Detailed information for compound 1380978

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 821.364 | Formula: C21H37Li3N7O18P3S
  • H donors: 11 H acceptors: 16 LogP: -6.73 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 4
  • SMILES: SCCNC(=O)CCNC(=O)C(C(COP(=O)(OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(O)[O-])O)n1cnc2c1ncnc2N)[O-])[O-])(C)C)O.[Li+].[Li+].[Li+].O.O
  • InChi: 1S/C21H36N7O16P3S.3Li.2H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;;2*1H2/q;3*+1;;/p-3/t11-,14-,15-,16?,20-;;;;;/m1...../s1
  • InChiKey: VYMAJVUGLWJGOO-JVQAMNNVSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.034 0.0393 0.3112
Plasmodium falciparum serine/threonine protein kinase, putative 0.0505 0.0762 0.6432
Echinococcus granulosus rho-associated protein kinase 1 0.0875 0.159 0.3491
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0248 0.0187 0.0192
Schistosoma mansoni protein kinase 0.1049 0.1981 0.6618
Schistosoma mansoni serine/threonine protein kinase 0.0498 0.0747 0.2497
Echinococcus granulosus casein kinase I delta 0.0325 0.036 0.079
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.044 0.0616 0.0632
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.034 0.0393 0.0393
Echinococcus granulosus dual specificity protein kinase clk2 0.0673 0.1138 0.2499
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0663 0.1116 0.245
Plasmodium falciparum calcium-dependent protein kinase 1 0.0261 0.0215 0.1245
Brugia malayi casein kinase I 0.0325 0.036 0.036
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1007 0.1885 0.4139
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0641 0.1067 0.9342
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0413 0.0555 0.0533
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.028 0.0259 0.0865
Loa Loa (eye worm) hypothetical protein 0.0202 0.0084 0.0061
Onchocerca volvulus 0.0418 0.0567 0.0556
Schistosoma mansoni serine/threonine protein kinase 0.0875 0.159 0.5312
Echinococcus granulosus titin 0.0198 0.0074 0.0162
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.019 0.0056 0.0057
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0413 0.0555 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0056 0.0187
Loa Loa (eye worm) TK/ALK protein kinase 0.263 0.5522 0.5511
Brugia malayi Temporarily assigned gene name protein 59 0.0248 0.0187 0.0187
Echinococcus multilocularis protein kinase c iota type 0.0256 0.0204 0.0209
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0709 0.1219 0.2676
Trichomonas vaginalis AGC family protein kinase 0.0505 0.0762 0.471
Leishmania major protein kinase A catalytic subunit 0.034 0.0393 0.1652
Onchocerca volvulus 0.1394 0.2754 0.2745
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0325 0.036 0.0338
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0413 0.0555 0.0533
Brugia malayi C1-like domain containing protein 0.0479 0.0703 0.0703
Echinococcus multilocularis dual specificity testis specific protein kinase 0.1049 0.1981 0.2031
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0761 0.1335 0.1315
Giardia lamblia Kinase, NEK 0.0641 0.1067 0.6595
Loa Loa (eye worm) hypothetical protein 0.0594 0.0961 0.094
Brugia malayi Protein kinase domain containing protein 0.0761 0.1335 0.1335
Brugia malayi Protein kinase domain containing protein 0.1518 0.303 0.303
Brugia malayi Stress-activated protein kinase jnk-1 0.1339 0.2629 0.2629
Echinococcus granulosus cyclin dependent kinase 9 0.0192 0.0061 0.0133
Loa Loa (eye worm) hypothetical protein 0.0333 0.0378 0.0355
Plasmodium vivax glycogen synthase kinase 3, putative 0.06 0.0976 0.8403
Brugia malayi hypothetical protein 0.131 0.2564 0.2564
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.019 0.0056 0.0057
Echinococcus granulosus cyclin dependent kinase 19 0.0932 0.1718 0.3772
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0176 0.0025 0.0002
Echinococcus multilocularis rho associated protein kinase 0.0875 0.159 0.1631
Toxoplasma gondii AGC kinase 0.034 0.0393 0.3112
Leishmania major protein kinase, putative 0.0203 0.0085 0.0005
Loa Loa (eye worm) hypothetical protein 0.0348 0.0411 0.0388
Trichomonas vaginalis CK1 family protein kinase 0.0325 0.036 0.2225
Echinococcus granulosus tyrosine protein kinase Src42A 0.044 0.0616 0.1354
Echinococcus multilocularis activated cdc42 kinase 1 0.1027 0.1932 0.1981
Entamoeba histolytica protein kinase domain containing protein 0.0203 0.0085 0.0636
Brugia malayi Tyrosine-protein kinase abl-1 0.0563 0.0892 0.0892
Entamoeba histolytica protein kinase, putative 0.0761 0.1335 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.1037 0.1953 0.2003
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.06 0.0976 0.4772
Echinococcus granulosus contactin 0.0176 0.0025 0.0054
Onchocerca volvulus 0.0214 0.011 0.0098
Brugia malayi p70 ribosomal S6 kinase beta 0.019 0.0056 0.0056
Plasmodium falciparum protein kinase 5 0.0358 0.0434 0.3318
Echinococcus granulosus casein kinase I delta 0.0325 0.036 0.079
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Echinococcus multilocularis casein kinase i 0.0325 0.036 0.0369
Trichomonas vaginalis CMGC family protein kinase 0.0358 0.0434 0.2681
Echinococcus granulosus tyrosine protein kinase Blk 0.0373 0.0467 0.1026
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0505 0.0762 0.5707
Entamoeba histolytica protein kinase, putative 0.0261 0.0215 0.1613
Trichomonas vaginalis CMGC family protein kinase 0.0673 0.1138 0.7035
Echinococcus granulosus glycogen synthase kinase 3 beta 0.06 0.0976 0.2142
Schistosoma mansoni serine/threonine protein kinase 0.0727 0.1259 0.4207
Schistosoma mansoni Neurotrimin precursor (hNT) 0.035 0.0416 0.1389
Loa Loa (eye worm) AGC/PKN protein kinase 0.019 0.0056 0.0033
Echinococcus granulosus raf serine:threonine protein kinase 0.0189 0.0055 0.0121
Echinococcus granulosus dual specificity 0.0761 0.1335 0.2931
Echinococcus granulosus serine:threonine protein kinase TAO1 0.131 0.2564 0.563
Trichomonas vaginalis CMGC family protein kinase 0.06 0.0976 0.6031
Trypanosoma cruzi casein kinase, putative 0.0325 0.036 0.1476
