Detailed information for compound 1338545

Basic information

Technical information
  • TDR Targets ID: 1338545
  • Name: 3-(3-acetylphenyl)-1-[1-[(2,4-dichlorophenyl) methyl]pyrazol-4-yl]urea
  • MW: 403.262 | Formula: C19H16Cl2N4O2
  • H donors: 2 H acceptors: 3 LogP: 3.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cnn(c1)Cc1ccc(cc1Cl)Cl)Nc1cccc(c1)C(=O)C
  • InChi: 1S/C19H16Cl2N4O2/c1-12(26)13-3-2-4-16(7-13)23-19(27)24-17-9-22-25(11-17)10-14-5-6-15(20)8-18(14)21/h2-9,11H,10H2,1H3,(H2,23,24,27)
  • InChiKey: FNDRFDTUZWUUER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-acetylphenyl)-1-[1-[(2,4-dichlorophenyl)methyl]-4-pyrazolyl]urea
  • 3-(3-acetylphenyl)-1-[1-(2,4-dichlorobenzyl)pyrazol-4-yl]urea
  • 1-[1-[(2,4-dichlorophenyl)methyl]pyrazol-4-yl]-3-(3-ethanoylphenyl)urea
  • ZINC02858454
  • MLS000537698
  • N-(3-acetylphenyl)-N'-[1-(2,4-dichlorobenzyl)-1H-pyrazol-4-yl]urea
  • SMR000143935
  • IVK/1639749

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0024 0.004
Leishmania major C-8 sterol isomerase-like protein 0.0103 0.0525 0.9291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0055 0.0214 0.0661
Echinococcus granulosus neuropeptide receptor A26 0.0582 0.3676 0.609
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Schistosoma mansoni amine GPCR 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi SWIRM domain containing protein 0.0109 0.0565 0.1742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.006 0.0099
Schistosoma mansoni glycogen phosphorylase 0.0516 0.3246 0.5377
Loa Loa (eye worm) sodium/hydrogen exchanger 0.0037 0.0095 0.0294
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0037 0.0095 0.0158
Schistosoma mansoni hypothetical protein 0.0026 0.0024 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Entamoeba histolytica hypothetical protein 0.0043 0.0136 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0031 0.0053 0.0057
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0024 0.004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0024 0.004
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0063 0.0265 0.0439
Trypanosoma cruzi UDP-galactopyranose mutase 0.0109 0.0565 1
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) glutamate receptor 1 0.0047 0.0157 0.0483
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0024 0.004
Echinococcus granulosus glycogen phosphorylase 0.0516 0.3246 0.5377
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0214 0.0355
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0109 0.0565 0.0937
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0144 0.0238
Echinococcus multilocularis neuropeptide receptor A26 0.0582 0.3676 0.609
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0037 0.0095 0.0158
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0031 0.0053 0.0053
Brugia malayi Serotonin receptor 0.0289 0.1748 0.5386
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.0073 0.1294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0026 0.0024 0.004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0103 0.0525 0.9291
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0118 0.0625 0.1036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0023
Echinococcus multilocularis neuropeptide s receptor 0.0582 0.3676 0.609
Brugia malayi RE15519p 0.0026 0.0024 0.0075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0026 0.0024 0.004
Echinococcus granulosus fmrfamide receptor 0.0026 0.0024 0.004
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis serotonin receptor 0.0096 0.0481 0.0796
Toxoplasma gondii histone lysine-specific demethylase 0.0109 0.0565 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi larval opioid receptor 0.0026 0.0024 0.0075
Brugia malayi Glutamate receptor 2 precursor 0.0047 0.0157 0.0483
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0024 0.004
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0565 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.0073 0.1294
Echinococcus granulosus glycogen phosphorylase 0.0516 0.3246 0.5377
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0024 0.0075
Schistosoma mansoni sodium/hydrogen exchanger 0.0037 0.0095 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.006 0.0099
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0024 0.004
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0109 0.0565 0.0937
Echinococcus multilocularis 0.0109 0.0565 0.0937
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0024 0.004
Schistosoma mansoni glutamate receptor NMDA 0.0127 0.0686 0.1137
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0136 0.0226
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0024 0.0075
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0024 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0032 0.006 0.0184
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.003 0.0049 0.0081
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0109 0.0565 1
Brugia malayi Serotonin receptor 0.0026 0.0024 0.0075
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0024 0.004
Echinococcus granulosus glutamate receptor NMDA 0.0068 0.0297 0.0492
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.0037 0.0095 0.0158
