Detailed information for compound 1361617

Basic information

Technical information
  • TDR Targets ID: 1361617
  • Name: [2-[(4-fluorophenyl)amino]-2-oxoethyl] 5-nitr othiophene-2-carboxylate
  • MW: 324.284 | Formula: C13H9FN2O5S
  • H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)F)COC(=O)c1ccc(s1)[N+](=O)[O-]
  • InChi: 1S/C13H9FN2O5S/c14-8-1-3-9(4-2-8)15-11(17)7-21-13(18)10-5-6-12(22-10)16(19)20/h1-6H,7H2,(H,15,17)
  • InChiKey: SRDYJLLFOUJHOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(4-fluorophenyl)amino]-2-oxo-ethyl] 5-nitrothiophene-2-carboxylate
  • 5-nitro-2-thiophenecarboxylic acid [2-[(4-fluorophenyl)amino]-2-oxoethyl] ester
  • 5-nitrothiophene-2-carboxylic acid [2-[(4-fluorophenyl)amino]-2-keto-ethyl] ester
  • T5551236
  • ZINC03496547

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 6, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 7 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens caspase 8, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 6 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_131076 All targets in OG5_131076
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum ko:K08596 sentrin-specific protease 7, putative Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus granulosus sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Brugia malayi Cell death protein 3 precursor caspase 6, apoptosis-related cysteine peptidase 293 aa 270 aa 34.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0424 0.2152
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0325 0.0325
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0085 0.0723 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0325 0.1289
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0131 0.0473
Echinococcus multilocularis protein kinase c epsilon type 0.0031 0.0159 0.0159
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.095 0.4701
Trypanosoma brucei RNA helicase, putative 0.0205 0.196 1
Schistosoma mansoni hypothetical protein 0.0286 0.2809 0.9849
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.095 0.4701
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0963 0.3377
Trichomonas vaginalis Sentrin-specific protease, putative 0.0111 0.0991 0.4377
Echinococcus multilocularis sentrin specific protease 1 0.0047 0.0321 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.001 0.0035
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0078 0.064 0.3215
Brugia malayi phosphofructokinase 0.0107 0.095 0.4824
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0142
Echinococcus granulosus expressed conserved protein 0.0163 0.1525 0.5525
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Leishmania major trypanothione reductase 0.0046 0.031 0.326
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0137 0.1893
Onchocerca volvulus 0.0047 0.0325 0.1289
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1553
Trypanosoma cruzi metacaspase 5, putative 0.0085 0.0723 0.7291
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0325 0.1177
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.001 0.0036
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0282 0.2761 0.2761
Brugia malayi Matrixin family protein 0.0187 0.1781 0.904
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0137 0.0604
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0321 0.1125
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0198 0.0957
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.001 0.0051
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.095 0.4701
Onchocerca volvulus 0.0047 0.0321 0.127
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0137 0.0634
Schistosoma mansoni lipoxygenase 0.0019 0.0038 0.0133
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0393 0.1376
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0137 0.4266
Brugia malayi jmjC domain containing protein 0.0035 0.0198 0.1003
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0038 0.0137
Schistosoma mansoni hypothetical protein 0.011 0.0976 0.3423
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0393 0.1993
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0173 0.1634 0.1634
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0674 0.339
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0321 0.4438
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.095 0.095
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0094 0.0816 0.414
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0137 0.1893
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1038 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.031 0.4286
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.001 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Brugia malayi hypothetical protein 0.0019 0.0038 0.0192
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0393 0.0393
Brugia malayi jmjC domain containing protein 0.0094 0.0815 0.4137
Loa Loa (eye worm) hypothetical protein 0.0094 0.0816 0.411
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0464 0.2315
Onchocerca volvulus Matrilysin homolog 0.0172 0.162 0.7105
Echinococcus multilocularis peroxidasin 0.0081 0.0674 0.0674
Plasmodium falciparum metacaspase-like protein 0.0085 0.0723 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0085 0.0723 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0081 0.0674 0.339
