Detailed information for compound 1287153

Basic information

Technical information
  • TDR Targets ID: 1287153
  • Name: N-butyl-2-(4-ethoxyphenyl)sulfanylquinoline-4 -carboxamide
  • MW: 380.503 | Formula: C22H24N2O2S
  • H donors: 1 H acceptors: 2 LogP: 5.46 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)c1cc(Sc2ccc(cc2)OCC)nc2c1cccc2
  • InChi: 1S/C22H24N2O2S/c1-3-5-14-23-22(25)19-15-21(24-20-9-7-6-8-18(19)20)27-17-12-10-16(11-13-17)26-4-2/h6-13,15H,3-5,14H2,1-2H3,(H,23,25)
  • InChiKey: MPMYMCYZNIUVFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-2-(4-ethoxyphenyl)sulfanyl-quinoline-4-carboxamide
  • N-butyl-2-[(4-ethoxyphenyl)thio]-4-quinolinecarboxamide
  • N-butyl-2-[(4-ethoxyphenyl)thio]cinchoninamide
  • EU-0064725
  • K786-9057
  • NCGC00140220-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0078 0.0136 0.1874
Mycobacterium ulcerans esterase/lipase LipP 0.0154 0.0309 0.0893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.003 0.0398
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0174 0.0459
Echinococcus multilocularis protein patched 0.0094 0.0173 0.0171
Toxoplasma gondii thioredoxin reductase 0.0037 0.0044 0.1085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0094 0.0173 0.2377
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0152 0.0388
Plasmodium falciparum importin beta, putative 0.0031 0.003 0.5837
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0125
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.003 0.0181
Schistosoma mansoni aryl hydrocarbon receptor 0.0174 0.0356 0.4923
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0302 0.0301
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0011 0.0135
Loa Loa (eye worm) hypothetical protein 0.0045 0.0061 0.0827
Loa Loa (eye worm) hypothetical protein 0.0105 0.0197 0.272
Brugia malayi hypothetical protein 0.0024 0.0014 0.0065
Schistosoma mansoni patched 1 0.0094 0.0173 0.2377
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Onchocerca volvulus 0.0154 0.0309 1
Brugia malayi beta-lactamase family protein 0.0154 0.0309 0.6202
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.003 0.0398
Echinococcus multilocularis protein dispatched 1 0.0107 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0234 0.0491 0.6804
Brugia malayi hypothetical protein 0.0234 0.0491 1
Brugia malayi bHLH-PAS transcription factor 0.0044 0.006 0.1016
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0309 1
Plasmodium falciparum glutathione reductase 0.0037 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0219 0.302
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.003 0.0398
Schistosoma mansoni ran 0.0023 0.0011 0.0135
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.003 0.0634
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.004 0.095
Brugia malayi nuclear receptor NHR-88 0.0031 0.003 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Schistosoma mansoni coup transcription factor 0.0031 0.003 0.0398
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0154 0.0309 0.6202
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0744
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0634
Loa Loa (eye worm) beta-lactamase 0.0154 0.0309 0.4271
Trichomonas vaginalis esterase, putative 0.0154 0.0309 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0302 0.4179
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.003 0.0398
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0014 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0093 0.274
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.003 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.003 0.0398
Echinococcus granulosus GPCR family 2 0.0068 0.0113 0.0702
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0154 0.0309 0.0906
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0309 0.4271
Onchocerca volvulus 0.0045 0.0061 0.1981
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Trichomonas vaginalis penicillin-binding protein, putative 0.0154 0.0309 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0044 0.0584
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0222 0.0465 0.6438
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0982 0.2196 0.715
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0003 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0044 0.0028
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0152 0.0388
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.136 0.3058 1
Brugia malayi PHD-finger family protein 0.0027 0.0021 0.0209
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.003 0.0029
Echinococcus granulosus single minded 2 0.0044 0.006 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Echinococcus granulosus expressed conserved protein 0.0205 0.0427 0.268
Loa Loa (eye worm) hypothetical protein 0.0146 0.0292 0.4038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0152 0.0286
Loa Loa (eye worm) hypothetical protein 0.0214 0.0447 0.6183
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0309 1
Brugia malayi glutathione reductase 0.0037 0.0044 0.0673
Onchocerca volvulus 0.0129 0.0253 0.8199
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.003 0.0398
Mycobacterium ulcerans hypothetical protein 0.0154 0.0309 0.0893
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.004 0.8754
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0219 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0174 0.0358
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.003 0.0977
Onchocerca volvulus 0.0031 0.003 0.0977
Loa Loa (eye worm) hypothetical protein 0.0094 0.0173 0.2377
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.003 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.003 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.003 0.0398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0116 0.1585
Schistosoma mansoni hypothetical protein 0.0146 0.0292 0.4038
Schistosoma mansoni zinc finger protein 0.0022 0.0008 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0067 0.1159
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0174 0.0459
Echinococcus granulosus importin subunit beta 1 0.0031 0.003 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.003 0.0634
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0014 0.0964
Echinococcus granulosus Niemann Pick C1 protein 0.0219 0.0457 0.287
Echinococcus granulosus tar DNA binding protein 0.0069 0.0116 0.0718
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0197 0.272
Mycobacterium ulcerans putative regulatory protein 0.0044 0.006 0.0068
Mycobacterium ulcerans AcrR family transcriptional regulator 0.136 0.3058 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.003 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0015 0.0192
Brugia malayi beta-lactamase family protein 0.0154 0.0309 0.6202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0154 0.0309 0.4271
