Detailed information for compound 1378618

Basic information

Technical information
  • TDR Targets ID: 1378618
  • Name: 4-(3,5-dimethylpyrazol-1-yl)-N-(5-methyl-1,3, 4-thiadiazol-2-yl)benzamide
  • MW: 313.378 | Formula: C15H15N5OS
  • H donors: 1 H acceptors: 4 LogP: 2.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc(s1)NC(=O)c1ccc(cc1)n1nc(cc1C)C
  • InChi: 1S/C15H15N5OS/c1-9-8-10(2)20(19-9)13-6-4-12(5-7-13)14(21)16-15-18-17-11(3)22-15/h4-8H,1-3H3,(H,16,18,21)
  • InChiKey: VIQBWXIQEBPZGU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-(3,5-dimethyl-1-pyrazolyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide
  • T5245911
  • MLS000565987
  • SMR000153073
  • ZINC02654330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Mycobacterium ulcerans hypothetical protein 0.0031 0.0186 0.0416
Echinococcus granulosus serine/threonine protein kinase 0.0024 0.0111 0.0131
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.1988 1
Echinococcus multilocularis rho associated protein kinase 0.0125 0.1152 0.1137
Echinococcus granulosus protein kinase C gamma type 0.0025 0.0116 0.0137
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0024 0.0111 0.0094
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0116 0.0099
Mycobacterium ulcerans hypothetical protein 0.0029 0.0156 0.0298
Loa Loa (eye worm) ctsf protein 0.002 0.0069 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0386 0.3859 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0095 0.0366
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0405
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8489 0.8486
Schistosoma mansoni hypothetical protein 0.0164 0.1555 0.1832
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0213 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1152 0.1357
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0266 0.0249
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0658 0.3247
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0196 0.0231
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0025 0.0116 0.0301
Onchocerca volvulus Cathepsin L homolog 0.002 0.0069 0.0505
Schistosoma mansoni chromobox protein 0.0067 0.0557 0.0656
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0301
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0025 0.0116 0.0301
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0069 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.028 0.2043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0211
Leishmania major cathepsin L-like protease 0.0077 0.0658 0.3247
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0032 0.0196 0.5248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0069 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0296 0.1139
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0151 0.0178
Onchocerca volvulus Cathepsin F homolog 0.002 0.0069 0.0505
Toxoplasma gondii exonuclease III APE 0.0023 0.0095 0.2272
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0296 0.1139
Loa Loa (eye worm) AGC/PKG protein kinase 0.0032 0.0196 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0081 0.3563
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0151 0.3936
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0069 0.0267
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0151 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0136 0.0526
Onchocerca volvulus 0.003 0.0166 0.1211
Onchocerca volvulus 0.0125 0.1152 0.8401
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0069 0.0082
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0021
Onchocerca volvulus 0.002 0.0069 0.0505
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0095 0.433
Brugia malayi isocitrate dehydrogenase 0.0015 0.0018 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0658 0.3247
Leishmania major cathepsin L-like protease 0.002 0.0069 0.0261
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0023 0.0101 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus granulosus peregrin 0.0028 0.0151 0.0178
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.0966
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0025 0.0116 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0405
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Echinococcus multilocularis expressed conserved protein 0.0032 0.0196 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0111 0.0474
Brugia malayi Heterochromatin protein 1 0.0067 0.0557 0.1443
Echinococcus granulosus geminin 0.0164 0.1555 0.1832
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus granulosus NDR protein kinase 0.0025 0.0116 0.0137
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0025 0.0116 0.0099
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0095 0.0391
Onchocerca volvulus Alhambra homolog 0.0028 0.0151 0.1105
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0815 0.096
Entamoeba histolytica protein kinase, putative 0.0048 0.0357 0.1118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Schistosoma mansoni ap endonuclease 0.0023 0.0095 0.0112
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0042 0.0296 0.0766
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0018 0.0021
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0069 0.0179
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0105 0.0442
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0069 0.2882
Echinococcus multilocularis serine threonine protein kinase 0.0025 0.0116 0.0099
Echinococcus multilocularis chromobox protein 1 0.0067 0.0557 0.054
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0023 0.0101 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Plasmodium vivax vivapain-2 0.002 0.0069 0.3842
Leishmania major cathepsin L-like protease 0.002 0.0069 0.0261
Brugia malayi Protein kinase domain containing protein 0.0386 0.3859 1
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0213 0.0251
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0151 0.0134
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0018 0.0021
Leishmania major cathepsin L-like protease 0.002 0.0069 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0405
Echinococcus granulosus protein kinase c epsilon type 0.0025 0.0116 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0196 0.0231
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.052
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0069 0.0267
Onchocerca volvulus 0.002 0.0069 0.0505
Echinococcus multilocularis serine:threonine protein kinase 38 0.0025 0.0116 0.0099
Echinococcus granulosus nervana 2 0.0023 0.0101 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0069 0.3711
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0018 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Onchocerca volvulus 0.002 0.0069 0.0505
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0658 0.3247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0211
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0069 0.0082
Echinococcus granulosus serine:threonine protein kinase N2 0.0025 0.0116 0.0137
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0095 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.0095 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0018 0.0046
