TDR Targets

Basic information

Technical information

TDR Targets ID: 1380763
Name: (3aS,5aS,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-(2 -methylpropoxyimino)-2-[3-(phenoxy)phenyl]-4, 5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoind ole-1,3-dione
MW: 492.563 | Formula: C28H32N2O6
H donors: 2 H acceptors: 4 LogP: 3.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(CO/N=C\1/C[C@@H](O)[C@H]([C@H]2[C@@H]1CC[C@H]1[C@H]2C(=O)N(C1=O)c1cccc(c1)Oc1ccccc1)O)C
InChi: 1S/C28H32N2O6/c1-16(2)15-35-29-22-14-23(31)26(32)24-20(22)11-12-21-25(24)28(34)30(27(21)33)17-7-6-10-19(13-17)36-18-8-4-3-5-9-18/h3-10,13,16,20-21,23-26,31-32H,11-12,14-15H2,1-2H3/b29-22-/t20-,21+,23-,24+,25-,26-/m1/s1
InChiKey: SZZJXBASWOBABK-OMJRKORBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3aS,5aS,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-isobutoxyimino-2-[3-(phenoxy)phenyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindole-1,3-dione
(3aS,5aS,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-isobutoxyimino-2-[3-(phenoxy)phenyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindole-1,3-quinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0053	0.0198	0.0272
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0053	0.0198	0.1169
Leishmania major	hypothetical protein, conserved	0.0107	0.0518	1
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0053	0.0198	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0188	0.0188
Brugia malayi	hypothetical protein	0.0107	0.0518	0.0518
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0053	0.0198	0.1169
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0065	0.009
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0225	0.122	1
Brugia malayi	Trypsin family protein	0.0023	0.0017	0.0017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1242	0.728	1
Echinococcus granulosus	expressed protein	0.0053	0.0198	0.0272
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0017	0.0221
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0326	0.182	0.182
Brugia malayi	MH1 domain containing protein	0.0064	0.0262	0.0262
Echinococcus granulosus	mothers against decapentaplegic 6	0.0052	0.0188	0.0259
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0053	0.0198	0.0272
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0326	0.182	0.2501
Toxoplasma gondii	PAN domain-containing protein	0.0067	0.0276	0.0433
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0326	0.182	0.2501
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0015	0.0299
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0062	0.0248	0.4623
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0031	0.0063	0.1222
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0015	0.0127
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Onchocerca volvulus		0.0067	0.0276	0.1221
Plasmodium falciparum	cysteine repeat modular protein 1	0.0062	0.0248	0.4623
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0015	0.0091
Loa Loa (eye worm)	G protein alpha subunit 3	0.0053	0.0198	0.0198
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Schistosoma mansoni	hypothetical protein	0.0326	0.182	0.2501
Echinococcus granulosus	GPCR family 2	0.0326	0.182	0.2501
Entamoeba histolytica	G protein alpha subunit, putative	0.0053	0.0198	0.1169
Echinococcus multilocularis	transmembrane protease serine 3	0.0023	0.0017	0.0023
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0116	0.057	0.0783
Mycobacterium tuberculosis	Probable reductase	0.0202	0.1085	0.8898
Brugia malayi	MH1 domain containing protein	0.0064	0.0262	0.0262
Plasmodium falciparum	ataxin-2 like protein, putative	0.0107	0.0518	1
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0116	0.057	0.0783
Schistosoma mansoni	hypothetical protein	0.0062	0.0248	0.034
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0225	0.122	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0065	0.009
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0031	0.0063	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.1242	0.728	0.728
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0023	0.0017	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0198	0.0198
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0015	0.0299
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Plasmodium vivax	SET domain protein, putative	0.0031	0.0065	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0641	0.0641
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.0248	0.4784
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0326	0.182	0.182
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.1811	0.2488
Plasmodium falciparum	thioredoxin reductase	0.0031	0.0063	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0198	0.0198
Echinococcus granulosus	tissue type plasminogen activator	0.0062	0.0248	0.034
Echinococcus granulosus	tar DNA binding protein	0.0324	0.1811	0.2488
