Detailed information for compound 1376266

Basic information

Technical information
  • TDR Targets ID: 1376266
  • Name: 2-[(4-methylquinazolin-2-yl)amino]-6-phenyl-1 H-pyrimidin-4-one
  • MW: 329.355 | Formula: C19H15N5O
  • H donors: 2 H acceptors: 5 LogP: 4.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(Nc2nc(C)c3c(n2)cccc3)nc(c1)c1ccccc1
  • InChi: 1S/C19H15N5O/c1-12-14-9-5-6-10-15(14)21-18(20-12)24-19-22-16(11-17(25)23-19)13-7-3-2-4-8-13/h2-11H,1H3,(H2,20,21,22,23,24,25)
  • InChiKey: VCZKMOAQDFHXKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-methyl-2-quinazolinyl)amino]-6-phenyl-1H-pyrimidin-4-one
  • STK036589
  • 2-[(4-methyl-2-quinazolinyl)amino]-6-phenyl-4-pyrimidinol
  • MLS000061794
  • SMR000070267
  • ZINC05013092
  • ChemDiv1_018374
  • 2-(4-Methyl-quinazolin-2-ylamino)-6-phenyl-pyrimidin-4-ol
  • BAS 01095109

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase 0.0115 0.5132 0.5034
Schistosoma mansoni hypothetical protein 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Trypanosoma cruzi protein kinase, putative 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0198 0.3665
Brugia malayi Tyrosine-protein kinase PR2 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0115 0.5132 0.759
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0992 0.0898
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Giardia lamblia Kinase, NEK 0.0115 0.5132 1
Leishmania major protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0115 0.5132 0.759
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosin kinase, putative 0.0115 0.5132 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0485 0.0583
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0485 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0115 0.5132 0.7624
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Brugia malayi Guanylyl cyclase protein 23 0.0115 0.5132 0.7624
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0115 0.5132 0.5034
Echinococcus multilocularis activated cdc42 kinase 1 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase HCK 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0583 0.0782
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Brugia malayi hypothetical protein 0.0115 0.5132 0.7624
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0115 0.5132 0.5034
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0485 1
Entamoeba histolytica cysteine surface protein, putative 0.0115 0.5132 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0485 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.5132 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1861 0.337
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Echinococcus multilocularis activin receptor type 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Plasmodium falciparum tyrosine kinase-like protein 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Onchocerca volvulus 0.0115 0.5132 1
Brugia malayi SRC-1 0.0115 0.5132 0.7624
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0115 0.5132 0.5034
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0583 0.0971
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0115 0.5132 0.5034
Schistosoma mansoni serine/threonine RGC 0.0115 0.5132 0.5034
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.003 0.0583 0.0737
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Echinococcus granulosus c src tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Leishmania major DNA polymerase eta, putative 0.0038 0.0992 0.1609
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.122 0.2072
Echinococcus multilocularis tyrosine protein kinase HCK 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0115 0.5132 0.5034
Leishmania major basic transcription factor 3a, putative 0.0042 0.122 0.2072
Echinococcus granulosus raf serine:threonine protein kinase 0.0115 0.5132 0.5034
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Onchocerca volvulus 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica hypothetical protein 0.0042 0.122 0.2072
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0115 0.5132 1
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/DDR protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0115 0.5132 0.5034
Echinococcus granulosus activin receptor type 0.0115 0.5132 0.5034
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Plasmodium vivax protein kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0115 0.5132 0.5034
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0115 0.5132 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0485 1
Schistosoma mansoni tyrosine protein kinase 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Srms 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase Srms 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Trichomonas vaginalis protein tyrosine kinase, putative 0.0115 0.5132 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0115 0.5132 0.5034
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0198 0.2642
Loa Loa (eye worm) TK/EGFR protein kinase 0.0115 0.5132 0.759
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0115 0.5132 0.5034
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Echinococcus multilocularis insulin receptor 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/ROR protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi hypothetical protein 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0115 0.5132 1
Giardia lamblia Protein 21.1 0.0115 0.5132 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Trichomonas vaginalis TK family protein kinase 0.0115 0.5132 1
Echinococcus granulosus protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase csk 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosin kinase, putative 0.0115 0.5132 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0115 0.5132 0.5034
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0198 0.3665
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis AGC family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0115 0.5132 0.5034
Echinococcus granulosus epidermal growth factor receptor 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0115 0.5132 0.5034
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Echinococcus multilocularis protein kinase 0.0115 0.5132 0.5034
Brugia malayi SH2 domain containing protein 0.0115 0.5132 0.7624
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Echinococcus multilocularis protein tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.122 0.2072
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus fibroblast growth factor receptor 4 0.0115 0.5132 0.5034
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0115 0.5132 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.6732 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0115 0.5132 0.5034
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0992 0.1609
