Detailed information for compound 1268276

Basic information

Technical information
  • TDR Targets ID: 1268276
  • Name: (5E)-3-cyclohexyl-5-[(5-methylfuran-2-yl)meth ylidene]-2-sulfanylidene-1,3-thiazolidin-4-on e
  • MW: 307.431 | Formula: C15H17NO2S2
  • H donors: 0 H acceptors: 1 LogP: 4.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1S/C(=C/c2ccc(o2)C)/C(=O)N1C1CCCCC1
  • InChi: 1S/C15H17NO2S2/c1-10-7-8-12(18-10)9-13-14(17)16(15(19)20-13)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3/b13-9+
  • InChiKey: KOIYSFDNAAXVLR-UKTHLTGXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-3-cyclohexyl-5-[(5-methyl-2-furyl)methylene]-2-thioxo-thiazolidin-4-one
  • (5E)-3-cyclohexyl-5-[(5-methyl-2-furyl)methylene]-2-thioxo-4-thiazolidinone
  • ZINC02701162

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0208 0.5
Trypanosoma brucei ISWI complex protein 0.0018 0.012 0.378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.018 0.018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0244 0.48 0.48
Echinococcus multilocularis cpg binding protein 0.0039 0.0546 0.0546
Schistosoma mansoni thyroid hormone receptor 0.0244 0.48 0.48
Echinococcus multilocularis zinc finger protein 0.0026 0.0269 0.0269
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1554 0.2957
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0244 0.48 0.48
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0457 0.087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0244 0.48 0.9137
Brugia malayi PHD-finger family protein 0.0032 0.0403 0.0766
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0208 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0244 0.48 0.9137
Brugia malayi Cytochrome P450 family protein 0.0016 0.0067 0.0127
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0115 0.2125 0.2125
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0164 0.0164
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0164 0.0164
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0208 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0244 0.48 0.9137
Echinococcus granulosus zinc finger protein 0.0026 0.0269 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0244 0.48 0.9137
Brugia malayi Nuclear hormone receptor E75 0.0115 0.2125 0.4045
Echinococcus granulosus cpg binding protein 0.0039 0.0546 0.0546
Brugia malayi nuclear receptor NHR-88 0.0115 0.2125 0.4045
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Echinococcus granulosus thyroid hormone receptor alpha 0.0115 0.2125 0.2125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0208 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0244 0.48 0.48
Echinococcus multilocularis thyroid hormone receptor alpha 0.0244 0.48 0.48
Schistosoma mansoni gabp alpha 0.0087 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Echinococcus granulosus nuclear receptor nhr 48 0.0115 0.2125 0.2125
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0129 0.2411 0.459
Brugia malayi CXXC zinc finger family protein 0.0035 0.0457 0.087
Brugia malayi Nuclear hormone receptor E75 0.0115 0.2125 0.4045
Schistosoma mansoni RAR-like nuclear receptor 0.0244 0.48 0.48
Brugia malayi Nuclear hormone receptor-like 1 0.0129 0.2411 0.459
Brugia malayi nuclear receptor RXR 0.0129 0.2411 0.459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0244 0.48 0.9137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0208 1
Brugia malayi nuclear receptor RXR 0.0115 0.2125 0.4045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0244 0.48 0.48
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0129 0.2411 0.2411
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0208 1
Brugia malayi Ets-domain containing protein 0.0087 0.1554 0.2957
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0208 0.0208
Leishmania major hypothetical protein, conserved 0.0018 0.012 0.378
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0244 0.48 0.48
Schistosoma mansoni cpg binding protein 0.0039 0.0546 0.0546
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.2125 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0244 0.48 0.9137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0208 0.0397
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0067 0.0127
Onchocerca volvulus 0.0115 0.2125 0.3841
Brugia malayi steroid hormone receptor 0.0244 0.48 0.9137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0244 0.48 0.9137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.2125 0.2125
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0244 0.48 0.48
Brugia malayi Cytochrome P450 family protein 0.0016 0.0067 0.0127
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0208 0.5
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Schistosoma mansoni zinc finger protein 0.0026 0.0269 0.0269
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0254 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0244 0.48 0.9137
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.2125 0.3841
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0244 0.48 0.48
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0244 0.48 1
Schistosoma mansoni ap endonuclease 0.0023 0.0208 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0244 0.48 0.9137
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0244 0.48 0.48
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0129 0.2411 0.2411
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0208 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.0208 0.0208
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0208 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0115 0.2125 0.2125
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0282 0.0537
Onchocerca volvulus Protein ultraspiracle homolog 0.0244 0.48 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1276 0.1276
Brugia malayi Ets-domain containing protein 0.0087 0.1554 0.2957
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0244 0.48 0.48
Loa Loa (eye worm) fli-1 protein 0.0265 0.5253 1
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1554 0.1554
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1554 0.1554
Brugia malayi nuclear hormone receptor family member odr-7 0.0115 0.2125 0.4045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0244 0.48 0.9137
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0004 0.0009
Onchocerca volvulus 0.0115 0.2125 0.3841
Echinococcus granulosus FTZ F1 alpha 0.0244 0.48 0.48
Onchocerca volvulus 0.0244 0.48 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0244 0.48 0.9137
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0208 1
Schistosoma mansoni ets-related 0.0265 0.5253 0.5253
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.2125 0.2125
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0343 0.0343
Onchocerca volvulus Bile acid receptor homolog 0.0244 0.48 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0638 0.0638