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0031	0.0063	0.0951
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0015	0.0091
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0053	0.0198	0.0272
Leishmania major	trypanothione reductase	0.0089	0.0408	0.7887
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0053	0.0198	0.0198
Toxoplasma gondii	thioredoxin reductase	0.0089	0.0408	0.0653
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.0766	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0067	0.0276	0.0276
Schistosoma mansoni	hypothetical protein	0.0023	0.0017	0.0023
Schistosoma mansoni	Smad4	0.0116	0.057	0.0783
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0065	0.009
Schistosoma mansoni	smad	0.0116	0.057	0.0783
Schistosoma mansoni	hypothetical protein	0.0326	0.182	0.2501
Toxoplasma gondii	subtilisin SUB12	0.0067	0.0276	0.0433
Onchocerca volvulus		0.0053	0.0198	0.0853
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0015	0.0021
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0053	0.0198	0.0198
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0031	0.0063	0.1222
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Schistosoma mansoni	smad1 5 8 and	0.0116	0.057	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Mycobacterium tuberculosis	Probable dehydrogenase	0.0202	0.1085	0.8898
Plasmodium falciparum	ataxin-2 like protein, putative	0.0107	0.0518	1
Brugia malayi	hypothetical protein	0.0053	0.0198	0.0198
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0053	0.0198	0.0272
Trichomonas vaginalis	mercuric reductase, putative	0.0031	0.0063	0.0373
Toxoplasma gondii	microneme protein MIC17B	0.0067	0.0276	0.0433
Brugia malayi	Cytochrome P450 family protein	0.0032	0.0068	0.0068
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1242	0.728	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0053	0.0198	0.0272
Treponema pallidum	fructose-bisphosphate aldolase	0.0305	0.1694	1
Brugia malayi	glutathione reductase	0.0089	0.0408	0.0408
Schistosoma mansoni	ap endonuclease	0.0023	0.0015	0.0021
Loa Loa (eye worm)	MH1 domain-containing protein	0.0052	0.0188	0.0188
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0015	0.0299
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.1242	0.728	0.728
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0053	0.0198	0.1169
Onchocerca volvulus		0.0067	0.0276	0.1221
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0015	0.0091
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0065	0.0065
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Schistosoma mansoni	hypothetical protein	0.0326	0.182	0.2501
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.1222
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0053	0.0198	0.0198
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Loa Loa (eye worm)	PAN domain-containing protein	0.0067	0.0276	0.0276
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0053	0.0198	0.0272
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1242	0.728	1
Toxoplasma gondii	PAN domain-containing protein	0.0067	0.0276	0.0433
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0089	0.0408	0.3349
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0202	0.1085	0.8898
Toxoplasma gondii	PAN domain-containing protein	0.0067	0.0276	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Plasmodium falciparum	thioredoxin reductase	0.0089	0.0408	0.7822
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.1811	0.2488
Loa Loa (eye worm)	TK/ROR protein kinase	0.0062	0.0248	0.0248
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Onchocerca volvulus	Huntingtin homolog	0.0128	0.0641	0.2937
Schistosoma mansoni	hypothetical protein	0.0048	0.0166	0.0228
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0305	0.1694	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0023	0.0015	0.0015
Plasmodium vivax	glutathione reductase, putative	0.0089	0.0408	0.7822
Schistosoma mansoni	Smad4	0.0052	0.0188	0.0259
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0053	0.0198	0.0272
Loa Loa (eye worm)	hypothetical protein	0.038	0.2141	0.2141
Onchocerca volvulus		0.0067	0.0276	0.1221
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.1811	0.2488
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.0087
Leishmania major	hypothetical protein, conserved	0.0062	0.0248	0.4784
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0053	0.0198	0.0198
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	latrophilin 2 splice variant baaae	0.0704	0.4072	0.4072
Echinococcus multilocularis	enteropeptidase	0.0023	0.0017	0.0023
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0023	0.0017	0.0023
Schistosoma mansoni	smad	0.0052	0.0188	0.0259
Onchocerca volvulus		0.0067	0.0276	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0262	0.0262
