Detailed information for compound 1305627

Basic information

Technical information
  • TDR Targets ID: 1305627
  • Name: ethyl 2-[(2-chlorobenzoyl)amino]-4,5,6,7-tetr ahydro-1-benzothiophene-3-carboxylate
  • MW: 363.858 | Formula: C18H18ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 5.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)c2ccccc2Cl)sc2c1CCCC2
  • InChi: 1S/C18H18ClNO3S/c1-2-23-18(22)15-12-8-4-6-10-14(12)24-17(15)20-16(21)11-7-3-5-9-13(11)19/h3,5,7,9H,2,4,6,8,10H2,1H3,(H,20,21)
  • InChiKey: NFCXBJTVQVOXRL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[(2-chlorobenzoyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
  • 2-[[(2-chlorophenyl)-oxomethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • 2-[(2-chlorobenzoyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • ethyl 2-[(2-chlorophenyl)carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • EU-0002620
  • NCGC00141926-01
  • Oprea1_875128
  • BAS 00745290
  • Oprea1_343804
  • ZINC01841090
  • A0306/0013987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus transient receptor potential gamma protein 0.0042 0.0443 0.0312
Echinococcus granulosus allatostatin A receptor 0.0048 0.052 0.0398
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.052 0.0398
Echinococcus multilocularis short transient receptor potential channel 6 0.0042 0.0443 0.0312
Brugia malayi putative neuropeptide receptor 0.0048 0.052 0.0542
Echinococcus granulosus voltage gated potassium channel 0.0187 0.2529 0.2634
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0443 0.0296
Trichomonas vaginalis DNA helicase recq1, putative 0.0034 0.0321 0.015
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0042 0.0442 0.4148
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0042 0.0443 0.0458
Leishmania major protein kinase, putative 0.0085 0.1066 1
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0442 0.0296
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Brugia malayi ion channel NompC 0.0042 0.0443 0.0458
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0085 0.106 0.1037
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0042 0.0443 0.0296
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0442 0.0295
Echinococcus multilocularis ryanodine receptor 44f 0.0042 0.0443 0.0312
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Schistosoma mansoni myosin xvIII 0.0048 0.052 0.0375
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0127 0.1673 0.18
Loa Loa (eye worm) hypothetical protein 0.0021 0.0133 0.0109
Onchocerca volvulus 0.0048 0.052 0.0178
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Brugia malayi Melatonin receptor type 1A 0.0048 0.052 0.0542
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0274 0.0094
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Onchocerca volvulus 0.0048 0.052 0.0178
Schistosoma mansoni amine GPCR 0.0048 0.052 0.0375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0342 0.02
Schistosoma mansoni two-pore calcium channel 0.0042 0.0443 0.0296
Trichomonas vaginalis hypothetical protein 0.0059 0.0686 0.0588
Brugia malayi Serotonin receptor 0.0048 0.052 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Onchocerca volvulus 0.0048 0.052 0.0178
Trypanosoma cruzi cAMP response protein 1, putative 0.0085 0.106 1
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0085 0.106 0.1135
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.052 0.0398
Trypanosoma brucei cAMP binding protein, putative 0.0085 0.106 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.052 0.0375
Echinococcus granulosus somatostatin receptor 0.0048 0.052 0.0398
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0274 0.0124
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis shaker cognate 0.0042 0.0443 0.0312
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.052 0.0534
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Echinococcus multilocularis fmrfamide receptor 0.0048 0.052 0.0398
Brugia malayi Dopamine receptor 0.0048 0.052 0.0542
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0042 0.0443 0.0312
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0085 0.106 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0274 0.2333
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.052 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0085 0.106 0.1037
Mycobacterium ulcerans hypothetical protein 0.0085 0.106 0.648
Loa Loa (eye worm) hypothetical protein 0.0559 0.7914 0.865
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.052 0.0542
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0085 0.106 0.1127
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0059 0.0686 0.0588
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0042 0.0443 0.399
Loa Loa (eye worm) hypothetical protein 0.0182 0.2468 0.2672
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0032 0.0288 0.1663
Loa Loa (eye worm) ion channel NompC 0.0042 0.0443 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.106 0.1037
Onchocerca volvulus 0.0048 0.052 0.0178
Schistosoma mansoni glycogen phosphorylase 0.0286 0.3966 0.3873
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.052 0.0534
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0342 0.02
