Detailed information for compound 1295905

Basic information

Technical information
  • TDR Targets ID: 1295905
  • Name: 7-(4-ethoxy-3-methoxyphenyl)-5-methyl-N,2-di( phenyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyr imidine-6-carboxamide
  • MW: 481.546 | Formula: C28H27N5O3
  • H donors: 2 H acceptors: 3 LogP: 5.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C1C(=C(C)Nc2n1nc(n2)c1ccccc1)C(=O)Nc1ccccc1
  • InChi: 1S/C28H27N5O3/c1-4-36-22-16-15-20(17-23(22)35-3)25-24(27(34)30-21-13-9-6-10-14-21)18(2)29-28-31-26(32-33(25)28)19-11-7-5-8-12-19/h5-17,25H,4H2,1-3H3,(H,30,34)(H,29,31,32)
  • InChiKey: KEHRETNXCOJDQE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-(4-ethoxy-3-methoxy-phenyl)-5-methyl-N,2-di(phenyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • NCGC00100215-01
  • Oprea1_182651
  • EU-0080967

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0007 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0209 0.1232
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Mycobacterium ulcerans epoxide hydrolase EphF 0.0023 0.0013 0.0033
Brugia malayi TAR-binding protein 0.0064 0.0218 0.0218
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.003 0.175
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0348 0.1351
Brugia malayi hydrolase, alpha/beta fold family protein 0.0023 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0035 0.0071 0.0277
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0153 0.0183
Brugia malayi hypothetical protein 0.0119 0.0486 0.0486
Mycobacterium tuberculosis Probable reductase 0.0116 0.0475 0.1195
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0023 0.0028
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.003 0.0178
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0032 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0047
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.003 0.0117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0092 0.0232
Schistosoma mansoni choline dehydrogenase 0.0021 0.0007 0.0026
Schistosoma mansoni histone deacetylase 0.0043 0.0113 0.0439
Entamoeba histolytica hypothetical protein 0.0037 0.0083 0.055
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.003 0.175
Loa Loa (eye worm) aminopeptidase N 0.0049 0.0143 0.0143
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0071
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0173 0.1019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Mycobacterium tuberculosis Probable hydrolase 0.0021 0.0007 0.0017
Echinococcus multilocularis histone deacetylase 1 0.0043 0.0113 0.0135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0032 0.021
Schistosoma mansoni neprilysin 0.0097 0.038 0.1474
Loa Loa (eye worm) glutathione reductase 0.0051 0.0153 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0013 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0218 0.0846
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0218 0.0846
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.0412 0.1931 0.1931
Brugia malayi Alpha/beta hydrolase 0.0023 0.0013 0.0013
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0007 0.0007
Loa Loa (eye worm) intermediate filament protein 0.003 0.005 0.005
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Mycobacterium ulcerans haloalkane dehalogenase 0.0023 0.0013 0.0033
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.003 0.175
Leishmania major hypothetical protein, conserved 0.0023 0.0013 0.0077
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0113 0.0749
Mycobacterium tuberculosis Conserved protein 0.0023 0.0013 0.0033
Entamoeba histolytica hypothetical protein 0.0037 0.0083 0.055
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0153 0.0273
Brugia malayi RNA binding protein 0.0064 0.0218 0.0218
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0023 0.0013 0.0077
Plasmodium falciparum thioredoxin reductase 0.0051 0.0153 0.8828
Plasmodium falciparum histone deacetylase 1 0.0043 0.0113 0.6536
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0032 0.0104
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0092 0.0358
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0007 0.0044
Onchocerca volvulus Lipase homolog 0.0023 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0038 0.0089 0.0344
Leishmania major hydrolase-like protein,esterase-like protein 0.0023 0.0013 0.0077
Onchocerca volvulus 0.0322 0.1484 0.4225
Loa Loa (eye worm) histone deacetylase 1 0.0043 0.0113 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Echinococcus granulosus aminopeptidase N 0.0134 0.0561 0.1004
Echinococcus multilocularis abhydrolase domain containing 3 0.0023 0.0013 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0092 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0092 0.0544
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0136 0.0563
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.003 0.0054
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.003 0.0117
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0475 0.1195
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1696 1
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0049 0.0143 0.0172
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0091 0.0348 0.1351
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Leishmania major hypothetical protein, conserved 0.0023 0.0013 0.0077
Brugia malayi hypothetical protein 0.0026 0.003 0.003
Brugia malayi peptidase family M13 containing protein 0.0091 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0322 0.1484 0.1484
Loa Loa (eye worm) peptidase family M13 containing protein 0.0412 0.1931 0.1931
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0145 0.0615 0.0615
Mycobacterium ulcerans lipase/esterase 0.0023 0.0013 0.0033
Schistosoma mansoni integrin alpha-ps 0.0072 0.0256 0.0994
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0021 0.0007 0.0012
