Detailed information for compound 1354307

Basic information

Technical information
  • TDR Targets ID: 1354307
  • Name: 2-chloro-6-(4-methoxyphenyl)pyrimidine-4-carb onitrile
  • MW: 245.664 | Formula: C12H8ClN3O
  • H donors: 0 H acceptors: 3 LogP: 2.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc(Cl)nc(c1)C#N
  • InChi: 1S/C12H8ClN3O/c1-17-10-4-2-8(3-5-10)11-6-9(7-14)15-12(13)16-11/h2-6H,1H3
  • InChiKey: WVRVBCXEHFTJDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-6-(4-methoxyphenyl)-4-pyrimidinecarbonitrile
  • MLS000767859
  • 2-Chloro-6-(4-methoxy-phenyl)-pyrimidine-4-carbonitrile
  • STOCK2S-44954
  • AO-567/40646566
  • SMR000430188
  • ZINC02028866

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.0522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0148 0.0338
Entamoeba histolytica hypothetical protein 0.0023 0.019 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0045 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0249 0.2685 0.8364
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0219 0.0677
Schistosoma mansoni helicase 0.0006 0.000002863 0.0000065514
Brugia malayi steroid hormone receptor 0.001 0.0046 0.0064
Schistosoma mansoni DNA polymerase eta 0.0019 0.0146 0.0334
Echinococcus multilocularis BRK domain 0.0011 0.0063 0.0143
Brugia malayi SET domain containing protein 0.0007 0.0009 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0046 0.0106
Echinococcus granulosus Chromo domain 0.0011 0.0063 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0106
Echinococcus granulosus geminin 0.0205 0.22 0.5034
Echinococcus granulosus cpg binding protein 0.0063 0.0629 0.1439
Schistosoma mansoni hypothetical protein 0.0205 0.22 0.5034
Schistosoma mansoni coup transcription factor 0.001 0.0046 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0354 0.1082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0014 0.0032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0783 0.2391
Schistosoma mansoni smad 0.001 0.0045 0.0104
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0146 0.045
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0069 0.0214
Loa Loa (eye worm) glutaminase 0.0268 0.29 0.8859
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0146 0.045
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0783 0.1791
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.014 0.0461
Brugia malayi Flap endonuclease-1 0.0026 0.0219 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0007 0.0000098982
Giardia lamblia DINP protein human, muc B family 0.0019 0.0146 0.039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0032 0.0044
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0341 0.3705 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0401 0.437 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0148 0.0338
Schistosoma mansoni smad1 5 8 and 0.001 0.0045 0.0104
Echinococcus granulosus Smad4 0.001 0.0045 0.0104
Schistosoma mansoni importin beta-1 0.0028 0.0249 0.057
Loa Loa (eye worm) glutaminase 2 0.0268 0.29 0.8859
Brugia malayi nuclear receptor NHR-88 0.001 0.0046 0.0064
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0219 0.0677
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0019 0.0151 0.0556
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1556 0.356
Schistosoma mansoni smad1 5 8 and 0.001 0.0045 0.0104
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.0522
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0249 0.2685 0.8364
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1486 0.4626
Echinococcus granulosus flap endonuclease 1 0.0026 0.0219 0.0501
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.014 0.0433
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0014 0.0032
Brugia malayi glutaminase DH11.1 0.0268 0.29 0.3999
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.014 0.0194
Toxoplasma gondii RNA-directed DNA polymerase 0.0249 0.2685 1
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0019 0.0151 0.0561
Onchocerca volvulus 0.001 0.0046 0.0046
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0146 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0081 0.0247
Onchocerca volvulus 0.0038 0.0354 0.0354
Plasmodium vivax DEAD/DEAH helicase, putative 0.001 0.005 0.0186
Brugia malayi nuclear hormone receptor 0.001 0.0046 0.0064
Echinococcus granulosus importin subunit beta 1 0.0028 0.0249 0.057
Brugia malayi MH1 domain containing protein 0.001 0.0045 0.0062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0146 0.0334
Echinococcus multilocularis smad 0.001 0.0045 0.0104
Echinococcus granulosus muscleblind protein 0.0146 0.1556 0.356
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0014 0.0032
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0146 0.045
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0146 0.0498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0146 0.045
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0148 0.0455
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0783 0.1791
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1486 0.4626
Brugia malayi hypothetical protein 0.0035 0.0327 0.045
Schistosoma mansoni smad1 5 8 and 0.001 0.0045 0.0104
Echinococcus granulosus smad 0.001 0.0045 0.0104
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0106
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0219 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0064
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0148 0.0338
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0354 0.081
Loa Loa (eye worm) Smad1 0.001 0.0045 0.0138
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0148 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0081 0.0247
Schistosoma mansoni flap endonuclease-1 0.0023 0.0192 0.0439
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0219 0.0669
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0498 0.1546
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.321 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0146 0.0445
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0146 0.0334
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0219 0.0815
Brugia malayi MH2 domain containing protein 0.001 0.0045 0.0062
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.001 0.005 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0146 0.045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0146 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0046 0.0106
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0151 0.0561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0151 0.0029
Trypanosoma brucei unspecified product 0.0019 0.0146 0.045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0146 0.0035
Echinococcus multilocularis global transcription activator snf2l2 0.0066 0.0665 0.1521
Echinococcus granulosus polybromo 1 0.0006 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0397 0.1232
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0002 0.0006
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0219 0.0732
Brugia malayi RNA, U transporter 1 0.008 0.0825 0.1138
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1531 0.4678
Trypanosoma brucei telomerase reverse transcriptase 0.0249 0.2685 0.8364
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0046 0.0141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.019 0.0632
