Detailed information for compound 1376046

Basic information

Technical information
  • TDR Targets ID: 1376046
  • Name: 3-[(4-fluorophenyl)methoxy]-2-methylquinoline
  • MW: 267.298 | Formula: C17H14FNO
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)COc1cc2ccccc2nc1C
  • InChi: 1S/C17H14FNO/c1-12-17(10-14-4-2-3-5-16(14)19-12)20-11-13-6-8-15(18)9-7-13/h2-10H,11H2,1H3
  • InChiKey: UCKMAYAEGOOXBZ-UHFFFAOYSA-N  


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Synonyms

  • 3-[(4-fluorophenyl)methoxy]-2-methyl-quinoline
  • 3-(4-fluorobenzyl)oxy-2-methyl-quinoline
  • MLS000547371
  • SMR000180270
  • 1W-0903
  • ZINC04051032
  • 3-[(4-fluorobenzyl)oxy]-2-methylquinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Caenorhabditis elegans Protein SKN-1, isoform B Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Caenorhabditis elegans Protein HSP-16.2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128990 All targets in OG5_128990
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128990 All targets in OG5_128990
Loa Loa (eye worm) small heat shock protein Get druggable targets OG5_128990 All targets in OG5_128990
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Protein lethal(2)essential for life homolog Get druggable targets OG5_128990 All targets in OG5_128990
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi small heat shock protein - nematode Get druggable targets OG5_128990 All targets in OG5_128990
Brugia malayi Hsp20/alpha crystallin family protein Get druggable targets OG5_128990 All targets in OG5_128990
Loa Loa (eye worm) small heat shock protein Get druggable targets OG5_128990 All targets in OG5_128990
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128990 All targets in OG5_128990
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Small heat shock protein OV25-1 Get druggable targets OG5_128990 All targets in OG5_128990
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Protein lethal(2)essential for life homolog Get druggable targets OG5_128990 All targets in OG5_128990
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Protein lethal(2)essential for life homolog Get druggable targets OG5_128990 All targets in OG5_128990
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Hsp20/alpha crystallin family protein Get druggable targets OG5_128990 All targets in OG5_128990
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) small heat shock protein Get druggable targets OG5_128990 All targets in OG5_128990
Onchocerca volvulus Get druggable targets OG5_128990 All targets in OG5_128990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Protein lethal(2)essential for life homolog Get druggable targets OG5_128990 All targets in OG5_128990
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Hsp20/alpha crystallin family protein Get druggable targets OG5_128990 All targets in OG5_128990
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) small heat shock protein Get druggable targets OG5_128990 All targets in OG5_128990
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Hsp20/alpha crystallin family protein Get druggable targets OG5_128990 All targets in OG5_128990
Onchocerca volvulus Get druggable targets OG5_128990 All targets in OG5_128990
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi small heat shock protein 12.6, identical Get druggable targets OG5_128990 All targets in OG5_128990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum small heat shock protein, putative Protein HSP-16.2 145 aa 136 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Onchocerca volvulus 0.0033 0.0157 0.0146
Onchocerca volvulus Protein lethal(2)essential for life homolog 0.0047 0.0307 0.0448
Brugia malayi STAT protein, DNA binding domain containing protein 0.0191 0.18 0.3297
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0227 0.9573
Schistosoma mansoni endoplasmin 0.0039 0.0227 0.0169
Schistosoma mansoni heat shock protein 0.0039 0.0227 0.0169
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0084 0.0155
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0087 0.0722 0.0643
Onchocerca volvulus Protein lethal(2)essential for life homolog 0.0047 0.0307 0.0448
Echinococcus multilocularis beta catenin 0.0097 0.0832 0.0754
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0084 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0144 0.4815
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0084 0.0155
Echinococcus granulosus hypothetical protein 0.0302 0.2956 0.3419
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0227 0.9631
Brugia malayi neuropeptide F receptor 0.0026 0.0084 0.0155
Brugia malayi Matrixin family protein 0.0189 0.1788 0.3275
Brugia malayi larval opioid receptor 0.0026 0.0084 0.0155
Brugia malayi neuropeptide F receptor 0.0026 0.0084 0.0155
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0234 0.0437
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Loa Loa (eye worm) RNA binding protein 0.0076 0.0614 0.1124
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0773 0.7859 0.9257
Echinococcus multilocularis lamin 0.0033 0.0157 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi sulfakinin receptor protein 0.0026 0.0084 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Brugia malayi G protein-coupled receptor 0.0026 0.0084 0.0155
