Detailed information for compound 1273441

Basic information

Technical information
  • TDR Targets ID: 1273441
  • Name: 3-hydroxy-6-(hydroxymethyl)-2-[pyridin-2-yl-[ [3-(trifluoromethyl)phenyl]amino]methyl]pyran -4-one
  • MW: 392.329 | Formula: C19H15F3N2O4
  • H donors: 3 H acceptors: 4 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc(=O)c(c(o1)C(c1ccccn1)Nc1cccc(c1)C(F)(F)F)O
  • InChi: 1S/C19H15F3N2O4/c20-19(21,22)11-4-3-5-12(8-11)24-16(14-6-1-2-7-23-14)18-17(27)15(26)9-13(10-25)28-18/h1-9,16,24-25,27H,10H2
  • InChiKey: QXXFYAVFYIHEBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroxy-6-(hydroxymethyl)-2-[2-pyridyl-[[3-(trifluoromethyl)phenyl]amino]methyl]pyran-4-one
  • 3-hydroxy-6-(hydroxymethyl)-2-[2-pyridyl-[[3-(trifluoromethyl)phenyl]amino]methyl]-4-pyranone
  • 3-hydroxy-6-methylol-2-[2-pyridyl-[[3-(trifluoromethyl)phenyl]amino]methyl]pyran-4-one
  • MLS000766783
  • SMR000339679
  • 3-hydroxy-6-(hydroxymethyl)-2-(pyridin-2-yl{[3-(trifluoromethyl)phenyl]amino}methyl)-4H-pyran-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens amyloid beta (A4) precursor protein-binding, family A, member 1 No references
Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) X11 protein Get druggable targets OG5_130749 All targets in OG5_130749
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis amyloid beta A4 protein Get druggable targets OG5_130749 All targets in OG5_130749
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130749 All targets in OG5_130749
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative Get druggable targets OG5_130749 All targets in OG5_130749
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi hypothetical protein Get druggable targets OG5_130749 All targets in OG5_130749
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni amyloid beta A4 protein related Get druggable targets OG5_130749 All targets in OG5_130749
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus amyloid beta A4 protein Get druggable targets OG5_130749 All targets in OG5_130749
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04531 amyloid beta (A4) precursor protein-binding, family A, member 1, putative Get druggable targets OG5_130749 All targets in OG5_130749
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0212 0.0979 0.6455
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Entamoeba histolytica cysteine proteinase, putative 0.0212 0.0979 0.5663
Echinococcus granulosus voltage dependent calcium channel 0.0116 0.05 0.1226
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0422 0.0582
Loa Loa (eye worm) hypothetical protein 0.01 0.0422 0.2675
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Onchocerca volvulus 0.0317 0.1502 0.1415
Echinococcus granulosus cathepsin l cysteine peptidase 0.0317 0.1502 0.3682
Plasmodium falciparum cysteine proteinase falcipain 1 0.0163 0.0735 0.275
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1682 0.629
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.064 0.4156
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0058 0.0213 0.0796
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0058 0.0213 0.0931
Echinococcus granulosus voltage dependent calcium channel 0.0024 0.0042 0.0104
Onchocerca volvulus Cathepsin F homolog 0.0317 0.1502 0.1415
Brugia malayi cathepsin F-like cysteine proteinase 0.0058 0.0213 0.0294
Onchocerca volvulus 0.0317 0.1502 0.1415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Echinococcus multilocularis cathepsin L cysteine protease 0.0317 0.1502 0.3682
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.0213 0.1265
Leishmania major cathepsin L-like protease 0.0317 0.1502 0.2527
Brugia malayi Cathepsin L-like cysteine proteinase 0.0212 0.0979 0.1351
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0062 0.0792
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1175 0.7782
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0422 0.1035
Loa Loa (eye worm) cysteine protease 0.0317 0.1502 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0213 0.1256
Echinococcus multilocularis cysteine protease 0.0317 0.1502 0.3682
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0213 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Onchocerca volvulus Cathepsin L homolog 0.0317 0.1502 0.1415
Trypanosoma cruzi cysteine peptidase, putative 0.1207 0.5945 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Plasmodium falciparum serine repeat antigen 8 0.0058 0.0213 0.0796
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Brugia malayi cathepsin L-like cysteine proteinase 0.0058 0.0213 0.0294
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.05 0.1226
Echinococcus granulosus cathepsin L 0.0163 0.0735 0.1803
Giardia lamblia Hypothetical protein 0.0058 0.0213 0.0796
Plasmodium falciparum glutathione reductase 0.0046 0.0149 0.0557
Onchocerca volvulus 0.0058 0.0213 0.0113
Toxoplasma gondii RNA-directed DNA polymerase 0.0552 0.2674 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0062 0.0232
Plasmodium vivax telomerase reverse transcriptase, putative 0.0552 0.2674 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0979 0.5822
