Detailed information for compound 1346203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.537 | Formula: C24H33N3O4
  • H donors: 2 H acceptors: 2 LogP: 3.28 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)C(=O)NCC(=O)NCC(c1ccco1)N1CCCCC1
  • InChi: 1S/C24H33N3O4/c1-2-3-15-30-20-11-9-19(10-12-20)24(29)26-18-23(28)25-17-21(22-8-7-16-31-22)27-13-5-4-6-14-27/h7-12,16,21H,2-6,13-15,17-18H2,1H3,(H,25,28)(H,26,29)
  • InChiKey: FVWMYIFEQVVRDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0028 0.03 0.0598
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0532 0.4318
Loa Loa (eye worm) patched family protein 0.0006 0.0018 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0532 0.6716
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0214
Echinococcus granulosus hypothetical protein 0.0026 0.0281 0.056
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0468 0.086
Echinococcus granulosus nibrin 0.001 0.0066 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0214
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0151 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Brugia malayi hypothetical protein 0.001 0.0066 0.0121
Toxoplasma gondii cathepsin CPL 0.0016 0.0151 0.1968
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0116 0.0801
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0016 0.0151 0.0278
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1184 0.236
Treponema pallidum DNA ligase (lig) 0.001 0.0066 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) hypothetical protein 0.005 0.0586 0.1077
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.0116 0.0801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0402 0.3152
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0023
Onchocerca volvulus 0.0013 0.0116 0.0214
Brugia malayi hypothetical protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Brugia malayi Cathepsin L-like precursor 0.0011 0.0083 0.0152
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0013 0.0116 0.0397
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0151 0.3657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.007 0.0128
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0054 0.0099
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0051 0.053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0359 0.4413
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1689 0.3366
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0402 0.539
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0066 0.0121
Onchocerca volvulus Protein patched homolog 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0468 0.0932
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0151 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0532 0.727
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1791 0.3294
Loa Loa (eye worm) tumor suppressor 0.0311 0.3932 0.7232
Loa Loa (eye worm) hypothetical protein 0.0041 0.0468 0.086
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0532 0.7385
Plasmodium vivax vivapain-1 0.0008 0.0051 0.1034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0051 0.0593
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0013 0.0116 0.0397
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0402 0.8513
Loa Loa (eye worm) hypothetical protein 0.0095 0.1165 0.2142
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0359 0.4413
Brugia malayi cathepsin F-like cysteine proteinase 0.0005 0.0012 0.0023
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0402 0.8513
Onchocerca volvulus 0.0016 0.0151 0.0278
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.0116 0.0801
Echinococcus granulosus cpg binding protein 0.0029 0.032 0.0638
Echinococcus multilocularis cathepsin L 0.0008 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0281 0.0517
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.0116 0.0801
Echinococcus granulosus cathepsin L 0.0008 0.0051 0.0101
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0066 0.0708
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0151 0.0151
Brugia malayi hypothetical protein 0.0429 0.5437 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0151 0.0278
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0697 0.1389
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0051 0.0101
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0354 0.618
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0051 0.0093
Leishmania major cathepsin L-like protease 0.0016 0.0151 0.0566
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0532 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0012 0.0023
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0697 0.0697
Entamoeba histolytica hypothetical protein 0.001 0.0066 0.0136
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0151 0.3657
Mycobacterium ulcerans hypothetical protein 0.0046 0.0532 0.7385
Loa Loa (eye worm) cysteine protease 0.0016 0.0151 0.0278
Echinococcus multilocularis nibrin 0.001 0.0066 0.0066
Brugia malayi tumor suppressor. 0.0311 0.3932 0.7232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0116 0.0397
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0013 0.0116 0.0232
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi DKFZp564C0469 protein 0.001 0.0066 0.0121
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0359 0.4413
Echinococcus granulosus expressed conserved protein 0.009 0.1091 0.2174
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0383 1
Brugia malayi hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0151 0.0278
Echinococcus granulosus smad 0.001 0.007 0.0139
Brugia malayi MH1 domain containing protein 0.0005 0.0013 0.0025
Echinococcus multilocularis smad 0.001 0.007 0.007
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0116 0.0801
Onchocerca volvulus 0.0016 0.0151 0.0278
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.0116 0.0397
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0402 0.539
Echinococcus multilocularis cysteine protease 0.0016 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0152
