Detailed information for compound 138491

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.634 | Formula: C30H39NO6
  • H donors: 3 H acceptors: 5 LogP: 2.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNCc1cccc(c1)C(=O)OCC(=O)[C@@]1(O)CCC2C1(C)CC(O)C1C2CCC2=CC(=O)CCC12C
  • InChi: 1S/C30H39NO6/c1-28-11-9-21(32)14-20(28)7-8-22-23-10-12-30(36,29(23,2)15-24(33)26(22)28)25(34)17-37-27(35)19-6-4-5-18(13-19)16-31-3/h4-6,13-14,22-24,26,31,33,36H,7-12,15-17H2,1-3H3/t22?,23?,24?,26?,28?,29?,30-/m0/s1
  • InChiKey: PWUFRIJEAVEYSP-SJRNCHPASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Onchocerca volvulus 0.0027 0.0183 0.0473
Loa Loa (eye worm) prolyl oligopeptidase 0.017 0.1977 0.4907
Schistosoma mansoni myosin xvIII 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Onchocerca volvulus 0.0024 0.0146 0.037
Onchocerca volvulus 0.0024 0.0146 0.037
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0162 0.1792
Brugia malayi Importin beta-1 subunit 0.0031 0.0236 0.061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi Dopamine receptor protein 2 0.0024 0.0146 0.0364
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0843 0.1336
Echinococcus granulosus g protein coupled receptor 0.0024 0.0146 0.0217
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0648 0.0986
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0717 0.1093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0256 0.0635
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0106 0.1124
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0262 0.3135 0.4852
Mycobacterium tuberculosis Conserved protein 0.0079 0.0843 0.1336
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0015 0.0032 0.0355
Plasmodium falciparum geranylgeranyltransferase, putative 0.0015 0.0032 0.0355
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0843 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0272 0.3268 0.8112
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.017 0.1977 0.5469
Onchocerca volvulus 0.0024 0.0146 0.037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0648 0.765
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0075 0.0751
Trypanosoma cruzi MFS transporter, putative 0.0027 0.0183 0.2046
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0146 0.0217
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0366 0.5
Schistosoma mansoni biogenic amine receptor 0.0024 0.0146 0.0206
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.0535 0.6291
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0146 0.014
Onchocerca volvulus 0.0027 0.0183 0.0473
Brugia malayi sulfakinin receptor protein 0.0024 0.0146 0.0364
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0366 0.6758
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0146 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0146 0.014
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0146 0.014
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0106 0.0255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0027 0.0183 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0015 0.0032 0.0223
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0146 0.014
Brugia malayi neuropeptide F receptor 0.0024 0.0146 0.0364
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0146 0.0206
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0106 0.1124
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0146 0.0364
Toxoplasma gondii protease inhibitor PI2 0.0018 0.0075 0.0751
Schistosoma mansoni cpg binding protein 0.0035 0.0279 0.0413
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0146 0.0363
Brugia malayi Melatonin receptor type 1A 0.0024 0.0146 0.0364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0366 0.0909
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0648 0.1022
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0146 0.037
Loa Loa (eye worm) hypothetical protein 0.0027 0.018 0.0446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0448 0.119
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0106 0.1124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus granulosus dna polymerase kappa 0.0021 0.0106 0.0156
Schistosoma mansoni DNA polymerase eta 0.0021 0.0106 0.0145
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0299 0.3604 0.5574
Brugia malayi putative neuropeptide receptor 0.0024 0.0146 0.0364
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0055 0.0535 0.6291
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0055 0.0535 0.1429
Schistosoma mansoni neuropeptide receptor 0.0024 0.0146 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.0143
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0561 0.0861
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0162 0.1792
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0146 0.014
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.2287
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0055 0.0535 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.002 0.0101 0.0251
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0015 0.0032 0.0051
Schistosoma mansoni hypothetical protein 0.0299 0.3604 0.5574
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0843 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0366 0.0558
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi ORL1-like opioid receptor 0.0024 0.0146 0.0364
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0075 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0648 0.765
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0015 0.0032 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Brugia malayi neuropeptide F receptor 0.0024 0.0146 0.0364
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0101 0.1683
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0015
Onchocerca volvulus 0.0079 0.0843 0.2312
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.002 0.0101 0.0095
Onchocerca volvulus 0.0024 0.0146 0.037
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0015 0.0032 0.0029
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0101 0.1059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Onchocerca volvulus 0.0024 0.0146 0.037
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0146 0.0217
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0561 0.66
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0183 0.0465
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.002 0.0101 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Trypanosoma brucei unspecified product 0.0014 0.0025 0.0143