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0393 0.1422
Mycobacterium tuberculosis Probable reductase 0.0104 0.0917 0.8837
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.095 0.4849
Brugia malayi hypothetical protein 0.0019 0.0038 0.0192
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0464 0.0464
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0047 0.0321 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Onchocerca volvulus 0.0081 0.0674 0.2858
Plasmodium falciparum sentrin-specific protease 1 0.0047 0.0321 0.4438
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1763 0.1763
Brugia malayi hypothetical protein 0.0036 0.0205 0.1039
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0674 0.339
Echinococcus multilocularis caspase 8 0.0085 0.0723 0.0723
Giardia lamblia PHD finger protein 15 0.0029 0.0135 0.4198
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0917 0.8837
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0917 0.4573
Echinococcus granulosus jumonji domain containing protein 0.004 0.0252 0.0912
Brugia malayi mbt repeat family protein 0.0047 0.0325 0.1649
Trypanosoma brucei metacaspase 0.0085 0.0723 0.3688
Schistosoma mansoni peroxidasin 0.0081 0.0674 0.2364
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1332 0.6745
Brugia malayi Matrixin family protein 0.0078 0.064 0.325
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0402 0.0402
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.0973
Plasmodium vivax sentrin-specific protease 2, putative 0.0047 0.0321 0.4438
Echinococcus granulosus RNA directed DNA polymerase 0.0077 0.064 0.2318
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0137 0.4266
Toxoplasma gondii AGC kinase 0.0017 0.001 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0453 0.226
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0137 0.1893
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0282 0.2761 1
Echinococcus granulosus protein kinase c iota type 0.0029 0.0133 0.0483
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1553
Loa Loa (eye worm) hypothetical protein 0.0077 0.064 0.3214
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0614 0.2151
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0917 0.8837
Onchocerca volvulus 0.0081 0.0674 0.2858
Schistosoma mansoni caspase-7 (C14 family) 0.0085 0.0723 0.2534
Brugia malayi DnaJ domain containing protein 0.0061 0.0464 0.2355
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.0973
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0137 0.1893
Toxoplasma gondii thioredoxin reductase 0.0046 0.031 0.4286
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Loa Loa (eye worm) hypothetical protein 0.0047 0.0321 0.1585
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1628
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Schistosoma mansoni serine/threonine kinase 0.0017 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0321 0.1585
Trypanosoma brucei trypanothione reductase 0.0046 0.031 0.1581
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0252 0.0252
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0325 0.1139
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0135 0.0488
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0051
Loa Loa (eye worm) Ulp1 protease 0.0047 0.0321 0.1585
Echinococcus granulosus protein kinase c epsilon type 0.0031 0.0159 0.0576
Echinococcus granulosus peroxidasin 0.0081 0.0674 0.2443
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.095 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0047 0.0321 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1628
Brugia malayi 6-phosphofructokinase 0.0107 0.095 0.4824
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.095 0.4196
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.021 0.2011 1
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2265 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0142 0.072
Echinococcus granulosus caspase 8 0.0085 0.0723 0.2618
Trypanosoma cruzi metacaspase, putative 0.0085 0.0723 0.7291
Onchocerca volvulus 0.0029 0.0142 0.0467
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0723 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Schistosoma mansoni atypical protein kinase C 0.0029 0.0133 0.0468
Trypanosoma brucei SUMO1/Ulp2, putative 0.0047 0.0321 0.1637
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0047 0.0321 0.3236
Echinococcus multilocularis serine threonine protein kinase 0.0097 0.084 0.084
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0094 0.0816 0.7858
Echinococcus granulosus RUN 0.0019 0.0038 0.0137
Trypanosoma brucei metacaspase MCA3 0.0085 0.0723 0.3688
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0424 0.4461
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0464 0.168
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.095 0.4196
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.001 0.001
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0991 0.4377
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0137 0.1893
Echinococcus granulosus protein kinase C gamma type 0.0097 0.084 0.3042
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0674 0.2858
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.095 0.6063
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Loa Loa (eye worm) matrixin family protein 0.0172 0.162 0.8215
