Detailed information for compound 1287153

Basic information

Technical information
  • TDR Targets ID: 1287153
  • Name: N-butyl-2-(4-ethoxyphenyl)sulfanylquinoline-4 -carboxamide
  • MW: 380.503 | Formula: C22H24N2O2S
  • H donors: 1 H acceptors: 2 LogP: 5.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)c1cc(Sc2ccc(cc2)OCC)nc2c1cccc2
  • InChi: 1S/C22H24N2O2S/c1-3-5-14-23-22(25)19-15-21(24-20-9-7-6-8-18(19)20)27-17-12-10-16(11-13-17)26-4-2/h6-13,15H,3-5,14H2,1-2H3,(H,23,25)
  • InChiKey: MPMYMCYZNIUVFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-2-(4-ethoxyphenyl)sulfanyl-quinoline-4-carboxamide
  • N-butyl-2-[(4-ethoxyphenyl)thio]-4-quinolinecarboxamide
  • N-butyl-2-[(4-ethoxyphenyl)thio]cinchoninamide
  • EU-0064725
  • K786-9057
  • NCGC00140220-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0042 0.0055 0.091
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Brugia malayi beta-lactamase 0.0154 0.0309 0.6202
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.0721 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.003 0.0398
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0017 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0309 0.4271
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Schistosoma mansoni hypothetical protein 0.0146 0.0292 0.4038
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0292 0.5853
Loa Loa (eye worm) hypothetical protein 0.0105 0.0197 0.272
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0094 0.0173 0.2377
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0309 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0017 0.018
Mycobacterium ulcerans hypothetical protein 0.0047 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0115 0.0221 0.3046
Schistosoma mansoni ran 0.0023 0.0011 0.0135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0049 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.003 0.0181
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0045 0.0043
Brugia malayi Importin beta-1 subunit 0.0031 0.003 0.0393
Loa Loa (eye worm) hypothetical protein 0.0146 0.0292 0.4038
Onchocerca volvulus 0.0129 0.0253 0.8199
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0011 0.0135
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0178
Brugia malayi beta-lactamase family protein 0.0154 0.0309 0.6202
Mycobacterium ulcerans TetR family transcriptional regulator 0.136 0.3058 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Schistosoma mansoni coup transcription factor 0.0031 0.003 0.0398
Schistosoma mansoni thyroid hormone receptor 0.0031 0.003 0.0398
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.003 0.0398
Onchocerca volvulus 0.0154 0.0309 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.003 0.0398
Mycobacterium ulcerans hypothetical protein 0.0154 0.0309 0.0893
Plasmodium vivax glutathione reductase, putative 0.0037 0.0044 0.1085
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0634
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0491 0.3084
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Brugia malayi Bromodomain containing protein 0.0083 0.0147 0.2832
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0212 0.1327
Mycobacterium tuberculosis Probable hydrolase 0.0154 0.0309 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.003 0.0398
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0174 0.0459
Echinococcus multilocularis protein dispatched 1 0.0107 0.0203 0.0201
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0491 0.049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.003 0.0029
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0067 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0154 0.0309 0.0906
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Echinococcus granulosus FTZ F1 alpha 0.0031 0.003 0.0181
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Brugia malayi nuclear receptor NHR-88 0.0031 0.003 0.0395
Loa Loa (eye worm) beta-lactamase 0.0154 0.0309 0.4271
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0014 0.0105
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0152 0.0388
Echinococcus multilocularis protein patched 0.0094 0.0173 0.0171
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0894
Leishmania major hypothetical protein, conserved 0.0154 0.0309 1
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.136 0.3058 1
Echinococcus multilocularis importin subunit beta 1 0.0031 0.003 0.0029
Brugia malayi nuclear hormone receptor 0.0031 0.003 0.0395
Mycobacterium tuberculosis Probable lipase LipE 0.0154 0.0309 0.0906
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.003 0.0398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.003 0.0395
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0093 0.274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.003 0.0395
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0045 0.0272
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0011 0.001
Echinococcus multilocularis Niemann Pick C1 protein 0.0313 0.0671 0.067
Loa Loa (eye worm) glutathione reductase 0.0037 0.0044 0.0584
Echinococcus granulosus tumor protein p63 0.0715 0.1589 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0011 0.0061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.003 0.0181
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0044 0.1085
Echinococcus multilocularis aryl hydrocarbon receptor 0.013 0.0254 0.0253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0109 0.0675
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Echinococcus granulosus aryl hydrocarbon receptor 0.013 0.0254 0.1593
Brugia malayi hypothetical protein 0.0234 0.0491 1
Schistosoma mansoni hypothetical protein 0.0335 0.0721 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0302 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0093 0.0191
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0114 0.0218 0.4301
Entamoeba histolytica hypothetical protein 0.0025 0.0017 0.012
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0219 0.0457 1
Plasmodium vivax hypothetical protein, conserved 0.0154 0.0309 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.0152 0.0388
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Mycobacterium leprae Probable lipase LipE 0.0154 0.0309 0.0809
Brugia malayi bHLH-PAS transcription factor 0.0044 0.006 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.003 0.0395
Schistosoma mansoni survival motor neuron protein 0.0048 0.0067 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.003 0.0395
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.003 0.0181
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0093 0.1268
Echinococcus granulosus Protein patched homolog 1 0.0094 0.0173 0.1078