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0505 0.0762 0.1673
Loa Loa (eye worm) TK/ABL protein kinase 0.1125 0.215 0.2132
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0358 0.0434 0.0952
Brugia malayi Protein kinase domain containing protein 0.0208 0.0098 0.0098
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0261 0.0215 0.1472
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.06 0.0976 0.85
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0248 0.0828
Echinococcus multilocularis 0.0406 0.0541 0.0555
Echinococcus granulosus serine:threonine kinase SAD 1 0.0202 0.0084 0.0185
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1037 0.1953 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0709 0.1219 0.125
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.06 0.0976 0.1001
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.034 0.0393 0.2929
Brugia malayi Protein kinase domain containing protein 0.0932 0.1718 0.1718
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.034 0.0393 0.1652
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.0074 0.0247
Brugia malayi Protein kinase domain containing protein 0.077 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Fyn 0.044 0.0616 0.1354
Echinococcus granulosus cyclin dependent kinase 0.0358 0.0434 0.0952
Echinococcus multilocularis casein kinase I alpha 0.0325 0.036 0.0369
Echinococcus multilocularis protein KINase family member (kin 25) 0.0471 0.0687 0.0704
Loa Loa (eye worm) CMGC/GSK protein kinase 0.06 0.0976 0.0955
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0204 0.0681
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.044 0.0616 0.0632
Plasmodium falciparum calcium-dependent protein kinase 5 0.0261 0.0215 0.1245
Schistosoma mansoni protein kinase 0.0203 0.0085 0.0284
Schistosoma mansoni tyrosine kinase 0.0382 0.0486 0.1625
Brugia malayi Protein kinase domain containing protein 0.2631 0.5524 0.5524
Brugia malayi putative serine/threonine kinase SADA gamma 0.0202 0.0084 0.0084
Brugia malayi cell division control protein 2 homolog 0.0358 0.0434 0.0434
Echinococcus multilocularis NCK adaptor protein 0.0166 0.0002 0.0002
Onchocerca volvulus 0.0795 0.1412 0.1402
Schistosoma mansoni vesicular amine transporter 0.035 0.0416 0.1389
Trypanosoma cruzi aurora B kinase, putative 0.0505 0.0762 0.3628
Echinococcus granulosus cyclin dependent kinase 9 0.0175 0.0023 0.0051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0261 0.0215 0.0221
Entamoeba histolytica protein kinase, putative 0.0261 0.0215 0.1613
Brugia malayi Protein kinase domain containing protein 0.0413 0.0555 0.0555
Trypanosoma cruzi cdc2-related kinase 3 0.0358 0.0434 0.1871
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Echinococcus multilocularis roundabout 2 0.0176 0.0025 0.0025
Echinococcus granulosus cyclin dependent kinase 5 0.0358 0.0434 0.0952
Onchocerca volvulus 0.0214 0.011 0.0098
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0673 0.1138 0.564
Brugia malayi protein kinase C II. 0.0256 0.0204 0.0204
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0176 0.0025 0.0025
Entamoeba histolytica protein kinase domain containing protein 0.06 0.0976 0.7308
Loa Loa (eye worm) AGC/PKA protein kinase 0.034 0.0393 0.0371
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0887 0.1618 0.8207
Echinococcus granulosus tyrosine kinase 0.0214 0.011 0.0241
Echinococcus multilocularis mitogen activated protein kinase 11 0.1037 0.1953 0.2003
Giardia lamblia Kinase, CMGC CDK 0.0358 0.0434 0.2681
Loa Loa (eye worm) hypothetical protein 0.0348 0.0411 0.0388
Entamoeba histolytica p21-activated kinase 0.0183 0.0042 0.0314
Echinococcus granulosus c-Jun N-terminal kinases 0.1339 0.2629 0.5772
Loa Loa (eye worm) hypothetical protein 0.0366 0.0451 0.0429
Toxoplasma gondii aurora kinase 0.0505 0.0762 0.6525
Schistosoma mansoni serine/threonine protein kinase 0.0673 0.1138 0.3802
Echinococcus granulosus titin 0.0198 0.0074 0.0162
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0337 0.0386 0.0396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0358 0.0434 0.0412
Echinococcus multilocularis tyrosine protein kinase Fgr 0.044 0.0616 0.0632
Loa Loa (eye worm) hypothetical protein 0.035 0.0416 0.0394
Loa Loa (eye worm) hypothetical protein 0.035 0.0416 0.0394
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0648 0.1082 0.2374
Entamoeba histolytica protein kinase domain containing protein 0.0175 0.0023 0.0173
Loa Loa (eye worm) TK protein kinase 0.0283 0.0265 0.0242
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0862
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.0434 0.1449
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0248 0.0187 0.0411
Entamoeba histolytica protein kinase domain containing protein 0.0761 0.1335 1
Entamoeba histolytica protein kinase, putative 0.017 0.0011 0.0084
Echinococcus multilocularis dual specificity mitogen activated protein 0.0887 0.1618 0.1659
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0373 0.0467 0.0479
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1925 0.3943 0.3929
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0761 0.1335 0.6695
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.047 0.0684 0.0702
Entamoeba histolytica SH2-protein kinase domain containing protein 0.017 0.0011 0.0084
Plasmodium vivax casein kinase 1, putative 0.0325 0.036 0.2344
Brugia malayi Tyrosine-protein kinase abl-1 0.0629 0.1039 0.1039
Schistosoma mansoni growth factor receptor-bound protein 0.0166 0.0002 0.0008
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0202 0.0084 0.0061
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0358 0.0434 0.3491
Giardia lamblia Kinase, STE STE20 0.0887 0.1618 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0261 0.0215 0.0221
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0256 0.0204 0.0209
Brugia malayi Protein kinase domain containing protein 0.1027 0.1932 0.1932
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0862
Giardia lamblia Kinase, CMGC GSK 0.06 0.0976 0.6031
Brugia malayi Protein kinase domain containing protein 0.0439 0.0614 0.0614
