Detailed information for compound 1268798

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 235.345 | Formula: C13H17NOS
  • H donors: 1 H acceptors: 1 LogP: 2.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=S)c1ccccc1O
  • InChi: 1S/C13H17NOS/c1-10-6-8-14(9-7-10)13(16)11-4-2-3-5-12(11)15/h2-5,10,15H,6-9H2,1H3
  • InChiKey: MYTNDQBMUZXFAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei polo-like protein kinase 0.0114 0.0045 0.0577
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0037 0.077
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Leishmania major hypothetical protein, unknown function 0.0069 0.0023 0.0562
Echinococcus granulosus TRP transient receptor potential channel 0.0069 0.0023 0.0427
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 2.0127 1 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0069 0.0023 0.0423
Echinococcus multilocularis potassium large conductance calcium activated 0.0069 0.0023 0.0423
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0069 0.0023 0.0427
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0012 0.0159
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0069 0.0023 0.0423
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0069 0.0023 0.0562
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0036 0.0751
Echinococcus granulosus hyperpolarization activated cyclic 0.0069 0.0023 0.0427
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0069 0.0023 0.0423
Schistosoma mansoni kinase 0.0058 0.0017 0.0283
Schistosoma mansoni rab6-interacting 0.0048 0.0012 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0006 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0069 0.0023 0.0427
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0069 0.0023 0.0562
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0012 0.0159
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus granulosus shaker cognate 0.0069 0.0023 0.0427
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus multilocularis sodium leak channel non selective protein 0.0069 0.0023 0.0423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0011 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Schistosoma mansoni ryanodine receptor related 0.0069 0.0023 0.0423
Brugia malayi hypothetical protein 0.0048 0.0012 0.0298
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0012 0.0162
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0069 0.0023 0.0562
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0036 0.0886
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0017 0.0284
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0025 0.0025
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0069 0.0023 0.0423
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0069 0.0023 0.0562
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0845 0.0409 1
Echinococcus granulosus ryanodine receptor 44f 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0069 0.0023 0.0423
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0012 0.0305
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0009 0.0079
Schistosoma mansoni patched 1 0.0041 0.0009 0.0075
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0069 0.0023 0.0423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0011 0.0121
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0845 0.0409 1
Onchocerca volvulus 0.0048 0.0012 0.0298
Loa Loa (eye worm) hypothetical protein 0.005 0.0014 0.0332
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0145
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0069 0.0023 0.0562
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0069 0.0023 0.0423
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0069 0.0023 0.0562
Echinococcus granulosus sodium channel protein 0.0069 0.0023 0.0427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0011 0.0117
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Schistosoma mansoni two-pore calcium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0286 0.0131 0.3194
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0011 0.0261
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0012 0.0159
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0069 0.0023 0.0427
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0069 0.0023 0.0423
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.0025 0.0619
Schistosoma mansoni lipoxygenase 0.0209 0.0093 0.2149
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0023 0.0423
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0045 0.0976
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0012 0.0298
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0012 0.0155
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0845 0.0409 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0069 0.0023 0.0562
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Onchocerca volvulus 0.005 0.0013 0.0325
Echinococcus multilocularis calcium activated potassium channel 0.007 0.0023 0.0428
Echinococcus multilocularis transient receptor potential gamma protein 0.0069 0.0023 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis conserved hypothetical protein 0.0069 0.0023 0.0423
Echinococcus multilocularis protein dispatched 1 0.0047 0.0012 0.0147
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.003 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0011 0.0117
Onchocerca volvulus 0.0048 0.0012 0.0298
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0069 0.0023 0.0562
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0069 0.0023 0.0423
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Toxoplasma gondii transporter, cation channel family protein 0.0069 0.0023 0.0411
