Detailed information for compound 1283489

Basic information

Technical information
  • TDR Targets ID: 1283489
  • Name: N-[di(phenyl)phosphorylmethyl]-N-ethylethanam ine
  • MW: 287.336 | Formula: C17H22NOP
  • H donors: 0 H acceptors: 1 LogP: 3.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CP(=O)(c1ccccc1)c1ccccc1)CC
  • InChi: 1S/C17H22NOP/c1-3-18(4-2)15-20(19,16-11-7-5-8-12-16)17-13-9-6-10-14-17/h5-14H,3-4,15H2,1-2H3
  • InChiKey: ZZLNOYOQQDEVPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[di(phenyl)phosphorylmethyl]-N-ethyl-ethanamine
  • di(phenyl)phosphorylmethyl-diethyl-amine
  • MLS000104695
  • SMR000054628

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0093 0.1372 0.1508
Brugia malayi chromobox protein homolog 3 0.0042 0.0271 0.019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1905 0.4363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0175 0.3184 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.012 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.2191 1
Brugia malayi nuclear receptor RXR 0.0083 0.1155 0.1218
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0108 0.0043
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0108 0.0108
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0686 0.2025
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0165 0.2965 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0175 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Brugia malayi hypothetical protein 0.0132 0.2235 0.2474
Echinococcus multilocularis geminin 0.0166 0.2972 0.9309
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.012 0.0065
Brugia malayi orphan nuclear receptor NR2E1 0.0083 0.1155 0.1218
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0175 0.3184 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0175 0.3184 0.3578
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.032 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1429 0.4296
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0048 0.0392 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0175 0.3184 0.3578
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.0175 0.3184 1
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0466 0.0458
Brugia malayi nuclear receptor RXR 0.0093 0.1372 0.1471
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0048 0.0392 0.1573
Schistosoma mansoni RAR-like nuclear receptor 0.0175 0.3184 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0175 0.3184 0.3578
Schistosoma mansoni nuclear receptor nhr-48 0.0083 0.1155 0.3404
Brugia malayi Heterochromatin protein 1 0.0076 0.0998 0.1036
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1429 0.4296
Brugia malayi nuclear receptor NHR-67 0.0083 0.1155 0.1218
Trypanosoma brucei trypanothione reductase 0.0051 0.0466 0.1255
Echinococcus multilocularis thymidylate synthase 0.0117 0.1916 0.5877
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Brugia malayi Nuclear hormone receptor E75 0.0083 0.1155 0.1218
Echinococcus granulosus dihydrofolate reductase 0.0048 0.0392 0.0925
Brugia malayi nuclear hormone receptor family member nhr-6 0.0083 0.1155 0.1218
Loa Loa (eye worm) hypothetical protein 0.0093 0.1372 0.1508
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Schistosoma mansoni retinoic acid receptor RXR 0.0175 0.3184 1
Brugia malayi nuclear hormone receptor 0.0175 0.3184 0.3578
Onchocerca volvulus 0.0035 0.0108 0.0038
Echinococcus multilocularis nuclear receptor nhr 48 0.0083 0.1155 0.3404
Brugia malayi Nuclear hormone receptor E75 0.0083 0.1155 0.1218
Schistosoma mansoni steroid hormone receptor ad4bp 0.0175 0.3184 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1905 0.4363
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0083 0.1155 0.3404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0686 0.188
Echinococcus multilocularis dihydrofolate reductase 0.0048 0.0392 0.0925
Brugia malayi hypothetical protein 0.0083 0.1155 0.1218
Plasmodium vivax glutathione reductase, putative 0.0051 0.0466 0.1255
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0175 0.3184 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0686 0.188
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.032 0.0742
Loa Loa (eye worm) nuclear receptor NHR-67 0.0083 0.1155 0.1256
Loa Loa (eye worm) hypothetical protein 0.0042 0.0271 0.0232
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Brugia malayi ecdysone receptor 0.0083 0.1155 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0175 0.3184 0.3606
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0175 0.3184 1
Loa Loa (eye worm) thymidylate synthase 0.0117 0.1916 0.2137
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0083 0.1155 0.1218
Schistosoma mansoni nuclear receptor 0.0083 0.1155 0.3404
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0165 0.2965 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1905 0.4363
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0175 0.3184 0.3578
Echinococcus granulosus ecdysone induced protein 78C 0.0175 0.3184 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0175 0.3184 0.3578
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1429 0.4296
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0466 0.1255
Schistosoma mansoni hypothetical protein 0.0056 0.0572 0.1508
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.032 0.1173
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0083 0.1155 0.3404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0175 0.3184 0.3578
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.032 0.0689
Brugia malayi thymidylate synthase 0.0117 0.1916 0.2103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0708 0.3319
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.032 0.5
Onchocerca volvulus 0.0175 0.3184 0.3136
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0083 0.1155 0.1256
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.032 0.0742
Brugia malayi hypothetical protein 0.0093 0.1372 0.1471
Loa Loa (eye worm) hypothetical protein 0.0061 0.0686 0.0713
Onchocerca volvulus 0.0074 0.0957 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0271 0.0271
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.8706 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0165 0.2965 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1429 0.4296
