Detailed information for compound 1381328

Basic information

Technical information
  • TDR Targets ID: 1381328
  • Name: 4-amino-N'-[2-[(4-fluorophenyl)methylamino]-1 -(4-hydroxyphenyl)-2-oxoethyl]-N'-(pyridin-3- ylmethyl)-1,2-thiazole-3,5-dicarboxamide
  • MW: 534.562 | Formula: C26H23FN6O4S
  • H donors: 4 H acceptors: 6 LogP: 2.56 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc(cc1)C(N(C(=O)c1snc(c1N)C(=O)N)Cc1cccnc1)C(=O)NCc1ccc(cc1)F
  • InChi: 1S/C26H23FN6O4S/c27-18-7-3-15(4-8-18)13-31-25(36)22(17-5-9-19(34)10-6-17)33(14-16-2-1-11-30-12-16)26(37)23-20(28)21(24(29)35)32-38-23/h1-12,22,34H,13-14,28H2,(H2,29,35)(H,31,36)
  • InChiKey: ZBUFKIPJMMZHBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-N'-[2-[(4-fluorophenyl)methylamino]-1-(4-hydroxyphenyl)-2-oxo-ethyl]-N'-(3-pyridylmethyl)isothiazole-3,5-dicarboxamide
  • 4-amino-N'-[2-[(4-fluorophenyl)methylamino]-1-(4-hydroxyphenyl)-2-oxoethyl]-N'-(3-pyridylmethyl)isothiazole-3,5-dicarboxamide
  • 4-amino-N'-[2-[(4-fluorobenzyl)amino]-1-(4-hydroxyphenyl)-2-keto-ethyl]-N'-(3-pyridylmethyl)isothiazole-3,5-dicarboxamide
  • 4-amino-N'-[2-[(4-fluorophenyl)methylamino]-1-(4-hydroxyphenyl)-2-oxo-ethyl]-N'-(pyridin-3-ylmethyl)-1,2-thiazole-3,5-dicarboxamide
  • ASN 04450718
  • Oprea1_096852

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0154 0.3888
Toxoplasma gondii aldo-keto reductase 0.0009 0.0039 0.057
Schistosoma mansoni hypothetical protein 0.0173 0.2119 0.4216
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0176 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0513 0.0915
Trypanosoma brucei prostaglandin f synthase 0.0033 0.0335 0.9227
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Echinococcus granulosus geminin 0.0173 0.2119 0.3795
Loa Loa (eye worm) oxidoreductase 0.0033 0.0335 0.0595
Brugia malayi hypothetical protein 0.001 0.004 0.0067
Echinococcus granulosus FTZ F1 alpha 0.002 0.0176 0.0311
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0472 0.0842
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0472 0.7325
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0245 0.5166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0154 0.4196
Schistosoma mansoni cpg binding protein 0.003 0.0297 0.0587
Brugia malayi Matrixin family protein 0.0039 0.0418 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.004 0.0075
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0362 0.0645
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0245 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0241 0.5111
Schistosoma mansoni zinc finger protein 0.001 0.004 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0513 0.1016
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.004 0.0037
Echinococcus multilocularis muscleblind protein 1 0.0444 0.5578 0.5577
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0176 0.0346
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0154 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0176 0.0173
Brugia malayi Matrixin family protein 0.0039 0.0418 0.0746
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.004 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0154 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0093
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0245 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0278 0.5897
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0176 0.0311
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0297 0.3697 0.5
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5021 0.9
Brugia malayi hypothetical protein 0.0011 0.0055 0.0093
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0154 0.4196
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0176 0.0311
Leishmania major aldo-keto reductase-like protein 0.0033 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Onchocerca volvulus 0.0039 0.0418 0.3839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0176 0.0311
Echinococcus granulosus snurportin 1 0.0372 0.4653 0.8341
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Loa Loa (eye worm) matrixin family protein 0.0087 0.1027 0.1837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0513 0.1016
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0154 0.4196
Onchocerca volvulus 0.0033 0.0335 0.299
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Echinococcus multilocularis aldo keto reductase 0.0033 0.0335 0.0332
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Schistosoma mansoni hypothetical protein 0.0008 0.0021 0.0037
Loa Loa (eye worm) matrix metalloproteinase 0.0039 0.0418 0.0746
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0039 0.0863
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0021 0.0033
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.004 0.0067
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0154 0.4196
Brugia malayi ecdysone receptor 0.001 0.004 0.0067
Brugia malayi nuclear receptor NHR-67 0.001 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0008 0.0021 0.0033
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0075
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0241 0.3723
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0093
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0154 0.3873
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0241 0.6843
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0154 0.0271
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0075
Mycobacterium ulcerans oxidoreductase 0.0033 0.0335 0.605
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0449
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Echinococcus granulosus aldehyde reductase 0.0023 0.0214 0.0379
Echinococcus multilocularis muscleblind protein 0.0444 0.5578 0.5577
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0679 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0426 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0176 0.0346
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0176 0.0346
Onchocerca volvulus 0.001 0.004 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0176 0.0346
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.004 0.0037
Onchocerca volvulus 0.0056 0.0627 0.5953
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0513 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0176 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0051 0.0087