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0024 0.004
Echinococcus multilocularis sex peptide receptor 0.0026 0.0024 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus granulosus nmda type glutamate receptor 0.0081 0.038 0.063
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0214 0.0355
Schistosoma mansoni opsin-like receptor 0.0026 0.0024 0.004
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0024 0.004
Echinococcus granulosus sex peptide receptor 0.0026 0.0024 0.004
Brugia malayi MAP kinase sur-1 0.0034 0.0073 0.0225
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0294
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0798 0.246
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0024 0.0075
Entamoeba histolytica hypothetical protein 0.0043 0.0136 0.042
Onchocerca volvulus Glycogen phosphorylase homolog 0.0516 0.3246 1
Onchocerca volvulus 0.0109 0.0565 0.168
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Echinococcus multilocularis mitogen activated protein kinase 0.0034 0.0073 0.0121
Echinococcus multilocularis glycogen phosphorylase 0.0516 0.3246 0.5377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0024 0.004
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0223 0.1319 0.142
Brugia malayi hypothetical protein 0.0192 0.111 0.3419
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0024 0.004
Echinococcus granulosus neuropeptide s receptor 0.0582 0.3676 0.609
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0109 0.0565 0.0937
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0798 0.246
Echinococcus granulosus g protein coupled receptor 0.0026 0.0024 0.004
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0226
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0024 0.004
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.003 0.0049 0.0081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.0565 0.0609
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0034 0.0073 0.1294
Loa Loa (eye worm) hypothetical protein 0.0096 0.0481 0.148
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0063 0.0265 0.0439
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0024 0.0075
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0024 0.004
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0144 0.2545
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0144 0.0238
Brugia malayi carbohydrate phosphorylase 0.0516 0.3246 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0059 0.024 0.0398
Echinococcus granulosus lysine specific histone demethylase 1A 0.0109 0.0565 0.0937
Brugia malayi AKH receptor 0.0026 0.0024 0.0075
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0034 0.0073 0.1294
Schistosoma mansoni hypothetical protein 0.0026 0.0024 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0024 0.004
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0157 0.026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0157 0.026
Echinococcus multilocularis glutamate receptor 2 0.0059 0.024 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0024 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0024 0.004
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0144 0.274
Entamoeba histolytica hypothetical protein 0.0043 0.0136 0.042
Brugia malayi Dopamine receptor 0.0026 0.0024 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus granulosus somatostatin receptor 0.0026 0.0024 0.004
Brugia malayi hypothetical protein 0.0043 0.0136 0.042
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0037 0.0095 0.0158
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0032 0.006 0.0184
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Mycobacterium ulcerans oxidoreductase 0.0109 0.0565 0.0565
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1544 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0024 0.004
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1435 0.9285 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0024 0.0075
Plasmodium falciparum protoporphyrinogen oxidase 0.0109 0.0565 1
Echinococcus granulosus geminin 0.0118 0.0625 0.1036
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Brugia malayi Dopamine receptor protein 2 0.0026 0.0024 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.006 0.0099
Schistosoma mansoni adenoreceptor 0.0026 0.0024 0.004
Echinococcus multilocularis conserved hypothetical protein 0.0393 0.2437 0.4036
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0034 0.0073 0.1393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Echinococcus multilocularis NMDA receptor 0.0025 0.0014 0.0023
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0059 0.024 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi Glutamate receptor 1 precursor 0.0047 0.0157 0.0483
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0157 0.026
Echinococcus multilocularis sodium:hydrogen exchanger 0.0037 0.0095 0.0158
Schistosoma mansoni glycogen phosphorylase 0.0516 0.3246 0.5377
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0024 0.004
Schistosoma mansoni amine oxidase 0.0109 0.0565 0.0937
Echinococcus granulosus mitogen activated protein kinase 0.0034 0.0073 0.0121