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0069 0.0023 0.0562
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0069 0.0023 0.0427
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0069 0.0023 0.0427
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0069 0.0023 0.0423
Echinococcus granulosus potassium large conductance calcium activated 0.0069 0.0023 0.0427
Echinococcus multilocularis protein patched 0.0041 0.0009 0.0075
Onchocerca volvulus 0.0048 0.0012 0.0305
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0145
Echinococcus granulosus expressed conserved protein 0.009 0.0033 0.0683
Brugia malayi voltage-dependent calcium channel 0.0069 0.0023 0.0562
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0045 0.1107
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0045 0.1107
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0069 0.0023 0.0562
Schistosoma mansoni chromobox protein 0.0084 0.003 0.0606
Onchocerca volvulus 0.0037 0.0007 0.0169
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.765 0.3794 0.5
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0069 0.0023 0.0562
Echinococcus multilocularis chromobox protein 1 0.0084 0.003 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0069 0.0023 0.0423
Echinococcus multilocularis RUN 0.0048 0.0012 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0069 0.0023 0.0423
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0145
Echinococcus multilocularis two pore calcium channel protein 1 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0069 0.0023 0.0427
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0069 0.0023 0.0423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0023 0.0411
Echinococcus granulosus voltage dependent calcium channel 0.0069 0.0023 0.0427
Brugia malayi cation channel family protein 0.0069 0.0023 0.0562
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0069 0.0023 0.0423
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.0025 0.0619
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0057 0.126
Brugia malayi Doublecortin family protein 0.0048 0.0012 0.0298
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0131 0.3113
Leishmania major hypothetical protein, conserved 0.0069 0.0023 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0017 0.0284
Schistosoma mansoni voltage-gated ion channel 0.0069 0.0023 0.0423
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Echinococcus multilocularis ryanodine receptor 44f 0.0069 0.0023 0.0423
Onchocerca volvulus 0.0177 0.0076 0.1871
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0069 0.0023 0.0423
Loa Loa (eye worm) calcium channel 0.0069 0.0023 0.0562
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0045 0.0577
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0069 0.0023 0.0423
Loa Loa (eye worm) voltage-gated potassium channel 0.0069 0.0023 0.0562
Echinococcus granulosus voltage gated potassium channel 0.0069 0.0023 0.0427
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0069 0.0023 0.0562
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0006 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0023 0.0443
Brugia malayi hypothetical protein 0.0177 0.0076 0.1871
Echinococcus multilocularis potassium voltage gated channel protein 0.0069 0.0023 0.0423
Echinococcus multilocularis voltage gated potassium channel 0.0069 0.0023 0.0423
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0012 0.0293
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0036 0.0006 0.0158
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0845 0.0409 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0069 0.0023 0.0427
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0045 0.1107
Echinococcus granulosus voltage gated hydrogen channel 1 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0845 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Brugia malayi CHE-14 protein 0.0041 0.0009 0.022
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0069 0.0023 0.0562
Echinococcus multilocularis voltage dependent calcium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis potassium voltage gated channel protein 0.0069 0.0023 0.0423
Echinococcus multilocularis potassium voltage gated channel protein 0.0069 0.0023 0.0423
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0069 0.0023 0.0562
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0012 0.0155
Echinococcus granulosus chromobox protein 1 0.0084 0.003 0.061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0014 0.0336
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0057 0.1263
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0131 0.3093
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0012 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0011 0.0261
Brugia malayi Pre-SET motif family protein 0.0036 0.0006 0.0158
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0845 0.0409 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0069 0.0023 0.0423
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0069 0.0023 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0006 0.0012
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0069 0.0023 0.0427
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0036 0.0886
Loa Loa (eye worm) hypothetical protein 0.0177 0.0076 0.1871
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0069 0.0023 0.0427
Schistosoma mansoni transient receptor potential channel 0.0069 0.0023 0.0423
Schistosoma mansoni hypothetical protein 0.0048 0.0012 0.0155
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0023 0.0411
Trichomonas vaginalis chromobox protein, putative 0.0084 0.003 0.0625
