Detailed information for compound 1387352

Basic information

Technical information
  • TDR Targets ID: 1387352
  • Name: N'-(1,3-dimethyl-2,4-dioxopteridin-6-yl)-4-ni trobenzohydrazide
  • MW: 371.308 | Formula: C15H13N7O5
  • H donors: 2 H acceptors: 7 LogP: 0.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])NNc1cnc2c(n1)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C15H13N7O5/c1-20-12-11(14(24)21(2)15(20)25)17-10(7-16-12)18-19-13(23)8-3-5-9(6-4-8)22(26)27/h3-7H,1-2H3,(H,17,18)(H,19,23)
  • InChiKey: FPVVNMCCYOPHOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(1,3-dimethyl-2,4-dioxo-pteridin-6-yl)-4-nitro-benzohydrazide
  • N'-(1,3-dimethyl-2,4-dioxo-6-pteridinyl)-4-nitrobenzohydrazide
  • N'-(2,4-diketo-1,3-dimethyl-pteridin-6-yl)-4-nitro-benzohydrazide
  • MLS001004634
  • SMR000348226
  • T0503-7525

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.0687 0.4853 0.7927
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Schistosoma mansoni cell adhesion molecule 0.01 0.0522 0.0852
Trichomonas vaginalis cyclin B, putative 0.0036 0.0048 0.0245
Loa Loa (eye worm) TK/KIN16 protein kinase 0.074 0.5242 0.7407
Brugia malayi cell division control protein 2 homolog 0.0094 0.0479 0.0783
Schistosoma mansoni hypothetical protein 0.0205 0.1294 0.2114
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Trypanosoma brucei mitotic cyclin 6 0.0036 0.0048 0.0202
Entamoeba histolytica protein kinase domain containing protein 0.0032 0.0018 0.0092
Echinococcus granulosus tyrosine kinase 0.0092 0.0461 0.0752
Onchocerca volvulus 0.0036 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0046 0.0121 0.062
Schistosoma mansoni nephrin 0.0047 0.0129 0.0211
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0234 0.1509 0.2464
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Trypanosoma cruzi aurora B kinase, putative 0.0234 0.1509 0.7711
Echinococcus multilocularis tyrosine protein kinase shark 0.0033 0.0027 0.0044
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0089 0.0145
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0106 0.0543
Echinococcus multilocularis tyrosine kinase 0.0033 0.0027 0.0044
Echinococcus granulosus c src tyrosine kinase 0.004 0.0082 0.0133
Echinococcus granulosus cyclin dependent kinase 0.0094 0.0479 0.0783
Loa Loa (eye worm) AUR protein kinase 0.0234 0.1509 0.2131
Entamoeba histolytica protein kinase domain containing protein 0.0143 0.0838 0.4287
Loa Loa (eye worm) plexin A 0.0041 0.0088 0.0124
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Loa Loa (eye worm) AGC/AKT protein kinase 0.0075 0.0335 0.0474
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0479 0.2453
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0033 0.0027 0.0044
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0308 0.0503
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.0479 0.0783
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.0479 0.0783
Echinococcus granulosus cyclin B3 1 0.0036 0.0048 0.0078
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0099 0.0515 0.0842
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0047 0.0129 0.0211
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0044
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.005 0.0149 0.0938
Schistosoma mansoni protein kinase 0.0034 0.0032 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0106 0.0543
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Schistosoma mansoni tyrosine kinase 0.0581 0.4069 0.6647
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.0479 0.0677
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0008 0.0013
Echinococcus multilocularis cyclin B 0.0036 0.0048 0.0078
Brugia malayi Furin-like cysteine rich region family protein 0.0859 0.6121 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0044
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0071 0.0305 0.0431
Onchocerca volvulus 0.011 0.0595 0.1215
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.018 0.092
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0015 0.0021
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.052 0.2661
Schistosoma mansoni alpha-glucosidase 0.0169 0.1034 0.1689
Echinococcus multilocularis Immunoglobulin 0.0069 0.0291 0.0476
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0099 0.0515 0.0842
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0031 0.0015 0.0024
Entamoeba histolytica protein kinase, putative 0.0234 0.1509 0.7721
Trichomonas vaginalis AGC family protein kinase 0.0234 0.1509 0.7721
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0294 0.1954 0.3192
Schistosoma mansoni ephrin receptor 0.0037 0.0055 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0106 0.0543
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0044
Echinococcus granulosus cyclin b3 0.0036 0.0048 0.0078
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1236 0.2019