Mycobacterium tuberculosis Possible oxidoreductase 0.0109 0.0565 0.0609
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.0481 0.0796
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0109 0.0565 0.0565
Brugia malayi Stress-activated protein kinase jnk-1 0.0152 0.085 0.2618
Loa Loa (eye worm) hypothetical protein 0.0103 0.0525 0.1618
Echinococcus granulosus glutamate NMDA receptor subunit 0.0183 0.1056 0.1749
Schistosoma mansoni hypothetical protein 0.0118 0.0625 0.1036
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0183 0.1056 0.1749
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0037 0.0095 0.0158
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0109 0.0565 1
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.0073 0.0225
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0024 0.0075
Echinococcus multilocularis mitogen activated protein kinase 3 0.0034 0.0073 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0025 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Entamoeba histolytica glycogen phosphorylase, putative 0.0223 0.1319 0.4063
Echinococcus multilocularis sodium:hydrogen exchanger 0.0037 0.0095 0.0158
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0024 0.004
Mycobacterium ulcerans monoamine oxidase 0.0109 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Trypanosoma brucei C-8 sterol isomerase, putative 0.0103 0.0525 1
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0031 0.0053 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.024 0.0398
Echinococcus multilocularis somatostatin receptor 0.0026 0.0024 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Brugia malayi STAT protein, DNA binding domain containing protein 0.0062 0.0258 0.0794
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0077 0.0128
Echinococcus multilocularis geminin 0.0118 0.0625 0.1036
Schistosoma mansoni glycogen phosphorylase 0.0223 0.1319 0.2184
Trichomonas vaginalis glycogen phosphorylase, putative 0.0516 0.3246 1
Schistosoma mansoni amine oxidase 0.0109 0.0565 0.0937
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0025 0.0014 0.0023
Echinococcus multilocularis serotonin receptor 0.0096 0.0481 0.0796
Schistosoma mansoni amine GPCR 0.0026 0.0024 0.004
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0024 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.0073 0.0225
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0024 0.004
Schistosoma mansoni glutamate receptor NMDA 0.0183 0.1056 0.1749
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0063 0.0265 0.4684
Echinococcus granulosus sodium:hydrogen exchanger 0.0037 0.0095 0.0158
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0034 0.0073 0.1294
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.024 0.0398
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0055 0.0214 0.0661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.006 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.006 0.0099
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0025 0.0014 0.0023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0024 0.0075
Brugia malayi putative neuropeptide receptor 0.0026 0.0024 0.0075
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0109 0.0565 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0024 0.004
Schistosoma mansoni inositol monophosphatase 0.0045 0.0144 0.0238
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0136 0.0226
Schistosoma mansoni microtubule-associated protein tau 0.0941 0.6037 1
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni neuropeptide receptor 0.0026 0.0024 0.004
Schistosoma mansoni amine GPCR 0.0026 0.0024 0.004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0144 0.2545
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0024 0.004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0024 0.004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.0481 0.0796
Schistosoma mansoni myosin xvIII 0.0026 0.0024 0.004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0024 0.004
Entamoeba histolytica glycogen phosphorylase, putative 0.0223 0.1319 0.4063
Schistosoma mansoni histamine h1 receptor 0.0026 0.0024 0.004
Brugia malayi GnHR receptor homolog 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Giardia lamblia Sodium/hydrogen exchanger 3 0.0037 0.0095 0.0294
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0024 0.004
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0034 0.0073 0.0225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0024 0.0075
Echinococcus granulosus mitogen activated protein kinase 3 0.0034 0.0073 0.0121
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0024 0.0075
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0063 0.0265 0.0816
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus lysine specific histone demethylase 1A 0.0109 0.0565 0.0937
Echinococcus multilocularis nmda type glutamate receptor 0.0081 0.038 0.063
Brugia malayi G protein-coupled receptor 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0152 0.085 0.2618
Loa Loa (eye worm) glutamate receptor 2 0.0047 0.0157 0.0483