Echinococcus granulosus casein kinase I alpha 0.0325 0.036 0.079
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.034 0.0393 0.1652
Brugia malayi Protein kinase domain containing protein 0.0214 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0682 0.1158 0.1137
Trichomonas vaginalis CMGC family protein kinase 0.06 0.0976 0.6031
Echinococcus multilocularis casein kinase I delta 0.0325 0.036 0.0369
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0261 0.0215 0.0702
Schistosoma mansoni tyrosine kinase 0.0471 0.0687 0.2295
Leishmania major protein kinase, putative 0.0673 0.1138 0.564
Brugia malayi Protein kinase domain containing protein 0.0358 0.0434 0.0434
Echinococcus granulosus casein kinase I alpha 0.0325 0.036 0.079
Echinococcus multilocularis insulin receptor 0.0697 0.1192 0.1223
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0727 0.1259 0.2765
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0023 0.0077
Onchocerca volvulus 0.0246 0.0182 0.017
Loa Loa (eye worm) hypothetical protein 0.034 0.0393 0.0371
Echinococcus granulosus TGF beta receptor type 1 0.047 0.0684 0.1502
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0325 0.036 0.0338
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0641 0.1067 0.9299
Brugia malayi protein unc-22 0.0198 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0094 0.0579
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0358 0.0434 0.0412
Echinococcus granulosus dual specificity mitogen activated protein 0.0887 0.1618 0.3552
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0887 0.1618 0.1598
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Schistosoma mansoni protein kinase 0.0325 0.036 0.1202
Schistosoma mansoni tyrosine kinase 0.0949 0.1756 0.5866
Schistosoma mansoni serine/threonine kinase 0.019 0.0056 0.0187
Loa Loa (eye worm) hypothetical protein 0.1027 0.1932 0.1913
Schistosoma mansoni tyrosine kinase 0.0214 0.011 0.0367
Plasmodium vivax calcium-dependent protein kinase, putative 0.0261 0.0215 0.0922
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0261 0.0215 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0641 0.1067 0.6595
Echinococcus multilocularis neuroglian 0.0453 0.0645 0.0662
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0261 0.0215 0.0221
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.035 0.0416 0.1389
Loa Loa (eye worm) CMGC/GSK protein kinase 0.06 0.0976 0.0955
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0025 0.0025
Loa Loa (eye worm) TK protein kinase 0.0766 0.1346 0.1326
Echinococcus multilocularis mitogen activated protein kinase 14 0.1037 0.1953 0.2003
Echinococcus granulosus casein kinase I alpha 0.0325 0.036 0.079
Brugia malayi Protein kinase domain containing protein 0.0214 0.011 0.011
Entamoeba histolytica protein kinase, putative 0.0283 0.0265 0.1984
Echinococcus multilocularis epidermal growth factor receptor 0.0382 0.0486 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0055 0.0185
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0663 0.1116 0.1145
Entamoeba histolytica PH domain containing protein kinase, putative 0.0359 0.0435 0.3256
Brugia malayi Protein kinase domain containing protein 0.019 0.0056 0.0056
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0176 0.0025 0.0054
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0471 0.0687 0.1508
Giardia lamblia Kinase, CMGC GSK 0.06 0.0976 0.6031
Entamoeba histolytica protein kinase, putative 0.019 0.0056 0.042
Trichomonas vaginalis STE family protein kinase 0.0887 0.1618 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0865 0.1569 0.1609
Schistosoma mansoni vav2 0.0175 0.0023 0.0078
Brugia malayi intracellular kinase 0.06 0.0976 0.0976
Echinococcus granulosus dual specificity testis-specific protein kinase 0.1049 0.1981 0.4349
Echinococcus granulosus protein kinase c iota type 0.0256 0.0204 0.0447
Schistosoma mansoni tyrosine kinase 0.1034 0.1948 0.6508
Onchocerca volvulus 0.0214 0.011 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0084 0.0281
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0261 0.0215 0.1472
Entamoeba histolytica protein kinase domain containing protein 0.0505 0.0762 0.5707
Entamoeba histolytica casein kinase, putative 0.0325 0.036 0.2696
Schistosoma mansoni tyrosine kinase 0.044 0.0616 0.206
Giardia lamblia Kinase, NEK 0.0641 0.1067 0.6595
Schistosoma mansoni serine/threonine protein kinase 0.131 0.2564 0.8568
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0761 0.1335 0.6695
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0246 0.0182 0.0526
Loa Loa (eye worm) hypothetical protein 0.045 0.0639 0.0617
Loa Loa (eye worm) AGC/PKA protein kinase 0.034 0.0393 0.0371
Echinococcus granulosus cyclin dependent kinase 1 0.0358 0.0434 0.0952
Schistosoma mansoni serine/threonine protein kinase 0.0567 0.0901 0.301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0366 0.0451 0.0451
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0815 0.1457 0.1437
Trichomonas vaginalis AGC family protein kinase 0.0505 0.0762 0.471
Trichomonas vaginalis STE family protein kinase 0.0887 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.051 0.0774 0.0752
Echinococcus granulosus hypothetical protein 0.0594 0.0961 0.2109
Schistosoma mansoni hypothetical protein 0.0248 0.0187 0.0625
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0248 0.0187 0.0625
Entamoeba histolytica cell division protein kinase 2, putative 0.0375 0.0471 0.353
Brugia malayi Protein kinase domain containing protein 0.0815 0.1457 0.1457
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Trichomonas vaginalis CK1 family protein kinase 0.0325 0.036 0.2225
Onchocerca volvulus 0.0333 0.0378 0.0366
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0328 0.0365 0.0801
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0779 0.1376 0.1376
Echinococcus granulosus activated cdc42 kinase 1 0.1027 0.1932 0.4241
Schistosoma mansoni protein kinase 0.0406 0.0541 0.1809
Giardia lamblia Kinase, CAMK CAMKL 0.0219 0.0122 0.0752
Plasmodium falciparum glycogen synthase kinase 3 0.06 0.0976 0.846