Echinococcus granulosus neuroglian 0.0047 0.0129 0.0211
Onchocerca volvulus 0.0035 0.0041 0.003
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0069 0.0291 0.0476
Echinococcus granulosus defective proboscis extension response 0.0069 0.0291 0.0476
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.0274 0.0447
Schistosoma mansoni roundabout 0.0035 0.0045 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0129 0.0211
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0294 0.1954 0.2761
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.0129 0.0211
Echinococcus multilocularis nervana 2 0.0041 0.0089 0.0145
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.0129 0.0211
Schistosoma mansoni tyrosine kinase 0.0737 0.5226 0.8538
Trypanosoma brucei glucosidase, putative 0.0044 0.0106 0.0502
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0048 0.0078
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0089 0.0145
Plasmodium falciparum casein kinase 2, alpha subunit 0.0143 0.0838 0.5527
Giardia lamblia Kinase, AGC PKA 0.005 0.0149 0.0532
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0106 0.0173
Echinococcus multilocularis c src tyrosine kinase 0.004 0.0082 0.0133
Loa Loa (eye worm) hypothetical protein 0.0086 0.0419 0.0592
Echinococcus granulosus epidermal growth factor receptor 0.0581 0.4069 0.6647
Schistosoma mansoni tyrosine kinase 0.0061 0.0232 0.038
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0055 0.019 0.0268
Loa Loa (eye worm) hypothetical protein 0.008 0.0375 0.053
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.0479 0.2419
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0354
Brugia malayi Plexin repeat family protein 0.0035 0.0041 0.0067
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0047 0.0129 0.0211
Plasmodium falciparum cyclin 0.0036 0.0048 0.0262
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0234 0.1509 0.7721
Echinococcus granulosus muscleblind protein 0.018 0.1115 0.1822
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0099 0.0515 0.0842
Giardia lamblia Kinase, CMGC CK2 0.0143 0.0838 0.4143
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Toxoplasma gondii aurora kinase 0.0234 0.1509 1
Schistosoma mansoni tyrosine kinase 0.0033 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0069 0.0291 0.0412
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0046 0.0121 0.0171
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0086 0.014
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.005 0.0149 0.0938
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.018 0.1115 0.1576
Echinococcus multilocularis epidermal growth factor receptor 0.0859 0.6121 1
Echinococcus multilocularis aurora kinase A 0.0234 0.1509 0.2464
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0106 0.0502
Entamoeba histolytica protein kinase 2, putative 0.005 0.0149 0.0764
Echinococcus multilocularis muscleblind protein 0.018 0.1115 0.1822
Echinococcus granulosus cyclin B 0.0036 0.0048 0.0078
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0234 0.1509 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0292 0.0413
Brugia malayi ephrin receptor 1 precursor 0.0077 0.0353 0.0577
Onchocerca volvulus Serine\/threonine kinase homolog 0.0294 0.1954 0.412
Brugia malayi hypothetical protein 0.003 0.0009 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0308 0.0503
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0048 0.0078
Loa Loa (eye worm) hypothetical protein 0.0047 0.0129 0.0183
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.052 0.2661
Echinococcus granulosus hemicentin 1 0.0035 0.0045 0.0074
Echinococcus granulosus cyclins 0.0036 0.0048 0.0078
Brugia malayi Protein kinase domain containing protein 0.0538 0.3758 0.6139
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0581 0.4069 0.6647
Schistosoma mansoni tyrosine kinase 0.0099 0.0515 0.0842
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0143 0.0838 0.1183
Echinococcus granulosus roundabout 2 0.0047 0.0129 0.0211
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0106 0.0543
Echinococcus granulosus nervana 2 0.0041 0.0089 0.0145
Schistosoma mansoni septate junction protein 0.0035 0.0045 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0033 0.0027 0.0044
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0015 0.0024
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Echinococcus multilocularis tyrosine protein kinase Abl 0.004 0.0082 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Echinococcus multilocularis roundabout 2 0.0047 0.0129 0.0211
Schistosoma mansoni tyrosine kinase 0.0859 0.6121 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0035 0.0045 0.0064
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0041 0.0088 0.013
Echinococcus multilocularis geminin 0.0205 0.1294 0.2114
Echinococcus granulosus contactin 0.0047 0.0129 0.0211