Brugia malayi	N-terminal motif family protein	0.038	0.2141	0.2141
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.057	0.057
Toxoplasma gondii	PAN domain-containing protein	0.0067	0.0276	0.0433
Brugia malayi	hypothetical protein	0.0128	0.0641	0.0641
Brugia malayi	G-protein alpha subunit	0.0053	0.0198	0.0198
Plasmodium vivax	ataxin-2 like protein, putative	0.0107	0.0518	1
Onchocerca volvulus		0.0067	0.0276	0.1221
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0053	0.0198	0.1169
Echinococcus granulosus	mothers against decapentaplegic 2	0.0052	0.0188	0.0259
Echinococcus multilocularis	GPCR, family 2	0.0326	0.182	0.2501
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0067	0.0276	0.0433
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.135	0.7971
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.1222
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0053	0.0198	0.0272
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0305	0.1694	1
Brugia malayi	Thioredoxin reductase	0.0089	0.0408	0.0408
Onchocerca volvulus		0.0067	0.0276	0.1221
Schistosoma mansoni	Smad4	0.0052	0.0188	0.0259
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.0087
Loa Loa (eye worm)	transcription factor SMAD2	0.1699	1	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0053	0.0198	0.1169
Onchocerca volvulus		0.0053	0.0198	0.0853
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0048	0.0166	0.0228
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0065	0.009
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0015	0.0015
Plasmodium vivax	thioredoxin reductase, putative	0.0089	0.0408	0.7822
Loa Loa (eye worm)	glutathione reductase	0.0089	0.0408	0.0408
Brugia malayi	Calcitonin receptor-like protein seb-1	0.103	0.6012	0.6012
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0023	0.0017	0.0017
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0089	0.0412	0.0565
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0023	0.0017	0.0023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Loa Loa (eye worm)	hypothetical protein	0.0326	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0198	0.0198
Echinococcus granulosus	Mastin	0.0023	0.0017	0.0023
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0202	0.1085	0.7034
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0023	0.0017	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Echinococcus multilocularis	Smad4	0.0116	0.057	0.0783
Schistosoma mansoni	hypothetical protein	0.0704	0.4072	0.5594
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0053	0.0198	0.0198
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0053	0.0198	0.0272
Plasmodium falciparum	glutathione reductase	0.0031	0.0063	0.0951
Echinococcus multilocularis	glycoprotein Antigen 5	0.0023	0.0017	0.0023
Brugia malayi	RNA recognition motif domain containing protein	0.0324	0.1811	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0326	0.182	0.2501
Toxoplasma gondii	microneme protein MIC17C	0.0067	0.0276	0.0433
Onchocerca volvulus		0.0067	0.0276	0.1221
Echinococcus multilocularis	tar DNA binding protein	0.0324	0.1811	0.2488
Loa Loa (eye worm)	Smad1	0.0116	0.057	0.057
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0031	0.0063	0.5
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Loa Loa (eye worm)	PAN domain-containing protein	0.0067	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.103	0.6012	0.6012
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0065	0.009
Echinococcus granulosus	glycoprotein Antigen 5	0.0023	0.0017	0.0023
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0053	0.0198	0.0272
Schistosoma mansoni	hypothetical protein	0.0326	0.182	0.2501
Brugia malayi	MH1 domain containing protein	0.0116	0.057	0.057
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0052	0.0188	0.0808
Brugia malayi	MH2 domain containing protein	0.0052	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0704	0.4072	0.4072
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0053	0.0198	0.0198
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0031	0.0063	0.0951
Brugia malayi	Pre-SET motif family protein	0.0031	0.0065	0.0065
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1242	0.728	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0053	0.0198	0.0198
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0015	0.0021
Toxoplasma gondii	PAN domain-containing protein	0.1033	0.6034	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0031	0.0063	0.0826
Schistosoma mansoni	ap endonuclease	0.0023	0.0015	0.0021
Echinococcus granulosus	thioredoxin glutathione reductase	0.0089	0.0412	0.0565
Loa Loa (eye worm)	thioredoxin reductase	0.0089	0.0408	0.0408
Toxoplasma gondii	microneme protein, putative	0.0067	0.0276	0.0433
Brugia malayi	mothers against decapentaplegic homolog 3	0.0052	0.0188	0.0188
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Onchocerca volvulus		0.0062	0.0248	0.1087