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0025 0.0116 0.0137
Brugia malayi Egg laying defective protein 4 0.0032 0.0196 0.0508
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0151 0.3936
Echinococcus multilocularis peregrin 0.0028 0.0151 0.0134
Schistosoma mansoni serine/threonine kinase 0.0025 0.0116 0.0137
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0069 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0081 0.4751
Loa Loa (eye worm) hypothetical protein 0.0025 0.0116 0.0301
Echinococcus granulosus protein kinase c iota type 0.0025 0.0116 0.0137
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) AGC/PKN protein kinase 0.0025 0.0116 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Entamoeba histolytica cysteine protease, putative 0.002 0.0069 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0196 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0111 0.0348
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0703
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1988 1
Plasmodium vivax vivapain-2 0.002 0.0069 0.3842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0588 0.2896
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0196 0.0231
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) glutaminase 2 0.0264 0.2595 0.6723
Brugia malayi Protein kinase domain containing protein 0.0042 0.0296 0.0766
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0018 0.0021
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0081 0.4585
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0156 0.0298
Echinococcus granulosus rho-associated protein kinase 1 0.0125 0.1152 0.1357
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0095 0.0366
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0095 0.0078
Giardia lamblia PHD finger protein 15 0.0028 0.0151 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0111 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Onchocerca volvulus 0.0146 0.1371 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0018 0.0049 0.0191
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0018 0.0049 0.0191
Echinococcus multilocularis cysteine protease 0.002 0.0069 0.0052
Echinococcus granulosus GPCR family 2 0.0015 0.0018 0.0021
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0156 0.0298
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0151 0.0393
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0359 0.0929
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0018 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0296 0.1139
Leishmania major cysteine peptidase A (CPA) 0.002 0.0069 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0025 0.0116 0.0099
Echinococcus multilocularis protein kinase c epsilon type 0.0025 0.0116 0.0099
Echinococcus multilocularis nervana 2 0.0023 0.0101 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0069 0.3711
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8489 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0105 0.0094
Entamoeba histolytica protein kinase, putative 0.0048 0.0357 0.1118
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8489 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0156 0.0489
Echinococcus multilocularis nervana 2 0.0023 0.0101 0.0084
Leishmania major cathepsin L-like protease 0.002 0.0069 0.0261
Echinococcus multilocularis cysteine protease 0.002 0.0069 0.0052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0095 0.0391
Schistosoma mansoni hypothetical protein 0.0028 0.0151 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0298
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0156 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0298
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0021
Onchocerca volvulus 0.002 0.0069 0.0505
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0489
Echinococcus multilocularis geminin 0.0164 0.1555 0.154
Onchocerca volvulus 0.0029 0.0156 0.114
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0156 0.5
Echinococcus granulosus Protein kinase C brain isozyme 0.0025 0.0116 0.0137
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0018 0.0049 0.0191
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0111 0.0131
Loa Loa (eye worm) hypothetical protein 0.0048 0.036 0.0933
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0557 0.1443
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0025 0.0116 0.0099
Leishmania major cathepsin L-like protease 0.002 0.0069 0.0261
Onchocerca volvulus 0.0124 0.1142 0.8327
Echinococcus granulosus cathepsin l1 0.002 0.0069 0.0082
Toxoplasma gondii cathepsin CPL 0.002 0.0069 0.1512
Entamoeba histolytica protein kinase, putative 0.0048 0.0357 0.1118
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0095 0.0391
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0211
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Mycobacterium ulcerans hypothetical protein 0.0024 0.0105 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0179
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0025 0.0116 0.0301
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0815 0.0799
Loa Loa (eye worm) hypothetical protein 0.003 0.0166 0.043
Loa Loa (eye worm) cysteine protease 0.002 0.0069 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Plasmodium falciparum cGMP-dependent protein kinase 0.0032 0.0196 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0105 0.0404
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0018 0.0049 0.0191
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0251 0.1827
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0095 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) AGC/AKT protein kinase 0.0048 0.0357 0.0926
Entamoeba histolytica protein kinase 2, putative 0.0024 0.0111 0.0348
Brugia malayi chromobox protein homolog 3 0.0038 0.0251 0.0649
Brugia malayi p70 ribosomal S6 kinase beta 0.0048 0.0357 0.0926
Leishmania major cathepsin L-like protease 0.0077 0.0658 0.3247
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0069 0.0052
Echinococcus multilocularis rac serine:threonine kinase 0.0024 0.0111 0.0094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0213 0.0251
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0359 0.0929
Trichomonas vaginalis chromobox protein, putative 0.0041 0.028 0.108
Entamoeba histolytica protein kinase, putative 0.0025 0.0116 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Echinococcus granulosus chromobox protein 1 0.0067 0.0557 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Brugia malayi protein kinase C II. 0.0025 0.0116 0.0301
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0095 0.0054
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0081 0.5
Trypanosoma cruzi Protein kinase B 0.0024 0.0111 0.0474
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0105 0.6287
Trichomonas vaginalis chromobox protein, putative 0.0041 0.028 0.108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.0116 0.0099
Brugia malayi PHD-finger family protein 0.0028 0.0151 0.0393
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0359 0.0929
Brugia malayi jmjC domain containing protein 0.0034 0.0213 0.0552