Trichomonas vaginalis AGC family protein kinase 0.0234 0.1509 0.7721
Echinococcus multilocularis casein kinase ii subunit alpha 0.0143 0.0838 0.1368
Brugia malayi Peroxidasin 0.0036 0.0046 0.0076
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0308 0.0503
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0308 0.0503
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.4853 0.7927
Brugia malayi plexin A 0.0041 0.0088 0.0144
Brugia malayi serine/threonine protein kinase 6 0.0234 0.1509 0.2464
Schistosoma mansoni protein kinase 0.0143 0.0838 0.1368
Entamoeba histolytica cyclin, putative 0.0036 0.0048 0.0245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Schistosoma mansoni protein kinase 0.0034 0.0032 0.0052
Echinococcus multilocularis epidermal growth factor receptor 0.0581 0.4069 0.6647
Onchocerca volvulus Tyrosine kinase homolog 0.0667 0.4703 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0092 0.0461 0.0752
Entamoeba histolytica protein kinase, putative 0.0075 0.0335 0.1716
Echinococcus multilocularis cyclin b3 0.0036 0.0048 0.0078
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Giardia lamblia Aurora kinase 0.0234 0.1509 0.7664
Brugia malayi hypothetical protein 0.0033 0.0027 0.0044
Trypanosoma cruzi Protein kinase B 0.0054 0.018 0.088
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0189 0.031
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.0479 0.0677
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0308 0.0503
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0047 0.0129 0.0211
Trichomonas vaginalis cyclin B, putative 0.0036 0.0048 0.0245
Echinococcus granulosus lachesin 0.0035 0.0045 0.0074
Echinococcus multilocularis neuroglian 0.0047 0.0129 0.0211
Brugia malayi Prion-like- 0.0035 0.0045 0.0074
Echinococcus multilocularis nervana 2 0.0041 0.0089 0.0145
Brugia malayi hypothetical protein 0.008 0.0375 0.0613
Loa Loa (eye worm) hypothetical protein 0.018 0.1115 0.1576
Brugia malayi Cyclin, N-terminal domain containing protein 0.0036 0.0048 0.0078
Trypanosoma brucei Casein kinase II 0.0143 0.0838 0.4261
Echinococcus multilocularis roundabout 2 0.0116 0.0637 0.104
Echinococcus multilocularis hemicentin 1 0.0035 0.0045 0.0074
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.018 0.092
Trichomonas vaginalis cyclin B, putative 0.0036 0.0048 0.0245
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0086 0.0121
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0035 0.0045 0.0074
Echinococcus granulosus roundabout 2 0.0116 0.0637 0.104
Echinococcus granulosus neuroglian 0.0084 0.0406 0.0663
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0035 0.0045 0.0064
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.0479 0.2453
Schistosoma mansoni cell adhesion molecule 0.0047 0.0129 0.0211
Loa Loa (eye worm) cyclin domain-containing protein 0.0036 0.0048 0.0068
Schistosoma mansoni tyrosine kinase 0.004 0.0082 0.0133
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0046 0.0121 0.062
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.0479 0.2419
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.0479 0.2453
Brugia malayi serine/threonine-protein kinase 6 0.0234 0.1509 0.2464
Loa Loa (eye worm) TK/INSR protein kinase 0.0737 0.5226 0.7385
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0089 0.0438 0.0715
Schistosoma mansoni plexin 0.0035 0.0041 0.0067
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1236 0.2019
Echinococcus granulosus serine/threonine protein kinase 0.0054 0.018 0.0294
Schistosoma mansoni cell adhesion molecule 0.0035 0.0045 0.0074
Brugia malayi protein unc-22 0.0035 0.0043 0.0071
Schistosoma mansoni serine/threonine-protein kinase 0.0054 0.018 0.0294
Echinococcus multilocularis neuroglian 0.0084 0.0406 0.0663
Brugia malayi Protein kinase domain containing protein 0.0075 0.0335 0.0548
Echinococcus multilocularis roundabout 2 0.0047 0.0129 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.1509 0.2464
Echinococcus granulosus tyrosine protein kinase shark 0.0033 0.0027 0.0044
Echinococcus granulosus roundabout 2 0.0047 0.0129 0.0211
Echinococcus multilocularis cyclin B3 1 0.0036 0.0048 0.0078
Leishmania major casein kinase II, putative 0.0143 0.0838 0.4261
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Loa Loa (eye worm) hypothetical protein 0.011 0.0595 0.0841
Loa Loa (eye worm) TK protein kinase 0.0041 0.0086 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Toxoplasma gondii CMGC kinase, CK2 family 0.0143 0.0838 0.5527
Trypanosoma cruzi casein kinase II, putative 0.0143 0.0838 0.4261
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Echinococcus granulosus tyrosine protein kinase ABL1 0.0033 0.0027 0.0044
Echinococcus multilocularis tyrosine protein kinase Srms 0.0092 0.0461 0.0752
Trichomonas vaginalis cyclins, putative 0.0036 0.0048 0.0245
Brugia malayi p70 ribosomal S6 kinase beta 0.0071 0.0305 0.0498
