Detailed information for compound 1272990

Basic information

Technical information
  • TDR Targets ID: 1272990
  • Name: N-[4-(9H-fluoren-2-yl)-1,3-thiazol-2-yl]benza mide
  • MW: 368.451 | Formula: C23H16N2OS
  • H donors: 1 H acceptors: 2 LogP: 5.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1scc(n1)c1ccc2c(c1)Cc1c2cccc1
  • InChi: 1S/C23H16N2OS/c26-22(15-6-2-1-3-7-15)25-23-24-21(14-27-23)17-10-11-20-18(13-17)12-16-8-4-5-9-19(16)20/h1-11,13-14H,12H2,(H,24,25,26)
  • InChiKey: JDTDDIGNQWTQCT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[4-(9H-fluoren-2-yl)thiazol-2-yl]benzamide
  • N-[4-(9H-fluoren-2-yl)-2-thiazolyl]benzamide
  • Oprea1_775075
  • EU-0034038
  • MLS000561268
  • SMR000174988
  • ZINC00826953
  • Oprea1_334522
  • BAS 00432503
  • N-[4-(9H-Fluoren-2-yl)-thiazol-2-yl]-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0154
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0023 0.4718
Schistosoma mansoni retinoic acid receptor RXR 0.001 0 0.0003
Toxoplasma gondii cathepsin CPL 0.002 0.0009 0.182
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.0668 0.9687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0074 0.1072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0022 0.1075
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.000000023177 0.00000099947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Leishmania major hypothetical protein, conserved 0.0036 0.0022 0.2752
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0022 0.1093
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0001 0.0091
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0009 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0009 0.1549
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0003 0.0047
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0074 1
Echinococcus granulosus GPCR family 2 0.0015 0.0005 0.0066
Brugia malayi beta-lactamase family protein 0.0036 0.0022 0.1075
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0022 0.094
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0002 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0 0.0011
Onchocerca volvulus 0.002 0.0009 0.0376
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0066
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0009 0.0126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0 0.0003
Mycobacterium ulcerans lipase LipD 0.0036 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0022 0.2949
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0 0.0003
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0008 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.3875
Loa Loa (eye worm) cysteine protease 0.002 0.0009 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0022 0.094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0 0.0011
Brugia malayi CHE-14 protein 0.0042 0.0027 0.1332
Mycobacterium ulcerans TetR family transcriptional regulator 1.1955 1 1
Loa Loa (eye worm) ctsf protein 0.002 0.0009 0.043
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Schistosoma mansoni coup transcription factor 0.001 0 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Brugia malayi ecdysteroid receptor 0.001 0 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Brugia malayi hypothetical protein 0.002 0.0008 0.0406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0022 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0 0.0011
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0 0.0019
Entamoeba histolytica hypothetical protein 0.0036 0.0022 0.2949
Leishmania major cathepsin L-like protease 0.0077 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Echinococcus granulosus geminin 0.0205 0.0163 0.2366
Loa Loa (eye worm) glutamate receptor 0.004 0.0025 0.1249
Schistosoma mansoni hypothetical protein 0.0205 0.0163 0.2366
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0405 0.5879
Schistosoma mansoni cpg binding protein 0.0037 0.0022 0.0326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0023 0.0328
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0009 0.0126
Leishmania major hypothetical protein, conserved 0.003 0.0017 0.1799
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0 0.0003
Echinococcus multilocularis protein patched 0.0042 0.0027 0.0392
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0027 0.1332
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0009 0.5048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.003 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0022 0.4552
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0009 0.0376
Onchocerca volvulus 0.002 0.0009 0.0376
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.003 0.0434
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0069
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0109 0.1582
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.3069
Brugia malayi CXXC zinc finger family protein 0.0035 0.0021 0.1027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0023 0.0328
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0 0.0002
Loa Loa (eye worm) glutamate receptor 0.0016 0.0005 0.0246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Plasmodium vivax vivapain-2 0.002 0.0009 0.3857
Plasmodium vivax vivapain-1 0.001 0.0001 0.0226
Onchocerca volvulus Cathepsin F homolog 0.002 0.0009 0.0376
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Plasmodium vivax vivapain-2 0.002 0.0009 0.3857
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0017 0.3069
Echinococcus granulosus cathepsin l1 0.002 0.0009 0.0126
Loa Loa (eye worm) steroid hormone receptor 0.001 0 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0022 0.0316
Onchocerca volvulus 0.0036 0.0022 0.094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0022 0.0316
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0022 0.094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0032 0.1586
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0001 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0017 0.3069
Brugia malayi steroid hormone receptor 0.001 0 0.0011
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0 0.0003
Echinococcus multilocularis geminin 0.0205 0.0163 0.2366
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0022 0.0316
Entamoeba histolytica hypothetical protein 0.0036 0.0022 0.2949
Loa Loa (eye worm) hypothetical protein 0.0049 0.0033 0.1631
Echinococcus multilocularis protein dispatched 1 0.0048 0.0032 0.0464
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0009 0.043
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0003 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0022 0.9648