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Onchocerca volvulus 0.0317 0.1502 0.1415
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0116 0.05 0.1226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0058 0.0213 0.0796
Loa Loa (eye worm) hypothetical protein 0.0105 0.0444 0.2822
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0735 0.4372
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.0213 0.1265
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0058 0.0213 0.0358
Toxoplasma gondii thioredoxin reductase 0.0046 0.0149 0.0557
Giardia lamblia Cathepsin L-like protease 0.0058 0.0213 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Entamoeba histolytica cysteine proteinase, putative 0.0317 0.1502 0.8889
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0062 1
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0058 0.0213 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0735 0.4157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0317 0.1502 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.0213 0.1265
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0058 0.0213 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0735 0.1237
Onchocerca volvulus 0.0286 0.1348 0.126
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0058 0.0213 0.0931
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0213 0.0358
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0213 0.1265
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Brugia malayi cathepsin Z-like cysteine proteinase 0.0058 0.0213 0.0294
Toxoplasma gondii hypothetical protein 0.0021 0.0028 0.0103
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0317 0.1502 0.3682
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Toxoplasma gondii preprocathepsin c precursor, putative 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Brugia malayi cathepsin F-like cysteine proteinase 0.0105 0.0444 0.0612
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0058 0.0213 0.0522
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1103 0.5422 0.9121
Brugia malayi cathepsin B-like cysteine proteinase 0.0058 0.0213 0.0294
Onchocerca volvulus 0.0317 0.1502 0.1415
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0062 1
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0444 0.0746
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Plasmodium falciparum serine repeat antigen 9 0.0058 0.0213 0.0796
Leishmania major telomerase reverse transcriptase, putative 0.0552 0.2674 0.4498
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Plasmodium falciparum serine repeat antigen 4 0.0058 0.0213 0.0796
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4079 1
Giardia lamblia Hypothetical protein 0.0058 0.0213 0.0796
Giardia lamblia Cysteine protease 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0317 0.1502 0.893
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0074 0.0291 0.0402
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Echinococcus granulosus amyloid beta A4 protein 0.0083 0.0335 0.0821
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0101 0.0247
Giardia lamblia Encystation-specific protease 0.0058 0.0213 0.0796
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0062 0.0104
Loa Loa (eye worm) hypothetical protein 0.0212 0.0979 0.6455
Toxoplasma gondii cathepsin CPC2 0.0058 0.0213 0.0796
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0781 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1682 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0049 0.0167 0.0409
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0058 0.0213 0.0796
Plasmodium vivax serine-repeat antigen (SERA) 0.0058 0.0213 0.0796
Onchocerca volvulus 0.01 0.0422 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0735 0.1803
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0152 0.0373
Loa Loa (eye worm) fibroinase 0.0317 0.1502 1
Plasmodium vivax vivapain-1 0.0163 0.0735 0.275
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Giardia lamblia Cathepsin L-like protease 0.0058 0.0213 0.0796
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0499 0.6386
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0116 0.05 0.069
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0116 0.05 0.1226
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0105 0.0444 0.0612
Echinococcus multilocularis cathepsin b 0.0058 0.0213 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0116 0.05 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0058 0.0213 0.1265
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0735 0.1803
Schistosoma mansoni voltage-gated cation channel 0.0116 0.05 0.1226
Plasmodium vivax glutathione reductase, putative 0.0046 0.0149 0.0557
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0062 0.0792
Plasmodium falciparum thioredoxin reductase 0.0046 0.0149 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0101 0.0247
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Trypanosoma cruzi cysteine peptidase, putative 0.0317 0.1502 0.2527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0058 0.0213 0.0522