Entamoeba histolytica tyrosin kinase, putative 0.0032 0.0018 0.0092
Trypanosoma cruzi cyclin 6, putative 0.0036 0.0048 0.0202
Echinococcus granulosus epidermal growth factor receptor 0.0859 0.6121 1
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.4853 0.7927
Loa Loa (eye worm) TK/EGFR protein kinase 0.0859 0.6121 0.8649
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0232 0.1499 0.2448
Loa Loa (eye worm) hypothetical protein 0.0089 0.0438 0.0619
Schistosoma mansoni tyrosine kinase 0.0555 0.3882 0.6342
Loa Loa (eye worm) hypothetical protein 0.008 0.0375 0.053
Echinococcus granulosus cyclins 0.0036 0.0048 0.0078
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0033 0.0027 0.0138
Entamoeba histolytica cyclin family protein 0.0036 0.0048 0.0245
Schistosoma mansoni ephrin receptor 0.0135 0.0782 0.1278
Schistosoma mansoni tyrosine kinase 0.0581 0.4069 0.6647
Trypanosoma cruzi cyclin, putative 0.0036 0.0048 0.0202
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0046 0.0121 0.075
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0106 0.0543
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0012
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0069 0.0291 0.0476
Trichomonas vaginalis AGC family protein kinase 0.0234 0.1509 0.7721
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0294 0.1954 0.3192
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0048 0.0245
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0234 0.1509 0.7721
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0043 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0535 0.274
Echinococcus granulosus nervana 2 0.0041 0.0089 0.0145
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0092 0.0461 0.0752
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.0479 0.2419
Echinococcus multilocularis Immunoglobulin 0.0069 0.0291 0.0476
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0046 0.0121 0.0198
Loa Loa (eye worm) hypothetical protein 0.0288 0.1907 0.2694
Loa Loa (eye worm) TK protein kinase 0.0092 0.0461 0.0651
Onchocerca volvulus 0.0035 0.0043 0.0035
Giardia lamblia Kinase, PLK 0.0294 0.1954 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0294 0.1954 0.3192
Brugia malayi SRC-1 0.0099 0.0515 0.0842
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0046 0.0121 0.075
Brugia malayi SH2 domain containing protein 0.0033 0.0027 0.0044
Echinococcus multilocularis insulin receptor 0.0737 0.5226 0.8538
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0099 0.0515 0.0842
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0046 0.0121 0.0198
Trypanosoma brucei rac serine-threonine kinase, putative 0.0075 0.0335 0.1679
Trichomonas vaginalis cyclins, putative 0.0036 0.0048 0.0245
Schistosoma mansoni tyrosine kinase 0.0555 0.3882 0.6342
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.0479 0.0783
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0234 0.1509 0.2464
Plasmodium vivax protein kinase Crk2 0.0094 0.0479 0.3138
Entamoeba histolytica serine/threonine protein kinase, putative 0.0294 0.1954 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0749 0.531 0.8675
Echinococcus granulosus twitchin 0.0093 0.0467 0.0762
Echinococcus granulosus tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0106 0.0543
Echinococcus granulosus serine threonine protein kinase nrc 0.005 0.0149 0.0244
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0046 0.0121 0.0384
Echinococcus multilocularis titin 0.0035 0.0043 0.0071
Schistosoma mansoni alpha-glucosidase 0.0169 0.1034 0.1689
Brugia malayi Tyrosine-protein kinase abl-1 0.004 0.0082 0.0133
Schistosoma mansoni tyrosine kinase 0.004 0.0082 0.0133
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0106 0.0543
Plasmodium falciparum protein kinase 5 0.0094 0.0479 0.3138
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Trichomonas vaginalis cyclins, putative 0.0036 0.0048 0.0245
Echinococcus granulosus tyrosine protein kinase Srms 0.0033 0.0027 0.0044
Trypanosoma brucei polo-like protein kinase 0.0294 0.1954 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1115 0.1822
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0308 0.0435
Trypanosoma cruzi rac serine-threonine kinase, putative 0.005 0.0149 0.0723
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0036 0.0048 0.0078
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0129 0.0183
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0046 0.0121 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Loa Loa (eye worm) hypothetical protein 0.008 0.0375 0.053
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.004 0.0082 0.0133
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0988 0.7077 1
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0479 0.0783
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0189 0.031