Toxoplasma gondii STE kinase 0.0115 0.5132 1
Echinococcus multilocularis FL cytokine receptor 0.0115 0.5132 0.5034
Echinococcus granulosus activated cdc42 kinase 1 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Schistosoma mansoni protein tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Lyn 0.0115 0.5132 0.5034
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus insulin receptor 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Trypanosoma brucei Flagellum attachment zone protein 20 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Entamoeba histolytica tyrosin kinase, putative 0.0115 0.5132 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0115 0.5132 0.7624
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0094 0.5
Onchocerca volvulus 0.0115 0.5132 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi integrin-linked kinase 0.0115 0.5132 0.7624
Giardia lamblia Kinase, NEK 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis kinase suppressor of Ras 1 0.0115 0.5132 0.5034
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Brugia malayi SH2 domain containing protein 0.0115 0.5132 0.7624
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Echinococcus multilocularis epidermal growth factor receptor 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0115 0.5132 0.5034
Onchocerca volvulus 0.0115 0.5132 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1861 0.2764
Onchocerca volvulus 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Trypanosoma brucei protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Onchocerca volvulus 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0115 0.5132 1
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Brugia malayi Furin-like cysteine rich region family protein 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.6732 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0115 0.5132 0.5034
Echinococcus granulosus integrin linked protein kinase 0.0115 0.5132 0.5034
Leishmania major protein kinase, putative 0.0115 0.5132 1
Toxoplasma gondii protein kinase 0.0115 0.5132 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Brugia malayi C-terminal src kinase protein 1 0.0115 0.5132 0.7624
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0115 0.5132 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.122 0.2072
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0115 0.5132 0.5034
Leishmania major hypothetical protein, conserved 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0485 0.059
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus tyrosine protein kinase csk 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Plasmodium falciparum protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0485 0.0721
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi beta-NAC-like protein 0.0042 0.122 0.1813
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Echinococcus granulosus epidermal growth factor receptor 0.0115 0.5132 0.5034
Echinococcus multilocularis transfer RNA-Thr 0.0115 0.5132 0.5034
Entamoeba histolytica ankyrin repeat protein 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0115 0.5132 0.759
Brugia malayi hypothetical protein 0.003 0.0583 0.0866
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0485 0.0583
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0115 0.5132 0.7624
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/ABL protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Schistosoma mansoni hypothetical protein 0.0205 1 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0485 1
Schistosoma mansoni hypothetical protein 0.0205 1 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0115 0.5132 0.5034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0485 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0115 0.5132 0.7624
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Echinococcus granulosus transcription factor btf3 0.0042 0.122 0.1043
Echinococcus multilocularis heat shock protein 70 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi Receptor family ligand binding region containing protein 0.0115 0.5132 0.7624
Echinococcus multilocularis tyrosine protein kinase shark 0.0115 0.5132 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0485 0.059
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0115 0.5132 0.5034
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0115 0.5132 0.5034
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0583 0.0971
Onchocerca volvulus Tyrosine kinase homolog 0.0115 0.5132 1
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis protein kinase atn1, putative 0.0115 0.5132 1
Entamoeba histolytica tyrosin kinase, putative 0.0115 0.5132 1
Schistosoma mansoni transcription factor btf3 0.0042 0.122 0.1043
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi hypothetical protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.122 0.2235
Echinococcus multilocularis tyrosine protein kinase csk 0.0115 0.5132 0.5034
Schistosoma mansoni ephrin receptor 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase Abl 0.0115 0.5132 0.5034
Leishmania major DNA polymerase eta, putative 0.0054 0.1861 0.337
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis STE family protein kinase 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase csk 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0198 0.2642
Brugia malayi Raf kinase 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0094 0.139
Toxoplasma gondii protein kinase domain-containing protein 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Brugia malayi MH2 domain containing protein 0.0144 0.6732 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0115 0.5132 0.7624
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.122 0.2072
Echinococcus multilocularis protein kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0115 0.5132 0.5034
Toxoplasma gondii NAC domain-containing protein 0.0042 0.122 0.14
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Plasmodium falciparum protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0115 0.5132 0.759
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis natriuretic peptide receptor 1 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0115 0.5132 0.5034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0485 0.0583
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0198 0.0156
Echinococcus multilocularis integrin linked protein kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis transcription factor btf3 0.0042 0.122 0.1043
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis dna polymerase eta 0.0054 0.1861 0.1697
Echinococcus multilocularis ephrin type A receptor 4 A 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase shark 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase pr2 0.0115 0.5132 0.5034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.5132 0.7624