Loa Loa (eye worm) oxidoreductase 0.0033 0.0335 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Schistosoma mansoni ran 0.0026 0.0245 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0176 0.0311
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0154 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0176 0.0311
Trichomonas vaginalis ran, putative 0.0026 0.0245 0.5194
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0176 0.0311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0055 0.0093
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0039 0.0066
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0335 0.7085
Brugia malayi Matrixin family protein 0.0095 0.1127 0.2016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0335 0.7085
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0154 0.2354
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0176 0.0311
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0176 0.0311
Schistosoma mansoni hypothetical protein 0.0401 0.5021 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0048 0.0527 1
Entamoeba histolytica aldose reductase, putative 0.0033 0.0335 0.7838
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0176 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0176 0.0311
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0055 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0513 0.0915
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Echinococcus granulosus importin subunit beta 1 0.0035 0.0362 0.0645
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0335 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Echinococcus granulosus aldo keto reductase 0.0033 0.0335 0.0595
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.004 0.0067
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0245 0.0243
Schistosoma mansoni polycystin 1-related 0.0026 0.0251 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0513 0.051
Brugia malayi Muscleblind-like protein 0.0444 0.5578 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0154 0.0271
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0241 0.0428
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0335 0.7085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0176 0.0311
Entamoeba histolytica protein kinase rad3, putative 0.001 0.0051 0.1146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0176 0.0311
Brugia malayi steroid hormone receptor 0.002 0.0176 0.0311
Echinococcus multilocularis aldo keto reductase 0.0033 0.0335 0.0332
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.0051 0.0406
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0176 0.0311
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0143 0.1735 0.1733
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0176 0.0173
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0176 0.0346
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Onchocerca volvulus 0.001 0.004 0.001
Entamoeba histolytica hypothetical protein 0.0028 0.0278 0.6513
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0362 0.036
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0051 0.0049
Mycobacterium tuberculosis Probable oxidoreductase 0.0033 0.0335 0.605
Loa Loa (eye worm) oxidoreductase 0.0033 0.0335 0.0595
Schistosoma mansoni hypothetical protein 0.0173 0.2119 0.4216
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5021 0.5019
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Schistosoma mansoni cpg binding protein 0.0028 0.0277 0.0547
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0039 0.0066
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0241 0.0239
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0039 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0039 0.0037
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0048 0.0527 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.18 0.3224
Loa Loa (eye worm) DR-78 0.001 0.004 0.0067
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.004 0.001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.004 0.0067
Leishmania major prostaglandin f synthase, putative 0.0033 0.0335 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0176 0.0346
Schistosoma mansoni nuclear hormone receptor 0.002 0.0176 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Mycobacterium ulcerans hydrolase 0.0048 0.0527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0154 0.0271
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0245 0.6976
Echinococcus granulosus hypothetical protein 0.0033 0.0335 0.0595
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0245 0.6976
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0245 0.5729
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0067
Trichomonas vaginalis hypothetical protein 0.0007 0.0003 0.0057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0176 0.0173
Trypanosoma cruzi aldo/keto reductase, putative 0.0033 0.0335 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0245 0.3784
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0093
Brugia malayi FAT domain containing protein 0.0008 0.0021 0.0033
Onchocerca volvulus 0.0028 0.0277 0.2408
Echinococcus granulosus cpg binding protein 0.003 0.0297 0.0529
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0746
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.18 0.3582
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0278 0.5897
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0008 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Entamoeba histolytica Ran family GTPase 0.0026 0.0245 0.5729
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0176 0.0311
Plasmodium falciparum aldo-keto reductase, putative 0.0009 0.0039 0.0863
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0176 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0176 0.0311
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0154 0.4547
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0176 0.0311
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0335 0.7085
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0154 0.4547
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0362 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0176 0.0311
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0335 0.7085
Brugia malayi Matrixin family protein 0.0039 0.0418 0.0746
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0048 0.0527 0.0941
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0154 0.3873
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0176 0.0311