Leishmania major cathepsin L-like protease 0.1207 0.5945 1
Onchocerca volvulus Cathepsin L homolog 0.0317 0.1502 0.1415
Trypanosoma brucei trypanothione reductase 0.0046 0.0149 0.0251
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0735 0.1237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0735 0.1237
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0499 0.6075
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0163 0.0735 0.1237
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1348 0.8016
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.05 0.1226
Echinococcus multilocularis cathepsin L cysteine protease 0.0317 0.1502 0.3682
Giardia lamblia Cysteine protease 0.0058 0.0213 0.0796
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0781 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Loa Loa (eye worm) glutathione reductase 0.0046 0.0149 0.0823
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Trypanosoma cruzi cruzipain precursor, putative 0.0105 0.0444 0.0746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Entamoeba histolytica cysteine proteinase 2 0.0163 0.0735 0.4157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0062 0.0232
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0058 0.0213 0.0796
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0213 0.1265
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.0213 0.1265
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0062 0.0104
Brugia malayi Cathepsin L-like precursor 0.0212 0.0979 0.1351
Brugia malayi MH2 domain containing protein 0.0144 0.064 0.0884
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Trypanosoma cruzi cysteine peptidase, putative 0.1207 0.5945 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0058 0.0213 0.0796
Trypanosoma brucei telomerase reverse transcriptase 0.0552 0.2674 0.4498
Echinococcus multilocularis cathepsin b 0.0058 0.0213 0.0522
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0735 0.4157
Echinococcus granulosus cathepsin L cysteine proteinase 0.0317 0.1502 0.3682
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Echinococcus multilocularis sodium channel protein 0.0049 0.0167 0.0409
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0735 0.1237
Schistosoma mansoni cathepsin F (C01 family) 0.0212 0.0979 0.2401
Loa Loa (eye worm) hypothetical protein 0.0212 0.0979 0.6455
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0441 0.5644
Entamoeba histolytica cysteine proteinase 1, putative 0.0163 0.0735 0.4157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0979 0.5822
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Plasmodium falciparum serine repeat antigen 6 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.0213 0.1265
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0062 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0317 0.1502 0.3682
Loa Loa (eye worm) hypothetical protein 0.0116 0.05 0.3204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0735 0.4157
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0058 0.0213 0.1256
Giardia lamblia Telomerase catalytic subunit 0.0552 0.2674 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0735 0.1015
Schistosoma mansoni cathepsin C 0.0058 0.0213 0.0522
Schistosoma mansoni cathepsin S (C01 family) 0.0058 0.0213 0.0522
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0116 0.05 0.1226
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.0735 0.1237
Plasmodium falciparum serine repeat antigen 1 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Brugia malayi Pre-SET motif family protein 0.0251 0.1175 0.1621
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.05 0.1226
Echinococcus multilocularis cathepsin L 0.0058 0.0213 0.0522
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0058 0.0213 0.0796
Schistosoma mansoni cathepsin B (C01 family) 0.0058 0.0213 0.0522
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0058 0.0213 0.0358
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0273 0.046
Plasmodium vivax unspecified product 0.0163 0.0735 0.275
Echinococcus granulosus cathepsin b 0.0058 0.0213 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0422 0.1035
Onchocerca volvulus 0.0212 0.0979 0.0887
Schistosoma mansoni cathepsin F (C01 family) 0.0317 0.1502 0.3682
Leishmania major cathepsin L-like protease 0.0317 0.1502 0.2527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0441 0.5269
Plasmodium vivax vivapain-3 0.0163 0.0735 0.275
Echinococcus granulosus cathepsin l1 0.0212 0.0979 0.2401
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0552 0.2674 0.4498
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0058 0.0213 0.0796
Brugia malayi Cathepsin L-like precursor 0.0105 0.0444 0.0612
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1682 1
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0735 0.4157
Trypanosoma brucei cysteine peptidase C (CPC) 0.0058 0.0213 0.0358
Brugia malayi Telomerase reverse transcriptase 0.1468 0.7247 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0062 0.0368
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0552 0.2674 0.4498