Brugia malayi nuclear hormone receptor 0.001 0 0.0011
Brugia malayi Pre-SET motif family protein 0.0252 0.0203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0005 0.0066
Onchocerca volvulus 0.0037 0.0023 0.0975
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0 0.0003
Echinococcus granulosus microtubule associated protein 2 0.0833 0.0689 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0 0.0003
Onchocerca volvulus 0.002 0.0009 0.0376
Plasmodium vivax SET domain protein, putative 0.0037 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0001 0.0091
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0203 1
Echinococcus granulosus FTZ F1 alpha 0.001 0 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0009 0.118
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis replication factor c subunit 1 0.001 0.000000023177 0.00000033618
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0005 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0003 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.003 0.0434
Onchocerca volvulus 0.002 0.0009 0.0376
Loa Loa (eye worm) fibroinase 0.002 0.0009 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0027 0.1165
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.1955 1 1
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0069
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0051 0.9006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0023 0.0328
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0001 0.0069
Onchocerca volvulus Cathepsin L homolog 0.002 0.0009 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.003 0.0434
Brugia malayi beta-lactamase 0.0036 0.0022 0.1075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0023 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0023 0.0328
Brugia malayi beta-lactamase family protein 0.0036 0.0022 0.1075
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0022 0.3875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0 0.0009
Schistosoma mansoni hypothetical protein 0.0494 0.0405 0.5879
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0056 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0 0.0003
Leishmania major cathepsin L-like protease 0.0077 0.0056 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0054 0.079
Brugia malayi Cathepsin L-like precursor 0.0014 0.0003 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0 0.0011
Plasmodium vivax vivapain-3 0.001 0.0001 0.0226
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Mycobacterium ulcerans transcriptional regulator 1.1955 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0056 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0027
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0032 0.1586
Onchocerca volvulus 0.0014 0.0003 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.1114
Echinococcus multilocularis cathepsin L 0.001 0.0001 0.0007
Onchocerca volvulus 0.002 0.0009 0.0376
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0009 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0 0.0003
Schistosoma mansoni cpg binding protein 0.0037 0.0022 0.0326
Trypanosoma cruzi cysteine protease, putative 0.001 0.0001 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0 0.0011
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0 0.0003
Giardia lamblia Replication factor C, subunit 1 0.001 0.000000023177 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0005 0.0066
Onchocerca volvulus Cathepsin L homolog 0.002 0.0009 0.0376
Schistosoma mansoni cpg binding protein 0.0035 0.0021 0.0302
Brugia malayi nuclear receptor NHR-88 0.001 0 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Echinococcus granulosus replication factor c subunit 1 0.001 0.000000023177 0.00000033618
Schistosoma mansoni hypothetical protein 0.0205 0.0163 0.2366
Brugia malayi Pre-SET motif family protein 0.0037 0.0023 0.1114
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0001 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0032 0.1586
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Echinococcus multilocularis GPCR, family 2 0.0015 0.0005 0.0066
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0074 0.1072
Mycobacterium ulcerans beta-lactamase 0.0036 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0109 0.1582
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0001 0.0296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0022 0.0316
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0022 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.003 0.0434
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0056 1
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0002 0.0087
Onchocerca volvulus 0.0035 0.0021 0.0898
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0032 0.1586
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0 0.0003
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.000000023177 0.00000099947
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0405 0.5879
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0022 0.3875
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0001 0.0007
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Mycobacterium ulcerans AcrR family transcriptional regulator 1.1955 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.0689 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0009 0.118
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0014 0.0003 0.0047
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0003 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0 0.0011
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis cysteine protease 0.002 0.0009 0.0126
Schistosoma mansoni hypothetical protein 0.0033 0.0019 0.0281
Plasmodium vivax unspecified product 0.001 0.0001 0.0226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus granulosus cpg binding protein 0.0037 0.0022 0.0326
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0033 0.048
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0048 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0003 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0021 0.1027
Entamoeba histolytica hypothetical protein 0.0036 0.0022 0.2949
Echinococcus multilocularis expressed conserved protein 0.0092 0.0069 0.0999
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0005 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0001 0.0091
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0001 0.0091
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0074 0.3642
Brugia malayi Nuclear hormone receptor-like 1 0.001 0 0.0011
Loa Loa (eye worm) hypothetical protein 0.0098 0.0074 0.3642