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0115 0.5132 0.5034
Plasmodium falciparum tyrosine kinase-like protein 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0115 0.5132 0.759
Echinococcus granulosus dna polymerase eta 0.0054 0.1861 0.1697
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0115 0.5132 0.759
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0115 0.5132 0.5034
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0485 0.0721
Loa Loa (eye worm) hypothetical protein 0.0029 0.0485 0.059
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0115 0.5132 0.5034
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase pr2 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0115 0.5132 0.5034
Loa Loa (eye worm) SRC-1 0.0115 0.5132 0.759
Entamoeba histolytica receptor protein kinase, putative 0.0115 0.5132 1
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0583 0.0782
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0115 0.5132 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus multilocularis geminin 0.0205 1 1
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0115 0.5132 0.5034
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Loa Loa (eye worm) TK protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni DNA polymerase eta 0.0054 0.1861 0.1697
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0115 0.5132 0.5034
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/RYK protein kinase 0.0115 0.5132 0.759
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.122 0.2072
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0485 0.0721
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0115 0.5132 0.5034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0485 0.0583
Loa Loa (eye worm) ICD-1 protein 0.0042 0.122 0.1696
Onchocerca volvulus 0.0115 0.5132 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0485 1
Onchocerca volvulus 0.0115 0.5132 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0485 0.0583
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1861 0.337
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus tyrosine kinase 0.0115 0.5132 0.5034
Plasmodium vivax tyrosine kinase-like protein, putative 0.0115 0.5132 1
Echinococcus granulosus protein tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.122 0.2072
Loa Loa (eye worm) hypothetical protein 0.0115 0.5132 0.759
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0485 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0485 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.0115 0.5132 0.7624
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0583 0.0782
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0485 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0485 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Echinococcus granulosus kinase suppressor of Ras 1 0.0115 0.5132 0.5034
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0115 0.5132 0.7624
Entamoeba histolytica ankyrin repeat protein 0.0115 0.5132 1
Brugia malayi protein-tyrosine kinase 0.0115 0.5132 0.7624
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Loa Loa (eye worm) serine/threonine protein kinase 0.0115 0.5132 0.759
Brugia malayi ephrin receptor 1 precursor 0.0115 0.5132 0.7624
Loa Loa (eye worm) protein kinase domain-containing protein 0.0115 0.5132 0.759
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0115 0.5132 0.759
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica receptor protein kinase, putative 0.0115 0.5132 1
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.122 0.2072
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Echinococcus multilocularis epidermal growth factor receptor 0.0115 0.5132 0.5034
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.122 0.2235
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Schistosoma mansoni ephrin receptor 0.0115 0.5132 0.5034
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0198 0.0293
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine protein kinase Src64B 0.0115 0.5132 0.5034
Echinococcus granulosus tyrosine kinase 0.0115 0.5132 0.5034
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0485 0.0583
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0115 0.5132 0.5034
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Mycobacterium ulcerans hypothetical protein 0.0029 0.0485 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Loa Loa (eye worm) hypothetical protein 0.0054 0.1861 0.2661
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Leishmania major hypothetical protein, conserved 0.003 0.0583 0.0782
Trypanosoma cruzi protein kinase, putative 0.0115 0.5132 1
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Trypanosoma brucei Pseudokinase, putative 0.0115 0.5132 1
Entamoeba histolytica tyrosine kinase, putative 0.0115 0.5132 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0115 0.5132 0.5034
Plasmodium vivax tyrosine kinase-like protein, putative 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0115 0.5132 0.5034
Loa Loa (eye worm) TK/FAK protein kinase 0.0115 0.5132 0.759
Echinococcus multilocularis c src tyrosine kinase 0.0115 0.5132 0.5034
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Echinococcus granulosus activated cdc42 kinase 1 0.0115 0.5132 0.5034
Entamoeba histolytica hypothetical protein, conserved 0.0115 0.5132 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.5132 1
Giardia lamblia Kinase 0.0115 0.5132 1
Trichomonas vaginalis TKL family protein kinase 0.0115 0.5132 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0583 0.0971
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Loa Loa (eye worm) TK/Met protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica hypothetical protein 0.0115 0.5132 1
Entamoeba histolytica serine/threonine kinase, putative 0.0115 0.5132 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.5132 1
Brugia malayi Protein kinase domain containing protein 0.0115 0.5132 0.7624
Schistosoma mansoni tyrosine kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase csk 0.0115 0.5132 0.5034
Entamoeba histolytica protein kinase, putative 0.0115 0.5132 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.5132 0.7624
Plasmodium falciparum protein kinase, putative 0.0115 0.5132 1
Onchocerca volvulus 0.0115 0.5132 1
Loa Loa (eye worm) TK/FER protein kinase 0.0115 0.5132 0.759
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0115 0.5132 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0115 0.5132 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis tyrosine protein kinase csk 0.0115 0.5132 0.5034
Schistosoma mansoni protein kinase 0.0115 0.5132 0.5034
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0115 0.5132 0.5034

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.669 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.