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Trypanosoma cruzi metacaspase 5, putative 0.0085 0.0723 0.7291
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0142 0.1962
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0078 0.064 0.2245
Brugia malayi Thioredoxin reductase 0.0046 0.031 0.1573
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0963 0.3377
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0917 0.8837
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.095 0.4798
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1628
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0142 0.0514
Echinococcus multilocularis protein kinase c iota type 0.0029 0.0133 0.0133
Onchocerca volvulus 0.0078 0.064 0.2705
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0917 0.8837
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0198 0.0693
Brugia malayi PHD-finger family protein 0.0029 0.0135 0.0684
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0321 0.1416
Echinococcus granulosus NDR protein kinase 0.0017 0.001 0.0036
Echinococcus granulosus caspase 3 0.0088 0.0747 0.2706
Echinococcus granulosus sentrin specific protease 1 0.0047 0.0321 0.1162
Loa Loa (eye worm) phosphofructokinase 0.0107 0.095 0.4798
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.001 0.0036
Brugia malayi Hemopexin family protein 0.011 0.0976 0.4957
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0917 0.8837
Plasmodium falciparum metacaspase 1 0.0085 0.0723 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0205 0.0717
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.0973
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0991 0.4906
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0424 0.4085
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1332 0.6745
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0135 0.1863
Onchocerca volvulus Alhambra homolog 0.0029 0.0135 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.001 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.031 0.3125
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0137 0.1893
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0135 0.1863
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0085 0.0723 1
Loa Loa (eye worm) MBCTL1 0.0054 0.0393 0.1952
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Schistosoma mansoni caspase-7 (C14 family) 0.0173 0.1634 0.573
Echinococcus multilocularis caspase 2 0.0085 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0047 0.0325 0.1606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0497
Giardia lamblia Sentrin specific protease, putative 0.0047 0.0321 1
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.095 0.3332
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0137 0.1893
Echinococcus multilocularis caspase 0.0173 0.1634 0.1634
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0497
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0325 0.1606
Trypanosoma cruzi metacaspase, putative 0.0085 0.0723 0.7291
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0135 0.0135
Schistosoma mansoni caspase-3 (C14 family) 0.0173 0.1634 0.573
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Brugia malayi Cell death protein 3 precursor 0.0085 0.0723 0.3669
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0016 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.001 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0135 0.1863
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0674 0.2858
Plasmodium vivax sentrin-specific protease 1, putative 0.0047 0.0321 0.4438
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0038 0.0524
Echinococcus multilocularis peregrin 0.0029 0.0135 0.0135
Onchocerca volvulus Cell death protein 3 homolog 0.0085 0.0723 0.3076
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0031 0.0159 0.076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0205 0.0741
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0316 0.1145
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.095 1
Brugia malayi Doublecortin family protein 0.0019 0.0038 0.0192
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0321 0.4438
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0321 0.3375
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0325 0.1139
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0424 0.1486
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0198 0.0693
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Loa Loa (eye worm) hypothetical protein 0.0085 0.0723 0.3637
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0991 0.4377
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0198 0.0198
Onchocerca volvulus Matrix metalloproteinase homolog 0.0172 0.162 0.7105
Onchocerca volvulus Chorion peroxidase homolog 0.0081 0.0674 0.2858
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.031 0.2985
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.095 0.4196
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0325 0.0325
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Plasmodium vivax glutathione reductase, putative 0.0046 0.031 0.4286
Echinococcus multilocularis sentrin specific protease 7 0.021 0.2011 0.2011
Echinococcus multilocularis conserved hypothetical protein 0.0289 0.2833 0.2833
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0077 0.064 0.064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0205 0.0205