Toxoplasma gondii ABC1 family protein 0.0154 0.0309 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0067 0.1168
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0116 0.1585
Onchocerca volvulus 0.0048 0.0067 0.2178
Onchocerca volvulus 0.0047 0.0067 0.2165
Schistosoma mansoni bromodomain containing protein 0.007 0.0118 0.1614
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0017 0.018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0152 0.0388
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.003 0.0398
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0017 0.018
Mycobacterium tuberculosis Probable reductase 0.0085 0.0152 0.0388
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0045 0.0272
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.003 0.0398
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0049 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0154 0.0309 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.003 0.0029
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0067 0.0091
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.003 0.0181
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0014 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.003 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.003 0.0395
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Trypanosoma brucei trypanothione reductase 0.0037 0.0044 0.1085
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0309 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0067 0.1869
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0214 0.0447 0.9069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Schistosoma mansoni single-minded 0.006 0.0096 0.1307
Brugia malayi Niemann-Pick C1 protein precursor 0.0219 0.0457 0.9291
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0067 0.1248
Schistosoma mansoni thyroid hormone receptor 0.0031 0.003 0.0398
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.003 0.0398
Brugia malayi TAR-binding protein 0.0069 0.0116 0.2174
Mycobacterium tuberculosis Probable lipase LipE 0.0154 0.0309 0.0906
Brugia malayi Bromodomain containing protein 0.0042 0.0055 0.091
Echinococcus multilocularis Niemann Pick C1 protein 0.0313 0.0671 0.067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0017 0.018
Loa Loa (eye worm) hypothetical protein 0.0047 0.0067 0.0908
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.003 0.0977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.003 0.0398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0093 0.0575
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0212 0.1327
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0044 0.0584
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0302 0.1894
Echinococcus granulosus sterol regulatory element binding protein 0.0094 0.0173 0.1078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.003 0.0395
Mycobacterium tuberculosis Probable esterase LipL 0.0154 0.0309 0.0906
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0011 0.0061
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.006 0.0059
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Brugia malayi ecdysteroid receptor 0.0031 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0014 0.0178
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0067 0.0091
Plasmodium falciparum thioredoxin reductase 0.0037 0.0044 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0044 0.1085
Schistosoma mansoni nuclear hormone receptor 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Loa Loa (eye worm) RNA binding protein 0.0069 0.0116 0.1585
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0015 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0214 0.0447 0.9069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0109 0.0107
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.003 0.0398
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.003 0.0398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.003 0.0181
Leishmania major hypothetical protein, conserved 0.0154 0.0309 1
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.003 0.0395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.003 0.0395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0302 0.0301
Schistosoma mansoni hypothetical protein 0.0111 0.0212 0.2927
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.003 0.0395
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0014 0.0964
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Loa Loa (eye worm) hypothetical protein 0.0115 0.0221 0.3046
Mycobacterium tuberculosis Conserved protein 0.0154 0.0309 0.0906
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.003 0.0977
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.003 0.0029
Plasmodium vivax importin-beta 2, putative 0.0031 0.003 0.0634
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0702
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.003 0.0029
Brugia malayi steroid hormone receptor 0.0031 0.003 0.0395
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.003 0.0398
Onchocerca volvulus 0.0154 0.0309 1
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0017 0.018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.003 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.003 0.0181
Echinococcus multilocularis aryl hydrocarbon receptor 0.013 0.0254 0.0253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0049 0.0299
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0113 0.1549
Loa Loa (eye worm) hypothetical protein 0.0114 0.0218 0.3003
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.003 0.0395
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0491 0.049
Leishmania major hypothetical protein, conserved 0.0024 0.0014 0.0105
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Schistosoma mansoni ran 0.0023 0.0011 0.0135
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Leishmania major trypanothione reductase 0.0037 0.0044 0.1085
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0014 0.0105
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.003 0.0395
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0093 0.1268
Mycobacterium ulcerans beta-lactamase 0.0154 0.0309 0.0893
Echinococcus multilocularis tumor protein p63 0.0715 0.1589 0.1588
Mycobacterium ulcerans transcriptional regulator 0.136 0.3058 1
Brugia malayi hypothetical protein 0.0111 0.0212 0.4187
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0015 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.003 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0154 0.0309 0.0893
Brugia malayi Thioredoxin reductase 0.0037 0.0044 0.0673
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.003 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0093 0.0177
Mycobacterium tuberculosis Probable hydrolase 0.0154 0.0309 0.0906
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0292 0.5853
Echinococcus granulosus Niemann Pick C1 protein 0.0313 0.0671 0.4217