Brugia malayi histone deacetylase 1 (HD1) 0.0043 0.0113 0.0113
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0698 0.271
Echinococcus granulosus lamin dm0 0.003 0.005 0.0089
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.0143 0.0845
Loa Loa (eye worm) hypothetical protein 0.0043 0.0113 0.0113
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0023 0.0013 0.0077
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0032 0.021
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0111 0.0199
Onchocerca volvulus 0.0069 0.0239 0.0663
Onchocerca volvulus Phospholipase A2 homolog 0.0293 0.1344 0.3824
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0023 0.0013 0.0033
Trypanosoma brucei unspecified product 0.0039 0.0092 0.0544
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0326 0.1508 1
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0023 0.0013 0.0051
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0264 0.1752
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0264 0.1026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0007 0.0017
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0023 0.0013 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0751 0.4426
Mycobacterium ulcerans hypothetical protein 0.0023 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Schistosoma mansoni histone deacetylase 0.0043 0.0113 0.0439
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0218 0.0218
Echinococcus multilocularis abhydrolase domain containing protein 0.0023 0.0013 0.0016
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Echinococcus granulosus leukotriene A 4 hydrolase 0.0145 0.0615 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0092 0.0092
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1696 1
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.005
Brugia malayi TATA binding protein associated factor 0.0026 0.003 0.003
Schistosoma mansoni DNA polymerase eta 0.0039 0.0092 0.0358
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0173 0.0718
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0218 0.0846
Onchocerca volvulus 0.003 0.005 0.0123
Echinococcus multilocularis histone deacetylase 3 0.0043 0.0113 0.0135
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0049 0.0143 0.095
Leishmania major hydrolase, alpha/beta fold family, putative 0.0023 0.0013 0.0077
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0007 0.0044
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0264 0.0264
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Loa Loa (eye worm) hydrolase 0.0023 0.0013 0.0013
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0007 0.0044
Entamoeba histolytica aminopeptidase, putative 0.0049 0.0143 0.095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.041 0.159
Toxoplasma gondii peptidase family M13 protein 0.051 0.241 1
Mycobacterium ulcerans hydrolase 0.0021 0.0007 0.0017
Toxoplasma gondii histone deacetylase HDAC2 0.0043 0.0113 0.0469
Loa Loa (eye worm) hypothetical protein 0.0069 0.0239 0.0239
Leishmania major DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Mycobacterium ulcerans lipase/esterase 0.0023 0.0013 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Mycobacterium leprae Probable exported protease 0.0023 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0014
Treponema pallidum phosphoglycolate phosphatase 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0092 0.0092
Trypanosoma cruzi aminopeptidase, putative 0.0049 0.0143 0.0845
Schistosoma mansoni lamin 0.003 0.005 0.0193
Brugia malayi hydrolase, alpha/beta fold family protein 0.0023 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0319 0.0319
Echinococcus granulosus integrin alpha ps 0.0035 0.0071 0.0128
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.003 0.005 0.0182
Schistosoma mansoni hypothetical protein 0.0544 0.2576 1
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0021 0.0007 0.0044
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0032 0.021
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0023 0.0013 0.0033
Leishmania major hydrolase-like protein,esterase-like protein 0.0023 0.0013 0.0077
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0023 0.0013 0.0033
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.003 0.0178
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0083 0.0148
Onchocerca volvulus Lipase homolog 0.0023 0.0013 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0122 0.05 0.05
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0143 0.0256
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0751 0.4426
Schistosoma mansoni hypothetical protein 0.0544 0.2576 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0083 0.0322
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0023 0.0013 0.0016
Schistosoma mansoni ephrin receptor 0.0069 0.0242 0.0941
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0013 0.0759
Giardia lamblia Phosphoglycolate phosphatase 0.0021 0.0007 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Mycobacterium ulcerans epoxide hydrolase EphA 0.0827 0.3971 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0143 0.0256
Loa Loa (eye worm) hypothetical protein 0.0412 0.1931 0.1931
Schistosoma mansoni neprilysin-2 (M13 family) 0.0188 0.0826 0.3208
Trypanosoma brucei histone deacetylase 1 0.0043 0.0113 0.0666
Giardia lamblia DINP protein human, muc B family 0.0039 0.0092 0.0612
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1696 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0326 0.1508 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0143 0.0172
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0092 0.0612
Onchocerca volvulus 0.0049 0.0143 0.0391
Echinococcus multilocularis lamin dm0 0.003 0.005 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0092 0.0544