Brugia malayi 6-phosphofructokinase 0.0107 0.095 0.4824
Trypanosoma brucei metacaspase MCA2 0.0085 0.0723 0.3688
Echinococcus granulosus caspase 2 0.0085 0.0723 0.2618
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.021 0.2011 0.7049
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0393 0.1422
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.001 0.001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0321 0.3236
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1038 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0815 0.0815
Brugia malayi Blistered cuticle protein 3 0.0081 0.0674 0.3423
Loa Loa (eye worm) Ulp1 protease 0.0111 0.0991 0.5007
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0674 0.3423
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.001 0.0051
Brugia malayi Bromodomain containing protein 0.0029 0.0135 0.0684
Onchocerca volvulus 0.011 0.0976 0.4214
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0159 0.0557
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0674 0.3423
Schistosoma mansoni hypothetical protein 0.0061 0.0464 0.1626
Schistosoma mansoni lipoxygenase 0.0055 0.0402 0.1409
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.095 0.9157
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Echinococcus multilocularis sentrin specific protease 8 0.0111 0.0991 0.0991
Brugia malayi MH2 domain containing protein 0.0144 0.1332 0.6762
Brugia malayi protein kinase C II. 0.0031 0.0159 0.0807
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Schistosoma mansoni rab6-interacting 0.0019 0.0038 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0142 0.0497
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.197 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0497
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0402 0.1456
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0384 0.191
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0051
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.095 0.9586
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0038 0.0137
Onchocerca volvulus Dual oxidase homolog 0.0081 0.0674 0.2858
Loa Loa (eye worm) hypothetical protein 0.0049 0.0348 0.1726
Schistosoma mansoni hypothetical protein 0.0029 0.0135 0.0472
Loa Loa (eye worm) hypothetical protein 0.0085 0.0723 0.3637
Schistosoma mansoni polycystin 1-related 0.0019 0.0038 0.0133
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0082 0.0685 0.2401
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1553
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1038 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Schistosoma mansoni glucose-6-phosphatase 0.0291 0.2852 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0077 0.064 0.064
Trypanosoma brucei Metacaspase-4 0.0085 0.0723 0.3688
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0815 0.2952
Trypanosoma cruzi metacaspase, putative 0.0085 0.0723 0.7291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0723 0.3191
Loa Loa (eye worm) hypothetical protein 0.0047 0.0321 0.1585
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0085 0.0723 0.2534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0142 0.0142
Trypanosoma brucei metacaspase 5, putative 0.0085 0.0723 0.3688
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.031 0.1529
Brugia malayi mbt repeat family protein 0.0047 0.0325 0.1649
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.095 0.3442
Brugia malayi Matrixin family protein 0.0078 0.064 0.325
Echinococcus multilocularis caspase 3 0.0088 0.0747 0.0747
Schistosoma mansoni peroxidasin 0.0081 0.0674 0.2364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0672
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0111 0.0991 0.3476
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0135 0.0472
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1763 0.6387
Plasmodium falciparum phd finger protein, putative 0.0029 0.0135 0.1863
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0321 0.1553
Onchocerca volvulus 0.0234 0.2265 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.001 0.001
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.095 0.4798
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0674 0.3423
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Schistosoma mansoni hypothetical protein 0.0036 0.0205 0.0717
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.008 0.0669 0.3364
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0137 0.144
Loa Loa (eye worm) hypothetical protein 0.0054 0.0393 0.1952
Brugia malayi Matrixin family protein 0.0078 0.064 0.325
Echinococcus granulosus peregrin 0.0029 0.0135 0.0488
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0038 0.0524
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0674 0.339
Loa Loa (eye worm) glutathione reductase 0.0046 0.031 0.1529
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0173 0.1634 0.592
Echinococcus granulosus sentrin specific protease 7 0.021 0.2011 0.7282
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0198 0.0716
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.095 0.4196
Echinococcus multilocularis RUN 0.0019 0.0038 0.0038
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Echinococcus granulosus sentrin specific protease 8 0.0111 0.0991 0.3591