Brugia malayi beta-lactamase 0.0154 0.0309 0.6202
Mycobacterium leprae conserved hypothetical protein 0.0154 0.0309 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.003 0.0395
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0116 0.0114
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0154 0.0309 0.4271
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.003 0.0181
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0044 0.1085
Brugia malayi CHE-14 protein 0.0094 0.0173 0.3362
Echinococcus granulosus zinc finger protein 0.0022 0.0008 0.004
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.003 0.0029
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0113 0.2121
Echinococcus multilocularis beta LACTamase domain containing family member 0.0154 0.0309 0.0307
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0014 0.0105
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0174 0.0459
Schistosoma mansoni hypothetical protein 0.009 0.0165 0.227
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Brugia malayi Importin beta-1 subunit 0.0031 0.003 0.0393
Echinococcus multilocularis zinc finger protein 0.0022 0.0008 0.0006
Mycobacterium leprae Probable lipase LipE 0.0154 0.0309 0.0809
Leishmania major importin beta-1 subunit, putative 0.0025 0.0017 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0067 0.1248
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0093 0.0191
Echinococcus granulosus Protein patched homolog 1 0.0094 0.0173 0.1078
Echinococcus multilocularis importin subunit beta 1 0.0031 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.003 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0154 0.0309 0.0906
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Echinococcus multilocularis sterol regulatory element binding protein 0.0094 0.0173 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0154 0.0309 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.003 0.0398
Brugia malayi RNA, U transporter 1 0.0089 0.0162 0.3137
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0014 0.0105
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0045 0.0043
Mycobacterium ulcerans lipase LipD 0.0154 0.0309 0.0893
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Mycobacterium ulcerans TetR family transcriptional regulator 0.136 0.3058 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0067 0.1248
Echinococcus granulosus beta LACTamase domain containing family member 0.0154 0.0309 0.1936
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0093 0.0091
Loa Loa (eye worm) hypothetical protein 0.0068 0.0113 0.1549
Loa Loa (eye worm) hypothetical protein 0.0219 0.0457 0.6331
Echinococcus granulosus FTZ F1 alpha 0.0031 0.003 0.0181
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.1549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.003 0.0181
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0491 0.3084
Echinococcus multilocularis expressed conserved protein 0.0205 0.0427 0.0426
Brugia malayi PAS domain containing protein 0.006 0.0096 0.1758
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0093 0.1268
Onchocerca volvulus 0.0154 0.0309 1
Trypanosoma brucei hypothetical protein, conserved 0.0154 0.0309 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0116 0.2174
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0067 0.0091
Entamoeba histolytica hypothetical protein 0.0025 0.0017 0.012
Loa Loa (eye worm) hypothetical protein 0.0129 0.0253 0.3498
Brugia malayi nuclear hormone receptor 0.0031 0.003 0.0395
Mycobacterium ulcerans hypothetical protein 0.0047 0.0067 0.0091
Echinococcus multilocularis snurportin 1 0.0335 0.0721 0.072
Echinococcus granulosus snurportin 1 0.0335 0.0721 0.4533
Echinococcus multilocularis GPCR, family 2 0.0068 0.0113 0.0112
Entamoeba histolytica hypothetical protein 0.0111 0.0212 0.4507
Mycobacterium tuberculosis Probable lipase LipD 0.0154 0.0309 0.0906
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.003 0.0181
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.136 0.3058 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0302 0.6063
Schistosoma mansoni hypothetical protein 0.0335 0.0721 1
Echinococcus granulosus aryl hydrocarbon receptor 0.013 0.0254 0.1593
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.0721 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0109 0.0675
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0152 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0031 0.003 0.0398
Echinococcus granulosus tumor protein p63 0.0715 0.1589 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.004 0.5
Brugia malayi Bromodomain containing protein 0.0083 0.0147 0.2832
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0212 0.2927
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0398
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0067 0.0091
Loa Loa (eye worm) hypothetical protein 0.0154 0.0309 0.4271
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.003 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0302 0.4179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0302 0.1894
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0093 0.274
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0011 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0113 0.2121
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0173 0.542
Schistosoma mansoni importin beta-1 0.0031 0.003 0.0397
Onchocerca volvulus 0.0105 0.0197 0.6387
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0116 0.1585
Schistosoma mansoni hypothetical protein 0.0048 0.0067 0.0914
Schistosoma mansoni survival motor neuron protein 0.0048 0.0067 0.0914
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0067 0.0091
Plasmodium vivax glutathione reductase, putative 0.0037 0.0044 0.1085
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0154 0.0309 0.0906
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0702
Echinococcus multilocularis Niemann Pick C1 protein 0.0219 0.0457 0.0456
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.003 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.003 0.0395
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0528
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0112
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0114 0.0218 0.4301
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0214 0.0447 0.6183
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0067 0.0105
Brugia malayi RNA binding protein 0.0069 0.0116 0.2174
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0152 0.0388
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0212 0.0211
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.0894
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0067 0.0105
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0011 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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