Onchocerca volvulus	Huntingtin homolog	0.0128	0.0641	0.2937
Echinococcus multilocularis	tissue type plasminogen activator	0.0062	0.0248	0.034
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0225	0.122	1
Trichomonas vaginalis	glutathione reductase, putative	0.0031	0.0063	0.0373
Brugia malayi	Protein kinase domain containing protein	0.0062	0.0248	0.0248
Loa Loa (eye worm)	trypsin family protein	0.0023	0.0017	0.0017
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Trypanosoma cruzi	trypanothione reductase, putative	0.0031	0.0063	0.1222
Echinococcus granulosus	smad	0.0116	0.057	0.0783
Loa Loa (eye worm)	PAN domain-containing protein	0.0067	0.0276	0.0276
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1242	0.728	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0053	0.0198	0.1169
Echinococcus granulosus	Smad4	0.0116	0.057	0.0783
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0053	0.0198	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0198	0.0198
Onchocerca volvulus		0.0031	0.0065	0.0229
Brugia malayi	Trypsin family protein	0.0023	0.0017	0.0017
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0015	0.0299
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0031	0.0063	0.0079
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0053	0.0198	0.0198
Onchocerca volvulus		0.0067	0.0276	0.1221
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Toxoplasma gondii	PAN domain-containing protein	0.1033	0.6034	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0065	0.009
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0053	0.0198	0.0272
Onchocerca volvulus		0.0247	0.135	0.6279
Schistosoma mansoni	smad1 5 8 and	0.0116	0.057	0.0783
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0031	0.0063	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0053	0.0198	0.0272
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0031	0.0063	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0031	0.0063	0.0063
Loa Loa (eye worm)	MH2 domain-containing protein	0.0052	0.0188	0.0188
Onchocerca volvulus		0.0067	0.0276	0.1221
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.1811	0.2488
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Loa Loa (eye worm)	cytochrome P450 family protein	0.0032	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0031	0.0063	0.0951
Loa Loa (eye worm)	MH2 domain-containing protein	0.1699	1	1
Brugia malayi	hypothetical protein	0.0069	0.0292	0.0292
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0015	0.0202
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0031	0.0063	0.0826
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0202	0.1085	0.8898
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0031	0.0063	0.0826
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0015	0.0091
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0059	0.0081
Brugia malayi	Trypsin-like protease protein 5	0.0023	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0017	0.0017
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0031	0.0063	0.0519
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0053	0.0198	0.0198
Loa Loa (eye worm)	TAR-binding protein	0.0324	0.1811	0.1811
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	Trypsin family protein	0.0023	0.0017	0.0017
Mycobacterium tuberculosis	Probable oxidoreductase	0.0225	0.122	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0107	0.0518	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0031	0.0063	1
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0053	0.0198	0.0272
Brugia malayi	Smad1	0.0116	0.057	0.057
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.1172	0.1172
Schistosoma mansoni	smad1 5 8 and	0.0116	0.057	0.0783
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0053	0.0198	0.0272
Brugia malayi	MH1 domain containing protein	0.0116	0.057	0.057
Brugia malayi	Latrophilin receptor protein 2	0.0326	0.182	0.182
Brugia malayi	RNA binding protein	0.0324	0.1811	0.1811
Treponema pallidum	NADH oxidase	0.0031	0.0063	0.0285
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0202	0.1085	0.8898
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0053	0.0198	0.0198
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0023	0.0015	0.0015
Brugia malayi	MH2 domain containing protein	0.0116	0.057	0.057
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.038	0.2141	1
Onchocerca volvulus		0.0067	0.0276	0.1221
Echinococcus granulosus	transmembrane protease serine 3	0.0023	0.0017	0.0023
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Onchocerca volvulus		0.0067	0.0276	0.1221
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0067	0.0276	0.0433
Echinococcus multilocularis	Mastin	0.0023	0.0017	0.0023
Brugia malayi	Kringle domain containing protein	0.0062	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0198	0.0198
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.103	0.6012	0.6012
