Detailed information for compound 1315254

Basic information

Technical information
  • TDR Targets ID: 1315254
  • Name: N-(4-phenyl-1,3-thiazol-2-yl)-3-(trifluoromet hyl)benzenesulfonamide
  • MW: 384.396 | Formula: C16H11F3N2O2S2
  • H donors: 1 H acceptors: 3 LogP: 4.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1cccc(c1)C(F)(F)F)Nc1scc(n1)c1ccccc1
  • InChi: 1S/C16H11F3N2O2S2/c17-16(18,19)12-7-4-8-13(9-12)25(22,23)21-15-20-14(10-24-15)11-5-2-1-3-6-11/h1-10H,(H,20,21)
  • InChiKey: FWTCQPYLOXTLML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-phenylthiazol-2-yl)-3-(trifluoromethyl)benzenesulfonamide
  • N-(4-phenyl-2-thiazolyl)-3-(trifluoromethyl)benzenesulfonamide
  • T5384011
  • ZINC06623185

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase rad3, putative 0.0217 0.1746 0.1746
Echinococcus granulosus serine protein kinase ATM 0.0217 0.1746 0.1746
Entamoeba histolytica hypothetical protein 0.0148 0.1131 0.1131
Leishmania major phosphatidylinositol 3-kinase, putative 0.0085 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0478 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0383 0.3235 0.3235
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0105 0.0738 0.0738
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0905 0.7926 0.7926
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0085 0.0564 0.0762
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0104 0.0733 0.0733
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0085 0.0564 0.0564
Toxoplasma gondii FATC domain-containing protein 0.0217 0.1746 0.2363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0478 0.0478
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0104 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0141 0.1064 0.1064
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0478 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0108 0.0108
Echinococcus multilocularis protein kinase shaggy 0.0104 0.0733 0.0733
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.0478 0.0478
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0457 0.0457
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0076 0.0478 0.0646
Onchocerca volvulus 0.0104 0.0733 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0076 0.0478 0.0478
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0119 0.0864 0.0864
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0217 0.1746 0.1746
Loa Loa (eye worm) hypothetical protein 0.0134 0.1004 0.1004
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0095 0.0652 0.0652
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0085 0.0564 0.7684
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0478 0.6515
Loa Loa (eye worm) hypothetical protein 0.0166 0.1284 0.1284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0613 0.5309 0.5309
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.1746 0.1746
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0076 0.0478 0.0478
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0168 0.1304 0.1304
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0241 0.1966 0.266
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0217 0.1746 0.1746
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0138 0.1038 0.1038
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0076 0.0478 0.6515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0478 0.0478
Leishmania major phosphatidylinositol 3-kinase, putative 0.0383 0.3235 0.3235
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0076 0.0478 0.6515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.5843 0.5843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.7917 0.7917
Leishmania major phosphatidylinositol kinase, putative 0.0076 0.0478 0.0478
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0383 0.3235 0.3235
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0076 0.0478 0.0478
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0076 0.0478 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0105 0.0738 0.0738
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0478 0.0478
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0217 0.1746 0.1746
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.6515
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0217 0.1746 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.7917 0.7917
Giardia lamblia Phosphatidylinositol 4-kinase 0.0076 0.0478 0.0478
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0166 0.1284 0.1284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0076 0.0478 0.0478
Schistosoma mansoni cpg binding protein 0.0037 0.0125 0.0125
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0085 0.0564 0.7684
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0104 0.0733 0.0733
Giardia lamblia Kinase, CMGC GSK 0.0104 0.0733 0.0733
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0076 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0614 0.5317 0.5317
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4235 0.4235
Schistosoma mansoni hypothetical protein 0.0494 0.4235 0.4235
Entamoeba histolytica hypothetical protein 0.0076 0.0478 0.0478
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0168 0.1304 0.1304
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.0478
Schistosoma mansoni cpg binding protein 0.0037 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.6649 0.6649
Brugia malayi FAT domain containing protein 0.0166 0.1284 0.1284
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.0478
Loa Loa (eye worm) phosphatidylinositol kinase 0.0076 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0613 0.5309 0.5309
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0473 0.4049 0.4049
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0083 0.0546 0.0546
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0538 0.4635 0.4635
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0076 0.0478 0.0478
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0383 0.3235 0.3235
Entamoeba histolytica protein kinase, putative 0.0104 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0076 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0614 0.5317 0.5317
Schistosoma mansoni hypothetical protein 0.0166 0.1284 0.1284
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0085 0.0564 0.0564
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0733 0.0733
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0383 0.3235 0.3235
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0085 0.0564 0.0564
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0085 0.0564 0.0564
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0105 0.0738 0.0738
Plasmodium vivax hypothetical protein 0.0076 0.0478 0.6515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.1064 0.1064
Leishmania major phosphatidylinositol kinase related protein, putative 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0115 0.083 0.083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0217 0.1746 0.1746
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0076 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.6429 0.6429
Schistosoma mansoni fkbp-rapamycin associated protein 0.0217 0.1746 0.1746
Echinococcus granulosus cpg binding protein 0.0037 0.0125 0.0125
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0029 0.0056 0.0056
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0217 0.1746 0.1746
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0076 0.0478 0.6515
Trichomonas vaginalis PIKK family atypical protein kinase 0.097 0.8512 0.8512
Giardia lamblia Kinase, CMGC GSK 0.0104 0.0733 0.0733
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0076 0.0478 0.0646
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0733 0.0733
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0085 0.0564 0.0564