Echinococcus granulosus ephrin type A receptor 4 A 0.0161 0.0976 0.1594
Loa Loa (eye worm) hypothetical protein 0.0104 0.0553 0.0781
Schistosoma mansoni tyrosine kinase 0.0099 0.0515 0.0842
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0375 0.0613
Echinococcus multilocularis 0.0255 0.1666 0.2721
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Onchocerca volvulus 0.0626 0.4402 0.9354
Trypanosoma cruzi cyclin, putative 0.0036 0.0048 0.0202
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1236 0.2019
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.0479 0.2419
Echinococcus granulosus cyclins 0.0036 0.0048 0.0078
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.0479 0.2419
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0043 0.0071
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1236 0.1746
Loa Loa (eye worm) hypothetical protein 0.0104 0.0553 0.0781
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0143 0.0838 0.5527
Brugia malayi Immunoglobulin I-set domain containing protein 0.074 0.5242 0.8564
Echinococcus granulosus geminin 0.0205 0.1294 0.2114
Schistosoma mansoni nephrin 0.0096 0.049 0.0801
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0749 0.531 0.8675
Echinococcus granulosus cyclins 0.0036 0.0048 0.0078
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1339 0.9663 1
Loa Loa (eye worm) AUR protein kinase 0.0234 0.1509 0.2131
Plasmodium vivax unspecified product 0.0143 0.0838 0.5527
Trichomonas vaginalis cyclins, putative 0.0036 0.0048 0.0245
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0034 0.0032 0.0153
Entamoeba histolytica protein kinase domain containing protein 0.0234 0.1509 0.7721
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.005 0.0149 0.0244
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0034 0.0032 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0479 0.2453
Schistosoma mansoni septate junction protein 0.0035 0.0045 0.0074
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.0479 0.0783
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0308 0.0503
Loa Loa (eye worm) hypothetical protein 0.0069 0.0291 0.0412
Schistosoma mansoni cyclin B 0.0036 0.0048 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Echinococcus granulosus titin 0.0035 0.0043 0.0071
Schistosoma mansoni alpha glucosidase 0.0044 0.0106 0.0173
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0046 0.0121 0.0578
Echinococcus granulosus Immunoglobulin 0.0069 0.0291 0.0476
Entamoeba histolytica protein kinase, putative 0.0084 0.0405 0.2071
Schistosoma mansoni hypothetical protein 0.0205 0.1294 0.2114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.0129 0.0211
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0099 0.0515 0.0842
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0106 0.065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0074 0.0334 0.0545
Echinococcus multilocularis lachesin 0.0035 0.0045 0.0074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1236 0.2019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0099 0.0515 0.0842
Plasmodium falciparum protein kinase, putative 0.0034 0.0032 0.0153
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0046 0.0121 0.0578
Entamoeba histolytica cyclin family protein 0.0036 0.0048 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Brugia malayi Protein kinase domain containing protein 0.0094 0.0479 0.0783
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0046 0.0121 0.075
Echinococcus granulosus tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0026 0.0042
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0099 0.0515 0.0842
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0046 0.0121 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.1954 0.3192
Schistosoma mansoni cell adhesion molecule 0.0047 0.0129 0.0211
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0035 0.0045 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0129 0.0211
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.1954 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Brugia malayi Muscleblind-like protein 0.018 0.1115 0.1822
Echinococcus granulosus tyrosine protein kinase Btk29A 0.004 0.0082 0.0133
Loa Loa (eye worm) TK/ABL protein kinase 0.0033 0.0027 0.0038
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0308 0.0503
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0099 0.0515 0.0842
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0045 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0034 0.0032 0.0118
Brugia malayi SH2 domain containing protein 0.0033 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0068
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0034 0.0032 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0106 0.015
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0089 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Echinococcus granulosus casein kinase ii subunit alpha 0.0143 0.0838 0.1368
