Detailed information for compound 1399765

Basic information

Technical information
  • TDR Targets ID: 1399765
  • Name: (2-tert-butyl-5-methyl-4-phenylsulfanylpyrazo l-3-yl) 3-fluorobenzoate
  • MW: 384.467 | Formula: C21H21FN2O2S
  • H donors: 0 H acceptors: 2 LogP: 5.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)C(=O)Oc1c(Sc2ccccc2)c(nn1C(C)(C)C)C
  • InChi: 1S/C21H21FN2O2S/c1-14-18(27-17-11-6-5-7-12-17)19(24(23-14)21(2,3)4)26-20(25)15-9-8-10-16(22)13-15/h5-13H,1-4H3
  • InChiKey: RNJKCERVBHRMJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-tert-butyl-5-methyl-4-phenylsulfanyl-pyrazol-3-yl) 3-fluorobenzoate
  • 3-fluorobenzoic acid [2-tert-butyl-5-methyl-4-(phenylthio)-3-pyrazolyl] ester
  • 3-fluorobenzoic acid [2-tert-butyl-5-methyl-4-(phenylthio)pyrazol-3-yl] ester
  • C100-0505
  • NCGC00104333-01
  • Oprea1_835585
  • ZINC01447496

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0027 0.008 0.0101
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0628 0.6341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0523 0.1065
Loa Loa (eye worm) glutamate receptor 0.0162 0.1564 0.3183
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0317 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0357
Brugia malayi hypothetical protein 0.0124 0.1143 0.1443
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0533 0.5379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0144 0.0181
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.0323 0.0279
Echinococcus granulosus metabotropic glutamate receptor 2 0.0136 0.1275 0.161
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.099 0.3275
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0125 0.0157
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Brugia malayi Latrophilin receptor protein 2 0.0035 0.017 0.0214
Schistosoma mansoni adenoreceptor 0.0048 0.0317 0.0427
Onchocerca volvulus 0.0031 0.0125 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0125 0.0911
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Mycobacterium ulcerans hypothetical protein 0.0024 0.0049 0.0357
Schistosoma mansoni hypothetical protein 0.0048 0.0317 0.0427
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0707 0.0893
Echinococcus granulosus neuropeptide receptor 0.0048 0.0317 0.0401
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0317 0.0401
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.0412
Schistosoma mansoni metabotropic glutamate receptor 0.0136 0.1275 0.1717
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.099 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.099 1
Leishmania major glucose transporter, lmgt1 0.0068 0.0533 0.5379
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Brugia malayi GnHR receptor homolog 0.0048 0.0317 0.0401
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0317 0.0401
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0317 0.0401
Plasmodium vivax sugar transporter, putative 0.0031 0.0125 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0227 0.227 0.3055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0049 0.0357
Echinococcus granulosus solute carrier family 22 0.0031 0.0125 0.0157
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.0323 0.3266
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0035 0.017 0.0345
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0317 0.0401
Entamoeba histolytica phosphofructokinase, putative 0.011 0.099 0.3275
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0075 0.0056
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0083 0.0168
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0448 0.4692 0.9548
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.0412
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0125 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.0412
Trypanosoma brucei glucose transporter 1E 0.0068 0.0533 0.5379
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0466 0.0588
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Toxoplasma gondii PHD-finger domain-containing protein 0.0227 0.227 0.3401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Schistosoma mansoni neuropeptide receptor 0.0048 0.0317 0.0427
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.3023 1
Trypanosoma brucei glucose transporter 2A 0.0068 0.0533 0.5379
Schistosoma mansoni protein kinase 0.0067 0.0523 0.0704
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Onchocerca volvulus 0.0048 0.0317 0.0578
Brugia malayi G-protein coupled receptor 0.0048 0.0317 0.0401
Onchocerca volvulus 0.0048 0.0317 0.0578
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0317 0.0578
Echinococcus granulosus JmjC domain containing protein 4 0.0073 0.0588 0.0742
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0493
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Plasmodium falciparum hexose transporter 0.022 0.2193 0.2157
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus GPCR family 2 0.0035 0.017 0.0214
Loa Loa (eye worm) hypothetical protein 0.0124 0.1143 0.2326
Schistosoma mansoni zinc finger protein 0.0021 0.0021 0.0029
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0185 0.1808 0.2433
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0125 0.0157
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0049 0.0357
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0317 0.0401
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0125 0.0254
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.7429 0.938
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0317 0.0401
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0075 0.0094
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0317 0.0401
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0533 0.5379
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0125 1
Plasmodium vivax JmjC domain containing protein 0.0073 0.0588 0.0545
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Schistosoma mansoni neuropeptide receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Brugia malayi hypothetical protein 0.0031 0.0125 0.0157
Onchocerca volvulus 0.0031 0.0125 0.0163
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0523 0.1065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0614 0.0776
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.0323 0.107
Loa Loa (eye worm) hypothetical protein 0.0389 0.4044 0.8229
Schistosoma mansoni jumonji/arid domain-containing protein 0.0278 0.2832 0.3811
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1368 1
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0317 0.0401
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0228
Onchocerca volvulus 0.0031 0.0125 0.0163
Entamoeba histolytica hypothetical protein 0.0049 0.0323 0.107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0049 0.0027
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0104 0.0212
Onchocerca volvulus 0.0031 0.0125 0.0163
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0124 0.1143 0.2326
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0062
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0317 0.0401
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0015 0.003
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0653 0.0879
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0112 0.0369
Schistosoma mansoni histamine h1 receptor 0.0048 0.0317 0.0427
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0323 0.2365
Echinococcus granulosus lysine specific demethylase 5A 0.0278 0.2832 0.3575
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0707 0.0893
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0317 0.0401
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0045 0.0331
Brugia malayi sulfakinin receptor protein 0.0048 0.0317 0.0401