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0422 0.1035
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0058 0.0213 0.0796
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0441 0.5644
Leishmania major trypanothione reductase 0.0046 0.0149 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Echinococcus multilocularis amyloid beta A4 protein 0.0083 0.0335 0.0821
Plasmodium vivax unspecified product 0.0058 0.0213 0.0796
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Entamoeba histolytica cysteine proteinase, putative 0.0317 0.1502 0.8889
Loa Loa (eye worm) hypothetical protein 0.0317 0.1502 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0101 0.0377
Loa Loa (eye worm) ctsf protein 0.0317 0.1502 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0058 0.0213 0.0796
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0149 0.0251
Entamoeba histolytica hypothetical protein 0.0058 0.0213 0.0931
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0062 0.0792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Trypanosoma cruzi cruzipain precursor, putative 0.1207 0.5945 1
Mycobacterium tuberculosis Probable reductase 0.0104 0.0441 0.5644
Brugia malayi Cathepsin L-like precursor 0.0212 0.0979 0.1351
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0499 0.6386
Loa Loa (eye worm) cathepsin B 0.0058 0.0213 0.1256
Echinococcus granulosus cathepsin L cysteine protease 0.0163 0.0735 0.1803
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0058 0.0213 0.0522
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0213 0.1256
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0499 0.6386
Leishmania major cathepsin L-like protease 0.1207 0.5945 1
Echinococcus multilocularis voltage dependent calcium channel 0.0116 0.05 0.1226
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0213 0.0294
Loa Loa (eye worm) hypothetical protein 0.0105 0.0444 0.2822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Plasmodium vivax unspecified product 0.0105 0.0444 0.1659
Echinococcus granulosus cathepsin l1 0.0317 0.1502 0.3682
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Plasmodium falciparum cysteine proteinase falcipain 3 0.0317 0.1502 0.5617
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0317 0.1502 0.5617
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0149 0.0557
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0058 0.0213 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0735 0.4372
Brugia malayi Thioredoxin reductase 0.0046 0.0149 0.0206
Plasmodium falciparum serine repeat antigen 5 0.0058 0.0213 0.0796
Brugia malayi hypothetical protein 0.008 0.0319 0.044
Brugia malayi Cathepsin L-like precursor 0.0317 0.1502 0.2073
Echinococcus granulosus cysteine protease 0.0163 0.0735 0.1803
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0152 0.0373
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0101 0.0247
Plasmodium vivax serine-repeat antigen (SERA) 0.0058 0.0213 0.0796
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Echinococcus multilocularis cathepsin L 0.0163 0.0735 0.1803
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0735 0.1803
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0099
Echinococcus granulosus cathepsin b 0.0058 0.0213 0.0522
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0058 0.0213 0.0796
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Toxoplasma gondii cathepsin CPL 0.0317 0.1502 0.5617
Entamoeba histolytica cysteine protease, putative 0.0058 0.0213 0.0931
Echinococcus granulosus cathepsin L 0.0058 0.0213 0.0522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Loa Loa (eye worm) calcium channel 0.0116 0.05 0.3204
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0441 0.5644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1682 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0213 0.1265
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0058 0.0213 0.0294
Schistosoma mansoni cathepsin F (C01 family) 0.0317 0.1502 0.3682
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0058 0.0213 0.0796
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Trypanosoma cruzi major cysteine proteinase, putative 0.0949 0.4656 0.7831
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0094 0.0231
Loa Loa (eye worm) hypothetical protein 0.008 0.0319 0.1974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Loa Loa (eye worm) hypothetical protein 0.0105 0.0444 0.2822
Leishmania major cathepsin L-like protease 0.0317 0.1502 0.2527
Plasmodium falciparum telomerase reverse transcriptase 0.0552 0.2674 1
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0058 0.0213 0.1265
Trypanosoma cruzi cysteine peptidase, putative 0.1207 0.5945 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0116 0.05 0.1226
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0735 0.1015
Leishmania major cysteine peptidase A (CPA) 0.0317 0.1502 0.2527
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0317 0.1502 1
Trypanosoma cruzi cysteine protease, putative 0.0163 0.0735 0.1237
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0101 0.0247