Echinococcus granulosus protein tyrosine kinase 0.1501 0.2993 0.6571
Loa Loa (eye worm) hypothetical protein 0.064 0.1063 0.1043
Trichomonas vaginalis AGC family protein kinase 0.034 0.0393 0.2428
Brugia malayi cyclin-dependent kinase 7 homolog 0.0515 0.0785 0.0785
Schistosoma mansoni tyrosine kinase 0.0697 0.1192 0.3984
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0176 0.0025 0.0025
Brugia malayi SRC-1 0.044 0.0616 0.0616
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0176 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0204 0.0681
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0248 0.0187 0.0552
Giardia lamblia Kinase, CMGC CLK 0.0673 0.1138 0.7035
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0887 0.1618 0.8207
Loa Loa (eye worm) hypothetical protein 0.0904 0.1656 0.1636
Echinococcus granulosus TGF-beta receptor type-1 0.047 0.0684 0.1502
Echinococcus multilocularis tyrosine protein kinase Fyn 0.044 0.0616 0.0632
Schistosoma mansoni protein kinase 0.0815 0.1457 0.4868
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0709 0.1219 0.1199
Schistosoma mansoni tyrosine kinase 0.028 0.0259 0.0865
Schistosoma mansoni tyrosine kinase 0.0258 0.021 0.0702
Echinococcus granulosus activin receptor type 0.2199 0.4555 1
Loa Loa (eye worm) AUR protein kinase 0.0505 0.0762 0.0741
Loa Loa (eye worm) hypothetical protein 0.0261 0.0215 0.0193
Entamoeba histolytica cell division protein kinase 2, putative 0.0358 0.0434 0.3249
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0248 0.0187 0.0625
Echinococcus granulosus activated cdc42 kinase 1 0.1027 0.1932 0.4241
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0505 0.0762 0.5707
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0214 0.011 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.1339 0.2629 0.8784
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0261 0.0215 0.0922
Brugia malayi bone morphogenetic protein type 1 receptor 0.0514 0.0783 0.0783
Echinococcus granulosus roundabout 2 0.0176 0.0025 0.0054
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0648 0.1082 0.1109
Leishmania major protein kinase, putative 0.0261 0.0215 0.0702
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0203 0.0085 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0261 0.0215 0.0473
Echinococcus multilocularis roundabout 2 0.0176 0.0025 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Echinococcus multilocularis transfer RNA-Thr 0.1027 0.1932 0.1981
Schistosoma mansoni serine/threonine protein kinase 0.0673 0.1138 0.3802
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0261 0.0215 0.0473
Echinococcus multilocularis activin receptor type 0.2199 0.4555 0.4671
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0393 0.1312
Giardia lamblia Kinase, AGC PKA 0.034 0.0393 0.2428
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1078 0.2045 0.2027
Loa Loa (eye worm) hypothetical protein 0.045 0.0639 0.0617
Onchocerca volvulus 0.06 0.0976 0.0965
Echinococcus multilocularis c src tyrosine kinase 0.028 0.0259 0.0266
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0779 0.1376 0.1356
Schistosoma mansoni protein kinase 0.0887 0.1618 0.5405
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0393 0.1312
Echinococcus multilocularis mitogen activated protein kinase 11 0.1037 0.1953 0.2003
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1007 0.1885 0.1934
Schistosoma mansoni protein kinase 0.0865 0.1569 0.5242
Trypanosoma brucei aurora B kinase 0.0505 0.0762 0.3628
Echinococcus granulosus fibroblast growth factor receptor 4 0.0663 0.1116 0.245
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0261 0.0215 0.0193
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0673 0.1138 0.564
Entamoeba histolytica protein kinase, putative 0.06 0.0976 0.7308
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0261 0.0215 0.1472
Loa Loa (eye worm) TK/FAK protein kinase 0.1518 0.303 0.3014
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0727 0.1259 0.1292
Brugia malayi Protein kinase domain containing protein 0.0993 0.1855 0.1855
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0358 0.0434 0.1871
Echinococcus multilocularis tyrosine protein kinase Fyn 0.044 0.0616 0.0632
Loa Loa (eye worm) CAMK protein kinase 0.0198 0.0074 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0505 0.0762 0.471
Echinococcus granulosus roundabout 2 0.0526 0.0809 0.1776
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0932 0.1718 0.1699
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0203 0.0085 0.0005
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0406 0.0541 0.052
Onchocerca volvulus 0.0214 0.011 0.0098
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0887 0.1618 0.8207
Trichomonas vaginalis AGC family protein kinase 0.019 0.0056 0.0346
Loa Loa (eye worm) hypothetical protein 0.0352 0.042 0.0398
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0325 0.036 0.0338
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.019 0.0056 0.0033
Echinococcus multilocularis calcium dependent protein kinase 0.0182 0.0038 0.0039
Plasmodium falciparum calcium-dependent protein kinase 2 0.0261 0.0215 0.1245
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0713 0.1228 0.2696
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0261 0.0215 0.0193
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1037 0.1953 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0166 0.0002 0.0005
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0887 0.1618 0.1618
Trypanosoma brucei protein kinase, putative 0.06 0.0976 0.4772
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0865 0.1569 0.3445
Brugia malayi Immunoglobulin I-set domain containing protein 0.1925 0.3943 0.3943
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Echinococcus granulosus tyrosine protein kinase Fyn 0.044 0.0616 0.1354
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0328 0.0365 0.0374
Echinococcus granulosus c src tyrosine kinase 0.028 0.0259 0.0569
Echinococcus multilocularis casein kinase I alpha 0.0325 0.036 0.0369