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0273 0.0267
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0146 0.014
Echinococcus granulosus dna polymerase eta 0.0021 0.0106 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Echinococcus granulosus neuropeptide receptor 0.0024 0.0146 0.0217
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0146 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis dnaJ subfamily B 0.0466 0.5708 0.5706
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0106 0.1124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi hypothetical protein 0.006 0.0602 0.161
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0146 0.014
Brugia malayi hypothetical protein 0.0235 0.2806 0.764
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.002 0.0101 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.0143
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0327
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus granulosus lamin 0.0027 0.018 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0055 0.0535 0.0811
Leishmania major lanosterol synthase, putative 0.0045 0.0415 0.4841
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Onchocerca volvulus 0.0024 0.0146 0.037
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0075 0.0751
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0843 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.004 0.0348 0.4032
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0146 0.0217
Leishmania major DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Trypanosoma cruzi lanosterol synthase, putative 0.006 0.0603 0.71
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0106 0.1124
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0146 0.0217
Echinococcus multilocularis cpg binding protein 0.0035 0.0279 0.0273
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0015 0.0032 0.0029
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0183 0.0473
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0106 0.0255
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0304 0.3668 0.9106
Echinococcus granulosus orexin receptor type 2 0.0024 0.0146 0.0217
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0843 0.1336
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0146 0.014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0106 0.1124
Loa Loa (eye worm) hypothetical protein 0.006 0.0602 0.1493
Brugia malayi hypothetical protein 0.0027 0.0183 0.0465
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0183 0.0473
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0299 0.3604 0.8946
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Schistosoma mansoni hypothetical protein 0.0024 0.0146 0.0206
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0055 0.0535 0.6291
Echinococcus granulosus acylamino acid releasing enzyme 0.0013 0.0013 0.0011
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Mycobacterium ulcerans hypothetical protein 0.0079 0.0843 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0561 0.0555
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Echinococcus multilocularis somatostatin receptor 0.0024 0.0146 0.014
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Schistosoma mansoni hypothetical protein 0.0034 0.0273 0.0403
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0075 0.0171
Brugia malayi AKH receptor 0.0024 0.0146 0.0364
Trichomonas vaginalis esterase, putative 0.0079 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0033
Onchocerca volvulus 0.0027 0.018 0.0464
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus multilocularis agrin 0.0018 0.0075 0.0069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0146 0.0217
Loa Loa (eye worm) hypothetical protein 0.006 0.0602 0.1493
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0146 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.2333 0.2328
Brugia malayi prolyl oligopeptidase family protein 0.017 0.1977 0.5372
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0561 0.66
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Trypanosoma brucei unspecified product 0.0014 0.0025 0.0143
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0101 0.1059
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0055 0.0535 0.6291
Leishmania major importin beta-1 subunit, putative 0.0025 0.0162 0.1792
Schistosoma mansoni adenoreceptor 0.0024 0.0146 0.0206
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0146 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Leishmania major GTP-binding protein, putative 0.0023 0.0133 0.1439
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0843 0.0838
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0236 0.2685
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0133 0.0127
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0507 0.6229 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0015 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0032 0.0223
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0015 0.0032 0.0355
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0101 0.1683
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0366 0.0966
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0366 0.0568
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0843 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0162 0.1792
Schistosoma mansoni opsin-like receptor 0.0024 0.0146 0.0206
Giardia lamblia Rab geranylgeranyltransferase 0.0015 0.0032 0.0355
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0015 0.0032 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Schistosoma mansoni opsin-like receptor 0.0024 0.0146 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1199 0.3245
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0055 0.0535 0.1329
Loa Loa (eye worm) prolyl oligopeptidase 0.0013 0.0013 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0146 0.0217
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0146 0.014
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0015 0.0032 0.0223
Echinococcus granulosus caspase 2 0.006 0.0602 0.0923
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0843 0.1336
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.002 0.0101 0.1683
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0602 0.1639
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni ap endonuclease 0.0041 0.0366 0.0548
