Detailed information for compound 1271303

Basic information

Technical information
  • TDR Targets ID: 1271303
  • Name: 3-[2-(3,4-dimethoxyphenyl)ethylamino]-6-methy l-2H-1,2,4-triazin-5-one
  • MW: 290.318 | Formula: C14H18N4O3
  • H donors: 2 H acceptors: 4 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNc2nnc(c(n2)O)C)ccc1OC
  • InChi: 1S/C14H18N4O3/c1-9-13(19)16-14(18-17-9)15-7-6-10-4-5-11(20-2)12(8-10)21-3/h4-5,8H,6-7H2,1-3H3,(H2,15,16,18,19)
  • InChiKey: LHJXXNDIFDOUJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-6-methyl-4H-[1,2,4]triazin-5-one
  • BAS 03309186
  • Oprea1_591131
  • Oprea1_110352
  • MLS000124066
  • ST5183165
  • ZINC00138347
  • SMR000124575

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0046 0.1242
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.003 0.1775
Schistosoma mansoni Smad4 0.001 0.0004 0.0089
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.002 0.6744
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.002 0.0521
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.002 0.1191
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.1769
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.003 0.0793
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.003 0.1769
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0046 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0046 0.2772
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.0168 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0023 0.1323
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0004 0.0089
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0023 0.1323
Brugia malayi Smad1 0.001 0.0004 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0046 0.2772
Mycobacterium ulcerans transcriptional regulator 1.0109 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0137 0.3788
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.1769
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.1769
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0046 1
Echinococcus granulosus smad 0.001 0.0004 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0802
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0363 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0023 0.1323
Leishmania major GTP-binding protein, putative 0.0026 0.002 0.4197
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0046 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.003 0.0822
Brugia malayi Importin beta-1 subunit 0.0035 0.0029 0.1733
Trichomonas vaginalis ran, putative 0.0026 0.002 0.1164
Brugia malayi MH2 domain containing protein 0.001 0.0004 0.0259
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0089
Schistosoma mansoni ran 0.0026 0.002 0.0521
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0004 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0137 0.3788
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.002 0.4197
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0046 0.2772
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0004 0.0089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0049 0.136
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0004 0.0089
Loa Loa (eye worm) beta-lactamase 0.0036 0.003 0.0822
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0004 0.012
Brugia malayi MH2 domain containing protein 0.0144 0.0137 0.8181
Plasmodium falciparum importin beta, putative 0.0035 0.0029 1
Schistosoma mansoni importin beta-1 0.0035 0.0029 0.0773
Echinococcus multilocularis snurportin 1 0.0372 0.0363 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0046 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0029 0.9757
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0023 0.0991
Brugia malayi MH1 domain containing protein 0.001 0.0004 0.0259
Echinococcus multilocularis Smad4 0.001 0.0004 0.0089
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0046 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.003 0.0793
Leishmania major hypothetical protein, conserved 0.0036 0.003 0.6379
Entamoeba histolytica Ran family GTPase 0.0026 0.002 0.8795
Mycobacterium ulcerans AcrR family transcriptional regulator 1.0109 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.6224
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0049 0.1332
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.003 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0163 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0004 0.012
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.003 0.6379
Toxoplasma gondii ABC1 family protein 0.0036 0.003 0.6379
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.003 0.0793
Leishmania major importin beta-1 subunit, putative 0.0028 0.0023 0.4772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0049 0.1332
Echinococcus multilocularis smad 0.001 0.0004 0.0089
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0046 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0046 0.1242
Brugia malayi MH1 domain containing protein 0.001 0.0004 0.0259
Plasmodium vivax hypothetical protein, conserved 0.0036 0.003 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0029 0.6224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0049 0.1332
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0219 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0029 0.0773
Entamoeba histolytica hypothetical protein 0.0028 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0046 1
Brugia malayi MAP kinase sur-1 0.0052 0.0046 0.2743
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.002 0.4197
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0822
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0049 0.1332
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.002 0.0551
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.376
Brugia malayi beta-lactamase family protein 0.0036 0.003 0.1775
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0046 0.1242
Trypanosoma brucei protein kinase, putative 0.0052 0.0046 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0046 0.1242
Brugia malayi beta-lactamase family protein 0.0036 0.003 0.1775
Brugia malayi beta-lactamase 0.0036 0.003 0.1775
Brugia malayi RNA, U transporter 1 0.0099 0.0093 0.5519
Echinococcus granulosus Smad4 0.001 0.0004 0.0089
Echinococcus granulosus importin subunit beta 1 0.0035 0.0029 0.0773
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0046 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0046 0.127
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.6224
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0046 0.1242
Schistosoma mansoni hypothetical protein 0.0372 0.0363 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.002 0.658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0049 0.1332
Schistosoma mansoni smad1 5 8 and 0.001 0.0004 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0049 0.1332
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0004 0.0089
Onchocerca volvulus 0.0036 0.003 0.5
Schistosoma mansoni ran 0.0026 0.002 0.0521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0049 0.2937
Onchocerca volvulus 0.0036 0.003 0.5
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0002 0.0104
Brugia malayi MH2 domain containing protein 0.001 0.0004 0.0259
Trichomonas vaginalis esterase, putative 0.0036 0.003 0.1769
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0049 0.1332
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0001 0.0031
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.002 0.0521
Schistosoma mansoni smad 0.001 0.0004 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0046 0.2772
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.0109 1 1
Echinococcus granulosus snurportin 1 0.0372 0.0363 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.003 0.1769
Loa Loa (eye worm) Smad1 0.001 0.0004 0.012
Loa Loa (eye worm) hypothetical protein 0.0175 0.0168 0.463
Brugia malayi kap beta 3 protein 0.0007 0.0001 0.0068
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0001 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.376
Mycobacterium ulcerans TetR family transcriptional regulator 1.0109 1 1
Onchocerca volvulus 0.0036 0.003 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0065 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.