Detailed information for compound 1307949

Basic information

Technical information
  • TDR Targets ID: 1307949
  • Name: N-[2-(4-methoxyphenyl)-1,3-benzoxazol-5-yl]-1 ,3-benzodioxole-5-carboxamide
  • MW: 388.373 | Formula: C22H16N2O5
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1oc2c(n1)cc(cc2)NC(=O)c1ccc2c(c1)OCO2
  • InChi: 1S/C22H16N2O5/c1-26-16-6-2-13(3-7-16)22-24-17-11-15(5-9-18(17)29-22)23-21(25)14-4-8-19-20(10-14)28-12-27-19/h2-11H,12H2,1H3,(H,23,25)
  • InChiKey: GZZGHLIGTODRRW-UHFFFAOYSA-N  


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Synonyms

  • Benzo[1,3]dioxole-5-carboxylic acid [2-(4-methoxy-phenyl)-benzooxazol-5-yl]-amide
  • MLS000033946
  • SMR000014582
  • TULIP020204
  • BAS 07437591
  • ZINC00809550

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.037
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0013 0.0045 0.0053
Leishmania major diacylglycerol kinase, putative 0.0013 0.0045 0.2163
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0208 0.0633
Echinococcus granulosus Diacylglycerol kinase zeta 0.0013 0.0045 0.0053
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0039 0.0046
Brugia malayi nuclear receptor NHR-88 0.0012 0.0039 0.014
Leishmania major hypothetical protein, conserved 0.0013 0.0045 0.2163
Onchocerca volvulus 0.0012 0.0039 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0045 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0208 0.0633
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8497 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0039 0.014
Trichomonas vaginalis diacylglycerol kinase, putative 0.0013 0.0045 1
Schistosoma mansoni sphingosine kinase A B 0.0328 0.3293 0.3876
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0134 1
Plasmodium vivax diacylglycerol kinase, putative 0.0013 0.0045 0.3368
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0013 0.0045 1
Leishmania major hypothetical protein, conserved 0.0013 0.0045 0.2163
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0039
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0633
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0039 0.0046
Entamoeba histolytica hypothetical protein 0.0043 0.0361 0.1096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0039 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0119
Schistosoma mansoni sphingoid long chain base kinase 0.0328 0.3293 0.3876
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0406
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0361 0.0425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0039
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0208 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.014
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0013 0.0045 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Trichomonas vaginalis bmru protein, putative 0.0013 0.0045 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 1
Plasmodium vivax diacylglycerol kinase, putative 0.0013 0.0045 0.3368
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0633
Echinococcus multilocularis sphingosine kinase 1 0.0328 0.3293 0.3293
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0046
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0045 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0039 0.1878
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0039 0.0046
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0045 0.0137
Echinococcus granulosus Diacylglycerol kinase theta 0.0013 0.0045 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0039 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.014
Entamoeba histolytica hypothetical protein 0.0043 0.0361 0.1096
Trypanosoma cruzi diacylglycerol kinase, putative 0.0013 0.0045 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0208 0.0633
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0137
Trypanosoma cruzi Sphingosine kinase 0.0013 0.0045 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.014
Brugia malayi diacylglycerol kinase 0.0013 0.0045 0.0161
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0045 0.0137
Schistosoma mansoni hypothetical protein 0.0013 0.0045 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.014
Entamoeba histolytica hypothetical protein 0.0043 0.0361 0.1096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0119
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0013 0.0045 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0361 0.0361
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0013 0.0045 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Brugia malayi hypothetical protein 0.0013 0.0045 0.0161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0039 0.0046
Brugia malayi Eye-specific diacylglycerol kinase 0.0013 0.0045 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0633
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0013 0.0045 0.0053
Trypanosoma cruzi diacylglycerol kinase, putative 0.0013 0.0045 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.014
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0633
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0013 0.0045 1
Schistosoma mansoni diacylglycerol kinase theta 0.0013 0.0045 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0039
Brugia malayi hypothetical protein 0.0043 0.0361 0.1292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0406
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0134 0.0406
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0633
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.037
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8497 0.8497
Echinococcus granulosus ceramide kinase 0.0013 0.0045 0.0053