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.017 0.1977 0.3056
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.017 0.1977 0.3048
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0032 0.0223
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0146 0.014
Leishmania major protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0074 0.077 0.1912
Brugia malayi MH2 domain containing protein 0.0119 0.1339 0.3628
Schistosoma mansoni inhibitor of apoptosis protein 0.0299 0.3604 0.5574
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0366 0.4251
Schistosoma mansoni hypothetical protein 0.0525 0.6455 1
Schistosoma mansoni organic anion transporter 0.0027 0.0183 0.0264
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0101 0.1059
Brugia malayi Dopamine receptor 0.0024 0.0146 0.0364
Onchocerca volvulus 0.0033 0.0256 0.0676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.2333 0.2328
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0262 0.3135 0.4846
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0183 0.0465
Onchocerca volvulus 0.0027 0.018 0.0464
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0146 0.0364
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.002 0.0101 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0146 0.0363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0273 0.0711
Schistosoma mansoni ran 0.0023 0.0133 0.0185
Trichomonas vaginalis ran, putative 0.0023 0.0133 0.1439
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0146 0.0217
Schistosoma mansoni amine GPCR 0.0024 0.0146 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Brugia malayi beta-lactamase family protein 0.0079 0.0843 0.2272
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0146 0.014
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0146 0.0364
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0146 0.0217
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0146 0.0217
Echinococcus granulosus serotonin receptor 0.0024 0.0146 0.0217
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0366 0.4251
Brugia malayi beta-lactamase family protein 0.0079 0.0843 0.2272
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0146 0.014
Echinococcus granulosus allatostatin A receptor 0.0024 0.0146 0.0217
Echinococcus multilocularis serotonin receptor 0.0024 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis snurportin 1 0.0333 0.4029 0.4025
Brugia malayi RNA, U transporter 1 0.0089 0.0959 0.2587
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0146 0.0206
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0106 0.0145
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0561 0.0851
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0146 0.0206
Echinococcus granulosus follistatin 0.0018 0.0075 0.0108
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0146 0.0206
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.006 0.0603 0.0948
Echinococcus multilocularis musashi 0.0027 0.018 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0236 0.0586
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0366 0.036
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0106 0.1124
Schistosoma mansoni neuropeptide receptor 0.0024 0.0146 0.0206
Echinococcus granulosus apoptotic protease activating factor 1 0.006 0.0602 0.0923
Echinococcus multilocularis lamin 0.0027 0.018 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0843 0.1336
Onchocerca volvulus 0.0024 0.0146 0.037
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.002 0.0101 0.0241
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0106 0.1124
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.0329
Schistosoma mansoni hypothetical protein 0.0034 0.0273 0.0403
Echinococcus granulosus GPCR family 2 0.0034 0.0273 0.0414
Trypanosoma cruzi protein farnesyltransferase, putative 0.0055 0.0535 0.6291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0106 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.2333 0.6347
Schistosoma mansoni ap endonuclease 0.0041 0.0366 0.0548
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0648 0.0996
Echinococcus multilocularis apoptotic protease activating factor 1 0.006 0.0602 0.0596
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Schistosoma mansoni hypothetical protein 0.006 0.0602 0.0913
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Brugia malayi Serotonin receptor 0.0024 0.0146 0.0364
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Loa Loa (eye worm) hypothetical protein 0.0235 0.2806 0.6964
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0075 0.0171
Echinococcus multilocularis lamin dm0 0.0027 0.018 0.0174
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0146 0.014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0363 0.0544
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Toxoplasma gondii hypothetical protein 0.002 0.0101 0.1059
Onchocerca volvulus 0.0079 0.0843 0.2312
Schistosoma mansoni organic anion transporter 0.0027 0.0183 0.0264
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0146 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Brugia malayi Dopamine receptor protein 1 0.0024 0.0146 0.0364
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0843 0.2094
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0015 0.0032 0.0355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Plasmodium falciparum importin beta, putative 0.0031 0.0236 0.4268
Schistosoma mansoni hypothetical protein 0.0034 0.0273 0.0403
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0146 0.014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0366 0.4251
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0299 0.3604 0.36
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0146 0.0363
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0055 0.0535 0.0821
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0843 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0146 0.0206
Brugia malayi Cell death protein 3 precursor 0.006 0.0602 0.161
Onchocerca volvulus 0.0027 0.0183 0.0473
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0146 0.0217
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0236 0.2685
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0146 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Echinococcus granulosus g protein coupled receptor 0.0024 0.0146 0.0217
