TDR Targets

Basic information

Technical information

TDR Targets ID: 1393950
Name: 4-[1-[2-[(2,6-dimethylphenyl)amino]-2-oxoethy l]-2,4-dioxothieno[3,2-d]pyrimidin-3-yl]-N-(f uran-2-ylmethyl)butanamide
MW: 494.563 | Formula: C25H26N4O5S
H donors: 2 H acceptors: 4 LogP: 2.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NCc1ccco1)CCCn1c(=O)n(CC(=O)Nc2c(C)cccc2C)c2c(c1=O)scc2
InChi: 1S/C25H26N4O5S/c1-16-6-3-7-17(2)22(16)27-21(31)15-29-19-10-13-35-23(19)24(32)28(25(29)33)11-4-9-20(30)26-14-18-8-5-12-34-18/h3,5-8,10,12-13H,4,9,11,14-15H2,1-2H3,(H,26,30)(H,27,31)
InChiKey: ZXJLPKUOLZHBNG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[1-[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-2,4-dioxo-thieno[3,2-d]pyrimidin-3-yl]-N-(2-furylmethyl)butanamide
4-[1-[2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]-2,4-dioxo-3-thieno[3,2-d]pyrimidinyl]-N-(2-furylmethyl)butanamide
4-[1-[2-[(2,6-dimethylphenyl)amino]-2-keto-ethyl]-2,4-diketo-thieno[3,2-d]pyrimidin-3-yl]-N-(2-furylmethyl)butyramide
4-[1-[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-2,4-dioxo-thieno[3,2-d]pyrimidin-3-yl]-N-(furan-2-ylmethyl)butanamide
4-[1-{2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]-N-(2-furylmethyl)butanamide
MLS000087527
SMR000023750
MLS000876644

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Dual oxidase homolog	0.0081	0.0773	0.3018
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.1084	0.1084
Onchocerca volvulus	Chorion peroxidase homolog	0.0081	0.0773	0.3018
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0017	0.0029	0.0029
Brugia malayi	Animal haem peroxidase family protein	0.0081	0.0773	0.2475
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.1099	0.3353
Brugia malayi	Pre-SET motif family protein	0.003	0.0176	0.0538
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0348	0.1063
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.1099	0.3353
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0035
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0458	0.0458
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1084	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0408	0.1322
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0176	0.0176
Echinococcus granulosus	dnaJ subfamily C 6	0.0061	0.0538	0.1726
Leishmania major	glycosyl hydrolase-like protein	0.0016	0.0022	0.0104
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0449	0.1453
Brugia malayi	Hr1 repeat family protein	0.0017	0.0029	0.0058
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0168	0.054
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0458	0.1469
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.2123	0.6863
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0341	0.3003
Brugia malayi	Animal haem peroxidase family protein	0.0081	0.0773	0.2475
Loa Loa (eye worm)	animal heme peroxidase	0.0081	0.0773	0.2501
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0348	0.1118
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0176	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1178	0.3815
Brugia malayi	mbt repeat family protein	0.0047	0.0382	0.1206
Brugia malayi	Matrixin family protein	0.0078	0.0736	0.2356
Echinococcus granulosus	jumonji domain containing protein	0.004	0.03	0.0962
Onchocerca volvulus		0.011	0.1113	0.435
Trypanosoma brucei	glucosidase, putative	0.0044	0.0341	0.3076
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0164	0.0526
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.0653	0.1991
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0017	0.0029	0.0092
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0382	0.1165
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0239	0.0729
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.1084	1
Onchocerca volvulus	Alhambra homolog	0.0029	0.0168	0.0658
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0117	0.0988
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0382	0.1165
Onchocerca volvulus	Matrilysin homolog	0.0172	0.1836	0.7172
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0341	0.1257
Brugia malayi	Matrixin family protein	0.0188	0.2017	0.6517
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0458	0.1469
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0031	0.0196	0.0634
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0016	0.0051
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0022	0.0036
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0022	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0382	0.1237
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0011	0.0011
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0341	0.1257
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.006	0.0192
Brugia malayi	Animal haem peroxidase family protein	0.0081	0.0773	0.2475
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.2123	0.2123
Schistosoma mansoni	peroxidasin	0.0081	0.0773	0.2357
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0382	0.0382
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.1084	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.006	0.3057
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.0468	0.1503
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0239	0.0729
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0341	0.3076
Echinococcus multilocularis	protein kinase c iota type	0.0029	0.0167	0.0167
Echinococcus multilocularis	conserved hypothetical protein	0.0294	0.3256	0.3256
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.006	0.0194
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0017	0.0029	0.0093
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0341	0.3003
Echinococcus granulosus	NDR protein kinase	0.0017	0.0029	0.0092
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0171	0.5
Schistosoma mansoni	lipoxygenase	0.0055	0.0468	0.1429
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0239	0.0239
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0017	0.0029	0.0093
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0341	0.1257
Brugia malayi	follicle stimulating hormone receptor	0.028	0.3089	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0382	0.0382
Brugia malayi	DnaJ domain containing protein	0.0061	0.0538	0.1713