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.019 0.0056 0.0033
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0198 0.0074 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.077 0.1356 0.4531
Brugia malayi Fibronectin type III domain containing protein 0.0366 0.0451 0.0451
Brugia malayi Protein kinase domain containing protein 0.0673 0.1138 0.1138
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Schistosoma mansoni neuroglian 0.0176 0.0025 0.0082
Onchocerca volvulus 0.0214 0.011 0.0098
Plasmodium falciparum NIMA related kinase 1 0.0641 0.1067 0.9324
Onchocerca volvulus 0.0325 0.036 0.0348
Loa Loa (eye worm) hypothetical protein 0.0399 0.0525 0.0503
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0479 0.0703 0.0703
Schistosoma mansoni protein kinase 0.0865 0.1569 0.5242
Echinococcus granulosus mitogen activated protein kinase 14 0.1037 0.1953 0.4287
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0215 0.0719
Echinococcus multilocularis tyrosine protein kinase HCK 0.0283 0.0265 0.0272
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0259 0.021 0.0188
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0761 0.1335 0.6695
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0084 0.0281
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0673 0.1138 0.564
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0176 0.0025 0.0082
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.034 0.0393 0.1652
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0337 0.0386 0.0364
Echinococcus multilocularis death associated protein kinase 1 0.4519 0.9751 1
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.0434 0.1449
Brugia malayi Serine/threonine-protein kinase Pim-3 0.077 0.1356 0.1356
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1037 0.1953 1
Loa Loa (eye worm) gastrulation defective protein 1 0.0853 0.1541 0.1521
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.131 0.2564 0.263
Echinococcus multilocularis tyrosine protein kinase Src42A 0.044 0.0616 0.0632
Loa Loa (eye worm) TK/ROR protein kinase 0.0226 0.0137 0.0114
Brugia malayi hypothetical protein 0.0366 0.0451 0.0451
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0203 0.0085 0.0268
Loa Loa (eye worm) hypothetical protein 0.0333 0.0378 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Schistosoma mansoni atypical protein kinase C 0.0256 0.0204 0.0681
Loa Loa (eye worm) hypothetical protein 0.0516 0.0786 0.0765
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Echinococcus multilocularis TGF beta receptor type 1 0.047 0.0684 0.0702
Echinococcus multilocularis protein kinase shaggy 0.06 0.0976 0.1001
Brugia malayi Protein kinase domain containing protein 0.0697 0.1192 0.1192
Trichomonas vaginalis CK1 family protein kinase 0.0325 0.036 0.2225
Brugia malayi Immunoglobulin I-set domain containing protein 0.0259 0.021 0.021
Onchocerca volvulus 0.0399 0.0525 0.0514
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0505 0.0762 0.471
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0255 0.0202 0.0179
Echinococcus granulosus serine:threonine protein kinase N2 0.019 0.0056 0.0123
Loa Loa (eye worm) hypothetical protein 0.0366 0.0451 0.0429
Echinococcus multilocularis cyclin dependent kinase 9 0.0192 0.0061 0.0062
Schistosoma mansoni protein kinase 0.0514 0.0783 0.2615
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.019 0.0056 0.0123
Schistosoma mansoni protein kinase 0.0655 0.1097 0.3666
Echinococcus granulosus protein kinase C gamma type 0.019 0.0056 0.0123
Schistosoma mansoni kinase 0.0175 0.0023 0.0077
Schistosoma mansoni cell adhesion molecule 0.0423 0.058 0.1937
Echinococcus granulosus protein kinase c epsilon type 0.0256 0.0204 0.0447
Schistosoma mansoni tyrosine kinase 0.1501 0.2993 1
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0202 0.0084 0.0086
Echinococcus multilocularis tyrosine kinase 0.0214 0.011 0.0113
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.06 0.0976 0.326
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0604 0.0985 0.0964
Echinococcus granulosus Vam6:Vps39 protein 0.0248 0.0187 0.0411
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0673 0.1138 0.564
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0248 0.0187 0.0552
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0815 0.1457 0.1494
Echinococcus multilocularis cyclin dependent kinase 1 0.0358 0.0434 0.0445
Trypanosoma brucei protein kinase, putative 0.0203 0.0085 0.0005
Echinococcus multilocularis casein kinase I alpha 0.0325 0.036 0.0369
Brugia malayi protein-tyrosine kinase 0.0373 0.0467 0.0467
Echinococcus granulosus casein kinase i 0.0325 0.036 0.079
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.034 0.0393 0.2667
Schistosoma mansoni tyrosine kinase 0.028 0.0259 0.0865
Schistosoma mansoni tyrosine kinase 0.044 0.0616 0.206
Brugia malayi hypothetical protein 0.0333 0.0378 0.0378
Trypanosoma brucei casein kinase I, isoform 2 0.0325 0.036 0.1476
Echinococcus granulosus tyrosine protein kinase HCK 0.0283 0.0265 0.0582
Brugia malayi Hr1 repeat family protein 0.019 0.0056 0.0056
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.044 0.0616 0.1354
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0214 0.011 0.0824
Giardia lamblia Kinase, CMGC CDK 0.0358 0.0434 0.2681
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Schistosoma mansoni nephrin 0.0469 0.0681 0.2275
Onchocerca volvulus 0.0214 0.011 0.0098
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0373 0.0467 0.1026
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Echinococcus granulosus defective proboscis extension response 0.035 0.0416 0.0913
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0214 0.011 0.0113
Schistosoma mansoni tyrosine kinase 0.0382 0.0486 0.1625
Entamoeba histolytica protein kinase, putative 0.0505 0.0762 0.5707
Schistosoma mansoni serine/threonine protein kinase 0.0498 0.0747 0.2497
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.044 0.0616 0.0632
Schistosoma mansoni titin 0.0198 0.0074 0.0247
Echinococcus multilocularis aurora kinase A 0.0505 0.0762 0.0782