Schistosoma mansoni hypothetical protein 0.0054 0.0518 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0146 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0304 0.3668 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0146 0.014
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0366 0.5
Brugia malayi hypothetical protein 0.0044 0.0392 0.1037
Brugia malayi secreted modular calcium-binding protein 1 0.0018 0.0075 0.0171
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0106 0.0264
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0015 0.0032 0.004
Echinococcus multilocularis expressed protein 0.0018 0.0075 0.0069
Onchocerca volvulus 0.0024 0.0146 0.037
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0146 0.0364
Toxoplasma gondii exonuclease III APE 0.0041 0.0366 0.4251
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0146 0.014
Schistosoma mansoni neuropeptide receptor 0.0024 0.0146 0.0206
Schistosoma mansoni hypothetical protein 0.0048 0.0448 0.0675
Mycobacterium tuberculosis Conserved protein 0.0079 0.0843 0.1336
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0075 0.0171
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0055 0.0535 0.6291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0015 0.0032 0.0079
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0843 0.1336
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0561 0.66
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0648 0.0986
Echinococcus granulosus lamin dm0 0.0027 0.018 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0366 0.4251
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0648 0.765
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2333 0.3601
Leishmania major hypothetical protein, conserved 0.0079 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Loa Loa (eye worm) hypothetical protein 0.0299 0.3604 0.8946
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0843 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.4029 1
Brugia malayi hypothetical protein 0.0027 0.0183 0.0465
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0843 0.1336
Echinococcus granulosus Solute carrier organic anion transporter family 0.0027 0.0183 0.0274
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1683
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0055 0.0535 1
Loa Loa (eye worm) beta-lactamase 0.0079 0.0843 0.2094
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0624 0.7359
Onchocerca volvulus 0.002 0.0101 0.0245
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis prolyl endopeptidase 0.0013 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni hypothetical protein 0.0074 0.077 0.1176
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0015 0.0032 0.0026
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0146 0.0206
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0236 0.023
Schistosoma mansoni importin beta-1 0.0031 0.0236 0.0346
Onchocerca volvulus 0.0018 0.0075 0.0174
Brugia malayi GnHR receptor homolog 0.0024 0.0146 0.0364
Loa Loa (eye worm) hypothetical protein 0.0044 0.0392 0.0973
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0366 0.6758
Schistosoma mansoni ran 0.0023 0.0133 0.0185
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0055 0.0535 0.6291
Schistosoma mansoni hypothetical protein 0.0333 0.4029 0.6233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0187
Trypanosoma cruzi lanosterol synthase, putative 0.006 0.0603 0.71
Schistosoma mansoni amine GPCR 0.0024 0.0146 0.0206
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.1439
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0146 0.0217
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0015 0.0032 0.0223
Plasmodium vivax geranylgeranyltransferase, putative 0.0015 0.0032 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0146 0.0206
Onchocerca volvulus Putative organic anion transporter 0.0027 0.0183 0.0473
Onchocerca volvulus 0.0079 0.0843 0.2312
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0524 0.6437 0.6435
Brugia malayi G-protein coupled receptor 0.0024 0.0146 0.0364
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0106 0.1786
Plasmodium vivax importin-beta 2, putative 0.0031 0.0236 0.2685
Onchocerca volvulus 0.0024 0.0146 0.037
Loa Loa (eye worm) agrin synaptic family protein 0.0018 0.0075 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0146 0.014
Leishmania major farnesyltransferase beta subunit 0.0055 0.0535 0.6291
Echinococcus granulosus sex peptide receptor 0.0024 0.0146 0.0217
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0146 0.014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0146 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.0535 0.6291
Echinococcus multilocularis caspase 2 0.006 0.0602 0.0596
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.017 0.1977 0.1972
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1199 0.3245
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0146 0.0217
Trypanosoma cruzi protein farnesyltransferase, putative 0.0055 0.0535 0.6291
Schistosoma mansoni opsin-like receptor 0.0024 0.0146 0.0206
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.077 0.2072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1339 0.3324
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.002 0.0101 0.1683
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0106 0.1124
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0146 0.014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0272 0.3268 0.8905
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0187
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0146 0.0364
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0106 0.1124
Echinococcus granulosus tm gpcr rhodopsin 0.0524 0.6437 0.9971
Echinococcus granulosus somatostatin receptor 0.0024 0.0146 0.0217
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0273 0.0677
Echinococcus multilocularis geminin 0.0525 0.6455 0.6453
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0146 0.0206
Echinococcus granulosus prolyl endopeptidase 0.0013 0.0013 0.0011
Onchocerca volvulus 0.006 0.0602 0.1639
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0146 0.0364
Schistosoma mansoni hypothetical protein 0.0024 0.0146 0.0206
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0146 0.014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0106 0.01
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0146 0.0363
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.002 0.0101 0.1059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0843 0.1289