Schistosoma mansoni heat shock protein 0.0039 0.0227 0.0169
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0614 0.0534
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0167 0.67
Loa Loa (eye worm) small heat shock protein 0.0047 0.0307 0.0563
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Brugia malayi intermediate filament protein 0.0033 0.0157 0.0288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi RE15519p 0.0026 0.0084 0.0155
Brugia malayi putative neuropeptide receptor 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0084 0.0155
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Schistosoma mansoni pangolin 0.0065 0.0496 0.049
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0148 0.1357 0.2485
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0065 0.0496 0.0415
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0157 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Echinococcus multilocularis serotonin receptor 0.0144 0.1317 0.1243
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Brugia malayi Serotonin receptor 0.0026 0.0084 0.0155
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0227 0.5
Brugia malayi Dopamine receptor protein 1 0.0026 0.0084 0.0155
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0065 0.0496 0.049
Brugia malayi Endoplasmin precursor 0.0039 0.0227 0.0415
Brugia malayi Matrixin family protein 0.0189 0.1788 0.3275
Onchocerca volvulus Matrix metalloproteinase homolog 0.042 0.4187 0.8235
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1318 0.2413
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0234 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.0631
Brugia malayi RNA binding protein 0.0076 0.0614 0.1124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0084 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0133 0.5008
Brugia malayi Matrixin family protein 0.0189 0.1788 0.3275
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.0631
Loa Loa (eye worm) small heat shock protein 0.0047 0.0307 0.0563
Echinococcus granulosus tar DNA binding protein 0.0076 0.0614 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Schistosoma mansoni hypothetical protein 0.0237 0.2285 0.262
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0084 0.0155
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0227 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0133 0.5008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Schistosoma mansoni lamin 0.0033 0.0157 0.0087
Giardia lamblia Grp94/Hsp90 0.0031 0.0144 0.5735
Schistosoma mansoni transcription factor LCR-F1 0.0087 0.0722 0.0759
Echinococcus multilocularis endoplasmin 0.0031 0.0144 0.006
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0227 0.9631
Loa Loa (eye worm) HMG box family protein 0.0065 0.0496 0.0908
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0227 0.0415
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0097 0.083 0.0888
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0227 0.9573
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1318 0.2413
Echinococcus multilocularis heat shock protein 90 0.0039 0.0227 0.0143
Loa Loa (eye worm) STAT protein 0.0191 0.18 0.3297
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0144 0.1317 0.2412
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0231 0.2217 0.4061
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0084 0.0155
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0084 0.0155
Brugia malayi Dopamine receptor 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0231 0.2217 0.4061
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.0631
Brugia malayi heat shock protein 90 0.0039 0.0227 0.0415
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Entamoeba histolytica hypothetical protein 0.0087 0.0722 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.0631
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2788 0.2726
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0144 0.5735
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0084 0.0155
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0189 0.1788 0.3275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0274 0.2667 0.4886
Loa Loa (eye worm) small heat shock protein 0.0047 0.0307 0.0563
Schistosoma mansoni beta-catenin 0.0097 0.0832 0.089
Brugia malayi Melatonin receptor type 1A 0.0026 0.0084 0.0155
Echinococcus multilocularis heat shock protein 0.0039 0.0227 0.0143
Plasmodium vivax endoplasmin, putative 0.0039 0.0227 0.5
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0231 0.2217 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0144 0.0511
Brugia malayi small heat shock protein 12.6, identical 0.0047 0.0307 0.0563
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Schistosoma mansoni hypothetical protein 0.0269 0.2611 0.3008
Brugia malayi Hsp20/alpha crystallin family protein 0.0047 0.0307 0.0563
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.0277
Entamoeba histolytica hypothetical protein 0.0087 0.0722 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1788 0.3275
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0227 0.9573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0234 1
