0.0127
Echinococcus granulosus c src tyrosine kinase 0.0136 0.4279 0.4224
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0428 0.3652
Entamoeba histolytica cysteine surface protein, putative 0.003 0.022 0.03
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.007 0.1749 0.1671
Schistosoma mansoni tensin 0.0106 0.3139 0.4471
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.007 0.1749 0.1671
Echinococcus granulosus retinal guanylyl cyclase 2 0.003 0.022 0.0127
Echinococcus granulosus tyrosine kinase 0.003 0.022 0.0127
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0136 0.4279 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0136 0.4279 0.4224
Brugia malayi Variant SH3 domain containing protein 0.0106 0.3139 0.3131
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Schistosoma mansoni adapter molecule crk 0.0106 0.3139 0.4471
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus granulosus epidermal growth factor receptor 0.003 0.022 0.0127
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.022 0.0127
Echinococcus multilocularis signal transduction protein lnk realted 0.0106 0.3139 0.3074
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.003 0.022 0.0127
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.022 0.0127
Loa Loa (eye worm) beta-lactamase 0.0035 0.0428 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2006 0.2806
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.4365 0.4299
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) hypothetical protein 0.007 0.1749 0.1653
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi SH2 domain containing protein 0.0136 0.4279 0.4272
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.022 0.0127
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Entamoeba histolytica receptor protein kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0136 0.4279 0.4224
Loa Loa (eye worm) protein kinase domain-containing protein 0.003 0.022 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0516 0.0406
Echinococcus granulosus tyrosine protein kinase Lyn 0.0136 0.4279 0.4224
Echinococcus granulosus tyrosine protein kinase Blk 0.0136 0.4279 0.4224
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0106 0.3139 0.4471
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.007 0.1749 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.022 0.0127
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Onchocerca volvulus 0.0136 0.4279 0.6952
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.022 0.0208
Echinococcus granulosus tyrosine protein kinase Src42A 0.0136 0.4279 0.4224
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.1316 0.1305
Echinococcus multilocularis c src tyrosine kinase 0.0136 0.4279 0.4224
Echinococcus multilocularis dual specificity testis specific protein kinase 0.003 0.022 0.0127
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.022 0.0127
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0428 0.0336
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0428 0.0316
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1308 0.1297
Brugia malayi Raf kinase 0.003 0.022 0.0208
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.003 0.022 0.03
Echinococcus multilocularis SHC transforming protein 3 0.0106 0.3139 0.3074
Loa Loa (eye worm) TK/ALK protein kinase 0.003 0.022 0.0106
Onchocerca volvulus 0.0136 0.4279 0.6952
Brugia malayi beta-lactamase family protein 0.0035 0.0428 0.0416
Echinococcus granulosus SH2 motif 0.0106 0.3139 0.3074
Echinococcus granulosus dual specificity testis-specific protein kinase 0.003 0.022 0.0127
Echinococcus granulosus hypothetical protein 0.0106 0.3139 0.3074
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) TK protein kinase 0.003 0.022 0.0106
Echinococcus multilocularis insulin receptor 0.003 0.022 0.0127
Loa Loa (eye worm) TK/FER protein kinase 0.003 0.022 0.0106
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0106 0.3139 0.3074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0428 0.0489
Echinococcus granulosus activated cdc42 kinase 1 0.003 0.022 0.0127
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0106 0.3139 0.3074
Onchocerca volvulus 0.0035 0.0428 0.0355
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Loa Loa (eye worm) SRC-1 0.0136 0.4279 0.4212
Schistosoma mansoni hypothetical protein 0.003 0.022 0.0184
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0046 0.083 0.4744
Brugia malayi hypothetical protein 0.0106 0.3139 0.3131
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.4365 0.627
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Brugia malayi STAT protein, DNA binding domain containing protein 0.0106 0.3139 0.3131
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Entamoeba histolytica tyrosin kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis kinase suppressor of Ras 1 0.003 0.022 0.0127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0115 0.0021
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0106 0.3139 0.4471
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.022 0.0127
Schistosoma mansoni hypothetical protein 0.0058 0.1316 0.1793
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.003 0.022 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.022 0.0106
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.022 0.0127