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0104 0.0733 0.0992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.1746 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Plasmodium vivax glycogen synthase kinase 3, putative 0.0104 0.0733 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0478 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0383 0.3235 0.3235
Loa Loa (eye worm) hypothetical protein 0.0231 0.187 0.187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3235 0.3235
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0251 0.2055 0.2055
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0251 0.2055 0.2055
Leishmania major hypothetical protein, conserved 0.0076 0.0478 0.0478
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0168 0.1304 0.1304
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0905 0.7926 0.7926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.1746 0.1746
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0085 0.0564 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.1746 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0614 0.5317 0.5317
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0148 0.1131 0.1131
Loa Loa (eye worm) phosphatidylinositol 3 0.0383 0.3235 0.3235
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0085 0.0564 0.0564
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0733 0.0733
Leishmania major phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0307 0.2552 0.2552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0168 0.1304 0.1304
Brugia malayi intracellular kinase 0.0104 0.0733 0.0733
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0105 0.0738 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5903 0.5903
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0076 0.0478 0.0478
Leishmania major hypothetical protein, unknown function 0.0076 0.0478 0.0478
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0168 0.1304 0.1304
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0076 0.0478 0.0478
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.0478
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0085 0.0564 0.0762
Entamoeba histolytica hypothetical protein 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0105 0.0738 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0613 0.5309 0.5309
Echinococcus multilocularis cpg binding protein 0.0037 0.0125 0.0125
Toxoplasma gondii target of rapamycin (TOR), putative 0.0845 0.7392 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0168 0.1304 0.1304
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.1004 0.1004
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0383 0.3235 0.3235
Entamoeba histolytica hypothetical protein 0.0076 0.0478 0.0478
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0383 0.3235 0.3235
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0076 0.0478 0.6515
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0105 0.0738 0.0738
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0134 0.1004 0.1004
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0056 0.0056
Trypanosoma brucei protein kinase, putative 0.0104 0.0733 0.0733
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0076 0.0478 0.0646
Schistosoma mansoni cpg binding protein 0.0035 0.0108 0.0108
Onchocerca volvulus 0.0076 0.0478 0.5916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3235 0.3235
Schistosoma mansoni hypothetical protein 0.0076 0.0478 0.0478
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0105 0.0738 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5903 0.5903
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0085 0.0564 0.0564
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0166 0.1284 0.1284
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0383 0.3235 0.3235
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0085 0.0564 0.0564
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0141 0.1064 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.7392 0.7392
Brugia malayi CXXC zinc finger family protein 0.0035 0.0108 0.0108
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0076 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0085 0.0564 0.0564
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0085 0.0564 0.0564
Plasmodium falciparum glycogen synthase kinase 3 0.0104 0.0733 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.7917 0.7917
Loa Loa (eye worm) hypothetical protein 0.0241 0.1966 0.1966
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0733 0.0733
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0105 0.0738 0.0738
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0076 0.0478 0.0478
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0733 0.0733
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0085 0.0564 0.0564
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0383 0.3235 0.3235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.5843 0.5843
Echinococcus multilocularis Zinc finger, PHD finger 0.0085 0.0564 0.0564
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0138 0.1038 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3235 0.3235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0614 0.5317 0.5317
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0092 0.0623 0.0623
Echinococcus granulosus protein kinase shaggy 0.0104 0.0733 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.7917 0.7917
Echinococcus multilocularis 0.0076 0.0478 0.0478
Onchocerca volvulus 0.0076 0.0478 0.5916
Echinococcus multilocularis serine protein kinase ATM 0.0217 0.1746 0.1746
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0085 0.0564 0.0564
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.1746 0.1746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3235 0.3235
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0104 0.0733 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.5903 0.5903
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0085 0.0564 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1284 0.1284
Giardia lamblia Hypothetical protein 0.0076 0.0478 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.1966 0.1966
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0168 0.1304 0.1304
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0076 0.0478 0.0478
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0386 0.0523
Entamoeba histolytica hypothetical protein 0.0217 0.1746 0.1746
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0085 0.0564 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.3235 0.3235
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0076 0.0478 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.0478 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.0232 0.1881 0.1881
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0105 0.0738 0.0738
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.0478 0.0478
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0478 0.0478
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0085 0.0564 0.0564
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0134 0.1004 0.1004
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0217 0.1746 0.1746
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4235 0.4235
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1064 0.1064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0904 0.7917 0.7917
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0217 0.1746 0.1746
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0733 0.0733
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0251 0.2055 0.2055
Trypanosoma cruzi target of rapamycin kinase 3 0.0905 0.7926 0.7926
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0104 0.0733 0.0733

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5323 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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