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0082	0.0786	0.2399
Brugia malayi	hypothetical protein	0.0081	0.0773	0.2475
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1084	0.4185
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0057	0.0493	0.1505
Plasmodium vivax	SET domain protein, putative	0.003	0.0176	1
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0078	0.0736	0.0736
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0029	0.0087
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0341	0.1073
Schistosoma mansoni	hypothetical protein	0.0061	0.0538	0.1641
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0057	0.0493	0.4494
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0168	0.0545
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2229	0.7216
Brugia malayi	hypothetical protein	0.0019	0.006	0.0159
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1804	0.5504
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0022	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0874	0.2831
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0029	0.0058
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Brugia malayi	Protein kinase c protein 2	0.0092	0.0907	0.2913
Brugia malayi	PHD-finger family protein	0.0029	0.0168	0.0512
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0341	0.1257
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0176	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Onchocerca volvulus	Peroxidasin homolog	0.0081	0.0773	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Schistosoma mansoni	glucose-6-phosphatase	0.0296	0.3278	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0736	0.2383
Entamoeba histolytica	hypothetical protein	0.007	0.0653	0.5936
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.0653	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0736	0.2383
Onchocerca volvulus		0.0033	0.0212	0.0828
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.1997	0.6407
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0078	0.0736	0.2245
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.006	0.0192
Schistosoma mansoni	atypical protein kinase C	0.0029	0.0167	0.051
Loa Loa (eye worm)	animal heme peroxidase	0.0081	0.0773	0.2501
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1084	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0382	0.1226
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0017	0.0029	0.0165
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.2123	0.6812
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0017	0.0029	0.0092
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0239	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0212	0.0686
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0458	0.1453
Mycobacterium ulcerans	hydrolase	0.0094	0.0933	0.7439
Onchocerca volvulus		0.0114	0.1157	0.4522
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1084	0.351
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.0029
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Schistosoma mansoni	loxhd1	0.0019	0.006	0.0182
Schistosoma mansoni	lamin	0.0033	0.0212	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0458	0.1483
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0029	0.0087
Echinococcus multilocularis	dnaJ subfamily C 6	0.0061	0.0538	0.0538
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0016	0.0024	0.0009
Onchocerca volvulus	Peroxidase homolog	0.0081	0.0773	0.3018
Echinococcus granulosus	Protein kinase C brain isozyme	0.0109	0.1099	0.3526
Loa Loa (eye worm)	hypothetical protein	0.003	0.0176	0.0571
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0094	0.0933	0.859
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0016	0.0051
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0341	0.1094
Echinococcus multilocularis	conserved hypothetical protein	0.0294	0.3256	0.3256
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0117	0.0988
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.256	1
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1084	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0736	0.2383
Brugia malayi	Matrixin family protein	0.0078	0.0736	0.2356
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.1084	0.3479
Echinococcus granulosus	lamin dm0	0.0033	0.0212	0.068
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0458	0.1397
Brugia malayi	Hemopexin family protein	0.011	0.1113	0.3582
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0109	0.1099	0.1099
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0458	0.0458
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1084	1
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0239	0.0767
Schistosoma mansoni	hypothetical protein	0.0019	0.006	0.0182
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0348	0.0348
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0382	0.1492
Brugia malayi	Pre-SET motif family protein	0.0206	0.2229	0.7206
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0382	0.1165
Echinococcus multilocularis	lamin dm0	0.0033	0.0212	0.0212
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0176	0.0538
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0168	0.9848
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0117	0.3212
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0932	0.0932
Schistosoma mansoni	unc-13 (munc13)	0.0016	0.0022	0.0066
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0171	0.1401
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.0468	0.0468
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0168	0.0168
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.006	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0017	0.0029	0.0093
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0016	0.0022	0.0086
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.1084	0.351
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Loa Loa (eye worm)	animal heme peroxidase	0.0081	0.0773	0.2501
Schistosoma mansoni	hypothetical protein	0.0164	0.1743	0.5317
Onchocerca volvulus		0.0019	0.006	0.0234
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0341	0.1257
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0171	0.0586
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0348	0.1097
Echinococcus granulosus	peregrin	0.0029	0.0168	0.054