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Brugia malayi RNA binding protein 0.0076 0.2006 0.1996
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Entamoeba histolytica protein kinase, putative 0.0106 0.3139 0.7277
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2006 0.1929
Mycobacterium leprae Probable lipase LipE 0.0035 0.0428 0.2444
Brugia malayi Protein kinase domain containing protein 0.0136 0.4279 0.4272
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Schistosoma mansoni tensin-related 0.0106 0.3139 0.4471
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0106 0.3139 0.3074
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Schistosoma mansoni hypothetical protein 0.0027 0.0115 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.4365 0.4311
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0086 0.2351 0.2261
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.022 0.0106
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Loa Loa (eye worm) TK/EGFR protein kinase 0.003 0.022 0.0106
Schistosoma mansoni tyrosine protein kinase 0.003 0.022 0.0184
Schistosoma mansoni survival motor neuron protein 0.0058 0.1308 0.1781
Schistosoma mansoni serine/threonine RGC 0.003 0.022 0.0184
Schistosoma mansoni tyrosine kinase 0.0136 0.4279 0.6144
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.003 0.022 0.0127
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.022 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0428 0.3652
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0136 0.4279 0.4224
Onchocerca volvulus 0.0136 0.4279 0.6952
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0788 1
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Brugia malayi RhoGAP domain containing protein 0.0106 0.3139 0.3131
Brugia malayi SH2 domain containing protein 0.0106 0.3139 0.3131
Echinococcus granulosus GPCR family 2 0.0027 0.0115 0.0021
Loa Loa (eye worm) hypothetical protein 0.0136 0.4279 0.4212
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0106 0.3139 0.3059
Loa Loa (eye worm) TK/EPH protein kinase 0.003 0.022 0.0106
Echinococcus granulosus suppressor of cytokine signaling 6 0.0106 0.3139 0.3074
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.007 0.1749 1
Loa Loa (eye worm) TK/CSK protein kinase 0.003 0.022 0.0106
Echinococcus granulosus epidermal growth factor receptor 0.003 0.022 0.0127
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.022 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1314 0.1231
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0788 0.07
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0106 0.3139 0.3074
Echinococcus multilocularis SH2 domain containing protein 7 0.0106 0.3139 0.3074
Plasmodium vivax protein kinase, putative 0.003 0.022 0.1258
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Schistosoma mansoni shc transforming protein 0.0106 0.3139 0.4471
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0425 0.0333
Loa Loa (eye worm) TK/INSR protein kinase 0.003 0.022 0.0106
Echinococcus granulosus NCK adaptor protein 0.0106 0.3139 0.3074
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0106 0.3139 0.3059
Brugia malayi Variant SH3 domain containing protein 0.0106 0.3139 0.3131
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0106 0.3139 0.3131
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.003 0.022 0.0208
Brugia malayi Bromodomain containing protein 0.0073 0.1886 0.1876
Echinococcus multilocularis SH2 motif 0.0106 0.3139 0.3074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.4365 0.4311
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.003 0.022 0.0208
Echinococcus multilocularis tensin 0.0106 0.3139 0.3074
Leishmania major hypothetical protein, conserved 0.0035 0.0428 0.3652
Schistosoma mansoni tyrosine-protein kinase fps85d 0.003 0.022 0.0184
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.003 0.022 0.0127
Schistosoma mansoni SH2A 0.0106 0.3139 0.4471
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Toxoplasma gondii STE kinase 0.003 0.022 0.1258
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Echinococcus granulosus signal transduction protein lnk realted 0.0106 0.3139 0.3074
Echinococcus multilocularis protein kinase 0.003 0.022 0.0127
Brugia malayi Protein kinase domain containing protein 0.0136 0.4279 0.4272
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) SH2 domain-containing protein 0.0106 0.3139 0.3059
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0788 1
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.022 0.0184
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.003 0.022 0.0208
Loa Loa (eye worm) TK/Met protein kinase 0.003 0.022 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.2969 0.2887
Echinococcus granulosus tensin 0.0106 0.3139 0.3074
Echinococcus multilocularis peptidase Clp (S14 family) 0.0046 0.083 0.0742
Echinococcus multilocularis tyrosine protein kinase Abl 0.0136 0.4279 0.4224
Schistosoma mansoni serine/threonine protein kinase 0.003 0.022 0.0184
Brugia malayi SRC-1 0.0136 0.4279 0.4272
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0106 0.3139 0.4471
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0136 0.4279 0.4224
Loa Loa (eye worm) RNA binding protein 0.0076 0.2006 0.1913
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0788 1