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus voltage dependent calcium channel 0.0069 0.0023 0.0427
Echinococcus granulosus two pore calcium channel protein 2 0.0069 0.0023 0.0427
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0012 0.0298
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Echinococcus granulosus chromobox protein 1 0.0084 0.003 0.061
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0041 0.0009 0.022
Schistosoma mansoni hypothetical protein 0.004 0.0008 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus hypothetical protein 0.0069 0.0023 0.0427
Schistosoma mansoni hypothetical protein 0.004 0.0008 0.0057
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0069 0.0023 0.0562
Onchocerca volvulus 0.0069 0.0023 0.0562
Trichomonas vaginalis chromobox protein, putative 0.0084 0.003 0.0625
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Schistosoma mansoni hypothetical protein 0.004 0.0008 0.0057
Schistosoma mansoni polycystin 1-related 0.0048 0.0012 0.0155
Echinococcus multilocularis hyperpolarization activated cyclic 0.0069 0.0023 0.0423
Schistosoma mansoni hypothetical protein 0.0058 0.0017 0.0286
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0069 0.0023 0.0562
Toxoplasma gondii transporter, cation channel family protein 0.0069 0.0023 0.0411
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus granulosus sodium leak channel non selective protein 0.0069 0.0023 0.0427
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0069 0.0023 0.0562
Echinococcus granulosus potassium voltage gated channel protein 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0012 0.0298
Brugia malayi Heterochromatin protein 1 0.0084 0.003 0.0743
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0069 0.0023 0.0427
Schistosoma mansoni voltage-dependent calcium channel 0.0069 0.0023 0.0423
Echinococcus granulosus potassium voltage gated channel protein 0.0069 0.0023 0.0427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0006 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Onchocerca volvulus 0.0286 0.0131 0.3199
Echinococcus granulosus calcium activated potassium channel 0.007 0.0023 0.0432
Echinococcus multilocularis transient receptor potential cation channel 0.0069 0.0023 0.0423
Schistosoma mansoni rab6-interacting 0.0048 0.0012 0.0155
Echinococcus granulosus RUN 0.0048 0.0012 0.0159
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0069 0.0023 0.0423
Brugia malayi hypothetical protein 0.0048 0.0012 0.0298
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0025 0.048
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0045 0.1107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0013 0.0182
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0045 0.1107
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0014 0.0214
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Schistosoma mansoni 60S ribosomal protein L21 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Onchocerca volvulus 0.0058 0.0017 0.0428
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.0381 0.932
Schistosoma mansoni lipoxygenase 0.0123 0.005 0.1091
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0069 0.0023 0.0427
Echinococcus multilocularis expressed conserved protein 0.009 0.0033 0.068
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0014 0.0214
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0023 0.0443
Loa Loa (eye worm) voltage-gated calcium channel 0.0069 0.0023 0.0562
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0023 0.0423
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0069 0.0023 0.0423
Echinococcus multilocularis chromobox protein 1 0.0084 0.003 0.0606
Loa Loa (eye worm) hypothetical protein 0.0047 0.0012 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0009 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0845 0.0409 1
Schistosoma mansoni hypothetical protein 0.004 0.0008 0.0057
Brugia malayi hypothetical protein 0.0035 0.0006 0.0145
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0023 0.0427
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0069 0.0023 0.0423
Brugia malayi Pre-SET motif family protein 0.0251 0.0114 0.2777
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0114 0.2777
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0009 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0131 0.3096
Echinococcus granulosus potassium voltage gated channel protein 0.0069 0.0023 0.0427
Schistosoma mansoni calcium-activated potassium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) ryanodine receptor 0.0069 0.0023 0.0562
Brugia malayi hypothetical protein 0.0286 0.0131 0.3194
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0069 0.0023 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0012 0.017
Echinococcus multilocularis shaker cognate 0.0069 0.0023 0.0423
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Entamoeba histolytica hypothetical protein 0.0035 0.0006 0.0145
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0069 0.0023 0.0423
Echinococcus multilocularis tumor protein p63 0.0329 0.0152 0.3631
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.0012 0.0143
Schistosoma mansoni vesicular amine transporter 0.0069 0.0023 0.0423
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0069 0.0023 0.0423
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0069 0.0023 0.0423
Brugia malayi cation channel family protein 0.0069 0.0023 0.0562
Echinococcus multilocularis potassium voltage gated channel protein 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated cation channel 0.0069 0.0023 0.0423
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0069 0.0023 0.0562
Brugia malayi olfactory channel protein osm-9 0.0069 0.0023 0.0562