Schistosoma mansoni	rab6-interacting	0.0019	0.006	0.0182
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.1997	0.1997
Onchocerca volvulus		0.0033	0.0212	0.0828
Echinococcus granulosus	serine:threonine protein kinase N2	0.0017	0.0029	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0196	0.0597
Echinococcus granulosus	RNA directed DNA polymerase	0.0078	0.0736	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0019	0.006	0.0194
Brugia malayi	hypothetical protein	0.0024	0.0117	0.0345
Schistosoma mansoni	rab6-interacting	0.0019	0.006	0.0182
Onchocerca volvulus		0.0078	0.0736	0.2875
Schistosoma mansoni	lipoxygenase	0.0019	0.006	0.0182
Echinococcus multilocularis	RNA directed DNA polymerase	0.0078	0.0736	0.0736
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.0493	0.1583
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0172	0.1836	0.7172
Entamoeba histolytica	protein kinase, putative	0.0017	0.0029	0.0061
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0022	0.0104
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0933	0.302
Entamoeba histolytica	protein kinase, putative	0.0017	0.0029	0.0061
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0168	0.9515
Entamoeba histolytica	protein kinase, putative	0.0017	0.0029	0.0061
Schistosoma mansoni	serine/threonine kinase	0.0017	0.0029	0.0087
Loa Loa (eye worm)	matrixin family protein	0.0172	0.1836	0.5944
Brugia malayi	Animal haem peroxidase family protein	0.0081	0.0773	0.2475
Onchocerca volvulus		0.003	0.0176	0.0689
Loa Loa (eye worm)	animal heme peroxidase	0.0081	0.0773	0.2501
Brugia malayi	Doublecortin family protein	0.0019	0.006	0.0159
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0341	0.1257
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0017	0.0029	0.0093
Brugia malayi	hypothetical protein	0.007	0.0653	0.2085
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0205	0.0664
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1084	0.3308
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Onchocerca volvulus	Peroxidase homolog	0.0081	0.0773	0.3018
Echinococcus multilocularis	serine threonine protein kinase	0.0097	0.0961	0.0961
Toxoplasma gondii	AGC kinase	0.0017	0.0029	0.0537
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0168	0.4773
Brugia malayi	hypothetical protein	0.0019	0.006	0.0159
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1084	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1178	0.3793
Entamoeba histolytica	hypothetical protein	0.007	0.0653	0.5936
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0348	0.1063
Loa Loa (eye worm)	blistered cuticle protein 3	0.0081	0.0773	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0019	0.006	0.0194
Echinococcus multilocularis	peregrin	0.0029	0.0168	0.0168
Echinococcus granulosus	protein kinase C gamma type	0.0097	0.0961	0.3082
Brugia malayi	Matrixin family protein	0.0078	0.0736	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1084	0.4185
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0117	0.0379
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0017	0.0029	0.0092
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0171	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0168	0.0514
Brugia malayi	hypothetical protein	0.0016	0.0016	0.0017
Onchocerca volvulus	Peroxidasin homolog	0.0081	0.0773	0.3018
Entamoeba histolytica	protein kinase, putative	0.0017	0.0029	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0017	0.0029	0.0029
Onchocerca volvulus		0.0047	0.0382	0.1492
Brugia malayi	phosphofructokinase	0.0107	0.1084	0.3487
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.008	0.0769	0.249
Echinococcus multilocularis	geminin	0.0164	0.1743	0.1743
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0341	0.1257
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.0653	0.0653
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0036	0.0116
Echinococcus granulosus	protein kinase c iota type	0.0029	0.0167	0.0536
Brugia malayi	jmjC domain containing protein	0.0094	0.0932	0.2993
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0341	1
Echinococcus granulosus	peroxidasin	0.0081	0.0773	0.2479
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.03	0.03
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1084	0.351
Onchocerca volvulus		0.0081	0.0773	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0029	0.0058
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0011	0.0035
Echinococcus multilocularis	protein kinase c epsilon type	0.0031	0.0196	0.0196
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0117	0.0988
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0171	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0348	0.1118
Leishmania major	hypothetical protein, conserved	0.0024	0.0117	0.0988
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0017	0.0029	0.0029
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0171	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0168	0.0545
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0029	0.0087
Echinococcus granulosus	lamin	0.0033	0.0212	0.068
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0057	0.0493	0.4494
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0706	0.2154
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0094	0.0933	0.2995
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0171	0.4847
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.1084	1
Onchocerca volvulus		0.0234	0.256	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.0493	0.0493
Brugia malayi	p70 ribosomal S6 kinase beta	0.0017	0.0029	0.0058
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.3089	1
Entamoeba histolytica	hypothetical protein	0.007	0.0653	0.5936
Loa Loa (eye worm)	matrix metalloproteinase	0.0078	0.0736	0.2383
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0176	0.0538
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0029	0.0058
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0171	1
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0061	0.0538	0.1742
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.006	0.006
Echinococcus granulosus	intermediate filament protein	0.0033	0.0212	0.068
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0932	0.2991