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0009 0.043
Echinococcus granulosus cathepsin l1 0.0014 0.0003 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.003 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0022 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0022 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.003 0.0434
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0027 0.0392
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.002 0.0288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0184 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0 0.0011
Onchocerca volvulus 0.0036 0.0022 0.094
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0 0.0009
Brugia malayi hypothetical protein 0.0036 0.0022 0.1074
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0003 0.0154
Schistosoma mansoni thyroid hormone receptor 0.001 0 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0373
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0017 0.7642
Echinococcus granulosus cysteine protease 0.001 0.0001 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0005 0.0225
Onchocerca volvulus 0.002 0.0009 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0003 0.0135
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0019 0.0956
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0009 0.0126
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Toxoplasma gondii ATPase, AAA family protein 0.001 0.000000023177 0.0000048379
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.002 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Brugia malayi Steroid receptor seven-up type 2 0.001 0 0.0011
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0008 0.0401
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0009 0.5048
Brugia malayi Cathepsin L-like precursor 0.002 0.0009 0.043
Brugia malayi Receptor family ligand binding region containing protein 0.001 0 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0 0.0011
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0373
Onchocerca volvulus Bile acid receptor homolog 0.001 0 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0 0.0002
Onchocerca volvulus 0.001 0 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0069
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0009 0.0126
Onchocerca volvulus 0.0036 0.0022 0.094
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0042 0.7548
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0005 0.0225
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0001 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0022 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0376
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0022 0.1075
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0025 0.1249
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0154
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0022 0.0316
Chlamydia trachomatis DNA ligase 0.001 0 0.5
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.000000023177 0.00000099947
Onchocerca volvulus 0.0287 0.0232 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.1723
Brugia malayi cathepsin L-like precursor 0.0014 0.0003 0.0154
Loa Loa (eye worm) hypothetical protein 0.0042 0.0027 0.1332
Schistosoma mansoni patched 1 0.0042 0.0027 0.0392
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.1075
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0009 0.0126
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0027 0.0392
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0023 0.0328
Leishmania major cathepsin L-like protease 0.0077 0.0056 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0075 0.109
Trichomonas vaginalis esterase, putative 0.0036 0.0022 0.094
Schistosoma mansoni hypothetical protein 0.0041 0.0026 0.0373
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.002 0.0288
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.000000023177 0.0000031374
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0022 0.094
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0023 0.0328
Echinococcus multilocularis cysteine protease 0.002 0.0009 0.0126
Echinococcus multilocularis FTZ F1 alpha 0.001 0 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0 0.0003
Echinococcus granulosus expressed conserved protein 0.0092 0.0069 0.0999
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0852
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0017 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0021 0.0303
Schistosoma mansoni thyroid hormone receptor 0.001 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0011
Entamoeba histolytica cysteine protease, putative 0.001 0.0001 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0 0.0011
Treponema pallidum DNA ligase (lig) 0.001 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.001 0 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0019
Echinococcus multilocularis cpg binding protein 0.0037 0.0022 0.0326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.003 0.0434
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0033 0.048
Mycobacterium leprae Probable lipase LipE 0.0036 0.0022 0.0022
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0009 0.5048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0376
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0232 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0 0.0011
Mycobacterium ulcerans hypothetical protein 0.0036 0.0022 0.0022
Brugia malayi hypothetical protein 0.003 0.0017 0.0852
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0017 0.3606
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0009 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0001 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0056 1
Entamoeba histolytica cysteine proteinase 2 0.001 0.0001 0.0069
Onchocerca volvulus 0.002 0.0009 0.0376
Echinococcus granulosus cathepsin L 0.001 0.0001 0.0007
Loa Loa (eye worm) beta-lactamase 0.0036 0.0022 0.1075
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0003 0.0423
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.000000023177 0.00000033618
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.0689 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0027 0.0392
Echinococcus granulosus ecdysone induced protein 78C 0.001 0 0.0003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0009 0.043

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0206 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1585 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 0.5623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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