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0051 0.053
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0151 0.0278
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0116 0.1085
Leishmania major cathepsin L-like protease 0.0062 0.0735 1
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0051 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0697 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0116 0.1452
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0051 0.0101
Echinococcus multilocularis Protein lozenge 0.0054 0.0633 0.0633
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0116 0.0397
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.0116 0.0397
Loa Loa (eye worm) hypothetical protein 0.0429 0.5437 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0735 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.007 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0934
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0116 0.0397
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus multilocularis protein patched 0.0041 0.0468 0.0468
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0532 0.7385
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0013 0.0116 0.2699
Loa Loa (eye worm) fibroinase 0.0016 0.0151 0.0278
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Brugia malayi MH2 domain containing protein 0.001 0.007 0.0128
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Onchocerca volvulus 0.0016 0.0151 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0934
Schistosoma mansoni smad1 5 8 and 0.001 0.007 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0468 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0051 0.0593
Plasmodium vivax unspecified product 0.0008 0.0051 0.1034
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi protein C24B5.3 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0006 0.0018 0.0033
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.007 0.007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0051 0.0101
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0566 0.7656
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0383 1
Brugia malayi Inositol-1 0.0036 0.0402 0.0739
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0468 0.0932
Echinococcus multilocularis protein quaking 0.0026 0.0281 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0532 0.7385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0066 0.074
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi Smad1 0.001 0.007 0.0128
Echinococcus granulosus muscleblind protein 0.0145 0.1796 0.3581
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0735 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0005 0.0012 0.0023
Schistosoma mansoni cathepsin s 0.0005 0.0012 0.0025
Echinococcus multilocularis protein dispatched 1 0.0047 0.0542 0.0542
Plasmodium vivax vivapain-2 0.0016 0.0151 0.3749
Onchocerca volvulus 0.0006 0.0018 0.0033
Brugia malayi CHE-14 protein 0.0041 0.0468 0.086
Onchocerca volvulus 0.0013 0.0116 0.0214
Onchocerca volvulus 0.0006 0.0018 0.0033
Brugia malayi MH1 domain containing protein 0.001 0.007 0.0128
Echinococcus granulosus Smad4 0.001 0.007 0.0139
Echinococcus granulosus dnaJ subfamily B 0.0396 0.5016 1
Onchocerca volvulus 0.0013 0.0116 0.0214
Loa Loa (eye worm) hypothetical protein 0.0145 0.1796 0.3304
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0066 0.0934
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0013 0.0116 0.0397
Brugia malayi Cathepsin L-like precursor 0.0011 0.0083 0.0152
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0116 0.0397
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0532 0.7385
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0013 0.0116 0.0214
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0116 0.0801
Loa Loa (eye worm) hypothetical protein 0.0429 0.5437 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0697 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0934
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0151 0.1924
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0532 0.4318
Schistosoma mansoni hypothetical protein 0.0039 0.0449 0.0895
Loa Loa (eye worm) patched family protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.0705
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0354 0.4325
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0066 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0934
Loa Loa (eye worm) runx1 0.0054 0.0633 0.1164
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0116 0.144
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0697 0.1389
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0699 0.1394
Brugia malayi MH1 domain containing protein 0.0005 0.0013 0.0025
Leishmania major cathepsin L-like protease 0.0016 0.0151 0.0566
Loa Loa (eye worm) Smad1 0.001 0.007 0.0128
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0013 0.0116 0.1452
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1791 0.3294
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0402 0.0801
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0402 0.0402
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Schistosoma mansoni hypothetical protein 0.0039 0.0449 0.0895
Schistosoma mansoni cpg binding protein 0.0029 0.032 0.0638
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0066 0.0708
Echinococcus multilocularis muscleblind protein 0.0145 0.1796 0.1796
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus multilocularis expressed conserved protein 0.009 0.1091 0.1091
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0013 0.0116 0.1085
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0532 0.0978
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0116 0.144
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0116 0.144
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1165 0.2322
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0532 0.7385