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0021 0.0007 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.003 0.0054
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0538 0.1356
Mycobacterium ulcerans hydrolase 0.0023 0.0013 0.0033
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0122 0.05 0.05
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0023 0.0013 0.0087
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0023 0.0013 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0007 0.0039
Echinococcus granulosus abhydrolase domain containing protein 3 0.0023 0.0013 0.0023
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0023 0.0013 0.0033
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0218 0.0846
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0188 0.0826 0.3208
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0023 0.0013 0.0016
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0021 0.0007 0.0387
Loa Loa (eye worm) TK/EPH protein kinase 0.0088 0.0335 0.0335
Mycobacterium ulcerans bromoperoxidase BpoC 0.0023 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0023 0.0013 0.0077
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0264 0.1558
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0475 0.1195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.041 0.0733
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0293 0.1344 0.1344
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0847 0.2132
Toxoplasma gondii thioredoxin reductase 0.0051 0.0153 0.0634
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0014 0.0056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0021 0.0007 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.3504 0.3504
Schistosoma mansoni lamin 0.003 0.005 0.0193
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0086
Trypanosoma brucei Aminopeptidase M1, putative 0.0049 0.0143 0.0845
Loa Loa (eye worm) hypothetical protein 0.0126 0.0523 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Toxoplasma gondii aminopeptidase n, putative 0.0026 0.003 0.0126
Plasmodium falciparum glutathione reductase 0.0051 0.0153 0.8828
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0154 0.0906
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0007 0.0044
Echinococcus granulosus dna polymerase kappa 0.0039 0.0092 0.0165
Echinococcus granulosus abhydrolase domain containing protein 0.0023 0.0013 0.0023
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0698 0.0698
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0032 0.008
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0023 0.0013 0.0016
Brugia malayi Peptidase family M13 containing protein 0.051 0.241 0.241
Giardia lamblia ENC6 protein 0.0023 0.0013 0.0087
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.003
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0037 0.0083 0.055
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0173
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0154 0.0906
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0032 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0032 0.0104
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0475 0.1195
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0173 1
Brugia malayi alpha/beta hydrolase 0.0023 0.0013 0.0013
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0023 0.0013 0.0087
Brugia malayi Thioredoxin reductase 0.0051 0.0153 0.0153
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0007 0.0008
Trypanosoma brucei unspecified product 0.0027 0.0033 0.0195
Loa Loa (eye worm) hypothetical protein 0.051 0.241 0.241
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0023 0.0013 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0175 0.0175
Plasmodium vivax glutathione reductase, putative 0.0051 0.0153 0.8828
Mycobacterium ulcerans hypothetical protein 0.0023 0.0013 0.0033
Mycobacterium ulcerans hydrolase 0.0021 0.0007 0.0017
Giardia lamblia Histone deacetylase 0.0043 0.0113 0.0749
Brugia malayi hypothetical protein 0.0036 0.0077 0.0077
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0049 0.0143 0.095
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0116 0.077
Echinococcus multilocularis integrin alpha 3 0.0123 0.0508 0.0609
Brugia malayi histone deacetylase 3 (HD3) 0.0043 0.0113 0.0113
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0023 0.0013 0.0033
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0264 0.1558
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0698 0.0837
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0021 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0032 0.0187
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0023 0.0013 0.0033
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0023 0.0013 0.0016
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0023 0.0013 0.0013
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0136 0.7848
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0173 0.1019
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0264 0.0317
Echinococcus multilocularis dna polymerase eta 0.0039 0.0092 0.0111
Leishmania major hydrolase-like protein 0.0023 0.0013 0.0077
Brugia malayi Histone deacetylase 1 0.0043 0.0113 0.0113
Treponema pallidum fructose-bisphosphate aldolase 0.0326 0.1508 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Brugia malayi MH2 domain containing protein 0.013 0.0542 0.0542
Echinococcus multilocularis integrin alpha ps 0.0035 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0108 0.0432 0.0432
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0092 0.0544
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0153 0.09
Mycobacterium ulcerans hypothetical protein 0.0023 0.0013 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.005 0.005
Chlamydia trachomatis phosphoglycolate phosphatase 0.0021 0.0007 0.5
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0023 0.0013 0.0087