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0428 0.0336
Echinococcus granulosus tyrosine protein kinase csk 0.003 0.022 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0428 0.3652
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Schistosoma mansoni hypothetical protein 0.0205 0.6905 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.003 0.022 0.0127
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0428 0.0416
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0788 0.07
Loa Loa (eye worm) TK/KIN6 protein kinase 0.003 0.022 0.0106
Onchocerca volvulus 0.0035 0.0428 0.0355
Brugia malayi protein-tyrosine kinase 0.0136 0.4279 0.4272
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Brugia malayi hypothetical protein 0.003 0.022 0.0208
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03
Toxoplasma gondii protein kinase 0.003 0.022 0.1258
Loa Loa (eye worm) SH2 domain-containing protein 0.0106 0.3139 0.3059
Echinococcus granulosus tyrosine protein kinase ABL1 0.0136 0.4279 0.4224
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0106 0.3139 0.3059
Entamoeba histolytica serine/threonine kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1314 0.1231
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.4279 0.4212
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0136 0.4279 0.4224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.4365 0.4311
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0106 0.3139 0.3059
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.003 0.022 0.0106
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0106 0.3139 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0136 0.4279 0.4224
Entamoeba histolytica receptor protein kinase, putative 0.003 0.022 0.03
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.003 0.022 0.0184
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0046 0.083 0.0554
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0046 0.083 0.0554
Onchocerca volvulus 0.0136 0.4279 0.6952
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.022 0.0106
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Schistosoma mansoni protein kinase 0.003 0.022 0.0184
Entamoeba histolytica tyrosin kinase, putative 0.003 0.022 0.03
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Echinococcus granulosus N chimaerin 0.0106 0.3139 0.3074
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0106 0.3139 0.3074
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Brugia malayi ephrin receptor 1 precursor 0.003 0.022 0.0208
Brugia malayi Probable tyrosine-protein kinase kin-31 0.003 0.022 0.0208
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2006 0.1996
Brugia malayi Protein kinase domain containing protein 0.0136 0.4279 0.4272
Echinococcus multilocularis 0.0106 0.3139 0.3074
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus granulosus peptidase Clp S14 family 0.0046 0.083 0.0742
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.003 0.022 0.0127
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.022 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0428 0.3652
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.003 0.022 0.03
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Echinococcus multilocularis N chimaerin 0.0106 0.3139 0.3074
Brugia malayi Tyrosine-protein kinase PR2 0.003 0.022 0.0208
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.003 0.022 0.0127
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Entamoeba histolytica hypothetical protein 0.003 0.022 0.03
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0106 0.3139 0.3074
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.003 0.022 0.03
Echinococcus multilocularis tyrosine protein kinase csk 0.003 0.022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0106 0.3139 0.3059
Schistosoma mansoni hypothetical protein 0.0106 0.3139 0.4471
Schistosoma mansoni hypothetical protein 0.0106 0.3139 0.4471
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0136 0.4279 0.4224
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2006 0.2806
Onchocerca volvulus 0.0106 0.3139 0.5
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Brugia malayi Protein kinase domain containing protein 0.003 0.022 0.0208
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus granulosus tyrosine kinase 0.0136 0.4279 0.4224
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.007 0.1749 1
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0428 0.0316
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0788 0.07
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.007 0.1749 0.5
Echinococcus granulosus insulin receptor 0.003 0.022 0.0127
Entamoeba histolytica tyrosine kinase, putative 0.003 0.022 0.03
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Schistosoma mansoni tyrosine kinase 0.003 0.022 0.0184
Echinococcus granulosus SHC transforming protein 3 0.0106 0.3139 0.3074
Schistosoma mansoni ephrin receptor 0.003 0.022 0.0184
Entamoeba histolytica protein kinase, putative 0.003 0.022 0.03
Schistosoma mansoni protein tyrosine kinase 0.003 0.022 0.0184
Entamoeba histolytica protein kinase domain containing protein 0.003 0.022 0.03

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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