Brugia malayi cyclin-dependent kinase 9 0.0175 0.0023 0.0023
Plasmodium falciparum casein kinase 1 0.0325 0.036 0.2617
Trypanosoma cruzi cdc2-related kinase 1 0.0358 0.0434 0.1871
Echinococcus granulosus aurora kinase A 0.0505 0.0762 0.1673
Leishmania major protein kinase A catalytic subunit isoform 1 0.034 0.0393 0.1652
Echinococcus multilocularis titin 0.0198 0.0074 0.0076
Schistosoma mansoni nephrin 0.0176 0.0025 0.0082
Echinococcus granulosus protein kinase shaggy 0.06 0.0976 0.2142
Echinococcus granulosus calcium dependent protein kinase 0.0182 0.0038 0.0083
Schistosoma mansoni vam6/vps39 related 0.0248 0.0187 0.0625
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.077 0.1356 0.1391
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.019 0.0056 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Entamoeba histolytica casein kinase 1, putative 0.0325 0.036 0.2696
Giardia lamblia Aurora kinase 0.0505 0.0762 0.471
Echinococcus granulosus Immunoglobulin 0.035 0.0416 0.0913
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.044 0.0616 0.1354
Brugia malayi P38 map kinase family protein 2 0.1037 0.1953 0.1953
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Loa Loa (eye worm) hypothetical protein 0.0471 0.0687 0.0665
Leishmania major protein kinase A catalytic subunit isoform 2 0.034 0.0393 0.1652
Echinococcus multilocularis tyrosine protein kinase Srms 0.0373 0.0467 0.0479
Brugia malayi SH2 domain containing protein 0.0214 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0259 0.0211 0.0216
Schistosoma mansoni tyrosine kinase 0.0382 0.0486 0.1625
Loa Loa (eye worm) hypothetical protein 0.0248 0.0187 0.0164
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0673 0.1138 0.564
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0203 0.0085 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0393 0.1312
Schistosoma mansoni serine/threonine protein kinase 0.0393 0.0512 0.1712
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1125 0.215 0.2205
Brugia malayi Protein kinase domain containing protein 0.0337 0.0386 0.0386
Echinococcus granulosus tyrosine protein kinase shark 0.0214 0.011 0.0241
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0261 0.0215 0.0473
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0261 0.0215 0.0922
Echinococcus multilocularis serine:threonine protein kinase 38 0.019 0.0056 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0697 0.1192 0.3984
Echinococcus granulosus tyrosine protein kinase Src42A 0.0259 0.0211 0.0463
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0358 0.0434 0.0412
Loa Loa (eye worm) hypothetical protein 0.0176 0.0025 0.0002
Trypanosoma brucei cdc2-related kinase 1 0.0358 0.0434 0.1871
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0226 0.0137 0.0301
Echinococcus multilocularis serine:threonine protein kinase N2 0.019 0.0056 0.0057
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0993 0.1854 0.1902
Brugia malayi Protein kinase domain containing protein 0.0214 0.011 0.011
Trichomonas vaginalis CMGC family protein kinase 0.0358 0.0434 0.2681
Echinococcus multilocularis protein kinase c epsilon type 0.0256 0.0204 0.0209
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.034 0.0393 0.1652
Plasmodium vivax protein kinase Crk2 0.0358 0.0434 0.3071
Echinococcus granulosus epidermal growth factor receptor 0.0382 0.0486 0.1068
Giardia lamblia Kinase, CAMK CAMKL 0.0219 0.0122 0.0752
Loa Loa (eye worm) AGC/AKT protein kinase 0.0208 0.0098 0.0075
Schistosoma mansoni cell adhesion molecule 0.0176 0.0025 0.0082
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1037 0.1953 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.077 0.1356 0.1336
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1952 0.4003 0.8789
Onchocerca volvulus 0.0875 0.159 0.158
Brugia malayi protein C17H12.11 0.0333 0.0378 0.0378
Entamoeba histolytica hypothetical protein 0.0761 0.1335 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0479 0.0703 0.0681
Brugia malayi serine/threonine-protein kinase 6 0.0505 0.0762 0.0762
Echinococcus multilocularis 0.0594 0.0961 0.0985
Echinococcus granulosus protein kinase 0.0406 0.0541 0.1189
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1339 0.2629 0.2612
Echinococcus granulosus tyrosine kinase 0.0373 0.0467 0.1026
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0325 0.036 0.1476
Loa Loa (eye worm) hypothetical protein 0.0418 0.0567 0.0546
Echinococcus multilocularis twitchin 0.0182 0.0038 0.0039
Brugia malayi casein kinase 1, delta 0.0325 0.036 0.036
Toxoplasma gondii casein kinase I 0.0325 0.036 0.2808
Echinococcus granulosus tyrosine protein kinase Lyn 0.0519 0.0794 0.1743
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0727 0.1259 0.1239
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0709 0.1219 0.1219
Echinococcus multilocularis raf serine:threonine protein kinase 0.0189 0.0055 0.0057
Echinococcus granulosus neuroglian 0.0176 0.0025 0.0054
Leishmania major protein kinase, putative 0.0673 0.1138 0.564
Schistosoma mansoni tyrosine kinase 0.0258 0.021 0.0702
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0673 0.1138 0.1118
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0663 0.1116 0.1145
Loa Loa (eye worm) hypothetical protein 0.0408 0.0544 0.0522
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0862
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0498 0.0747 0.0726
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.06 0.0976 0.4772
Echinococcus multilocularis cyclin dependent kinase 1 0.0358 0.0434 0.0445
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.034 0.0393 0.1652
Loa Loa (eye worm) hypothetical protein 0.0315 0.0337 0.0315
Echinococcus multilocularis cyclin dependent kinase 9 0.0175 0.0023 0.0024
Trichomonas vaginalis STE family protein kinase 0.0641 0.1067 0.6595
Plasmodium falciparum calcium-dependent protein kinase 4 0.0261 0.0215 0.1245
Giardia lamblia Kinase, AGC AKT 0.0537 0.0834 0.5157
Trypanosoma cruzi casein kinase, putative 0.0325 0.036 0.1476
Loa Loa (eye worm) TK/EGFR protein kinase 0.0382 0.0486 0.0464