Giardia lamblia Hydrolase, putative 0.0021 0.0007 0.0044
Leishmania major trypanothione reductase 0.0051 0.0153 0.09
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0116 0.6719
Leishmania major histone deacetylase, putative 0.0043 0.0113 0.0666
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0264 0.1558
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0013 0.0077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0475 0.1195
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Loa Loa (eye worm) hypothetical protein 0.0089 0.0338 0.0338
Trichomonas vaginalis hydrolase, putative 0.0023 0.0013 0.0087
Trypanosoma cruzi Aminopeptidase M1, putative 0.0049 0.0143 0.0845
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0348 0.1351
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0154 0.0906
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.003 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0007 0.0007
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0218 0.0261
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0049 0.0143 0.0845
Trypanosoma brucei unspecified product 0.0027 0.0033 0.0195
Trypanosoma brucei aminopeptidase, putative 0.0026 0.003 0.0178
Mycobacterium leprae Probable exported protease 0.0023 0.0013 0.0027
Toxoplasma gondii hypothetical protein 0.0059 0.0191 0.0792
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Mycobacterium ulcerans hypothetical protein 0.0026 0.0032 0.008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0218 0.0218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Entamoeba histolytica hypothetical protein 0.0023 0.0013 0.0087
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0188 0.0826 0.3208
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0264 0.0473
Loa Loa (eye worm) integrin alpha pat-2 0.0248 0.1121 0.1121
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0014
Mycobacterium ulcerans exported protease 0.0023 0.0013 0.0033
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Echinococcus granulosus abhydrolase domain containing protein 11 0.0023 0.0013 0.0023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0264 0.0264
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.051 0.241 0.6067
Plasmodium vivax alpha/beta hydrolase, putative 0.0023 0.0013 0.0759
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Onchocerca volvulus Phospholipase A2 homolog 0.0732 0.3504 1
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0023 0.0013 0.0033
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0145 0.0615 0.0737
Echinococcus granulosus histone deacetylase 1 0.0043 0.0113 0.0202
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0013
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0023 0.0013 0.0018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0136 0.09
Brugia malayi Peptidase family M1 containing protein 0.0026 0.003 0.003
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0032 0.008
Mycobacterium ulcerans epoxide hydrolase EphB 0.0023 0.0013 0.0033
Onchocerca volvulus 0.0134 0.0561 0.1586
Loa Loa (eye worm) hypothetical protein 0.0056 0.0175 0.0175
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0113 0.0666
Loa Loa (eye worm) peptidase family M1 containing protein 0.0111 0.0448 0.0448
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0021 0.0007 0.0026
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.041 0.159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0089
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0092 0.0232
Loa Loa (eye worm) zinc metallopeptidase 4 0.0091 0.0348 0.0348
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0136 0.09
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0136 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0218 0.0846
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0153 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0173 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0092 0.0111
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0113 0.0749
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0092 0.0232
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0542 0.0542
Echinococcus multilocularis integrin alpha ps 0.0072 0.0256 0.0307
Mycobacterium ulcerans hypothetical protein 0.0023 0.0013 0.0033
Brugia malayi hypothetical protein 0.0055 0.0173 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Brugia malayi Peptidase family M1 containing protein 0.0134 0.0561 0.0561
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Schistosoma mansoni integrin alpha-ps 0.0038 0.0086 0.0334
Brugia malayi glutathione reductase 0.0051 0.0153 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0033 0.0195
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.0686 0.1728
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0092 0.0358
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.051 0.241 0.241
Echinococcus multilocularis aminopeptidase N 0.0134 0.0561 0.0673
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.0113 0.0666
Onchocerca volvulus 0.003 0.005 0.0123
Echinococcus multilocularis endothelin converting enzyme 1 0.051 0.241 0.2889
Mycobacterium ulcerans short chain dehydrogenase 0.003 0.005 0.0127
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.0686 0.2828
Echinococcus granulosus tar DNA binding protein 0.0064 0.0218 0.039
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0143 0.0256
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0023 0.0013 0.0759
Toxoplasma gondii aminopeptidase N, putative 0.0026 0.003 0.0126
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0538 0.1356
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0143 0.0172
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Echinococcus granulosus integrin alpha ps 0.0072 0.0256 0.0458
Schistosoma mansoni hypothetical protein 0.0037 0.0083 0.0322
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0153 0.0153