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0067 0.0091
Leishmania major trypanothione reductase 0.0037 0.0044 0.1085
Loa Loa (eye worm) hypothetical protein 0.0094 0.0173 0.2377
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0093 0.0091
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0003 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0093 0.1268
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Schistosoma mansoni single-minded 0.006 0.0096 0.1307
Mycobacterium ulcerans esterase/lipase LipP 0.0154 0.0309 0.0893
Loa Loa (eye worm) hypothetical protein 0.0219 0.0457 0.6331
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0067 0.1248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.003 0.0029
Onchocerca volvulus 0.0045 0.0061 0.1981
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Loa Loa (eye worm) hypothetical protein 0.0045 0.0061 0.0827
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0015 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0129 0.0253 0.3498
Echinococcus granulosus tar DNA binding protein 0.0069 0.0116 0.0718
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0309 1
Brugia malayi RNA binding protein 0.0069 0.0116 0.2174
Mycobacterium leprae conserved hypothetical protein 0.0154 0.0309 0.0809
Mycobacterium ulcerans lipase LipD 0.0154 0.0309 0.0893
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0067 0.0091
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.003 0.0395
Schistosoma mansoni importin beta-1 0.0031 0.003 0.0397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0067 0.0105
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.004 0.8754
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.003 0.0181
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0014 0.0964
Mycobacterium ulcerans putative regulatory protein 0.0044 0.006 0.0068
Brugia malayi RNA, U transporter 1 0.0089 0.0162 0.3137
Brugia malayi steroid hormone receptor 0.0031 0.003 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0214 0.0447 0.9069
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0152 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.003 0.0398
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.003 0.0395
Plasmodium vivax importin-beta 2, putative 0.0031 0.003 0.0634
Echinococcus multilocularis tumor protein p63 0.0715 0.1589 0.1588
Echinococcus multilocularis beta LACTamase domain containing family member 0.0154 0.0309 0.0307
Brugia malayi hypothetical protein 0.0024 0.0014 0.0065
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0049 0.0299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Echinococcus granulosus single minded 2 0.0044 0.006 0.0368
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0173 0.542
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Onchocerca volvulus 0.0048 0.0067 0.2178
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0152 0.0388
Toxoplasma gondii ABC1 family protein 0.0154 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0744
Echinococcus multilocularis GPCR, family 2 0.0068 0.0113 0.0112
Mycobacterium ulcerans transcriptional regulator 0.136 0.3058 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0067 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.003 0.0398
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.004 0.095
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0152 0.0388
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.003 0.0029
Brugia malayi Thioredoxin reductase 0.0037 0.0044 0.0673
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Echinococcus granulosus Niemann Pick C1 protein 0.0219 0.0457 0.287
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0152 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.003 0.0395
Schistosoma mansoni thyroid hormone receptor 0.0031 0.003 0.0398
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0197 0.272
Onchocerca volvulus 0.0031 0.003 0.0977
Loa Loa (eye worm) hypothetical protein 0.0114 0.0218 0.3003
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0154 0.0309 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0397
Echinococcus granulosus zinc finger protein 0.0022 0.0008 0.004
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0113 0.2121
Echinococcus granulosus expressed conserved protein 0.0205 0.0427 0.268
Echinococcus granulosus GPCR family 2 0.0068 0.0113 0.0702
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.003 0.0395
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0109 0.0107
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Leishmania major importin beta-1 subunit, putative 0.0025 0.0017 0.018
Loa Loa (eye worm) hypothetical protein 0.0068 0.0113 0.1549
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0114 0.0219 0.302
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0302 0.1894
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0015 0.0087
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.136 0.3058 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0634
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0174 0.0459
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0014 0.0105
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0044 0.0028
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0112
Schistosoma mansoni aryl hydrocarbon receptor 0.0174 0.0356 0.4923
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.003 0.0398
Echinococcus granulosus Niemann Pick C1 protein 0.0313 0.0671 0.4217
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.004 0.0015
Brugia malayi PHD-finger family protein 0.0027 0.0021 0.0209
Onchocerca volvulus 0.0047 0.0067 0.2165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.003 0.0395
Trypanosoma brucei trypanothione reductase 0.0037 0.0044 0.1085
Toxoplasma gondii thioredoxin reductase 0.0037 0.0044 0.1085
Schistosoma mansoni hypothetical protein 0.0048 0.0067 0.0914
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0702
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.003 0.0395
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0067 0.1168
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.003 0.0977
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0014 0.0105
Brugia malayi PAS domain containing protein 0.006 0.0096 0.1758
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0302 0.6063
Schistosoma mansoni hypothetical protein 0.0111 0.0212 0.2927
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.003 0.0181
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0067 0.0105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.003 0.0029
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.004 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0113 0.1549
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0067 0.1248