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0176 0.0173
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0067
Trypanosoma cruzi aldo-keto reductase 0.0033 0.0335 1
Leishmania major GTP-binding protein, putative 0.0026 0.0245 0.7309
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0245 0.0435
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0154 0.4547
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0362 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0278 0.831
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0114
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0039 0.1101
Brugia malayi nuclear receptor NHR-88 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0176 0.0311
Entamoeba histolytica hypothetical protein 0.0025 0.0241 0.5636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0176 0.0311
Toxoplasma gondii aldose reductase, putative 0.0033 0.0335 0.5177
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0039 0.0066
Schistosoma mansoni ran 0.0026 0.0245 0.0483
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0176 0.0311
Loa Loa (eye worm) oxidoreductase 0.0033 0.0335 0.0595
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0154 0.3873
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.001 0.0051 0.1146
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0154 0.0301
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0335 0.0595
Schistosoma mansoni importin beta-1 0.0035 0.0362 0.0717
Schistosoma mansoni hypothetical protein 0.0056 0.0627 0.1244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0335 0.0595
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0154 0.4561
Onchocerca volvulus 0.0033 0.0335 0.299
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1748 0.3129
Entamoeba histolytica aldose reductase, putative 0.0033 0.0335 0.7838
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0006 0.0129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0176 0.1386
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Onchocerca volvulus 0.0033 0.0335 0.299
Schistosoma mansoni thyroid hormone receptor 0.002 0.0176 0.0346
Brugia malayi Hemopexin family protein 0.0056 0.0627 0.112
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0066 0.0993
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0472 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4653 0.8341
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0362 0.5611
Brugia malayi nuclear receptor RXR 0.0011 0.0055 0.0093
Brugia malayi Importin beta-1 subunit 0.0035 0.0362 0.0645
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0176 0.0346
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0154 0.4547
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0021 0.0018
Echinococcus granulosus aldo keto reductase 0.0033 0.0335 0.0595
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0472 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) oxidoreductase 0.0033 0.0335 0.0595
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0335 0.7085
Brugia malayi nuclear hormone receptor 0.002 0.0176 0.0311
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0039 0.1016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0278 0.5897
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0513 0.051
Trypanosoma brucei aldo-keto reductase, putative 0.0033 0.0335 0.9227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Schistosoma mansoni pol-related 0.0033 0.0335 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Onchocerca volvulus 0.002 0.0176 0.1386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Echinococcus granulosus aldo keto reductase 0.0033 0.0335 0.0595
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.004 0.0067
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.004 0.0067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0154 0.0301
Brugia malayi tailless protein 0.001 0.004 0.0067
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0241 0.0428
Giardia lamblia Aldose reductase 0.0033 0.0335 0.6641
Brugia malayi Matrixin family protein 0.0039 0.0418 0.0746
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0472 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.004 0.0075
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0154 0.3564
Brugia malayi nuclear hormone receptor 0.001 0.004 0.0067
Brugia malayi nuclear receptor RXR 0.001 0.004 0.0067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0055 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0297 0.0587
Brugia malayi conserved hypotetical protein 0.001 0.004 0.0067
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0039 0.0863
Brugia malayi hypothetical protein 0.001 0.004 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0093 0.1105 0.2197
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0278 0.81
Echinococcus multilocularis cpg binding protein 0.003 0.0297 0.0295
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Brugia malayi nuclear receptor NHR-88 0.001 0.004 0.0067
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0039 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Onchocerca volvulus 0.0033 0.0335 0.299
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Schistosoma mansoni aldo-keto reductase 0.0033 0.0335 0.0661
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0241 0.0475
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0154 0.0151
Echinococcus granulosus muscleblind protein 0.0444 0.5578 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0009 0.0039 0.0778
Plasmodium falciparum importin beta, putative 0.0035 0.0362 0.8495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Brugia malayi CXXC zinc finger family protein 0.0028 0.0277 0.0492
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0176 0.0346
Schistosoma mansoni aldo-keto reductase 0.0033 0.0335 0.0661
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0176 0.1386
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0051 0.0087
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0008 0.0005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0245 0.6744
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.004 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0176 0.0311
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0005
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0335 0.0595
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0037
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0039 0.0831