Trypanosoma cruzi hydrolase-like protein, putative 0.0023 0.0013 0.0077
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0023 0.0013 0.0033
Mycobacterium ulcerans oxidoreductase 0.0023 0.0013 0.0033
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 0.008
Plasmodium vivax histone deacetylase 1, putative 0.0043 0.0113 0.6536
Loa Loa (eye worm) hypothetical protein 0.0412 0.1931 0.1931
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0021 0.0007 0.0008
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0023 0.0013 0.0027
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0021 0.0007 0.0044
Echinococcus multilocularis ephrin type A receptor 4 A 0.0069 0.0242 0.0291
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0023 0.0013 0.0013
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.003 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Brugia malayi Integrin alpha pat-2 precursor 0.0161 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Mycobacterium ulcerans zinc metalloprotease 0.051 0.241 0.6067
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0049 0.0143 0.0556
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0023 0.0013 0.0027
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0021 0.0007 0.0007
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0023 0.0013 0.0033
Toxoplasma gondii alpha/beta hydrolase, putative 0.0023 0.0013 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0092 0.0612
Brugia malayi intermediate filament protein 0.003 0.005 0.005
Echinococcus granulosus lamin 0.003 0.005 0.0089
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0021 0.0007 0.0007
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0173 1
Loa Loa (eye worm) acetyltransferase 0.0162 0.0698 0.0698
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0023 0.0013 0.0033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.041 0.041
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0092 0.0544
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.051 0.241 0.9353
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0475 0.1947
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0092 0.0544
Onchocerca volvulus 0.0026 0.003 0.0067
Mycobacterium ulcerans epoxide hydrolase EphE 0.0023 0.0013 0.0033
Echinococcus multilocularis lamin 0.003 0.005 0.0059
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0188 0.0826 0.3208
Mycobacterium ulcerans haloalkane dehalogenase 0.0023 0.0013 0.0033
Trypanosoma cruzi glycosyl hydrolase, putative 0.0021 0.0007 0.0039
Mycobacterium ulcerans hypothetical protein 0.0192 0.0847 0.2132
Schistosoma mansoni intermediate filament proteins 0.003 0.005 0.0193
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Brugia malayi hypothetical protein 0.0037 0.0083 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0032 0.0032
Mycobacterium ulcerans lignin peroxidase LipJ 0.0023 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0412 0.1931 0.1931
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0014 0.0017
Brugia malayi UPF0017 protein CG3488 0.0023 0.0013 0.0013
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0143 0.0172
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0827 0.3971 1
Trypanosoma cruzi hydrolase-like protein, putative 0.0023 0.0013 0.0077
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Brugia malayi Phospholipase A2 family protein 0.0732 0.3504 0.3504
Schistosoma mansoni endothelin-converting enzyme-related 0.0091 0.0348 0.1351
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Plasmodium falciparum alpha/beta hydrolase, putative 0.0023 0.0013 0.0759
Entamoeba histolytica hypothetical protein 0.0021 0.0007 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0751 0.4426
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0032 0.0187
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0023 0.0013 0.0077
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0143 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0013 0.0077
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.003 0.0178
Loa Loa (eye worm) peptidase family M13 containing protein 0.0412 0.1931 0.1931
Giardia lamblia Fructose-bisphosphate aldolase 0.0326 0.1508 1
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0021 0.0007 0.0387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0083 0.0099
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0538 0.2213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.041 0.041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0538 0.1356
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0091 0.0348 0.1351
Echinococcus multilocularis musashi 0.003 0.005 0.0059
Brugia malayi ephrin receptor 1 precursor 0.0033 0.0064 0.0064
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0092 0.0544
Leishmania major DNA polymerase eta, putative 0.0039 0.0092 0.0544
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0032 0.008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0032 0.008
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.003 0.0178
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0021 0.0007 0.0044
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.0143 0.0256
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0013 0.0759
Mycobacterium ulcerans aminopeptidase N PepN 0.0049 0.0143 0.0361
Schistosoma mansoni hydrolase 0.0023 0.0013 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0013 0.0759
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0089 0.0089
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.003 0.005 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0033 0.0195
Schistosoma mansoni hypothetical protein 0.0097 0.038 0.1474
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0475 0.1195
Loa Loa (eye worm) hypothetical protein 0.051 0.241 0.241
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0013 0.0087