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0024 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0024 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0024 0.004
Brugia malayi MH2 domain containing protein 0.0144 0.0798 0.246
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0024 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0024 0.004
Echinococcus granulosus glutamate receptor 2 0.0034 0.0077 0.0128
Echinococcus granulosus neuropeptide receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0024 0.0075
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0024 0.004
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0037 0.0095 0.0158
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0024 0.004
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0025 0.0014 0.0023
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0157 0.026
Entamoeba histolytica glycogen phosphorylase, putative 0.0516 0.3246 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0024 0.004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0063 0.0265 0.0439
Loa Loa (eye worm) hypothetical protein 0.0109 0.0565 0.1742
Echinococcus granulosus glutamate receptor subunit protein glur 0.0025 0.0014 0.0023
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0056 0.0216 0.0358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.006 0.0099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0136 0.0226
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0144 0.0443
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0063 0.0265 0.0816
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0144 0.0443
Schistosoma mansoni amine GPCR 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus sodium:hydrogen exchanger 0.0037 0.0095 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0024 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0024 0.0075
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0037 0.0095 0.0221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0294
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi Dopamine receptor protein 1 0.0026 0.0024 0.0075
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0157 0.026
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0144 0.0443
Brugia malayi Melatonin receptor type 1A 0.0026 0.0024 0.0075
Brugia malayi neuropeptide F receptor 0.0026 0.0024 0.0075
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0109 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0024 0.0075
Schistosoma mansoni neuropeptide receptor 0.0026 0.0024 0.004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0034 0.0073 0.1294
Leishmania major UDP-galactopyranose mutase 0.0109 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0109 0.0565 1
Giardia lamblia Glycogen phosphorylase 0.0516 0.3246 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0024 0.004
Schistosoma mansoni opsin-like receptor 0.0026 0.0024 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0059 0.024 0.0398
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis Glycosyl transferase, family 35 0.0516 0.3246 0.5377
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0152 0.085 0.1408
Echinococcus granulosus nmda type glutamate receptor 0.0123 0.0662 0.1097
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0063 0.0265 0.0439
Schistosoma mansoni amine GPCR 0.0026 0.0024 0.004
Chlamydia trachomatis glycogen phosphorylase 0.0516 0.3246 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0024 0.004
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0024 0.004
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0024 0.004
Echinococcus granulosus g protein coupled receptor 0.0026 0.0024 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0024 0.0075
Brugia malayi Inositol-1 0.0045 0.0144 0.0443
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0024 0.004
Trypanosoma brucei protein kinase, putative 0.0034 0.0073 0.1393
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0024 0.004
Schistosoma mansoni ATP-binding cassette transporter 0.0047 0.0157 0.026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.0941 0.6037 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni biogenic amine receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus microtubule associated protein 2 0.0941 0.6037 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0024 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.085 0.1408
Echinococcus granulosus Glycosyl transferase family 35 0.0516 0.3246 0.5377
Brugia malayi hypothetical protein 0.0109 0.0565 0.1742
Loa Loa (eye worm) hypothetical protein 0.0192 0.111 0.3419
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0063 0.0265 0.0439
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0037 0.0095 0.0158
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0024 0.004
Echinococcus multilocularis glycogen phosphorylase 0.0516 0.3246 0.5377
Loa Loa (eye worm) hypothetical protein 0.0096 0.0481 0.148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus orexin receptor type 2 0.0026 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Trichomonas vaginalis glycogen phosphorylase, putative 0.0516 0.3246 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.024 0.0398
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0024 0.0075