Schistosoma mansoni hypothetical protein 0.0048 0.052 0.0375
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0085 0.106 0.1135
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.052 0.0398
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0042 0.0443 0.0312
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0042 0.0443 0.3969
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0042 0.0443 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.052 0.0534
Schistosoma mansoni hypothetical protein 0.0048 0.052 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Echinococcus granulosus mitogen activated protein kinase 0.0042 0.0442 0.0311
Echinococcus granulosus hyperpolarization activated cyclic 0.0127 0.1673 0.1681
Brugia malayi Cytochrome P450 family protein 0.0014 0.0034 0.0008
Echinococcus granulosus shaker cognate 0.0042 0.0443 0.0312
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.052 0.0542
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0443 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0042 0.0443 0.0312
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0085 0.106 0.0999
Onchocerca volvulus 0.0048 0.052 0.0178
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0042 0.0443 0.0458
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0644 0.9144 1
Schistosoma mansoni hypothetical protein 0.0048 0.052 0.0375
Echinococcus granulosus bloom syndrome protein 0.0034 0.0321 0.0176
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0133 0.0085
Echinococcus multilocularis glycogen phosphorylase 0.0286 0.3966 0.4234
Brugia malayi MH2 domain containing protein 0.0144 0.1914 0.2071
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0085 0.106 0.9948
Onchocerca volvulus 0.0048 0.052 0.0178
Brugia malayi hypothetical protein 0.0042 0.0443 0.0458
Schistosoma mansoni biogenic amine receptor 0.0048 0.052 0.0375
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0085 0.106 0.9948
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0085 0.106 0.9948
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.052 0.0398
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1914 0.2064
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0042 0.0443 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0133 0.0969
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0133 0.0969
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.052 0.0398
Trypanosoma cruzi protein kinase A regulatory subunit 0.0085 0.106 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0085 0.106 0.236
Echinococcus granulosus ryanodine receptor 44f 0.0042 0.0443 0.0312
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0042 0.0443 0.0296
Echinococcus granulosus neuropeptide receptor 0.0048 0.052 0.0398
Echinococcus granulosus two pore calcium channel protein 1 0.0042 0.0443 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.1066 0.0929
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.052 0.0398
Echinococcus granulosus serotonin receptor 0.0048 0.052 0.0398
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0443 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0342 0.0194
Echinococcus granulosus hypothetical protein 0.0042 0.0443 0.0312
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0196 0.1579
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trypanosoma brucei protein kinase A regulatory subunit 0.0085 0.106 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0042 0.0443 0.0312
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.052 0.0398
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0042 0.0442 0.3979
Echinococcus granulosus fmrfamide receptor 0.0048 0.052 0.0398
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0042 0.0442 0.3979
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0042 0.0443 0.399
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.052 0.0375
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0042 0.0442 0.3958
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0163 0.153
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Schistosoma mansoni amine GPCR 0.0048 0.052 0.0375
Echinococcus multilocularis conserved hypothetical protein 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0085 0.106 1
Schistosoma mansoni amine GPCR 0.0048 0.052 0.0375
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.052 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Brugia malayi hypothetical protein 0.0021 0.0133 0.0118
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.052 0.0534
Brugia malayi ORL1-like opioid receptor 0.0048 0.052 0.0542
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.052 0.0398
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0042 0.0443 0.0296
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.052 0.0398
Echinococcus multilocularis short transient receptor potential channel 6 0.0042 0.0443 0.0312
Echinococcus granulosus glycogen phosphorylase 0.0286 0.3966 0.4234
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0042 0.0443 0.0458
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Trypanosoma brucei Flagellar Member 6 0.0085 0.106 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0042 0.0442 0.3979