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0341	0.3076
Schistosoma mansoni	hypothetical protein	0.0029	0.0168	0.0514
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1178	0.3815
Onchocerca volvulus		0.0081	0.0773	0.3018
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0526	0.1702
Brugia malayi	jmjC domain containing protein	0.0035	0.0239	0.0741
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0168	0.4773
Schistosoma mansoni	polycystin 1-related	0.0019	0.006	0.0182
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0171	0.4847
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0341	0.1104
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0171	0.9662
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501
Loa Loa (eye worm)	matrixin family protein	0.0188	0.2017	0.6529
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0061	0.0538	0.2033
Onchocerca volvulus	Matrilysin homolog	0.0078	0.0736	0.2875
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0117	0.6627
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0017	0.0029	0.0029
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0117	0.6627
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0341	0.1257
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0017	0.0029	0.0093
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0176	0.5016
Onchocerca volvulus		0.0081	0.0773	0.3018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0348	0.0348
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0382	0.1237
Brugia malayi	Blistered cuticle protein 3	0.0081	0.0773	0.2475
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0011	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0282	0.3117	0.3117
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0341	0.1257
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.006	0.0192
Brugia malayi	Peroxidasin	0.0081	0.0773	0.2475
Schistosoma mansoni	lamin	0.0033	0.0212	0.0646
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0017	0.0029	0.0029
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0348	0.1128
Brugia malayi	Animal haem peroxidase family protein	0.0081	0.0773	0.2475
Schistosoma mansoni	hypothetical protein	0.0164	0.1743	0.5317
Schistosoma mansoni	hypothetical protein	0.011	0.1113	0.3397
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0117	0.6403
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0011	0.0011
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0029	0.0087
Schistosoma mansoni	alpha glucosidase	0.0044	0.0341	0.104
Schistosoma mansoni	peroxidasin	0.0081	0.0773	0.2357
Schistosoma mansoni	hypothetical protein	0.0102	0.1025	0.3126
Echinococcus granulosus	protein kinase c epsilon type	0.0031	0.0196	0.0628
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0382	0.1226
Entamoeba histolytica	hypothetical protein	0.007	0.0653	0.5936
Loa Loa (eye worm)	MBCTL1	0.0054	0.0458	0.1483
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0057	0.0493	0.1567
Brugia malayi	Matrixin family protein	0.0078	0.0736	0.2356
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0212	0.0646
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0171	0.9662
Echinococcus multilocularis	RUN	0.0019	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0009	0.0029
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0282	0.3117	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.2123	0.6874
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0017	0.0029	0.0093
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0017	0.0029	0.0029
Brugia malayi	mbt repeat family protein	0.0047	0.0382	0.1206
Echinococcus multilocularis	musashi	0.0033	0.0212	0.0212
Schistosoma mansoni	alpha-glucosidase	0.0169	0.1804	0.5504
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0176	0.0538
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0036	0.0081
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1084	0.4185
Echinococcus multilocularis	peroxidasin	0.0081	0.0773	0.0773
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0011	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0017	0.0029	0.0026
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0212	0.0686
Brugia malayi	6-phosphofructokinase	0.0107	0.1084	0.3487
Echinococcus multilocularis	lamin	0.0033	0.0212	0.0212
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.006	0.006
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0017	0.0029	0.0093
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1084	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0022	0.0072
Schistosoma mansoni	hypothetical protein	0.0287	0.3171	0.9675
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.2123	0.2123
Brugia malayi	6-phosphofructokinase	0.0107	0.1084	0.3487
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0212	0.0653
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.1084	1
Trypanosoma brucei	RNA helicase, putative	0.0102	0.1025	0.9444
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0212	0.0686
Brugia malayi	protein kinase C II.	0.0031	0.0196	0.0601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0348	0.1063
Schistosoma mansoni	hypothetical protein	0.007	0.0653	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0029	0.0093
Onchocerca volvulus		0.0019	0.006	0.0234
Brugia malayi	intermediate filament protein	0.0033	0.0212	0.0653
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.1084	1
Brugia malayi	Bromodomain containing protein	0.0029	0.0168	0.0512
Echinococcus granulosus	RUN	0.0019	0.006	0.0192
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0171	0.4847
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0176	0.0566
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0171	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0736	0.2383
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0341	0.3076
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1084	0.4185
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0016	0.0016
Echinococcus granulosus	geminin	0.0164	0.1743	0.5592
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0773	0.2501

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.1345 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 29.9068 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1528790

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1393950