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0845 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0169
Loa Loa (eye worm) hypothetical protein 0.0096 0.0036 0.0886
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0069 0.0023 0.0562
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0006 0.0012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0021 0.0505
Schistosoma mansoni transient receptor potential channel 0.0069 0.0023 0.0423
Brugia malayi ion channel NompC 0.0069 0.0023 0.0562
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0017 0.0428
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 2.0127 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0069 0.0023 0.0423
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0209 0.0093 0.2152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0011 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Echinococcus granulosus voltage gated potassium channel 0.0069 0.0023 0.0427
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0009 0.0075
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0069 0.0023 0.0427
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0845 0.0409 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0036 0.0755
Echinococcus multilocularis sodium channel protein 0.0069 0.0023 0.0423
Echinococcus granulosus tumor protein p63 0.0329 0.0152 0.3634
Brugia malayi Cyclic-nucleotide gated cation channel 0.0069 0.0023 0.0562
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0069 0.0023 0.0562
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0069 0.0023 0.0427
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0045 0.0976
Brugia malayi hypothetical protein 0.0069 0.0023 0.0562
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0069 0.0023 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.0025 0.048
Echinococcus multilocularis transfer RNA-Gly 0.0069 0.0023 0.0423
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.0025 0.0025
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0845 0.0409 0.0409
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0069 0.0023 0.0423
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Schistosoma mansoni hypothetical protein 0.0069 0.0023 0.0423
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0069 0.0023 0.0427
Echinococcus granulosus hyperpolarization activated cyclic 0.0069 0.0023 0.0427
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Schistosoma mansoni survival motor neuron protein 0.0058 0.0017 0.0286
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0069 0.0023 0.0423
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0011 0.0117
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0845 0.0409 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0012 0.0155
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0009 0.0079
Echinococcus granulosus two pore calcium channel protein 1 0.0069 0.0023 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Echinococcus multilocularis hyperpolarization activated cyclic 0.0069 0.0023 0.0423
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0845 0.0409 1
Toxoplasma gondii hypothetical protein 0.0069 0.0023 0.0411
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0069 0.0023 0.0562
Echinococcus granulosus transient receptor potential gamma protein 0.0069 0.0023 0.0427
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0069 0.0023 0.0423
Schistosoma mansoni chromobox protein 0.0084 0.003 0.0606
Brugia malayi chromobox protein homolog 3 0.0047 0.0012 0.0293
Loa Loa (eye worm) ion channel NompC 0.0069 0.0023 0.0562
Echinococcus multilocularis voltage dependent calcium channel 0.0069 0.0023 0.0423
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.765 0.3794 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0069 0.0023 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0069 0.0023 0.0427
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0025 0.0484
Echinococcus granulosus potassium voltage gated channel protein 0.0069 0.0023 0.0427
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0069 0.0023 0.0427
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0045 0.0577
Loa Loa (eye worm) voltage-gated potassium channel 0.0069 0.0023 0.0562
Schistosoma mansoni transient receptor potential channel 0.0069 0.0023 0.0423
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0069 0.0023 0.0423
Loa Loa (eye worm) hypothetical protein 0.0069 0.0023 0.0562
Brugia malayi Transient-receptor-potential like protein 0.0069 0.0023 0.0562
Echinococcus multilocularis voltage gated potassium channel 0.0069 0.0023 0.0423
Echinococcus granulosus potassium voltage gated channel protein 0.0069 0.0023 0.0427
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0209 0.0093 0.2149
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0045 0.0994
Schistosoma mansoni loxhd1 0.0048 0.0012 0.0155
Toxoplasma gondii transporter, cation channel family protein 0.0069 0.0023 0.0411
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0045 0.0979
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Toxoplasma gondii hypothetical protein 0.0069 0.0023 0.0411
Onchocerca volvulus 0.0845 0.0409 1
Echinococcus granulosus transient receptor potential cation channel 0.0069 0.0023 0.0427
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 2.0127 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0011 0.0117
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0069 0.0023 0.0562
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0006 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 64 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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