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0133 0.1248
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.052 0.0534
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0042 0.0442 0.3958
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0443 0.4158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.052 0.0375
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Leishmania major hypothetical protein, conserved 0.0085 0.106 0.9946
Schistosoma mansoni hypothetical protein 0.0042 0.0443 0.0296
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0031 0.0274 0.0692
Giardia lamblia Kinase, CMGC MAPK 0.0042 0.0442 0.0734
Schistosoma mansoni transient receptor potential channel 0.0042 0.0443 0.0296
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) voltage-gated potassium channel 0.0042 0.0443 0.045
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Schistosoma mansoni vesicular amine transporter 0.0042 0.0443 0.0296
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.052 0.0398
Echinococcus granulosus patatin phospholipase domain containing protein 0.0085 0.106 0.0999
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.052 0.0534
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0127 0.1673 0.1681
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0085 0.106 0.1421
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0085 0.1066 0.1005
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0602 0.8532 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0042 0.0442 0.3979
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Echinococcus granulosus ubiquitin specific protease 41 0.0031 0.0274 0.0124
Schistosoma mansoni adenoreceptor 0.0048 0.052 0.0375
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0196 0.0494
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0443 0.4158
Echinococcus multilocularis microtubule associated protein 2 0.0573 0.8115 0.8854
Onchocerca volvulus 0.0085 0.106 0.1421
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.052 0.0534
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0443 0.0312
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0085 0.106 0.0999
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0059 0.0686 0.0588
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.052 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0127 0.1673 0.1681
Echinococcus granulosus TRP transient receptor potential channel 0.0042 0.0443 0.0312
Schistosoma mansoni amine GPCR 0.0048 0.052 0.0375
Trichomonas vaginalis adenylate cyclase type, putative 0.0059 0.0686 0.0588
Toxoplasma gondii hypothetical protein 0.0042 0.0443 0.4158
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0443 0.0296
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.1673 0.1545
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Brugia malayi Serotonin receptor 0.0048 0.052 0.0542
Echinococcus multilocularis glycogen phosphorylase 0.0286 0.3966 0.4234
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0085 0.106 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0042 0.0443 0.045
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Schistosoma mansoni histamine h1 receptor 0.0048 0.052 0.0375
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0274 0.0124
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Brugia malayi RE15519p 0.0048 0.052 0.0542
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0443 0.0312
Echinococcus multilocularis sex peptide receptor 0.0048 0.052 0.0398
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.0443 0.0312
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0602 0.8532 1
Echinococcus multilocularis g protein coupled receptor 0.0048 0.052 0.0398
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0042 0.0443 0.0312
Schistosoma mansoni 60S ribosomal protein L21 0.0102 0.1299 0.1165
Schistosoma mansoni neuropeptide receptor 0.0048 0.052 0.0375
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.006 0.0692 0.6408
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0163 0.0142
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0085 0.106 0.1135
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0042 0.0443 0.0458
Trichomonas vaginalis glycogen phosphorylase, putative 0.0286 0.3966 0.4523
Echinococcus multilocularis neuropeptide receptor 0.0048 0.052 0.0398
Schistosoma mansoni opsin-like receptor 0.0048 0.052 0.0375
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0085 0.106 0.1037
Trypanosoma cruzi cAMP response protein 1 0.0085 0.106 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0085 0.106 0.0923
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Echinococcus multilocularis calcium activated potassium channel 0.0043 0.0449 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.052 0.0542
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0442 0.0296
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.052 0.0398
Loa Loa (eye worm) ryanodine receptor 0.0042 0.0443 0.045
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0085 0.106 0.0923
Echinococcus multilocularis allatostatin A receptor 0.0048 0.052 0.0398
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Brugia malayi Egg laying defective protein 4 0.0085 0.1066 0.1141