Mycobacterium ulcerans hydrolase 0.0023 0.0013 0.0033
Toxoplasma gondii histone deacetylase HDAC3 0.0043 0.0113 0.0469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Echinococcus granulosus endothelin converting enzyme 1 0.051 0.241 0.4309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.041 0.159
Echinococcus granulosus histone deacetylase 3 0.0043 0.0113 0.0202
Mycobacterium ulcerans exported protease 0.0023 0.0013 0.0033
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.003 0.175
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0023 0.0013 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Leishmania major hypothetical protein, conserved 0.0055 0.0173 0.1019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.005 0.005
Trypanosoma brucei Aminopeptidase M1, putative 0.0049 0.0143 0.0845
Brugia malayi Peptidase family M1 containing protein 0.0049 0.0143 0.0143
Mycobacterium leprae probable zinc metalloprotease 0.051 0.241 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0032 0.008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.0686 0.1728
Mycobacterium ulcerans peroxidase BpoB 0.0023 0.0013 0.0033
Schistosoma mansoni hypothetical protein 0.0025 0.0023 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Onchocerca volvulus 0.0026 0.0032 0.0072
Echinococcus granulosus Solute carrier family 22 5 0.1156 0.5592 1
Loa Loa (eye worm) histone deacetylase 3 0.0043 0.0113 0.0113
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0092 0.0165
Entamoeba histolytica hypothetical protein 0.0037 0.0083 0.055
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1696 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.041 0.0491
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0032 0.008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0264 0.1558
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0092 0.0612
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0136 0.0563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Brugia malayi hypothetical protein 0.0049 0.0143 0.0143
Trypanosoma brucei trypanothione reductase 0.0051 0.0153 0.09
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0092 0.0092
Trypanosoma cruzi hydrolase-like protein 0.0023 0.0013 0.0077
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0097 0.038 0.1474
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0175 0.0175
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0145 0.0615 0.2387
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0017
Echinococcus granulosus integrin alpha 3 0.0123 0.0508 0.0908
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0542 0.0542
Echinococcus granulosus geminin 0.0544 0.2576 0.4607
Loa Loa (eye worm) hypothetical protein 0.051 0.241 0.241
Plasmodium falciparum epoxide hydrolase 1 0.0023 0.0013 0.0759
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0188 0.0826 0.3208
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0049 0.0143 0.0556
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0111 0.0134
Echinococcus granulosus ephrin type A receptor 4 A 0.0069 0.0242 0.0434
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0092 0.0092
Schistosoma mansoni integrin alpha 0.0161 0.0693 0.2688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.041 0.0733
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0023 0.0013 0.0054
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0173 0.1019
Echinococcus granulosus intermediate filament protein 0.003 0.005 0.0089
Mycobacterium tuberculosis Probable exported protease 0.0023 0.0013 0.0033
Loa Loa (eye worm) RNA binding protein 0.0064 0.0218 0.0218
Entamoeba histolytica histone deacetylase, putative 0.0043 0.0113 0.0749
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0023 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0092 0.0544
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.0113 0.0749
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0021 0.0007 0.0044
Echinococcus multilocularis geminin 0.0544 0.2576 0.3089
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0143 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0013 0.0077
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0154 0.0906
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.0113 0.0749
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0116 0.077
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0049 0.0143 0.0845
Mycobacterium tuberculosis Possible phosphatase 0.0021 0.0007 0.0017
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0023 0.0013 0.0077
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0348 0.1351
Echinococcus granulosus dna polymerase eta 0.0039 0.0092 0.0165
Echinococcus multilocularis integrin alpha ps 0.0072 0.0256 0.0307
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.003 0.0201
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.0143 0.0845
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.003 0.003
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0419 0.1963 0.1963
Mycobacterium ulcerans proline iminopeptidase PIP 0.0023 0.0013 0.0033
Leishmania major histone deacetylase, putative 0.0043 0.0113 0.0666
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0092 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.041 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0033 0.0195
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1508 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0676 0.1209
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0014 0.0085
Toxoplasma gondii aminopeptidase N protein 0.0026 0.003 0.0126
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0153 0.8828
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.003 0.0178
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1715 0.8341 1
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0021 0.0007 0.0017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.