Onchocerca volvulus 0.0299 0.3604 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.018 0.0456
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0146 0.0217
Mycobacterium leprae Probable lipase LipE 0.0079 0.0843 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0055 0.0535 0.6291
Echinococcus multilocularis inhibitor of apoptosis protein 0.0299 0.3604 0.36
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0015 0.0032 0.0223
Trypanosoma brucei unspecified product 0.0021 0.0106 0.1124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1339 0.3324
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0843 0.1336
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0146 0.0206
Onchocerca volvulus 0.0024 0.0146 0.037
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.002 0.0101 0.0147
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0561 0.1499
Plasmodium vivax prenyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Echinococcus granulosus fmrfamide receptor 0.0024 0.0146 0.0217
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0299 0.3604 0.9824
Toxoplasma gondii ABC1 family protein 0.0079 0.0843 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0013 0.0013 0.0007
Schistosoma mansoni lamin 0.0027 0.018 0.0259
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.002 0.0101 0.0147
Brugia malayi prostaglandin transporter 0.0027 0.0183 0.0465
Schistosoma mansoni amine GPCR 0.0024 0.0146 0.0206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0146 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0146 0.0217
Schistosoma mansoni cpg binding protein 0.0035 0.0279 0.0413
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0015 0.0032 0.0223
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0304 0.3668 0.5674
Echinococcus multilocularis follistatin 0.0018 0.0075 0.0069
Mycobacterium tuberculosis Conserved protein 0.0079 0.0843 0.1336
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0146 0.0206
Echinococcus granulosus cpg binding protein 0.0035 0.0279 0.0424
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0146 0.014
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0055 0.0535 0.6291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0366 0.4251
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.002 0.0101 0.0095
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0377
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0561 0.66
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.002 0.0101 0.1059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0146 0.014
Echinococcus granulosus hypothetical protein 0.0024 0.0146 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0025 0.0143
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0299 0.3604 0.5579
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0106 0.015
Echinococcus granulosus intermediate filament protein 0.0027 0.018 0.0269
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0146 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.2333 0.3608
Echinococcus granulosus snurportin 1 0.0333 0.4029 0.6237
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0236 0.2685
Schistosoma mansoni survival motor neuron protein 0.0048 0.0448 0.0675
Brugia malayi G protein-coupled receptor 0.0024 0.0146 0.0364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0273 0.0267
Brugia malayi larval opioid receptor 0.0024 0.0146 0.0364
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0146 0.0217
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0015 0.0032 0.0051
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0146 0.0364
Schistosoma mansoni follistatin 0.0018 0.0075 0.0097
Echinococcus granulosus agrin 0.0018 0.0075 0.0108
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Schistosoma mansoni hypothetical protein 0.0525 0.6455 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0075 0.0751
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0146 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2333 0.3601
Echinococcus granulosus neuropeptide receptor 0.0024 0.0146 0.0217
Brugia malayi RE15519p 0.0024 0.0146 0.0364
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.002 0.0101 0.0251
Mycobacterium ulcerans lipase LipD 0.0079 0.0843 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0027 0.0183 0.0465
Onchocerca volvulus 0.0027 0.0183 0.0473
Echinococcus multilocularis sex peptide receptor 0.0024 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Entamoeba histolytica hypothetical protein 0.0025 0.0162 0.2849
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0101 0.1059
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0843 0.1298
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0133 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0648 0.765
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.2333 0.3601
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0027 0.0183 0.0177
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0146 0.0217
Echinococcus multilocularis max protein X 0.0304 0.3668 0.3665
Schistosoma mansoni biogenic amine receptor 0.0024 0.0146 0.0206
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0146 0.0217
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0027 0.0183 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0843 1
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0304 0.3668 0.5674
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0146 0.014
Toxoplasma gondii transporter, major facilitator family protein 0.0027 0.0183 0.2046
Schistosoma mansoni lamin 0.0027 0.018 0.0259
Brugia malayi Serotonin receptor 0.0024 0.0146 0.0364
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0146 0.0363
Schistosoma mansoni agrin 0.0018 0.0075 0.0097
Onchocerca volvulus 0.0024 0.0146 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0146 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0431
Loa Loa (eye worm) hypothetical protein 0.0034 0.0273 0.0677
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0146 0.0206
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0146 0.0363
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0366 0.4251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0264
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.1439
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0133 0.1439
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0146 0.0217
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0018 0.0075 0.0751