Echinococcus multilocularis sodium channel protein 0.0042 0.0443 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0274 0.0124
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0187 0.2529 0.2634
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.052 0.0398
Schistosoma mansoni DNA helicase recq1 0.0023 0.0163 0.0012
Echinococcus multilocularis voltage gated potassium channel 0.0042 0.0443 0.0312
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0443 0.0296
Echinococcus granulosus sodium leak channel non selective protein 0.0042 0.0443 0.0312
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.052 0.0375
Leishmania major regulatory subunit of protein kinase a-like protein 0.0085 0.106 0.9946
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0443 0.0312
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0443 0.0312
Schistosoma mansoni voltage-gated potassium channel 0.0704 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.052 0.0398
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.0443 0.4158
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.052 0.0398
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0644 0.9144 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Brugia malayi N-terminal motif family protein 0.0085 0.106 0.1135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.0342 0.0339
Echinococcus multilocularis g protein coupled receptor 0.0048 0.052 0.0398
Schistosoma mansoni transient receptor potential channel 4 0.0042 0.0443 0.0296
Schistosoma mansoni hypothetical protein 0.0048 0.052 0.0375
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.052 0.0398
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0059 0.0686 0.0588
Trypanosoma cruzi Flagellar Member 6 0.0085 0.106 1
Brugia malayi voltage-dependent calcium channel 0.0042 0.0443 0.0458
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0442 0.0296
Echinococcus granulosus hypothetical protein 0.0048 0.052 0.0398
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0085 0.106 0.0923
Leishmania major protein kinase, putative 0.0085 0.1066 1
Leishmania major hypothetical protein, unknown function 0.0042 0.0443 0.3969
Echinococcus granulosus glycogen phosphorylase 0.0286 0.3966 0.4234
Echinococcus granulosus short transient receptor potential channel 6 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Entamoeba histolytica glycogen phosphorylase, putative 0.0286 0.3966 1
Echinococcus granulosus g protein coupled receptor 0.0048 0.052 0.0398
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.052 0.0534
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0163 0.0322
Onchocerca volvulus 0.0048 0.052 0.0178
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0127 0.1673 0.1545
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.052 0.0398
Brugia malayi AKH receptor 0.0048 0.052 0.0542
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.052 0.0375
Echinococcus granulosus cGMP dependent protein kinase 1 0.0085 0.1066 0.1005
Echinococcus multilocularis mitogen activated protein kinase 0.0042 0.0442 0.0311
Brugia malayi Cyclic-nucleotide gated cation channel 0.0127 0.1673 0.1807
Loa Loa (eye worm) hypothetical protein 0.0085 0.106 0.1127
Loa Loa (eye worm) RecQ helicase 0.0034 0.0321 0.0315
Schistosoma mansoni glycogen phosphorylase 0.0124 0.1618 0.149
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0442 0.0296
Treponema pallidum cyclic nucleotide binding protein 0.0085 0.106 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1914 0.2064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis g protein coupled receptor 0.0048 0.052 0.0398
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0187 0.2529 0.2634
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0443 0.0296
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0443 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Brugia malayi MAP kinase sur-1 0.0042 0.0442 0.0457
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) AGC/PKG protein kinase 0.0085 0.1066 0.1133
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0085 0.106 0.0999
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.2529 0.2414
Onchocerca volvulus 0.0343 0.4787 1
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.052 0.0398
Brugia malayi G-protein coupled receptor 0.0048 0.052 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.1066 0.0929
Brugia malayi olfactory channel protein osm-9 0.0042 0.0443 0.0458
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.052 0.0398
Toxoplasma gondii hypothetical protein 0.0042 0.0443 0.4158
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.052 0.0375
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0085 0.106 1
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0443 0.4158
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0085 0.106 0.0923
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0042 0.0443 0.0458
Echinococcus multilocularis neuropeptide receptor 0.0048 0.052 0.0398
Schistosoma mansoni hypothetical protein 0.0059 0.0686 0.0543
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0274 0.2345
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0042 0.0443 0.0296