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Echinococcus granulosus importin subunit beta 1 0.0031 0.003 0.018
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0174 0.0358
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.003 0.0398
Brugia malayi beta-lactamase family protein 0.0154 0.0309 0.6202
Onchocerca volvulus 0.0154 0.0309 1
Brugia malayi hypothetical protein 0.0111 0.0212 0.4187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.003 0.0395
Echinococcus granulosus sterol regulatory element binding protein 0.0094 0.0173 0.1078
Plasmodium falciparum thioredoxin reductase 0.0037 0.0044 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0302 0.0301
Echinococcus multilocularis Niemann Pick C1 protein 0.0219 0.0457 0.0456
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.003 0.0398
Mycobacterium tuberculosis Probable esterase LipL 0.0154 0.0309 0.0906
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Echinococcus granulosus snurportin 1 0.0335 0.0721 0.4533
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0014 0.0964
Brugia malayi CHE-14 protein 0.0094 0.0173 0.3362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.003 0.0398
Schistosoma mansoni ran 0.0023 0.0011 0.0135
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0309 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0154 0.0309 0.1936
Schistosoma mansoni patched 1 0.0094 0.0173 0.2377
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.003 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Onchocerca volvulus 0.0154 0.0309 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.003 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0302 0.4179
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0116 0.0114
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0093 0.274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.003 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0309 0.4271
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.003 0.0395
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0044 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.003 0.0395
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0174 0.0459
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.003 0.0181
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.003 0.0634
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0116 0.1585
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Trichomonas vaginalis esterase, putative 0.0154 0.0309 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.003 0.0398
Mycobacterium tuberculosis Probable lipase LipD 0.0154 0.0309 0.0906
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.003 0.0029
Echinococcus multilocularis expressed conserved protein 0.0205 0.0427 0.0426
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0116 0.1585
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0702
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0116 0.2174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0302 0.1894
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.003 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0044 0.0584
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0017 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0309 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.003 0.0398
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Loa Loa (eye worm) hypothetical protein 0.0234 0.0491 0.6804
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.003 0.0977
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Loa Loa (eye worm) RNA binding protein 0.0069 0.0116 0.1585
Loa Loa (eye worm) hypothetical protein 0.0078 0.0136 0.1874
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0154 0.0309 0.6202
Brugia malayi ecdysteroid receptor 0.0031 0.003 0.0395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0214 0.0447 0.9069
Plasmodium falciparum importin beta, putative 0.0031 0.003 0.5837
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0154 0.0309 0.4271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0214 0.0447 0.6183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0067 0.1248
Schistosoma mansoni bromodomain containing protein 0.007 0.0118 0.1614
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0093 0.0575
Loa Loa (eye worm) hypothetical protein 0.0214 0.0447 0.6183
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0154 0.0309 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.003 0.0395
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0212 0.2927
Brugia malayi Niemann-Pick C1 protein precursor 0.0219 0.0457 0.9291
Onchocerca volvulus 0.0105 0.0197 0.6387
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.003 0.0395
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0222 0.0465 0.6438
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0212 0.0211
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.003 0.0977
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0154 0.0309 0.0906
Echinococcus multilocularis zinc finger protein 0.0022 0.0008 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.003 0.0398
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0014 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0154 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0014 0.0105
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.003 0.0398
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0113 0.2121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0011 0.0125
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.003 0.0029
Leishmania major hypothetical protein, conserved 0.0024 0.0014 0.0105
Mycobacterium ulcerans AcrR family transcriptional regulator 0.136 0.3058 1
Plasmodium falciparum glutathione reductase 0.0037 0.0044 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.003 0.0395
Brugia malayi glutathione reductase 0.0037 0.0044 0.0673
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0982 0.2196 0.715
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Echinococcus multilocularis snurportin 1 0.0335 0.0721 0.072
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0011 0.5
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0017 0.018
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0152 0.0286
Brugia malayi TAR-binding protein 0.0069 0.0116 0.2174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.003 0.0398
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Echinococcus multilocularis sterol regulatory element binding protein 0.0094 0.0173 0.0171
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0015 0.0014
Schistosoma mansoni zinc finger protein 0.0022 0.0008 0.0088
Mycobacterium ulcerans beta-lactamase 0.0154 0.0309 0.0893

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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