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0133 0.1439
Echinococcus granulosus g protein coupled receptor 0.0024 0.0146 0.0217
Onchocerca volvulus 0.0024 0.0146 0.037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1199 0.2977
Giardia lamblia DINP protein human, muc B family 0.0021 0.0106 0.1786
Schistosoma mansoni neuropeptide receptor 0.0024 0.0146 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0015 0.0032 0.0223
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0146 0.014
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.002 0.0101 0.1683
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0146 0.014
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0146 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.2333 0.3608
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0133 0.2287
Echinococcus granulosus inhibitor of apoptosis protein 0.0299 0.3604 0.5579
Brugia malayi hypothetical protein 0.0024 0.0146 0.0364
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0146 0.0217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0273 0.0414
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0251
Schistosoma mansoni hypothetical protein 0.0024 0.0146 0.0206
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0648 0.0643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0843 0.1289
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0843 0.2272
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0146 0.014
Brugia malayi CXXC zinc finger family protein 0.0033 0.0256 0.0664
Echinococcus multilocularis serotonin receptor 0.0024 0.0146 0.014
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0561 0.66
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Brugia malayi beta-lactamase 0.0079 0.0843 0.2272
Brugia malayi intermediate filament protein 0.0027 0.018 0.0456
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0454
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0146 0.0217
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0299 0.3604 0.9824
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0106 0.015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.2333 0.5791
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.002 0.0101 0.1059
Entamoeba histolytica Ran family GTPase 0.0023 0.0133 0.2287
Echinococcus multilocularis dna polymerase eta 0.0021 0.0106 0.01
Echinococcus granulosus geminin 0.0525 0.6455 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0146 0.037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0366 0.4251
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0018 0.0075 0.0171
Brugia malayi G-protein coupled receptor 0.0024 0.0146 0.0364
Schistosoma mansoni amine GPCR 0.0024 0.0146 0.0206
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0843 1
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0146 0.0363
Echinococcus granulosus protein prenyltransferase alpha subunit 0.002 0.0101 0.0147
Onchocerca volvulus Deterin homolog 0.0299 0.3604 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0101 0.1059
Schistosoma mansoni biogenic amine receptor 0.0024 0.0146 0.0206
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0273 0.0711
Echinococcus granulosus dnaJ subfamily B 0.0466 0.5708 0.8842
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0133 0.1439
Loa Loa (eye worm) intermediate filament protein 0.0027 0.018 0.0446
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0027 0.0183 0.0454
Schistosoma mansoni intermediate filament proteins 0.0027 0.018 0.0259
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0366 0.6758
Schistosoma mansoni amine GPCR 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0079
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0602 0.0913
Schistosoma mansoni hypothetical protein 0.0024 0.0146 0.0206
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0106 0.01
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0273 0.0414
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0561 0.66
Onchocerca volvulus 0.0027 0.0183 0.0473
Schistosoma mansoni hypothetical protein 0.0034 0.0273 0.0403
Leishmania major geranylgeranyltransferase, putative 0.0015 0.0032 0.0223
Loa Loa (eye worm) hypothetical protein 0.0108 0.1199 0.2977
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.2806 0.2801
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0843 1
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0146 0.0217
Onchocerca volvulus 0.0048 0.0448 0.1212
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0843 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.018 0.0446
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0055 0.0535 0.053
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0146 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trypanosoma brucei lanosterol synthase 0.006 0.0603 0.71
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0146 0.014
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0843 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0262 0.3135 0.3131
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0015 0.0032 0.0223
Leishmania major DNA polymerase eta, putative 0.0021 0.0106 0.1124
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0648 0.765
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0366 0.4251
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0162 0.1792
Schistosoma mansoni histamine h1 receptor 0.0024 0.0146 0.0206
Echinococcus granulosus importin subunit beta 1 0.0031 0.0236 0.0357
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0363
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.2806 0.4341
Echinococcus multilocularis GPCR, family 2 0.0034 0.0273 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0106 0.1124
Mycobacterium ulcerans beta-lactamase 0.0079 0.0843 1
Giardia lamblia Prenyltransferase 0.0055 0.0535 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0146 0.0206
Schistosoma mansoni hypothetical protein 0.0466 0.5708 0.8841
Echinococcus granulosus max protein X 0.0304 0.3668 0.5679
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Loa Loa (eye worm) hypothetical protein 0.0079 0.0843 0.2094
Brugia malayi SPARC precursor 0.0018 0.0075 0.0171

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 25 min Ester prodrugs: T1/2 in human plasma ChEMBL. 2585438
T1/2 (ADMET) = 25 min Ester prodrugs: T1/2 in human plasma ChEMBL. 2585438

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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