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.052 0.0375
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0644 0.9144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.052 0.0398
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0274 0.0273
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0042 0.0443 0.0458
Schistosoma mansoni DNA helicase recq5 0.0023 0.0163 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.052 0.0398
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.052 0.0375
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0085 0.106 0.0999
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Loa Loa (eye worm) calcium channel 0.0042 0.0443 0.045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.052 0.0375
Entamoeba histolytica glycogen phosphorylase, putative 0.0124 0.1618 0.4081
Echinococcus granulosus cGMP dependent protein kinase 1 0.0085 0.1066 0.1005
Onchocerca volvulus 0.0048 0.052 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Onchocerca volvulus 0.0048 0.052 0.0178
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0085 0.106 0.0999
Onchocerca volvulus 0.0182 0.2468 0.4661
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0042 0.0443 0.0312
Echinococcus multilocularis serotonin receptor 0.0048 0.052 0.0398
Brugia malayi G protein-coupled receptor 0.0048 0.052 0.0542
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis potassium large conductance calcium activated 0.0042 0.0443 0.0312
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0274 0.0094
Schistosoma mansoni hypothetical protein 0.0085 0.106 0.0923
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0031 0.0274 0.0125
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0042 0.0442 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.052 0.0398
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.052 0.0398
Brugia malayi follicle stimulating hormone receptor 0.0048 0.052 0.0542
Schistosoma mansoni opsin-like receptor 0.0048 0.052 0.0375
Schistosoma mansoni biogenic amine receptor 0.0048 0.052 0.0375
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0042 0.0443 0.0312
Echinococcus multilocularis ubiquitin specific protease 41 0.0031 0.0274 0.0124
Trichomonas vaginalis adenylate cyclase type III, putative 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Loa Loa (eye worm) hypothetical protein 0.0343 0.4787 0.5217
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0085 0.106 0.0923
Loa Loa (eye worm) hypothetical protein 0.0031 0.0274 0.0264
Treponema pallidum catabolite gene activator (Crp) 0.0085 0.106 0.5
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0196 0.1571
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.052 0.0375
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0443 0.0312
Echinococcus multilocularis Glycosyl transferase, family 35 0.0286 0.3966 0.4234
Leishmania major hypothetical protein, conserved 0.0042 0.0443 0.3969
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0127 0.1673 0.1545
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.052 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Echinococcus multilocularis fmrfamide receptor 0.0048 0.052 0.0398
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Echinococcus multilocularis serotonin receptor 0.0048 0.052 0.0398
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0085 0.106 0.0999
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0042 0.0443 0.0296
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0342 0.0194
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Echinococcus multilocularis mitogen activated protein kinase 3 0.0042 0.0442 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0085 0.106 0.0999
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0085 0.106 0.0999
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0042 0.0443 0.0312
Echinococcus multilocularis bloom syndrome protein 0.0034 0.0321 0.0176
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0059 0.0686 0.0588
Schistosoma mansoni opsin-like receptor 0.0048 0.052 0.0375
Brugia malayi Cytochrome P450 family protein 0.0014 0.0034 0.0008
Loa Loa (eye worm) hypothetical protein 0.0343 0.4787 0.5217
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus cGMP dependent protein kinase 0.0085 0.1066 0.1005
Echinococcus granulosus Glycosyl transferase family 35 0.0286 0.3966 0.4234
Brugia malayi G-protein coupled receptor 0.0048 0.052 0.0542
Echinococcus granulosus mitogen activated protein kinase 3 0.0042 0.0442 0.0311
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.052 0.0398
Leishmania major protein kinase A regulatory subunit, putative 0.0085 0.106 0.9946
Schistosoma mansoni amine GPCR 0.0048 0.052 0.0375
Echinococcus granulosus potassium large conductance calcium activated 0.0042 0.0443 0.0312
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.052 0.0398
Schistosoma mansoni transient receptor potential channel 0.0042 0.0443 0.0296
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0443 0.0312
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0042 0.0443 0.399
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0644 0.9144 1
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.052 0.0398