Toxoplasma gondii transporter, cation channel family protein 0.0024 0.0042 0.0158
Onchocerca volvulus 0.0317 0.1502 0.1415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0101 0.0247
Loa Loa (eye worm) X11 protein 0.0083 0.0335 0.2084
Brugia malayi cathepsin L precursor 0.0058 0.0213 0.0294
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1682 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0105 0.0444 0.2822
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0101 0.0247
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0116 0.05 0.1226
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0062 0.0232
Leishmania major cathepsin L-like protease 0.0317 0.1502 0.2527
Giardia lamblia Cysteine protease 0.0058 0.0213 0.0796
Toxoplasma gondii cathepsin CPC1 0.0058 0.0213 0.0796
Brugia malayi Pre-SET motif family protein 0.0036 0.0101 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0213 0.1265
Brugia malayi glutathione reductase 0.0046 0.0149 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0101 0.0247
Plasmodium vivax vivapain-2 0.0317 0.1502 0.5617
Loa Loa (eye worm) hypothetical protein 0.0058 0.0213 0.1256
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0213 0.0294
Brugia malayi fibroinase precursor 0.0058 0.0213 0.0294
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0058 0.0213 0.0522
Plasmodium vivax vivapain-2 0.0317 0.1502 0.5617
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0149 0.1906
Plasmodium falciparum serine repeat antigen 7 0.0058 0.0213 0.0796
Giardia lamblia Cathepsin L precursor 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0213 0.1265
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0149 0.0823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0317 0.1502 0.893
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0058 0.0213 0.1265
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Schistosoma mansoni amyloid beta A4 protein related 0.0083 0.0335 0.0821
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0213 0.0294
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0058 0.0213 0.0796
Onchocerca volvulus 0.0317 0.1502 0.1415
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0273 0.046
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.064 0.4156
Onchocerca volvulus 0.0317 0.1502 0.1415
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Plasmodium falciparum serine repeat antigen 3 0.0058 0.0213 0.0796
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Entamoeba histolytica cysteine protease, putative 0.0317 0.1502 0.8889
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0317 0.1502 0.5617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0317 0.1502 0.893
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0101 0.0377
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0058 0.0213 0.0796
Leishmania major cathepsin L-like protease 0.0317 0.1502 0.2527
Schistosoma mansoni cathepsin s 0.0105 0.0444 0.1088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.0213 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1207 0.5945 1
Giardia lamblia Cysteine protease 0.0058 0.0213 0.0796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Brugia malayi Papain family cysteine protease containing protein 0.0317 0.1502 0.2073
Entamoeba histolytica cysteine protease, putative 0.0163 0.0735 0.4157
Brugia malayi cathepsin L-like precursor 0.0212 0.0979 0.1351
Loa Loa (eye worm) voltage-dependent calcium channel 0.0024 0.0042 0.0099
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0781 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0116 0.05 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0058 0.0213 0.1265
Echinococcus multilocularis cysteine protease 0.0317 0.1502 0.3682
Brugia malayi cathepsin Z-like cysteine proteinase 0.0058 0.0213 0.0294
Plasmodium falciparum serine repeat antigen 2 0.0058 0.0213 0.0796
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4079 1
Leishmania major cathepsin L-like protease 0.1207 0.5945 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0213 0.1265
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0441 0.5644
Giardia lamblia Cathepsin B precursor 0.0058 0.0213 0.0796
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0441 0.5644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0317 0.1502 0.893
Toxoplasma gondii cathepsin B 0.0058 0.0213 0.0796
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0058 0.0213 0.0796

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.09 uM PUBCHEM_BIOASSAY: uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay. Confirmatory Screen for inhibitors of association between Mint1-PDZ domains and N-type Ca2+ channel carboxyl-terminal peptide (NC peptide). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2093, AID2489, AID2496, AID434980] ChEMBL. No reference
IC50 (binding) = 8.71 um PUBCHEM_BIOASSAY: Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay. Confirmatory Screen for inhibitors of association between Mint1-PDZ domains and N-type Ca2+ channel carboxyl-terminal peptide (NC peptide). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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