Schistosoma mansoni helicase 0.0006 0.000002863 0.0000065514
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.321 1
Echinococcus granulosus disco interacting protein 2 0.0038 0.0354 0.081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.014 0.0433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0148 0.0338
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0064
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0002 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0075
Giardia lamblia Telomerase catalytic subunit 0.0249 0.2685 0.7247
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0046 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0141
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0033 0.0101
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0401 0.437 1
Loa Loa (eye worm) BRM protein 0.0034 0.0313 0.0956
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0046 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0019 0.0151 0.0345
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1661 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0046 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0046 0.0064
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0046 0.0106
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0046 0.0106
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0148 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0046 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0019 0.0151 0.0465
Brugia malayi MH2 domain containing protein 0.0144 0.1531 0.2112
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0148 0.0451
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0046 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0046 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.0772
Schistosoma mansoni cpg binding protein 0.0063 0.0629 0.1439
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0046 0.0106
Brugia malayi MH1 domain containing protein 0.001 0.0045 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0046 0.0106
Entamoeba histolytica hypothetical protein 0.0097 0.1009 0.2436
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0045 0.0104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0046 0.0106
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.0522
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1486 0.4626
Schistosoma mansoni cpg binding protein 0.0063 0.0629 0.1439
Brugia malayi Importin beta-1 subunit 0.0028 0.0249 0.0344
Brugia malayi CXXC zinc finger family protein 0.0061 0.0611 0.0843
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.014 0.0523
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0783 0.1791
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0148 0.0455
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0354 0.081
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0148 0.0544
Schistosoma mansoni nuclear hormone receptor 0.001 0.0046 0.0106
Loa Loa (eye worm) hypothetical protein 0.0146 0.1556 0.4753
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0783 0.2391
Loa Loa (eye worm) hypothetical protein 0.0146 0.1556 0.4753
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Schistosoma mansoni helicase 0.0066 0.0665 0.1521
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0014 0.0032
Brugia malayi isocitrate dehydrogenase 0.0019 0.0148 0.0204
Echinococcus multilocularis geminin 0.0205 0.22 0.5034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0045 0.0104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0046 0.0141
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0014 0.0032
Echinococcus granulosus FTZ F1 alpha 0.001 0.0046 0.0106
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.014 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.014 0.0433
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0219 0.0587
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0219 0.0677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0106
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0069 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0546 0.2027
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0007 0.0000098982
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0327 0.0747
Plasmodium vivax importin-beta 2, putative 0.0028 0.0249 0.0928
Brugia malayi BRM protein 0.0066 0.0665 0.0916
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.321 1
Mycobacterium ulcerans hypothetical protein 0.0156 0.1661 0.5726
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0783 0.1079
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0146 0.0479
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.019 0.0587
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0046 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.014 0.0429
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0148 0.055
Echinococcus multilocularis helicase 0.0006 0.000002863 0.00000000010135
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0219 0.0501
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1531 0.4678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0141
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0045 0.0138
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.014 0.0523
Toxoplasma gondii exonuclease III APE 0.0018 0.014 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0146 0.045
Leishmania major DNA polymerase kappa, putative 0.0019 0.0146 0.045
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Entamoeba histolytica hypothetical protein 0.0035 0.0327 0.0522
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Echinococcus multilocularis dna polymerase eta 0.0019 0.0146 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0046 0.0064
Echinococcus granulosus dna polymerase eta 0.0019 0.0146 0.0334
Toxoplasma gondii DNA methyltransferase 2, putative 0.0019 0.0151 0.0556
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.001 0.005 0.0186
Loa Loa (eye worm) helicase DNA-binding protein 0.0011 0.0063 0.0191
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0046 0.0046
Leishmania major importin beta-1 subunit, putative 0.0023 0.019 0.0587
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0146 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0146 0.0201
Leishmania major DNA polymerase eta, putative 0.0019 0.0146 0.045
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.437 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0106
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0046 0.0106
Brugia malayi Telomerase reverse transcriptase 0.0661 0.7251 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0397 0.1232
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0611 0.1867
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.014 0.0321
Schistosoma mansoni ap endonuclease 0.0018 0.014 0.0321
Brugia malayi TAR-binding protein 0.0076 0.0783 0.1079
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0397 0.1232
Brugia malayi MH2 domain containing protein 0.001 0.0045 0.0062
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0146 0.045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0064
Plasmodium falciparum telomerase reverse transcriptase 0.0249 0.2685 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.019 0.0632