Trypanosoma cruzi ISWI complex protein 0.0018 0.012 0.378
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0208 0.5
Brugia malayi Bromodomain containing protein 0.0093 0.1659 0.3159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0244 0.48 0.48
Brugia malayi hypothetical protein 0.0129 0.2411 0.459
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0208 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0115 0.2125 0.4045
Loa Loa (eye worm) DR-78 0.0115 0.2125 0.4045
Brugia malayi nuclear hormone receptor 0.0115 0.2125 0.4045
Echinococcus multilocularis nuclear receptor nhr 48 0.0115 0.2125 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0244 0.48 0.9137
Schistosoma mansoni nuclear receptor nhr-48 0.0115 0.2125 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0244 0.48 0.9137
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.018 0.018
Brugia malayi ecdysone receptor 0.0115 0.2125 0.4045
Schistosoma mansoni zinc finger protein 0.0115 0.2125 0.2125
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0067 0.0127
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0244 0.48 0.48
Brugia malayi nuclear receptor NHR-88 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.2125 0.2125
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0129 0.2411 0.2411
Brugia malayi tailless protein 0.0115 0.2125 0.4045
Brugia malayi Fli-1 protein 0.0265 0.5253 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.018 0.018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.2125 0.2125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0244 0.48 0.48
Schistosoma mansoni nuclear hormone receptor 0.0115 0.2125 0.2125
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0244 0.48 0.48
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0244 0.48 0.48
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0244 0.48 0.48
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0067 0.0127
Brugia malayi Cytochrome P450 family protein 0.0026 0.0282 0.0537
Loa Loa (eye worm) hypothetical protein 0.0129 0.2411 0.459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1265 0.1265
Loa Loa (eye worm) nuclear receptor NHR-67 0.0115 0.2125 0.4045
Trypanosoma cruzi ISWI complex protein 0.0018 0.012 0.378
Loa Loa (eye worm) hypothetical protein 0.0129 0.2411 0.459
Loa Loa (eye worm) steroid hormone receptor 0.0244 0.48 0.9137
Echinococcus multilocularis ecdysone induced protein 78C 0.0244 0.48 0.48
Brugia malayi photoreceptor-specific nuclear receptor 0.0244 0.48 0.9137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0638 0.0638
Schistosoma mansoni cpg binding protein 0.0035 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0053 0.0848 0.1614
Schistosoma mansoni zinc finger protein 0.0018 0.012 0.012
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0164 0.0164
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0115 0.2125 0.2125
Schistosoma mansoni nuclear hormone receptor 0.0244 0.48 0.48
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0208 0.0397
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0085 0.1511 0.2876
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0129 0.2411 0.459
Loa Loa (eye worm) hypothetical protein 0.0129 0.2411 0.459
Brugia malayi nuclear hormone receptor family member nhr-6 0.0115 0.2125 0.4045
Brugia malayi Steroid receptor seven-up type 2 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0021 0.018 0.0343
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.018 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0244 0.48 0.9137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0244 0.48 0.9137
Schistosoma mansoni hypothetical protein 0.0018 0.012 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0244 0.48 0.48
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0208 0.5
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1276 0.1276
Brugia malayi hypothetical protein 0.0115 0.2125 0.4045
Loa Loa (eye worm) hypothetical protein 0.0129 0.2411 0.459
Echinococcus granulosus ecdysone induced protein 78C 0.0244 0.48 0.48
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.2125 0.3841
Brugia malayi ecdysteroid receptor 0.0244 0.48 0.9137
Brugia malayi conserved hypotetical protein 0.0115 0.2125 0.4045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Schistosoma mansoni thyroid hormone receptor 0.0244 0.48 0.48
Schistosoma mansoni bromodomain containing protein 0.0078 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0208 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0115 0.2125 0.2125
Schistosoma mansoni nuclear hormone receptor 0.0115 0.2125 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.1161 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0699 0.1331
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.2125 0.2125
Echinococcus multilocularis FTZ F1 alpha 0.0244 0.48 0.48
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0244 0.48 0.48
Schistosoma mansoni nuclear receptor 0.0115 0.2125 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0075 0.129 0.2456
Brugia malayi Nuclear hormone receptor-like 1 0.0129 0.2411 0.459
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0115 0.2125 0.2125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0244 0.48 0.9137
Loa Loa (eye worm) nuclear hormone receptor 0.0115 0.2125 0.4045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.018 0.018
Brugia malayi hypothetical protein 0.0129 0.2411 0.459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0759 0.1444
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0244 0.48 0.48
Schistosoma mansoni coup transcription factor 0.0244 0.48 0.48
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0244 0.48 0.48
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0244 0.48 0.9137
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0244 0.48 0.48
Schistosoma mansoni retinoic acid receptor RXR 0.0244 0.48 0.48
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0129 0.2411 0.2411
Loa Loa (eye worm) hypothetical protein 0.0115 0.2125 0.4045
Brugia malayi nuclear hormone receptor 0.0244 0.48 0.9137
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0115 0.2125 0.4045
Brugia malayi hypothetical protein 0.0115 0.2125 0.4045
Loa Loa (eye worm) hypothetical protein 0.0244 0.48 0.9137
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0115 0.2125 0.4045
Schistosoma mansoni nuclear receptor 0.0115 0.2125 0.2125
Schistosoma mansoni cpg binding protein 0.0039 0.0546 0.0546
Schistosoma mansoni hypothetical protein 0.0025 0.0254 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0244 0.48 0.9137
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0208 0.5
Brugia malayi nuclear receptor NHR-67 0.0115 0.2125 0.4045
Brugia malayi Bromodomain containing protein 0.0046 0.0697 0.1328

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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