Echinococcus granulosus protein tyrosine kinase 0.0532 0.3713 0.6066
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0479 0.2453
Entamoeba histolytica protein kinase, putative 0.0075 0.0335 0.1716
Loa Loa (eye worm) hypothetical protein 0.0036 0.0046 0.0066
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0106 0.0502
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1384 1 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0038 0.0194
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0232 0.1499 0.2448
Brugia malayi Protein kinase domain containing protein 0.0737 0.5226 0.8538
Giardia lamblia Kinase, CMGC CDK 0.0094 0.0479 0.2263
Plasmodium vivax protein kinase, putative 0.0034 0.0035 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0031 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0036 0.0048 0.0078
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.004 0.0082 0.0133
Schistosoma mansoni tyrosine kinase 0.0033 0.0027 0.0044
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.01 0.052 0.0735
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0106 0.0543
Loa Loa (eye worm) TK/FAK protein kinase 0.0538 0.3758 0.531
Schistosoma mansoni titin 0.0035 0.0043 0.0071
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0034 0.0032 0.0118
Loa Loa (eye worm) TK protein kinase 0.0084 0.0405 0.0572
Trichomonas vaginalis cyclin B3, putative 0.0036 0.0048 0.0245
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.0479 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0535 0.274
Brugia malayi protein-tyrosine kinase 0.0092 0.0461 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.1954 1
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.0479 0.0783
Loa Loa (eye worm) CAMK protein kinase 0.0035 0.0043 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Schistosoma mansoni tyrosine kinase 0.0532 0.3713 0.6066
Schistosoma mansoni protein kinase 0.0034 0.0032 0.0052
Echinococcus granulosus tyrosine protein kinase Src42A 0.0099 0.0515 0.0842
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0129 0.0211
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0234 0.1509 0.7721
Entamoeba histolytica casein kinase, putative 0.0143 0.0838 0.4287
Echinococcus granulosus tyrosine protein kinase Blk 0.0092 0.0461 0.0752
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.0479 0.0677
Schistosoma mansoni serine/threonine-protein kinase 0.0054 0.018 0.0294
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.005 0.0149 0.0244
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0046 0.0121 0.0578
Entamoeba histolytica protein kinase , putative 0.0234 0.1509 0.7721
Echinococcus granulosus cyclins 0.0036 0.0048 0.0078
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0294 0.1954 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0092 0.0461 0.0752
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0838 0.4287
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Giardia lamblia Kinase, CMGC CDK 0.0094 0.0479 0.2263
Trichomonas vaginalis cyclin B, putative 0.0036 0.0048 0.0245
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.0479 0.3138
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0044
Entamoeba histolytica cyclin, putative 0.0036 0.0048 0.0245
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.0479 0.2419
Plasmodium falciparum serine/threonine protein kinase, putative 0.0234 0.1509 1
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0031 0.0015 0.0024
Loa Loa (eye worm) SRC-1 0.0099 0.0515 0.0728
Echinococcus granulosus tyrosine protein kinase HCK 0.0084 0.0405 0.0661
Schistosoma mansoni tyrosine kinase 0.0737 0.5226 0.8538
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.0479 0.2419
Leishmania major protein kinase, putative 0.0034 0.0032 0.0118
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.0479 0.2419
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0106 0.0543
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0064
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Schistosoma mansoni cyclins 0.0036 0.0048 0.0078
Echinococcus multilocularis protein tyrosine kinase 0.0532 0.3713 0.6066
Trichomonas vaginalis cyclin A, putative 0.0036 0.0048 0.0245
Brugia malayi jmjC domain containing protein 0.0071 0.0308 0.0503
Leishmania major cyclin 0.0036 0.0048 0.0202
Entamoeba histolytica protein kinase, putative 0.0234 0.1509 0.7721
Echinococcus granulosus tyrosine protein kinase otk 0.0035 0.0045 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0106 0.0543
Echinococcus granulosus tyrosine protein kinase Lyn 0.0107 0.0576 0.0941
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0106 0.0173
Trichomonas vaginalis cyclin D, putative 0.0036 0.0048 0.0245
Echinococcus multilocularis tyrosine protein kinase HCK 0.0084 0.0405 0.0661