Trichomonas vaginalis glutaminase, putative 0.0268 0.29 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0148 0.055
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0146 0.0498
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0146 0.0334
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0045 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0146 0.045
Plasmodium falciparum importin beta, putative 0.0028 0.0249 0.0928
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0007 0.0000098982
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0046 0.0064
Echinococcus multilocularis Chromo domain 0.0011 0.0063 0.0143
Echinococcus multilocularis cpg binding protein 0.0063 0.0629 0.1439
Schistosoma mansoni ap endonuclease 0.0018 0.014 0.0321
Onchocerca volvulus 0.0061 0.0611 0.0611
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.014 0.0461
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0046 0.0106
Echinococcus granulosus helicase 0.0006 0.000002863 0.00000000010135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0146 0.0334
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0046 0.0106
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0249 0.057
Toxoplasma gondii hypothetical protein 0.0083 0.0854 0.3176
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0045 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0148 0.0544
Echinococcus multilocularis Smad4 0.001 0.0045 0.0104
Plasmodium vivax telomerase reverse transcriptase, putative 0.0249 0.2685 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.014 0.0433
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0397 0.1232
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0354 0.0488
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.321 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0146 0.0334
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0046 0.0106
Schistosoma mansoni hypothetical protein 0.0302 0.3273 0.749
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0046 0.0106
Brugia malayi Muscleblind-like protein 0.0146 0.1556 0.2145
Echinococcus multilocularis muscleblind protein 0.0146 0.1556 0.356
Loa Loa (eye worm) hypothetical protein 0.0028 0.0249 0.0761
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.014 0.0375
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0327 0.0747
Loa Loa (eye worm) hypothetical protein 0.001 0.0046 0.0141
Loa Loa (eye worm) RNA binding protein 0.0076 0.0783 0.2391
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0148 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0046 0.0064
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.1009 0.2436
Loa Loa (eye worm) BRM protein 0.0042 0.0402 0.1227
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0146 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0046 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0046 0.0106
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0219 0.081
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.014 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0783 0.1791
Trichomonas vaginalis importin beta-1, putative 0.0023 0.019 0.0632
Schistosoma mansoni glutaminase 0.0268 0.29 0.6635
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0148 0.0338
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0046 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0046 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0046 0.0046
Echinococcus granulosus dna polymerase kappa 0.0019 0.0146 0.0334
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0148 0.0338
Echinococcus granulosus snurportin 1 0.0302 0.3273 0.749
Schistosoma mansoni hypothetical protein 0.0035 0.0327 0.0747
Schistosoma mansoni Smad4 0.001 0.0045 0.0104
Brugia malayi polybromodomain protein 0.0006 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0063 0.0086
Leishmania major modification methylase-like protein 0.0019 0.0151 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0046 0.0141
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.3273 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0146 0.0201
Trypanosoma brucei unspecified product 0.0013 0.0081 0.0247
Echinococcus granulosus tar DNA binding protein 0.0076 0.0783 0.1791
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0011 0.0063 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0046 0.0064
Leishmania major telomerase reverse transcriptase, putative 0.0249 0.2685 0.8364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0146 0.045
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0783 0.1791
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0046 0.0106
Plasmodium falciparum flap endonuclease 1 0.0026 0.0219 0.0815
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0045 0.0138
Trypanosoma brucei unspecified product 0.0013 0.0081 0.0247
Echinococcus multilocularis snurportin 1 0.0302 0.3273 0.749
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0148 0.0455
Schistosoma mansoni hypothetical protein 0.0013 0.008 0.0184
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0148 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0783 0.1791
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0019 0.0151 0.0345
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0327 0.0747
Brugia malayi ecdysteroid receptor 0.001 0.0046 0.0064
Brugia malayi Smad1 0.001 0.0045 0.0062
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.014 0.0479
Echinococcus granulosus DNA methyltransferase 2, putative 0.0019 0.0151 0.0345
Schistosoma mansoni hypothetical protein 0.0205 0.22 0.5034
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0249 0.0923
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0597 0.1366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0046 0.0141
Brugia malayi polk-prov protein 0.0006 0.0002 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0046 0.0106
Giardia lamblia DNA repair protein RAD52 0.0341 0.3705 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0046 0.0141
Brugia malayi RNA binding protein 0.0076 0.0783 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0081 0.0247
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0148 0.0455
Mycobacterium ulcerans glutaminase 0.0268 0.29 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.014 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0046 0.0064
Echinococcus granulosus global transcription activator snf2l2 0.0066 0.0665 0.1521
Schistosoma mansoni polybromo-1 0.0006 0.0004 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0146 0.045
Schistosoma mansoni thyroid hormone receptor 0.001 0.0046 0.0106
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0063 0.0143
Echinococcus multilocularis polybromo 1 0.0006 0.0004 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0146 0.045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0854 0.3179
Echinococcus granulosus BRK domain containing protein 0.0011 0.0063 0.0143
Schistosoma mansoni cpg binding protein 0.0061 0.0611 0.1398
Toxoplasma gondii hypothetical protein 0.0048 0.0465 0.1725

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 79.8 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) > 380 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 37.2 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) > 91.243 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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