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0051 0.0097
Onchocerca volvulus Matrix metalloproteinase homolog 0.0087 0.1027 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Schistosoma mansoni hypothetical protein 0.0372 0.4653 0.9267
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0154 0.4547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0176 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0196 0.5313
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0214 0.3583
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0027
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0143 0.1735 0.3107
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0277 0.0492
Onchocerca volvulus Matrilysin homolog 0.0039 0.0418 0.3839
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0046
Echinococcus multilocularis aldehyde reductase 0.0023 0.0214 0.0211
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.18 0.1798
Onchocerca volvulus 0.0033 0.0335 0.299
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0335 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) acetyltransferase 0.0148 0.18 0.3224
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0033 0.0335 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0176 0.0311
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.004 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0055 0.0104
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0426 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0154 0.3873
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0039 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0066 0.1406
Loa Loa (eye worm) hypothetical protein 0.0048 0.0527 0.0941
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0154 0.3564
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0154 0.3873
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0037
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0066 0.177
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0245 0.3363
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0066 0.1406
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0055 0.0093
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.004 0.0075
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0039 0.0831
Brugia malayi ecdysteroid receptor 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.0444 0.5578 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0055 0.0093
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0176 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Loa Loa (eye worm) hypothetical protein 0.0444 0.5578 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Plasmodium vivax aldehyde reductase, putative 0.0009 0.0039 0.0778
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0055 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0335 0.7085
Echinococcus multilocularis snurportin 1 0.0372 0.4653 0.4652
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.004 0.0067
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0176 0.1386
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0335 0.0595
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0426 1
Plasmodium falciparum aldehyde reductase, putative 0.0009 0.0039 0.0863
Brugia malayi hypothetical protein 0.0011 0.0055 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Entamoeba histolytica aldose reductase, putative 0.0033 0.0335 0.7838
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0067
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0644 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0006 0.0129
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0075
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0039 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0513 0.0915
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Echinococcus multilocularis aldo keto reductase 0.0033 0.0335 0.0332
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0472 0.7325
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.004 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0513 0.1016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0048
Schistosoma mansoni coup transcription factor 0.002 0.0176 0.0346
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0154 0.0271
Onchocerca volvulus Matrilysin homolog 0.0087 0.1027 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.004 0.0067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0311
Schistosoma mansoni potassium channel beta 0.0009 0.0039 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0051 0.1085
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0039 0.057
Onchocerca volvulus 0.0033 0.0335 0.299
Giardia lamblia Aldose reductase 0.0033 0.0335 0.6641
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0176 0.0173
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0176 0.0311
Echinococcus multilocularis aldo keto reductase 0.0033 0.0335 0.0332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0746
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0055 0.0093
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0154 0.4196
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0241 0.6635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0176 0.0311
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0176 0.0346
Echinococcus multilocularis geminin 0.0173 0.2119 0.2116
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0033 0.0335 0.605
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0176 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0196 0.0347
Plasmodium vivax importin-beta 2, putative 0.0035 0.0362 0.766
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0335 0.0332
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0033 0.0335 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0039 0.0831
Loa Loa (eye worm) hypothetical protein 0.0039 0.0418 0.0746
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0039 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Brugia malayi RNA, U transporter 1 0.0099 0.118 0.2111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0154 0.3253
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0039 0.0418 0.0828
Loa Loa (eye worm) matrixin family protein 0.0095 0.1127 0.2016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0176 0.0346
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0176 0.0173

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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