Plasmodium falciparum diacylglycerol kinase, putative 0.0013 0.0045 0.3368
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0039 0.0046
Mycobacterium tuberculosis Diacylglycerol kinase 0.0013 0.0045 0.0137
Brugia malayi diacylglycerol kinase 0.0013 0.0045 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0406
Trypanosoma brucei Sphingosine kinase 0.0013 0.0045 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0134 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.014
Loa Loa (eye worm) ceramide kinase 0.0013 0.0045 0.0137
Trichomonas vaginalis sphingosine kinase, putative 0.0013 0.0045 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.3293 1
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0013 0.0045 0.0045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0039 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0039 0.014
Schistosoma mansoni hypothetical protein 0.0043 0.0361 0.0425
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Mycobacterium ulcerans diacylglycerol kinase 0.0013 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0633
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0039 0.0119
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0039 0.0039
Brugia malayi nuclear hormone receptor 0.0012 0.0039 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0745
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0039 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0745
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0208 0.0633
Entamoeba histolytica hypothetical protein 0.0043 0.0361 0.1096
Entamoeba histolytica hypothetical protein, conserved 0.0328 0.3293 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0013 0.0045 1
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0013 0.0045 1
Brugia malayi Diacylglycerol kinase protein 2 0.0013 0.0045 0.0161
Trichomonas vaginalis sphingosine kinase, putative 0.0013 0.0045 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.014
Toxoplasma gondii diacylglycerol kinase, putative 0.0013 0.0045 1
Echinococcus granulosus sphingosine kinase 1 0.0328 0.3293 0.3876
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2794 0.8486
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0039 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0045 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0013 0.0045 0.3368
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0039 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0046
Trypanosoma cruzi Sphingosine kinase 0.0013 0.0045 1
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0013 0.0045 0.0053
Mycobacterium tuberculosis Conserved protein 0.0328 0.3293 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0013 0.0045 0.2163
Echinococcus multilocularis ceramide kinase 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0745
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0208 0.0633
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0137
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0361 0.0425
Loa Loa (eye worm) diacylglycerol kinase 2 0.0013 0.0045 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0039 0.014
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0039 0.0119
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0045 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0039 0.1878
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0633
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0013 0.0045 0.0137
Trypanosoma brucei diacylglycerol kinase, putative 0.0013 0.0045 1
Brugia malayi Ceramide kinase 0.0013 0.0045 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0119
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0013 0.0045 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0013 0.0045 1
Onchocerca volvulus 0.0029 0.0208 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0208 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0119
Brugia malayi steroid hormone receptor 0.0012 0.0039 0.014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0208 0.0633
Mycobacterium ulcerans hypothetical protein 0.0328 0.3293 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0039 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Trichomonas vaginalis bmru protein, putative 0.0013 0.0045 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0137
Onchocerca volvulus 0.0013 0.0045 0.2163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.014
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8497 1
Brugia malayi ecdysteroid receptor 0.0012 0.0039 0.014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0119
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0039 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0039
Leishmania major sphingosine kinase A, B, putative 0.0013 0.0045 0.2163
Entamoeba histolytica diacylglycerol kinase, putative 0.0013 0.0045 0.0137
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0013 0.0045 1
Leishmania major diacylglycerol kinase-like protein 0.0013 0.0045 0.2163
Schistosoma mansoni coup transcription factor 0.0012 0.0039 0.0046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0134 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0039 0.0046
Brugia malayi follicle stimulating hormone receptor 0.028 0.2794 1
Echinococcus multilocularis Diacylglycerol kinase theta 0.0013 0.0045 0.0045
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0039 0.1878
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0039 0.0046
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0013 0.0045 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 0.5623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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