Loa Loa (eye worm) HMP-2 protein 0.0097 0.0832 0.1523
Onchocerca volvulus Matrilysin homolog 0.0505 0.5066 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0773 0.7859 0.784
Brugia malayi polk-prov protein 0.003 0.0133 0.0244
Echinococcus granulosus hypothetical protein 0.0697 0.7068 0.8315
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Onchocerca volvulus 0.0033 0.0157 0.0146
Onchocerca volvulus 0.0047 0.0307 0.0448
Brugia malayi hypothetical protein 0.0087 0.0722 0.1322
Schistosoma mansoni hypothetical protein 0.0058 0.0424 0.0405
Brugia malayi Hsp20/alpha crystallin family protein 0.0047 0.0307 0.0563
Echinococcus granulosus pangolin 0.0065 0.0496 0.049
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0227 0.9573
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0234 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.4518
Entamoeba histolytica hypothetical protein 0.0087 0.0722 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1357 0.2554
Loa Loa (eye worm) matrix metalloproteinase 0.0189 0.1788 0.3275
Loa Loa (eye worm) matrixin family protein 0.042 0.4187 0.7668
Echinococcus granulosus biogenic amine 5HT receptor 0.0144 0.1317 0.1467
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Onchocerca volvulus Matrilysin homolog 0.0189 0.1788 0.342
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Onchocerca volvulus 0.0189 0.1788 0.342
Echinococcus granulosus intermediate filament protein 0.0033 0.0157 0.0087
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8483 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Echinococcus granulosus beta catenin 0.0097 0.0832 0.089
Onchocerca volvulus Protein lethal(2)essential for life homolog 0.0047 0.0307 0.0448
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0157 0.0288
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0084 0.0155
Treponema pallidum heat shock protein 90 0.0031 0.0144 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0424 0.0777
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.4518
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0234 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0234 1
Onchocerca volvulus Protein lethal(2)essential for life homolog 0.0047 0.0307 0.0448
Entamoeba histolytica hypothetical protein 0.0087 0.0722 1
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi Hsp20/alpha crystallin family protein 0.0047 0.0307 0.0563
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0274 0.2667 0.3076
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0234 1
Echinococcus multilocularis musashi 0.0033 0.0157 0.0073
Onchocerca volvulus Cirhin homolog 0.0097 0.0825 0.1487
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0097 0.0832 0.1523
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Echinococcus granulosus heat shock protein 90 0.0039 0.0227 0.0169
Brugia malayi hypothetical protein 0.0286 0.2788 0.5106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) small heat shock protein 0.0047 0.0307 0.0563
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Echinococcus multilocularis serotonin receptor 0.0144 0.1317 0.1243
Echinococcus multilocularis conserved hypothetical protein 0.0672 0.6802 0.6775
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0084 0.0155
Schistosoma mansoni survival motor neuron protein 0.0058 0.0424 0.0405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2788 0.3219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0227 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Echinococcus granulosus endoplasmin 0.0031 0.0144 0.007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0084 0.0155
Brugia malayi G-protein coupled receptor 0.0026 0.0084 0.0155
Brugia malayi TAR-binding protein 0.0076 0.0614 0.1124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Echinococcus multilocularis lamin dm0 0.0033 0.0157 0.0073
Schistosoma mansoni lamin 0.0033 0.0157 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0614 0.1124
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8483 0.847
Loa Loa (eye worm) hypothetical protein 0.0144 0.1317 0.2412
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Onchocerca volvulus Huntingtin homolog 0.0148 0.1357 0.2554
Echinococcus multilocularis heat shock protein 90 0.0031 0.0144 0.006
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Echinococcus multilocularis dna polymerase kappa 0.004 0.0234 0.0151
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Onchocerca volvulus 0.0269 0.2611 0.5072
Brugia malayi small heat shock protein - nematode 0.0047 0.0307 0.0563
Brugia malayi Matrixin family protein 0.0189 0.1788 0.3275
Loa Loa (eye worm) matrixin family protein 0.0543 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.2788 0.5106
Brugia malayi HMG box family protein 0.0065 0.0496 0.0908
Onchocerca volvulus 0.0058 0.0424 0.0682
Echinococcus granulosus lamin dm0 0.0033 0.0157 0.0087
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Onchocerca volvulus 0.0047 0.0307 0.0448
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0227 0.9631
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0614 0.1124
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0614 0.0631
Echinococcus granulosus heat shock protein 0.0039 0.0227 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0087 0.0722 0.0759