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1242	0.728	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0276	0.0276
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0031	0.0063	0.0951
Toxoplasma gondii	hypothetical protein	0.0067	0.0276	0.0433
Trypanosoma brucei	PAB1-binding protein , putative	0.0107	0.0518	1
Toxoplasma gondii	microneme protein MIC17A	0.0067	0.0276	0.0433
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0053	0.0198	0.0198
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0116	0.057	0.0783
Trypanosoma cruzi	PAB1-binding protein , putative	0.0107	0.0518	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0053	0.0198	0.0272
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0324	0.1811	0.1811
Schistosoma mansoni	tar DNA-binding protein	0.0324	0.1811	0.2488
Brugia malayi	PAN domain containing protein	0.0067	0.0276	0.0276
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0053	0.0198	0.0198
Plasmodium falciparum	glutathione reductase	0.0089	0.0408	0.7822
Brugia malayi	hypothetical protein	0.0023	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0518	0.0518
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0031	0.0063	0.1222
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Echinococcus multilocularis	smad	0.0116	0.057	0.0783
Toxoplasma gondii	hypothetical protein	0.0067	0.0276	0.0433
Loa Loa (eye worm)	RNA binding protein	0.0324	0.1811	0.1811
Brugia malayi	MH2 domain containing protein	0.0116	0.057	0.057
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0023	0.0017	0.0023
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0053	0.0198	0.1169
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0053	0.0198	0.0272
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0052	0.0188	0.0259
Onchocerca volvulus		0.0053	0.0198	0.0853
Toxoplasma gondii	LsmAD domain-containing protein	0.0107	0.0518	0.0835
Trypanosoma brucei	trypanothione reductase	0.0089	0.0408	0.7887
Loa Loa (eye worm)	nuclear factor I	0.0064	0.0262	0.0262
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.103	0.6012	0.6012
Toxoplasma gondii	NADPH-glutathione reductase	0.0031	0.0063	0.0079
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0053	0.0198	0.0272
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0326	0.182	0.2501
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0053	0.0198	0.1169
Echinococcus granulosus	enteropeptidase	0.0023	0.0017	0.0023
Brugia malayi	TAR-binding protein	0.0324	0.1811	0.1811
Echinococcus granulosus	mothers against decapentaplegic 5	0.0116	0.057	0.0783
Loa Loa (eye worm)	MH1 domain-containing protein	0.0116	0.057	0.057
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0641	0.0641
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0065	0.0083
Toxoplasma gondii	kringle domain-containing protein	0.0062	0.0248	0.0386
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0202	0.1085	0.8898
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0053	0.0198	0.0272
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0015	0.0015
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1242	0.728	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0031	0.0063	0.1222
Schistosoma mansoni	hypothetical protein	0.0023	0.0017	0.0023
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0116	0.057	0.0783
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Loa Loa (eye worm)	PAN domain-containing protein	0.0067	0.0276	0.0276
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0031	0.0063	0.1222
Brugia malayi	Pre-SET motif family protein	0.0217	0.1172	0.1172
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0065	0.009
Schistosoma mansoni	cercarial elastase (S01 family)	0.0023	0.0017	0.0023
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0052	0.0188	0.0259
Brugia malayi	Trypsin family protein	0.0023	0.0017	0.0017
Toxoplasma gondii	microneme protein MIC4	0.0067	0.0276	0.0433
Trypanosoma cruzi	trypanothione reductase, putative	0.0089	0.0408	0.7887
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0053	0.0198	0.0198
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0048	0.0166	0.0228
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0053	0.0198	0.0272
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0053	0.0198	0.0272
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.0766	0.6283
Echinococcus multilocularis	expressed protein	0.0053	0.0198	0.0272
Giardia lamblia	Fructose-bisphosphate aldolase	0.0305	0.1694	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0305	0.1694	1
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0053	0.0198	0.0272

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 5.011872336 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (ADMET)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1513431

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1380763