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0466 0.0871
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0708 0.195
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Brugia malayi Thioredoxin reductase 0.0051 0.0466 0.0417
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0466 0.1166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0637 0.172
Schistosoma mansoni zinc finger protein 0.0083 0.1155 0.3404
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0341 0.0273
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0175 0.3184 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1429 0.4296
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0117 0.1916 0.8677
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0708 0.1456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0686 0.188
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0175 0.3184 0.3578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0686 0.188
Loa Loa (eye worm) nuclear hormone receptor 0.0083 0.1155 0.1256
Mycobacterium tuberculosis Probable reductase 0.0117 0.1905 0.4363
Brugia malayi Nuclear hormone receptor-like 1 0.0175 0.3184 0.3578
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.032 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0175 0.3184 0.3578
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0165 0.2965 1
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.2191 0.5057
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0117 0.1916 0.5877
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0175 0.3184 1
Brugia malayi Nuclear hormone receptor-like 1 0.0093 0.1372 0.1471
Brugia malayi photoreceptor-specific nuclear receptor 0.0175 0.3184 0.3578
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.012 0.0057
Toxoplasma gondii thioredoxin reductase 0.0051 0.0466 0.1255
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0175 0.3184 0.3578
Echinococcus multilocularis chromobox protein 1 0.0076 0.0998 0.2894
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0093 0.1372 0.4111
Brugia malayi ecdysteroid receptor 0.0175 0.3184 0.3578
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0083 0.1155 0.3404
Schistosoma mansoni hypothetical protein 0.0166 0.2972 0.9309
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.032 0.032
Schistosoma mansoni thyroid hormone receptor 0.0175 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0344 0.6879 0.7884
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.032 0.0689
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0686 0.188
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0998 0.0998
Brugia malayi Steroid receptor seven-up type 2 0.0175 0.3184 0.3578
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0998 0.0998
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0175 0.3184 1
Loa Loa (eye worm) dihydrofolate reductase 0.0048 0.0392 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0567 0.0567
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1905 0.4363
Schistosoma mansoni thyroid hormone receptor 0.0175 0.3184 1
Brugia malayi glutathione reductase 0.0051 0.0466 0.0417
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0083 0.1155 0.3404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0093 0.1372 0.4111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0093 0.1372 0.4111
Echinococcus multilocularis ecdysone induced protein 78C 0.0175 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Loa Loa (eye worm) hypothetical protein 0.0093 0.1372 0.1508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0175 0.3184 1
Echinococcus granulosus chromobox protein 1 0.0076 0.0998 0.2894
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0083 0.1155 0.3404
Echinococcus granulosus thymidylate synthase 0.0117 0.1916 0.5877
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0083 0.1155 0.1092
Echinococcus multilocularis thyroid hormone receptor alpha 0.0175 0.3184 1
Brugia malayi Cytochrome P450 family protein 0.0077 0.1024 0.1065
Loa Loa (eye worm) beta-lactamase 0.0035 0.0108 0.0043
Onchocerca volvulus 0.0035 0.0108 0.0038
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0175 0.3184 0.3136
Schistosoma mansoni chromobox protein 0.0076 0.0998 0.2894
Brugia malayi conserved hypotetical protein 0.0083 0.1155 0.1218
Brugia malayi nuclear hormone receptor 0.0083 0.1155 0.1218
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0108 0.0108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.4228 1
Schistosoma mansoni coup transcription factor 0.0175 0.3184 1
Echinococcus granulosus nuclear receptor nhr 48 0.0083 0.1155 0.3404
Trichomonas vaginalis set domain proteins, putative 0.0487 1 1
Brugia malayi nuclear receptor NHR-88 0.0083 0.1155 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0175 0.3184 0.3606
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0083 0.1155 0.1092
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.2191 0.5057
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0165 0.2965 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.032 0.5
Plasmodium vivax SET domain protein, putative 0.0061 0.0686 0.2025
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0093 0.1372 0.1508
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0271 0.0202
Onchocerca volvulus 0.0083 0.1155 0.1092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0175 0.3184 0.3606
Brugia malayi hypothetical protein 0.0093 0.1372 0.1471
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0175 0.3184 1
Brugia malayi nuclear receptor NHR-88 0.0175 0.3184 0.3578
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0056 0.0567 0.1608
Echinococcus granulosus geminin 0.0166 0.2972 0.9309
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0175 0.3184 0.3606
Trichomonas vaginalis esterase, putative 0.0035 0.0108 0.0108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0175 0.3184 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0708 0.21
Onchocerca volvulus 0.0083 0.1155 0.1092
Mycobacterium ulcerans thymidylate synthase 0.0117 0.1916 1
Brugia malayi Inositol-1 0.0045 0.032 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0175 0.3184 0.3578
Loa Loa (eye worm) DR-78 0.0083 0.1155 0.1256
Echinococcus granulosus FTZ F1 alpha 0.0175 0.3184 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0175 0.3184 1