Schistosoma mansoni ryanodine receptor related 0.0042 0.0443 0.0296
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0187 0.2529 0.2745
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0085 0.106 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Chlamydia trachomatis glycogen phosphorylase 0.0286 0.3966 1
Brugia malayi larval opioid receptor 0.0048 0.052 0.0542
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.052 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0127 0.1673 0.1681
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Mycobacterium ulcerans hypothetical protein 0.0085 0.106 0.648
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Onchocerca volvulus 0.0048 0.052 0.0178
Echinococcus granulosus sex peptide receptor 0.0048 0.052 0.0398
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.052 0.0398
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0085 0.106 0.0999
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.052 0.0542
Mycobacterium leprae Conserved hypothetical protein 0.0085 0.106 1
Plasmodium falciparum cGMP-dependent protein kinase 0.0085 0.1066 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0042 0.0443 0.0458
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0042 0.0442 0.3979
Echinococcus multilocularis voltage gated potassium channel 0.0187 0.2529 0.2634
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0142
Echinococcus multilocularis somatostatin receptor 0.0048 0.052 0.0398
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.052 0.0542
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0042 0.0443 0.0296
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0085 0.106 0.0923
Entamoeba histolytica glycogen phosphorylase, putative 0.0286 0.3966 1
Loa Loa (eye worm) glycogen phosphorylase 0.0286 0.3966 0.4316
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.052 0.0375
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.052 0.0375
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0085 0.106 0.1037
Leishmania major cyclic nucleotide-binding protein-like protein 0.0085 0.106 0.9946
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.052 0.0375
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0274 0.2345
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0443 0.0312
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0059 0.0686 0.0588
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0085 0.106 0.0923
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0443 0.045
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0127 0.1673 0.1545
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.052 0.0398
Echinococcus multilocularis orexin receptor type 2 0.0048 0.052 0.0398
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.052 0.0398
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.052 0.0534
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.052 0.0542
Echinococcus granulosus neuropeptide s receptor 0.0048 0.052 0.0398
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0042 0.0443 0.0458
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Treponema pallidum cyclic nucleotide binding protein 0.0085 0.106 0.5
Brugia malayi carbohydrate phosphorylase 0.0286 0.3966 0.4321
Echinococcus granulosus voltage gated hydrogen channel 1 0.0042 0.0443 0.0312
Trichomonas vaginalis DNA helicase recq, putative 0.0034 0.0321 0.015
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0124 0.1618 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Echinococcus multilocularis hyperpolarization activated cyclic 0.0127 0.1673 0.1681
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.052 0.0375
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0443 0.0296
Brugia malayi neuropeptide F receptor 0.0048 0.052 0.0542
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0274 0.0094
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0042 0.0443 0.0458
Trichomonas vaginalis adenylate cyclase type, putative 0.0059 0.0686 0.0588
Schistosoma mansoni lozenge 0.0043 0.0452 0.0306
Trichomonas vaginalis glycogen phosphorylase, putative 0.0286 0.3966 0.4523
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0133 0.0969
Echinococcus multilocularis hyperpolarization activated cyclic 0.0127 0.1673 0.1681
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.106 1
Onchocerca volvulus 0.0085 0.106 0.1421
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis Protein lozenge 0.0043 0.0452 0.0322
Brugia malayi cation channel family protein 0.0042 0.0443 0.0458
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0274 0.2345
Echinococcus multilocularis transfer RNA-Gly 0.0042 0.0443 0.0312
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.052 0.0398
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0085 0.106 1
Leishmania major hypothetical protein, conserved 0.0085 0.106 0.9946
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.052 0.0534
Echinococcus granulosus short transient receptor potential channel 6 0.0042 0.0443 0.0312
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0127 0.1673 0.1772
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.052 0.0398
Echinococcus granulosus microtubule associated protein 2 0.0573 0.8115 0.8854