Brugia malayi Serine/threonine-protein kinase SULU 0.131 0.2564 0.2564
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Plasmodium falciparum calcium-dependent protein kinase 3 0.0261 0.0215 0.1245
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0761 0.1335 0.6695
Echinococcus granulosus tyrosine protein kinase Srms 0.0214 0.011 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0056 0.0187
Echinococcus multilocularis protein tyrosine kinase 0.1501 0.2993 0.307
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0056 0.0187
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Loa Loa (eye worm) TK/INSR protein kinase 0.0697 0.1192 0.1172
Brugia malayi hypothetical protein 0.0214 0.011 0.011
Echinococcus multilocularis neuroglian 0.0176 0.0025 0.0025
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0709 0.1219 0.1199
Schistosoma mansoni protein kinase 0.0505 0.0762 0.2546
Echinococcus multilocularis epidermal growth factor receptor 0.0382 0.0486 0.0499
Brugia malayi serine/threonine protein kinase 6 0.0505 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0682 0.1158 0.1137
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0084 0.0281
Echinococcus multilocularis Immunoglobulin 0.035 0.0416 0.0426
Trypanosoma cruzi casein kinase, putative 0.0325 0.036 0.1476
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0403
Onchocerca volvulus 0.0198 0.0074 0.0062
Brugia malayi probable protein kinase 0.0655 0.1097 0.1097
Entamoeba histolytica protein kinase, putative 0.019 0.0056 0.042
Schistosoma mansoni rap gtpase-activating protein 0.0248 0.0187 0.0625
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0505 0.0762 0.5707
Toxoplasma gondii histone kinase SNF1, putative 0.0202 0.0084 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0261 0.0215 0.1331
Echinococcus granulosus tyrosine protein kinase Fyn 0.044 0.0616 0.1354
Brugia malayi Protein kinase domain containing protein 0.0214 0.011 0.011
Echinococcus granulosus epidermal growth factor receptor 0.0382 0.0486 0.1068
Onchocerca volvulus 0.463 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0214 0.011 0.0087
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0556 0.0876 0.4239
Loa Loa (eye worm) IKK protein kinase 0.463 1 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0261 0.0215 0.0922
Loa Loa (eye worm) hypothetical protein 0.0333 0.0378 0.0355
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.077 0.1356 0.1346
Echinococcus multilocularis tyrosine protein kinase shark 0.0214 0.011 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0325 0.036 0.1202
Echinococcus granulosus tyrosine protein kinase ABL1 0.1125 0.215 0.4721
Onchocerca volvulus Tyrosine kinase homolog 0.162 0.3259 0.3251
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0393 0.0403
Loa Loa (eye worm) hypothetical protein 0.0575 0.092 0.0899
Brugia malayi Immunoglobulin I-set domain containing protein 0.0198 0.0074 0.0074
Echinococcus multilocularis serine threonine protein kinase 0.019 0.0056 0.0057
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0727 0.1259 0.1259
Entamoeba histolytica protein kinase, putative 0.0761 0.1335 1
Schistosoma mansoni serine/threonine protein kinase 0.0505 0.0762 0.2546
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.019 0.0056 0.0123
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0358 0.0434 0.1871
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0226 0.0137 0.014
Echinococcus multilocularis cyclin dependent kinase 7 0.0498 0.0747 0.0766
Echinococcus granulosus twitchin 0.0532 0.0823 0.1806
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0537 0.0834 0.0834
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Schistosoma mansoni protein kinase 0.0865 0.1569 0.5242
Echinococcus multilocularis dual specificity protein kinase clk2 0.0673 0.1138 0.1167
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0176 0.0025 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.0932 0.1718 0.574
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0815 0.1457 0.3199
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1037 0.1953 0.1934
Echinococcus granulosus NDR protein kinase 0.019 0.0056 0.0123
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0993 0.1854 0.4071
Schistosoma mansoni serine/threonine protein kinase 0.0779 0.1376 0.4596
Brugia malayi Protein kinase domain containing protein 0.019 0.0056 0.0056
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0505 0.0762 0.0782
Schistosoma mansoni protein kinase 0.1049 0.1981 0.6618
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0604 0.0985 0.0985
Echinococcus multilocularis tyrosine protein kinase Blk 0.0373 0.0467 0.0479
Echinococcus multilocularis cyclin dependent kinase 19 0.0932 0.1718 0.1762
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0261 0.0215 0.0221
Echinococcus multilocularis tyrosine protein kinase Src64B 0.044 0.0616 0.0632
Loa Loa (eye worm) hypothetical protein 0.0366 0.0451 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0204 0.0681
Echinococcus granulosus cyclin dependent kinase 7 0.0498 0.0747 0.1641
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0575 0.092 0.2019
Brugia malayi hypothetical protein 0.0248 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0472 0.0688 0.0666
Echinococcus multilocularis basement membrane specific heparan sulfate 0.035 0.0416 0.0426
Echinococcus multilocularis dual specificity 0.0761 0.1335 0.1369
Loa Loa (eye worm) hypothetical protein 0.0248 0.0187 0.0164
Echinococcus multilocularis casein kinase I delta 0.0325 0.036 0.0369
Entamoeba histolytica protein kinase, putative 0.0208 0.0098 0.0734
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0337 0.0387 0.0849
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0248 0.0187 0.0552
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0393 0.0512 0.0526
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.131 0.2564 0.2547
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0673 0.1138 1
Plasmodium falciparum protein kinase, putative 0.0203 0.0085 0.0009
Onchocerca volvulus 0.0248 0.0187 0.0175