Brugia malayi hypothetical protein 0.0148 0.1357 0.2485
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Trypanosoma brucei unspecified product 0.0034 0.0167 0.67
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0144 0.5
Schistosoma mansoni hypothetical protein 0.0087 0.0722 0.0759
Plasmodium falciparum heat shock protein 90 0.0039 0.0227 1
Brugia malayi Hemopexin family protein 0.0269 0.2611 0.4782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0047 0.0307 0.0563
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0227 0.9573
Brugia malayi GnHR receptor homolog 0.0026 0.0084 0.0155
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0084 0.0155
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0144 0.4815
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0227 0.5
Brugia malayi AKH receptor 0.0026 0.0084 0.0155
Schistosoma mansoni endoplasmin 0.0039 0.0227 0.0169
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0084 0.0155
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Brugia malayi Hsp20/alpha crystallin family protein 0.0047 0.0307 0.0563
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi Dopamine receptor protein 2 0.0026 0.0084 0.0155
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0144 0.007
Echinococcus multilocularis protein pangolin J 0.0065 0.0496 0.0415
Brugia malayi Matrixin family protein 0.0543 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1357 0.2485
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Mycobacterium ulcerans hydrolase 0.0231 0.2217 1
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0144 0.5735
Echinococcus granulosus dna polymerase kappa 0.004 0.0234 0.0178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0157 0.0288
Onchocerca volvulus 0.0047 0.0307 0.0448
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Echinococcus granulosus lamin 0.0033 0.0157 0.0087
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi G-protein coupled receptor 0.0026 0.0084 0.0155
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0084 0.0155
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0084 0.0155
Mycobacterium leprae PROBABLE HYDROLASE 0.0231 0.2217 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0234 1
Onchocerca volvulus 0.0047 0.0307 0.0448
Brugia malayi Small heat shock protein OV25-1 0.0047 0.0307 0.0563
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi Serotonin receptor 0.0026 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0288
Brugia malayi ORL1-like opioid receptor 0.0026 0.0084 0.0155
Leishmania major heat shock protein 83-1 0.0039 0.0227 1
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0084 0.0155
Brugia malayi hypothetical protein 0.0026 0.0084 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0227 0.9548
Trypanosoma brucei heat shock protein, putative 0.0039 0.0227 0.9631
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0234 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0157 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0234 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0614 0.1124
Loa Loa (eye worm) endoplasmin 0.0039 0.0227 0.0415
Echinococcus granulosus heat shock protein 90 0.0031 0.0144 0.007
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8483 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0144 0.1317 0.1467
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0144 0.4518
Brugia malayi MH2 domain containing protein 0.0144 0.1318 0.2413

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.909 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) = 21.055 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Secondary Assay to Identify Inhibitors of Hsp90. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007, AID434938] ChEMBL. No reference
EC50 (functional) > 160 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Measure Toxicity of Compounds Not in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007, AID434946] ChEMBL. No reference
EC50 (functional) > 180 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) > 285 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
IC50 (binding) = 3.466 um PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT3 inhibition. (Class of assay: confirmatory) [Related pubchem assays: 920, 1317, 1265, 1308, 862 ] ChEMBL. No reference
IC50 (functional) 7.88 uM PubChem BioAssay. SAR analysis of small molecule inhibitors of SKN-1 in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 9.02 uM PubChem BioAssay. SAR analysis of small molecule inhibitors of SKN-1 via a heat-shock counterscreen assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 12.2 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 24 uM PubChem BioAssay. Dose ResponseConfirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 55.7 um PUBCHEM_BIOASSAY: Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition. (Class of assay: confirmatory) [Related pubchem assays: 920, 1317, 1265, 1308, 862 ] ChEMBL. No reference
IC50 (functional) > 64 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits via a heat-shock counterscreen assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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