Onchocerca volvulus Matrilysin homolog 0.0078 0.064 0.2705
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0085 0.0723 0.3669
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0321 0.4438
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0604
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Brugia malayi hypothetical protein 0.0081 0.0674 0.3423
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0038 0.0038
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.001 0.0036
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.031 0.4286
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0038 0.0137
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0038 0.0142
Echinococcus granulosus caspase 0.0173 0.1634 0.592
Onchocerca volvulus 0.0081 0.0674 0.2858
Loa Loa (eye worm) hypothetical protein 0.0078 0.064 0.3215
Loa Loa (eye worm) matrixin family protein 0.0187 0.1781 0.9035
Echinococcus granulosus Protein kinase C brain isozyme 0.0109 0.0963 0.3489
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.0973
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.095 0.3332
Onchocerca volvulus Peroxidase homolog 0.0081 0.0674 0.2858
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0674 0.339
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0424 0.0424
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0047 0.0321 0.1416
Brugia malayi Matrixin family protein 0.0078 0.064 0.325
Echinococcus multilocularis conserved hypothetical protein 0.0289 0.2833 0.2833
Onchocerca volvulus Peroxidase homolog 0.0081 0.0674 0.2858
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.064 0.3215
Brugia malayi Pre-SET motif family protein 0.0206 0.197 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0142 0.1962
Loa Loa (eye worm) hypothetical protein 0.0089 0.0763 0.3843
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Echinococcus multilocularis expressed conserved protein 0.0163 0.1525 0.1525
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0142 0.0142
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0424 0.1536
Loa Loa (eye worm) matrix metalloproteinase 0.0078 0.064 0.3215
Plasmodium falciparum glutathione reductase 0.0046 0.031 0.4286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1038 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.001 0.001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0137 0.4266
Trypanosoma cruzi metacaspase, putative 0.0085 0.0723 0.7291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0085 0.0723 0.3191
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0464 0.2048
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0424 0.4461
Trypanosoma cruzi hypothetical protein 0.0111 0.0991 1
Brugia malayi glutathione reductase 0.0046 0.031 0.1573
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0325 0.1139
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.001 0.0035
Brugia malayi Hr1 repeat family protein 0.0017 0.001 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0017 0.001 0.0044
Plasmodium vivax metacaspase 1, putative 0.0085 0.0723 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Schistosoma mansoni rab6-interacting 0.0019 0.0038 0.0133
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0321 0.1125
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0424 0.4461
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.095 1
Mycobacterium ulcerans hydrolase 0.0094 0.0816 0.8581
Leishmania major metacaspase, putative 0.0085 0.0723 0.7605
Schistosoma mansoni loxhd1 0.0019 0.0038 0.0133
Brugia malayi Protein kinase c protein 2 0.0092 0.0793 0.4024
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0991 0.5033
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0133
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0321 0.1416
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0325 0.1177
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0674 0.3423
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0135 0.0636
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0674 0.3423
Schistosoma mansoni hypothetical protein 0.0205 0.196 0.6871
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.001 0.001
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0991 0.4377
Brugia malayi Peroxidasin 0.0081 0.0674 0.3423
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0109 0.0963 0.0963
Loa Loa (eye worm) hypothetical protein 0.0029 0.0135 0.0636
Loa Loa (eye worm) hypothetical protein 0.0081 0.0674 0.339

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 1.96 uM PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 18.6 uM PubChem BioAssay. Caspase 8 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 27.16 uM PubChem BioAssay. Caspase 9 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 103.961 uM PUBCHEM_BIOASSAY: Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 3.82 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2575, AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 4.05 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575, AID2582, AID434986] ChEMBL. No reference
IC50 (functional) = 6.29 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 8.43 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (binding) 64.19 uM PubChem BioAssay. Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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