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0443 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus granulosus sodium channel protein 0.0042 0.0443 0.0312
Brugia malayi Bloom's syndrome protein homolog 0.0034 0.0321 0.0324
Leishmania major hypothetical protein, unknown function 0.0085 0.106 0.9946
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.052 0.0398
Loa Loa (eye worm) voltage-gated potassium channel 0.0042 0.0443 0.045
Echinococcus granulosus single minded 2 0.0059 0.0686 0.0582
Schistosoma mansoni glycogen phosphorylase 0.0286 0.3966 0.3873
Schistosoma mansoni neuropeptide receptor 0.0048 0.052 0.0375
Leishmania major hypothetical protein, conserved 0.0021 0.0133 0.0964
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0085 0.106 0.0999
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0124 0.1618 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.0342 0.0347
Brugia malayi Transient-receptor-potential like protein 0.0042 0.0443 0.0458
Loa Loa (eye worm) hypothetical protein 0.0042 0.0443 0.045
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0443 0.0312
Trypanosoma brucei cAMP response protein 1, putative 0.0085 0.106 1
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0059 0.0686 0.0724
Echinococcus multilocularis transient receptor potential gamma protein 0.0042 0.0443 0.0312
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0085 0.1066 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0127 0.1673 0.18
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus multilocularis two pore calcium channel protein 2 0.0042 0.0443 0.0312
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.052 0.0542
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0085 0.106 0.1127
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.0443 0.4158
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0127 0.1673 0.1545
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0031 0.0274 0.0293
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0085 0.106 0.9948
Brugia malayi hypothetical protein 0.0343 0.4787 0.5221
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0085 0.106 0.9948
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0059 0.0686 0.0588
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0127 0.1673 0.1681
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.052 0.0534
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.052 0.0178
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0163 0.153
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0059 0.0686 0.0588
Schistosoma mansoni voltage-dependent calcium channel 0.0042 0.0443 0.0296
Schistosoma mansoni voltage-gated ion channel 0.0042 0.0443 0.0296
Schistosoma mansoni biogenic amine receptor 0.0048 0.052 0.0375
Brugia malayi Dopamine receptor protein 2 0.0048 0.052 0.0542
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0443 0.0312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0342 0.02
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.052 0.0398
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0085 0.1066 0.1005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0196 0.1579
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312
Entamoeba histolytica glycogenphosphorylase, putative 0.0124 0.1618 0.4081
Loa Loa (eye worm) runx1 0.0043 0.0452 0.0459
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0085 0.106 0.9941
Echinococcus granulosus g protein coupled receptor 0.0048 0.052 0.0398
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0163 0.0151
Onchocerca volvulus Glycogen phosphorylase homolog 0.0286 0.3966 0.811
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0085 0.106 0.0923
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0127 0.1673 0.1545
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.2529 0.2414
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.052 0.0398
Echinococcus granulosus calcium activated potassium channel 0.0043 0.0449 0.0318
Schistosoma mansoni microtubule-associated protein tau 0.0573 0.8115 0.8086
Brugia malayi sulfakinin receptor protein 0.0048 0.052 0.0542
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Mycobacterium ulcerans regulatory protein 0.0085 0.106 0.648
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.052 0.0542
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0127 0.1673 0.1681
Leishmania major hypothetical protein, conserved 0.0085 0.106 0.9946
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0127 0.1673 0.1772
Treponema pallidum catabolite gene activator 0.0085 0.106 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Echinococcus granulosus g protein coupled receptor 0.0048 0.052 0.0398
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0085 0.106 0.0923
Brugia malayi Dopamine receptor protein 1 0.0048 0.052 0.0542
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0059 0.0686 0.0588
Schistosoma mansoni transient receptor potential channel 0.0042 0.0443 0.0296
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0042 0.0443 0.399
Schistosoma mansoni voltage-gated potassium channel 0.0102 0.1299 0.1165
Mycobacterium ulcerans transcriptional regulatory protein 0.0085 0.106 0.648