Echinococcus granulosus chromobox protein 1 0.0067 0.0557 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1988 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0025 0.0116 0.0301
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0024 0.0111 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0069 0.3711
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0405
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0156 0.0298
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0018 0.0046
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0025 0.0116 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0095 0.5773
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0196 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0462 0.1197
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0095 0.0391
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0298
Brugia malayi hypothetical protein 0.0146 0.1371 0.3554
Giardia lamblia Kinase, AGC PKA 0.0024 0.0111 0.2868
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0069 0.2882
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0069 0.0179
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0196 0.0179
Schistosoma mansoni atypical protein kinase C 0.0025 0.0116 0.0137
Mycobacterium ulcerans glutaminase 0.0264 0.2595 1
Mycobacterium tuberculosis Conserved protein 0.0024 0.0105 0.6287
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0156 0.0298
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0557 0.2146
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0156 1
Brugia malayi Bromodomain containing protein 0.0028 0.0151 0.0393
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0069 0.0052
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.0966
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0156 1
Schistosoma mansoni glutaminase 0.0264 0.2595 0.3056
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0105 0.0094
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0025 0.0116 0.0099
Brugia malayi glutaminase DH11.1 0.0264 0.2595 0.6723
Echinococcus granulosus Glutaredoxin protein 5 0.0023 0.0101 0.0119
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0116 0.0447
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0069 0.0261
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0557 0.2146
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0095 0.5
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0105 0.0124
Schistosoma mansoni hypothetical protein 0.0164 0.1555 0.1832
Brugia malayi Hr1 repeat family protein 0.0025 0.0116 0.0301
Echinococcus granulosus serine threonine protein kinase nrc 0.0024 0.0111 0.0131
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0703
Echinococcus multilocularis Glutaredoxin protein 5 0.0023 0.0101 0.0084
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0024 0.0111 0.5239
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Brugia malayi Protein kinase domain containing protein 0.0048 0.0357 0.0926
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0619 0.0729
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0151 1
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0018 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0929
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0095 0.5572
Mycobacterium ulcerans hypothetical protein 0.0024 0.0105 0.0094
Brugia malayi Cathepsin L-like precursor 0.002 0.0069 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.0649
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0069 0.0082
Brugia malayi jmjC domain containing protein 0.0092 0.0815 0.2112
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0405
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Entamoeba histolytica hypothetical protein 0.0322 0.3196 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0069 0.0505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0213 0.0552
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Schistosoma mansoni chromobox protein 0.0067 0.0557 0.0656
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0069 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0095 0.0112
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0105 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0357 0.1377
Loa Loa (eye worm) hypothetical protein 0.0146 0.1371 0.3554
Onchocerca volvulus 0.002 0.0069 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0136 0.0526
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0041 0.0285 0.11
Trichomonas vaginalis glutaminase, putative 0.0264 0.2595 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0069 0.0052
Echinococcus granulosus nervana 2 0.0023 0.0101 0.0119
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0105 0.0087
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0048 0.0357 0.0926
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0105 0.0442
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0201 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0069 0.0267
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Echinococcus multilocularis protein kinase c iota type 0.0025 0.0116 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Onchocerca volvulus 0.002 0.0069 0.0505
Toxoplasma gondii AGC kinase 0.0048 0.0357 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0024 0.0111 0.6985
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Schistosoma mansoni hypothetical protein 0.0033 0.0201 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.0405
Loa Loa (eye worm) fibroinase 0.002 0.0069 0.0179
Onchocerca volvulus 0.002 0.0069 0.0505
Plasmodium falciparum phd finger protein, putative 0.0028 0.0151 0.75
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0095 0.0246
Echinococcus granulosus cGMP dependent protein kinase 0.0032 0.0196 0.0231
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0111 0.0474
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0393
Leishmania major hypothetical protein, conserved 0.0206 0.1988 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0487 0.238
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.0703
Trichomonas vaginalis AGC family protein kinase 0.0018 0.0049 0.0191
Loa Loa (eye worm) glutaminase 0.0264 0.2595 0.6723
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0211
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0018 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0658 0.3247
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0658 0.3247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0069 0.3711
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0105 0.0442
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0213 0.0196
Trypanosoma brucei rac serine-threonine kinase, putative 0.0048 0.0357 0.1723
Leishmania major cathepsin L-like protease 0.0077 0.0658 0.3247
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0266 0.0313
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0095 0.0297
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0116 0.0137
Echinococcus multilocularis chromobox protein 1 0.0067 0.0557 0.054
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0069 0.2882
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0111 0.0131

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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