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus multilocularis cpg binding protein 0.0029 0.032 0.032
Brugia malayi hypothetical protein 0.0026 0.0281 0.0517
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0532 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0013 0.0116 0.0116
Onchocerca volvulus 0.0016 0.0151 0.0278
Brugia malayi MH2 domain containing protein 0.0144 0.1791 0.3294
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0151 0.0904
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0532 0.6716
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0066 0.074
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0066 0.0934
Brugia malayi Cathepsin L-like precursor 0.0005 0.0012 0.0023
Plasmodium vivax vivapain-2 0.0016 0.0151 0.3749
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0151 0.0151
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0013 0.0116 0.096
Echinococcus granulosus protein quaking 0.0026 0.0281 0.056
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0151 0.0278
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0532 0.4318
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0006 0.0018 0.0033
Schistosoma mansoni hypothetical protein 0.0026 0.0281 0.056
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0151 0.0278
Leishmania major cathepsin L-like protease 0.0062 0.0735 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.03 0.0552
Brugia malayi Patched related family protein 12 0.0006 0.0018 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Brugia malayi MH2 domain containing protein 0.001 0.007 0.0128
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0697 0.9384
Onchocerca volvulus 0.001 0.0066 0.0121
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0697 0.1389
Toxoplasma gondii propionate-CoA ligase 0.0013 0.0116 0.1452
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.0281 0.0517
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0032 0.0064
Brugia malayi Patched related family protein 10 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0735 1
Brugia malayi Myosin head containing protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0402 0.5131
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0066 0.074
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0666 0.905
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0013 0.0116 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Onchocerca volvulus 0.0006 0.0018 0.0033
Schistosoma mansoni DNA ligase IV 0.001 0.0066 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0359 0.4413
Brugia malayi hypothetical protein 0.001 0.0066 0.0121
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1796 0.1796
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0383 0.481
Loa Loa (eye worm) patched family protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0083 0.1315
Schistosoma mansoni hypothetical protein 0.0396 0.5016 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0108
Schistosoma mansoni topbp1 0.001 0.0066 0.0131
Loa Loa (eye worm) ctsf protein 0.0016 0.0151 0.0278
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0023
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi Cathepsin L-like precursor 0.0016 0.0151 0.0278
Onchocerca volvulus 0.0429 0.5437 1
Schistosoma mansoni smad1 5 8 and 0.001 0.007 0.0139
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.0116 0.0801
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0066 0.0934
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0151 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0151 0.2864
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0051 0.0101
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0066 0.074
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.007 0.0128
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0066 0.0221
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0066 0.0934
Schistosoma mansoni topbp1 0.001 0.0066 0.0131
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0066 0.0934
Schistosoma mansoni lozenge 0.0054 0.0633 0.1261
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0051 0.053
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0013 0.0116 0.0397
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1689 0.1689
Schistosoma mansoni hypothetical protein 0.0039 0.0449 0.0895
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0152
Echinococcus multilocularis cysteine protease 0.0016 0.0151 0.0151
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0402 0.4614
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1165 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0402 0.8513
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0013 0.0116 0.096
Loa Loa (eye worm) hypothetical protein 0.0046 0.0532 0.0978
Loa Loa (eye worm) patched family protein 0.0006 0.0018 0.0033
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1165 0.2142
Schistosoma mansoni cpg binding protein 0.0029 0.032 0.0638
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0151 0.0302
Leishmania major cathepsin L-like protease 0.0016 0.0151 0.0566
Brugia malayi Patched related family protein 4 0.0006 0.0018 0.0033
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0016 0.0151 0.0278
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0116 0.0801
Brugia malayi Muscleblind-like protein 0.0145 0.1796 0.3304
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0083 0.0288
Onchocerca volvulus 0.0028 0.03 0.0552
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0735 1
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0066 0.1315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Brugia malayi hypothetical protein 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0013 0.0116 0.0214
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0032 0.0064
Brugia malayi hypothetical protein 0.0006 0.0018 0.0033
Onchocerca volvulus 0.0016 0.0151 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0066 0.0131
Onchocerca volvulus 0.0006 0.0018 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0402 0.5656