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.012 0.0041
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0341 0.0341
Brugia malayi Pre-SET motif family protein 0.0061 0.0686 0.0673
Onchocerca volvulus 0.0035 0.0108 0.0038
Onchocerca volvulus 0.0117 0.1916 0.1858
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0708 0.21
Schistosoma mansoni nuclear hormone receptor 0.0175 0.3184 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1429 0.4296
Brugia malayi steroid hormone receptor 0.0175 0.3184 0.3578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0175 0.3184 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1905 0.8628
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.012 0.0041
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0165 0.2965 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0175 0.3184 0.3578
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0083 0.1155 0.1218
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0708 0.195
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0217 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0043
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.032 0.0742
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1905 0.4363
Schistosoma mansoni nuclear hormone receptor 0.0083 0.1155 0.3404
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0083 0.1155 0.3404
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0048 0.0392 0.069
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0466 0.1255
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0175 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1372 0.1508
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0957 0.2761
Echinococcus granulosus thyroid hormone receptor alpha 0.0083 0.1155 0.3404
Brugia malayi dihydrofolate reductase family protein 0.0048 0.0392 0.0331
Brugia malayi tailless protein 0.0083 0.1155 0.1218
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0708 0.195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.1155 0.3404
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.032 0.0742
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0108 0.0108
Onchocerca volvulus Protein ultraspiracle homolog 0.0175 0.3184 0.3136
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0466 0.1166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0175 0.3184 0.3606
Chlamydia trachomatis dihydrofolate reductase 0.0048 0.0392 0.5
Schistosoma mansoni nuclear receptor 0.0083 0.1155 0.3404
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0093 0.1372 0.4111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0175 0.3184 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1429 0.1574
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0998 0.1074
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Schistosoma mansoni dihydrofolate reductase 0.0048 0.0392 0.0925
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0083 0.1155 0.3404
Brugia malayi Dihydrofolate reductase 0.0048 0.0392 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0271 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.0093 0.1372 0.1471
Leishmania major cytochrome p450-like protein 0.0035 0.012 0.0041
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0341 0.0341
Echinococcus multilocularis chromobox protein 1 0.0076 0.0998 0.2894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1429 0.4296
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.0567 0.1115
Brugia malayi hypothetical protein 0.0056 0.0567 0.0534
Schistosoma mansoni nuclear hormone receptor 0.0083 0.1155 0.3404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0175 0.3184 0.3606
Loa Loa (eye worm) CYP4Cod1 0.0035 0.012 0.0057
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0175 0.3184 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1429 0.1537
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0117 0.1916 0.4388
Loa Loa (eye worm) hypothetical protein 0.0093 0.1372 0.1508
Onchocerca volvulus Bile acid receptor homolog 0.0175 0.3184 0.3136
Echinococcus granulosus chromobox protein 1 0.0076 0.0998 0.2894
Echinococcus granulosus Nuclear hormone receptor HR96 0.0083 0.1155 0.3404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0708 0.3319
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0217 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0175 0.3184 0.3606
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0708 0.195
Loa Loa (eye worm) glutathione reductase 0.0051 0.0466 0.0458
Brugia malayi hypothetical protein 0.0083 0.1155 0.1218
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0708 0.3319
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.2191 0.5057
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.012 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0175 0.3184 0.3606
Loa Loa (eye worm) inositol-1 0.0045 0.032 0.0289
Loa Loa (eye worm) hypothetical protein 0.0175 0.3184 0.3606
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0175 0.3184 0.3578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0175 0.3184 0.3578
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0175 0.3184 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.1024 0.1104
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0175 0.3184 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0686 0.188
Trypanosoma brucei cytochrome P450, putative 0.0035 0.012 0.0041
Schistosoma mansoni inositol monophosphatase 0.0045 0.032 0.0689
Schistosoma mansoni inositol monophosphatase 0.0045 0.032 0.0689
Brugia malayi Cytochrome P450 family protein 0.0035 0.012 0.0014
Schistosoma mansoni hypothetical protein 0.0166 0.2972 0.9309
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0175 0.3184 1
Schistosoma mansoni chromobox protein 0.0076 0.0998 0.2894
Loa Loa (eye worm) hypothetical protein 0.0083 0.1155 0.1256
Brugia malayi Pre-SET motif family protein 0.0428 0.8706 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0083 0.1155 0.3404
Leishmania major trypanothione reductase 0.0051 0.0466 0.1255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.032 0.032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.1155 0.3404

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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