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0042 0.0443 0.0312
Schistosoma mansoni voltage-gated cation channel 0.0042 0.0443 0.0296
Schistosoma mansoni neuropeptide receptor 0.0048 0.052 0.0375
Brugia malayi cation channel family protein 0.0042 0.0443 0.0458
Brugia malayi neuropeptide F receptor 0.0048 0.052 0.0542
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.052 0.0398
Echinococcus multilocularis expressed conserved protein 0.0085 0.1066 0.1005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0031 0.0274 0.0125
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0085 0.106 0.0923
Echinococcus granulosus g-protein coupled receptor 0.0048 0.052 0.0398
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0443 0.0312
Onchocerca volvulus 0.0048 0.052 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0085 0.106 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.052 0.0398
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.052 0.0375
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0119 0.1113
Brugia malayi GnHR receptor homolog 0.0048 0.052 0.0542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.052 0.0375
Trypanosoma cruzi cAMP binding protein, putative 0.0085 0.106 1
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0042 0.0443 0.0312
Mycobacterium ulcerans hypothetical protein 0.0085 0.106 0.648
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0042 0.0443 0.0458
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0042 0.0443 0.0458
Schistosoma mansoni neuropeptide receptor 0.0048 0.052 0.0375
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0127 0.1673 0.18
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.052 0.0375
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.052 0.0398
Trichomonas vaginalis adenylate cyclase, putative 0.0059 0.0686 0.0588
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.052 0.0375
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0059 0.0686 0.0588
Giardia lamblia Glycogen phosphorylase 0.0286 0.3966 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0042 0.0443 0.0296
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0042 0.0443 0.0458
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Mycobacterium ulcerans transmembrane transport protein 0.0085 0.106 0.648
Trichomonas vaginalis adenylate cyclase type, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.052 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0686 0.0588
Loa Loa (eye worm) hypothetical protein 0.0101 0.1296 0.1385
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.052 0.0398
Echinococcus multilocularis two pore calcium channel protein 1 0.0042 0.0443 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.1066 0.0929
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Trichomonas vaginalis adenylate cyclase type III, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.052 0.0398
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0163 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.052 0.0398
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0443 0.0312
Entamoeba histolytica glycogen phosphorylase, putative 0.0124 0.1618 0.4081
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0443 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0342 0.0194
Loa Loa (eye worm) hypothetical protein 0.0187 0.2529 0.2739
Echinococcus granulosus two pore calcium channel protein 2 0.0042 0.0443 0.0312
Echinococcus granulosus hyperpolarization activated cyclic 0.0127 0.1673 0.1681
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0443 0.0312
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0274 0.0124
Mycobacterium ulcerans hypothetical protein 0.0085 0.106 0.648
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0059 0.0686 0.0588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.052 0.0375
Echinococcus granulosus voltage gated potassium channel 0.0042 0.0443 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.0534
Echinococcus granulosus neuropeptide receptor 0.0048 0.052 0.0398
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.052 0.0398
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0085 0.106 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0127 0.1673 0.1681
Trypanosoma brucei protein kinase, putative 0.0042 0.0442 0.3979
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0443 0.0296
Echinococcus granulosus orexin receptor type 2 0.0048 0.052 0.0398
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0127 0.1673 0.1681
Brugia malayi hypothetical protein 0.0048 0.052 0.0542
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.052 0.0375
Trichomonas vaginalis guanylate cyclase, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0342 0.02
Brugia malayi hypothetical protein 0.0182 0.2468 0.2678
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0085 0.106 0.0923
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.052 0.0398
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0059 0.0686 0.0588
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.052 0.0398
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0443 0.0312

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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