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.034 0.0393 0.1652
Schistosoma mansoni cell adhesion molecule 0.0176 0.0025 0.0082
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2554 0.535 0.5339
Entamoeba histolytica PH domain containing protein kinase, putative 0.0359 0.0435 0.3256
Onchocerca volvulus 0.045 0.0639 0.0627
Schistosoma mansoni tyrosine kinase 0.0209 0.0099 0.033
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0408 0.0544 0.1195
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0084 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0358 0.0434 0.2681
Trichomonas vaginalis STE family protein kinase 0.0887 0.1618 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.011 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0208 0.0098 0.0605
Loa Loa (eye worm) hypothetical protein 0.0279 0.0256 0.0234
Loa Loa (eye worm) AUR protein kinase 0.0505 0.0762 0.0741
Leishmania major protein kinase, putative 0.0505 0.0762 0.3628
Echinococcus multilocularis cyclin dependent kinase 0.0358 0.0434 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0993 0.1855 0.6197
Loa Loa (eye worm) AGC/NDR protein kinase 0.019 0.0056 0.0033
Echinococcus granulosus mitogen activated protein kinase 11 0.1037 0.1953 0.4287
Entamoeba histolytica protein kinase, putative 0.0183 0.0042 0.0314
Trypanosoma cruzi cdc2-related kinase 3 0.0358 0.0434 0.1871
Leishmania major casein kinase, putative 0.0325 0.036 0.1476
Echinococcus multilocularis Immunoglobulin 0.035 0.0416 0.0426
Entamoeba histolytica protein kinase, putative 0.0183 0.0042 0.0314
Entamoeba histolytica protein kinase , putative 0.0505 0.0762 0.5707
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0673 0.1138 0.564
Brugia malayi Protein kinase domain containing protein 0.0214 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.044 0.0616 0.0632
Schistosoma mansoni serine/threonine protein kinase 0.0393 0.0512 0.1712
Brugia malayi SH2 domain containing protein 0.0214 0.011 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.034 0.0393 0.1652
Schistosoma mansoni tyrosine kinase 0.0258 0.021 0.0702
Loa Loa (eye worm) hypothetical protein 0.2353 0.49 0.4888
Echinococcus multilocularis roundabout 2 0.0526 0.0809 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0038 0.0128
Giardia lamblia Kinase, NEK 0.0641 0.1067 0.6595
Schistosoma mansoni tyrosine kinase 0.0663 0.1116 0.3729
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0393 0.0512 0.1125
Echinococcus multilocularis tyrosine protein kinase Abl 0.0629 0.1039 0.1066
Entamoeba histolytica protein kinase, putative 0.0208 0.0098 0.0734
Brugia malayi Furin-like cysteine rich region family protein 0.0382 0.0486 0.0486
Loa Loa (eye worm) AUR protein kinase 0.0505 0.0762 0.0741
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0993 0.1855 0.1836
Trypanosoma cruzi cdc2-related kinase 1 0.0358 0.0434 0.1871
Echinococcus granulosus insulin receptor 0.0697 0.1192 0.2618
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.0084 0.063
Trypanosoma brucei rac serine-threonine kinase, putative 0.0208 0.0098 0.0074
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0382 0.0486 0.1068
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.0084 0.052
Schistosoma mansoni serine/threonine protein kinase 0.0761 0.1335 0.4461
Loa Loa (eye worm) SRC-1 0.044 0.0616 0.0595
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0514 0.0783 0.0761
Brugia malayi Protein kinase domain containing protein 0.2554 0.535 0.535
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0713 0.1228 0.1259
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0261 0.0215 0.0473
Schistosoma mansoni protein kinase C mu 0.0479 0.0703 0.2349
Echinococcus granulosus roundabout 2 0.0176 0.0025 0.0054
Brugia malayi serine/threonine-protein kinase PAK 7 0.1078 0.2045 0.2045
Trypanosoma cruzi casein kinase, putative 0.0325 0.036 0.1476
Loa Loa (eye worm) hypothetical protein 0.0248 0.0187 0.0164
Loa Loa (eye worm) TK protein kinase 0.0373 0.0467 0.0445
Entamoeba histolytica protein kinase, putative 0.0505 0.0762 0.5707
Loa Loa (eye worm) hypothetical protein 0.045 0.0639 0.0617
Brugia malayi serine/threonine kinase 12 0.0505 0.0762 0.0762
Giardia lamblia Kinase, CK1 Casein kinase 0.0325 0.036 0.2225
Trichomonas vaginalis AGC family protein kinase 0.019 0.0056 0.0346
Echinococcus multilocularis serine:threonine protein kinase N2 0.019 0.0056 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0766 0.1346 0.1346
Schistosoma mansoni tyrosine kinase 0.0283 0.0265 0.0886
Plasmodium falciparum protein serine/threonine kinase-1 0.0673 0.1138 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0256 0.0204 0.0181
Loa Loa (eye worm) hypothetical protein 0.051 0.0774 0.0752
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.077 0.1356 0.2978
Echinococcus multilocularis cyclin dependent kinase 5 0.0358 0.0434 0.0445
Schistosoma mansoni serine/threonine protein kinase 0.0648 0.1082 0.3614
Trypanosoma brucei cdc2-related kinase 3 0.0358 0.0434 0.1871
Echinococcus granulosus tyrosine protein kinase Src64B 0.044 0.0616 0.1354
Brugia malayi Cam kinase protein 1 0.0261 0.0215 0.0215
Toxoplasma gondii AGC kinase 0.034 0.0393 0.3112
Entamoeba histolytica protein kinase domain containing protein 0.06 0.0976 0.7308
Loa Loa (eye worm) CAMK/PIM protein kinase 0.077 0.1356 0.1336
Schistosoma mansoni protein kinase 0.047 0.0684 0.2285
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0648 0.1082 0.1061
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0505 0.0762 0.63
Echinococcus granulosus Protein kinase C brain isozyme 0.0256 0.0204 0.0447
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1339 0.2629 0.2696
Echinococcus granulosus neuroglian 0.0453 0.0645 0.1417
Trypanosoma cruzi casein kinase, putative 0.0325 0.036 0.1476
Plasmodium vivax serine/threonine kinase-1, putative 0.0673 0.1138 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.9601 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 40.5334 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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