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0034 0.0073 0.1294
Echinococcus granulosus allatostatin A receptor 0.0026 0.0024 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.006 0.0099
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0037 0.0095 0.0294
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0157 0.026
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0024 0.0075
Loa Loa (eye worm) glycogen phosphorylase 0.0516 0.3246 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0024 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.0073 0.0225
Echinococcus multilocularis glutamate receptor NMDA 0.0068 0.0297 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0024 0.004
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0109 0.0565 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0024 0.004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0144 0.2545
Entamoeba histolytica hypothetical protein 0.0043 0.0136 0.042
Brugia malayi sulfakinin receptor protein 0.0192 0.111 0.3419
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0024 0.0075
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0024 0.004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0144 0.2545
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0024 0.004
Schistosoma mansoni neuropeptide receptor 0.0026 0.0024 0.004
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus c-Jun N-terminal kinases 0.0152 0.085 0.1408
Echinococcus multilocularis protoporphyrinogen oxidase 0.0109 0.0565 0.0937
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0024 0.004
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0037 0.0095 0.0221
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0037 0.0095 0.0221
Brugia malayi amine oxidase, flavin-containing family protein 0.0109 0.0565 0.1742
Schistosoma mansoni inositol monophosphatase 0.0045 0.0144 0.0238
Echinococcus granulosus glutamate receptor 2 0.0059 0.024 0.0398
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0024 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0024 0.004
Giardia lamblia Kinase, CMGC MAPK 0.0034 0.0073 0.0225
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.024 0.0398
Echinococcus granulosus serotonin receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) inositol-1 0.0045 0.0144 0.0443
Brugia malayi G-protein coupled receptor 0.0026 0.0024 0.0075
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0103 0.0525 0.1618
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0024 0.004
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0024 0.004
Brugia malayi neuropeptide F receptor 0.0026 0.0024 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.0073 0.0225
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0025 0.0014 0.0023
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0024 0.0075
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0059 0.024 0.0398
Echinococcus granulosus hypothetical protein 0.042 0.261 0.4324
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0223 0.1319 0.1319
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0024 0.004
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0024 0.004
Brugia malayi G-protein coupled receptor 0.0026 0.0024 0.0075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0024 0.0075
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0024 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0024 0.004
Chlamydia trachomatis protoporphyrinogen oxidase 0.0109 0.0565 0.1605
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0024 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0024 0.004
Entamoeba histolytica glycogenphosphorylase, putative 0.0223 0.1319 0.4063
Mycobacterium ulcerans dehydrogenase 0.0109 0.0565 0.0565
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0031 0.0053 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0113 0.0122
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0024 0.004
Trypanosoma cruzi UDP-galactopyranose mutase 0.0109 0.0565 1
Echinococcus granulosus neuropeptide receptor 0.0026 0.0024 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0024 0.004
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0073 0.0121
Schistosoma mansoni biogenic amine receptor 0.0026 0.0024 0.004
Loa Loa (eye worm) STAT protein 0.0062 0.0258 0.0794
Echinococcus multilocularis nmda type glutamate receptor 0.0123 0.0662 0.1097
Loa Loa (eye worm) NHE-3 0.0037 0.0095 0.0294
Entamoeba histolytica glycogen phosphorylase, putative 0.0516 0.3246 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0024 0.004
Brugia malayi hypothetical protein 0.0026 0.0024 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0075
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0144 0.0443
Brugia malayi ORL1-like opioid receptor 0.0026 0.0024 0.0075
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0025 0.0014 0.0023
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.0037 0.0095 0.0294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0294

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0028 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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