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0013 0.0116 0.1085
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.5016 0.5016
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0532 0.0978
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Leishmania major cathepsin L-like protease 0.0016 0.0151 0.0566
Schistosoma mansoni patched 1 0.0041 0.0468 0.0932
Brugia malayi MH1 domain containing protein 0.001 0.007 0.0128
Plasmodium vivax patched family protein, putative 0.0006 0.0018 0.0145
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0151 0.0904
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Onchocerca volvulus Protein patched homolog 0.0006 0.0018 0.0033
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0383 0.5029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Echinococcus granulosus cathepsin l1 0.0016 0.0151 0.0302
Entamoeba histolytica cysteine protease, putative 0.0016 0.0151 0.0904
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0053 0.0097
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0013 0.0116 0.144
Brugia malayi Patched family protein 0.0006 0.0018 0.0033
Leishmania major cathepsin L-like protease 0.0062 0.0735 1
Schistosoma mansoni smad1 5 8 and 0.001 0.007 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) patched family protein 0.0006 0.0018 0.0033
Plasmodium falciparum cysteine proteinase falcipain 1 0.0008 0.0051 0.0901
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.007 0.0139
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0066 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0051 0.053
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0051 0.053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Brugia malayi CXXC zinc finger family protein 0.0028 0.03 0.0552
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0468 0.0468
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0619 0.8847
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0032 0.0032
Plasmodium vivax vivapain-3 0.0008 0.0051 0.1034
Brugia malayi topoisomerase 0.001 0.0066 0.0121
Schistosoma mansoni Smad4 0.001 0.007 0.0139
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0151 0.0151
Loa Loa (eye worm) inositol-1 0.0036 0.0402 0.0739
Plasmodium vivax acetyl-CoA synthetase, putative 0.0013 0.0116 0.2805
Onchocerca volvulus 0.0011 0.0083 0.0152
Loa Loa (eye worm) oxidoreductase 0.0013 0.0116 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0532 0.727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0083 0.1315
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0532 0.0978
Loa Loa (eye worm) nuclear factor I 0.0005 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0151 0.2864
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0532 0.7385
Schistosoma mansoni hypothetical protein 0.0026 0.0281 0.056
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0697 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0083 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0116 0.0801
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0066 0.0136
Brugia malayi protein C24B5.3 0.0006 0.0018 0.0033
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0402 1
Onchocerca volvulus 0.0046 0.0532 0.0978
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0532 0.7385
Echinococcus granulosus replication factor c subunit 1 0.001 0.0066 0.0131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.0705
Echinococcus granulosus cysteine protease 0.0008 0.0051 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0116 0.0214
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0697 1
Schistosoma mansoni smad 0.001 0.007 0.0139
Loa Loa (eye worm) hypothetical protein 0.0145 0.1796 0.3304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Schistosoma mansoni acetyl-CoA synthetase 0.0013 0.0116 0.0232
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0034 0.0383 0.0705
Loa Loa (eye worm) hypothetical protein 0.0046 0.0532 0.0978
Schistosoma mansoni inositol monophosphatase 0.0036 0.0402 0.0801
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0151 0.0278
Echinococcus granulosus cathepsin l1 0.0011 0.0083 0.0165
Schistosoma mansoni hypothetical protein 0.0039 0.0449 0.0895
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0532 0.6716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0735 1
Onchocerca volvulus 0.0006 0.0018 0.0033
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0066 0.1442
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0383 1
Echinococcus multilocularis Smad4 0.001 0.007 0.007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0402 0.5325
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0013 0.0116 0.059
Brugia malayi Patched protein homolog 1 0.0006 0.0018 0.0033
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0151 0.0566
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0151 0.0302
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0116 0.0214
Leishmania major cathepsin L-like protease 0.0016 0.0151 0.0566
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0121
Schistosoma mansoni inositol monophosphatase 0.0036 0.0402 0.0801
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0151 0.2864
Loa Loa (eye worm) hypothetical protein 0.0046 0.0532 0.0978
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.007 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0116 0.0801
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0033
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0151 0.3657
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0083 0.0165
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0151 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0151 0.2864
Trichomonas vaginalis antibiotic synthetase, putative 0.0013 0.0116 0.2075
Giardia lamblia Replication factor C, subunit 1 0.001 0.0066 0.5
Trichomonas vaginalis antibiotic synthetase, putative 0.0013 0.0116 0.2075
Brugia malayi cathepsin L-like precursor 0.0011 0.0083 0.0152

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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