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0054 0.018 0.088
Entamoeba histolytica protein kinase domain containing protein 0.0034 0.0032 0.0162
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0034 0.0032 0.0052
Entamoeba histolytica protein kinase, putative 0.0071 0.0305 0.156
Echinococcus granulosus activin receptor type 0.0034 0.0032 0.0052
Echinococcus granulosus plexin a4 0.0041 0.0088 0.0144
Brugia malayi Protein kinase domain containing protein 0.0313 0.2094 0.3421
Toxoplasma gondii AGC kinase 0.0071 0.0305 0.1975
Schistosoma mansoni vesicular amine transporter 0.0069 0.0291 0.0476
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0106 0.0173
Schistosoma mansoni lipoxygenase 0.0055 0.0189 0.031
Echinococcus multilocularis cyclins 0.0036 0.0048 0.0078
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.0479 0.0783
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0035 0.0043 0.0061
Trichomonas vaginalis cyclins, putative 0.0036 0.0048 0.0245
Loa Loa (eye worm) TK/EPH protein kinase 0.0165 0.1005 0.142
Echinococcus granulosus insulin receptor 0.0737 0.5226 0.8538
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0033 0.0027 0.0044
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.0274 0.0447
Echinococcus multilocularis tyrosine protein kinase otk 0.0035 0.0045 0.0074
Brugia malayi Fibronectin type III domain containing protein 0.008 0.0375 0.0613
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0106 0.0543
Echinococcus multilocularis peroxidasin 0.0036 0.0046 0.0076
Echinococcus granulosus peroxidasin 0.0036 0.0046 0.0076
Leishmania major protein kinase, putative 0.0234 0.1509 0.7711
Trypanosoma brucei aurora B kinase 0.0234 0.1509 0.7711
Schistosoma mansoni neuroglian 0.0047 0.0129 0.0211
Schistosoma mansoni tyrosine kinase 0.0555 0.3882 0.6342
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0046 0.0121 0.0198
Loa Loa (eye worm) AUR protein kinase 0.0234 0.1509 0.2131
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Brugia malayi Casein kinase II, alpha chain 0.0143 0.0838 0.1368
Echinococcus multilocularis rac serine:threonine kinase 0.0054 0.018 0.0294
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0038
Echinococcus multilocularis ephrin type A receptor 4 A 0.0161 0.0976 0.1594
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0106 0.0502
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0041 0.0086 0.014
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.1954 1
Schistosoma mansoni kinase 0.0425 0.2917 0.4766
Echinococcus granulosus aurora kinase A 0.0234 0.1509 0.2464
Schistosoma mansoni protein kinase 0.0234 0.1509 0.2464
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Echinococcus granulosus tyrosine kinase 0.0033 0.0027 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0234 0.1509 0.7721
Trichomonas vaginalis cyclin B, putative 0.0036 0.0048 0.0245
Trichomonas vaginalis cyclin D, putative 0.0036 0.0048 0.0245
Schistosoma mansoni titin 0.0035 0.0045 0.0074
Onchocerca volvulus 0.0114 0.0624 0.1276
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0046 0.0121 0.0198
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0068
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0041 0.0086 0.014
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0335 0.1716
Echinococcus multilocularis plexin a4 0.0041 0.0088 0.0144
Echinococcus multilocularis activin receptor type 0.0034 0.0032 0.0052
Brugia malayi jmjC domain containing protein 0.0071 0.0308 0.0503
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0479 0.0783
Trypanosoma brucei protein kinase, putative 0.0034 0.0032 0.0118
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0036 0.0048 0.0202
Schistosoma mansoni cyclin B3 0.0036 0.0048 0.0078
Brugia malayi serine/threonine kinase 12 0.0234 0.1509 0.2464
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0058
Trypanosoma cruzi CYC2-like cyclin, putative 0.0036 0.0048 0.0202
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0027 0.0038
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0044
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0089 0.0145
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0099 0.0515 0.0842
Echinococcus granulosus titin 0.0035 0.0043 0.0071
Echinococcus granulosus tyrosine protein kinase Src64B 0.0099 0.0515 0.0842
Echinococcus multilocularis hemicentin 1 0.0035 0.0045 0.0074

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2993 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 2.5119 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.881 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) 30.881 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 34.6491 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948] ChEMBL. No reference
Potency (functional) 34.6491 uM PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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