Leishmania major hypothetical protein, conserved 0.0073 0.0588 0.5937
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Brugia malayi Serotonin receptor 0.0048 0.0317 0.0401
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0074 0.0598 0.0845
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis Protein lozenge 0.0056 0.0402 0.0507
Trypanosoma brucei sugar transporter, putative 0.0031 0.0125 0.1259
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0049 0.0357
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0045 0.0141
Schistosoma mansoni glucose transport protein 0.022 0.2193 0.2951
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.3023 1
Echinococcus granulosus zinc finger protein 0.0021 0.0021 0.0027
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0524 0.048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0355 0.3675 0.555
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0077 0.0628 0.0891
Brugia malayi F/Y-rich N-terminus family protein 0.0085 0.0716 0.0904
Brugia malayi AKH receptor 0.0048 0.0317 0.0401
Onchocerca volvulus 0.0031 0.0125 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.017 0.0345
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0125 0.0157
Schistosoma mansoni hypothetical protein 0.0074 0.0598 0.0805
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0317 0.0401
Schistosoma mansoni hypothetical protein 0.0048 0.0317 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Brugia malayi hypothetical protein 0.0031 0.0125 0.0157
Brugia malayi neuropeptide F receptor 0.0048 0.0317 0.0401
Schistosoma mansoni lozenge 0.0056 0.0402 0.0541
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0588 0.1196
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.0412
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0054 0.0068
Schistosoma mansoni sugar transporter 0.0031 0.0125 0.0168
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0317 0.0427
Onchocerca volvulus 0.0031 0.0125 0.0163
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0125 0.0157
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0112 0.0067
Onchocerca volvulus 0.0048 0.0317 0.0578
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Giardia lamblia Sugar-proton symporter 0.0031 0.0125 0.0412
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0743 0.792 1
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0533 0.1762
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0317 0.0427
Schistosoma mansoni protein kinase 0.0067 0.0523 0.0704
Brugia malayi Dopamine receptor protein 2 0.0048 0.0317 0.0401
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0242 0.0492
Brugia malayi jmjC domain containing protein 0.0278 0.2832 0.3575
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0125 0.0168
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0317 0.0401
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0125 0.0911
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0317 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0125 0.0412
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0054 0.0068
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0112 0.0101
Loa Loa (eye worm) hypothetical protein 0.0066 0.0508 0.1034
Brugia malayi Dopamine receptor protein 1 0.0048 0.0317 0.0401
Toxoplasma gondii sugar transporter ST3 0.0031 0.0125 0.0121
Onchocerca volvulus 0.0048 0.0317 0.0578
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0317 0.0645
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0125 0.1259
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0317 0.0645
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0317 0.0427
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0125 0.0157
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.0323 0.3266
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0099
Echinococcus granulosus orexin receptor type 2 0.0048 0.0317 0.0401
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.099 0.724
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0493
Brugia malayi jmjC domain containing protein 0.0073 0.0588 0.0742
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0317 0.0427
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0533 0.5379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0049 0.0493
Echinococcus multilocularis serotonin receptor 0.0048 0.0317 0.0401
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni hypothetical protein 0.0048 0.0317 0.0427
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4317 0.545
Echinococcus granulosus General substrate transporter 0.0189 0.1854 0.2341
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.017 0.0214
Giardia lamblia Hexose transporter 0.0031 0.0125 0.0412
Plasmodium falciparum JmjC domain-containing protein, putative 0.0073 0.0588 0.0545
Schistosoma mansoni phd/f-box containing protein 0.0073 0.0588 0.0791
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.0508 0.0642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Toxoplasma gondii PHD-finger domain-containing protein 0.0074 0.0598 0.0845
Loa Loa (eye worm) hypothetical protein 0.0066 0.0508 0.1034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Echinococcus granulosus calcium dependent protein kinase 0.0063 0.0478 0.0603
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.099 0.724
Leishmania major glucose transporter, lmgt2 0.0068 0.0533 0.5379
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0317 0.0427
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0125 0.0911
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0317 0.0401
Entamoeba histolytica protein kinase, putative 0.0067 0.0523 0.173
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0045 0.0457
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0707 0.0952
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0707 0.0893
Brugia malayi G-protein coupled receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus fmrfamide receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Onchocerca volvulus 0.0031 0.0125 0.0163
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0524 0.048
Echinococcus granulosus peregrin 0.0229 0.2296 0.2899
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0533 0.1762
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0317 0.0578
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0524 0.048
Schistosoma mansoni glucose transport protein 0.022 0.2193 0.2951
Brugia malayi phosphofructokinase 0.011 0.099 0.125
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0054 0.0073
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.1564 0.1975
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0524 0.048
Schistosoma mansoni protein phosphatase 2C 0.0073 0.0588 0.0791
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0317 0.0645
Echinococcus multilocularis JmjC domain containing protein 4 0.0073 0.0588 0.0742
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.0508 0.1681
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0317 0.0401
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0049 0.0357
Brugia malayi PHD-finger family protein 0.0227 0.227 0.2866
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0049 0.0162
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.0323 0.2103
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Giardia lamblia PHD finger protein 15 0.0227 0.227 0.7508
Brugia malayi jmjC domain containing protein 0.0073 0.0588 0.0742
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0067 0.0523 0.1065
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0049 0.0162
Onchocerca volvulus Alhambra homolog 0.0227 0.227 0.4783
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.0508 0.3501
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0317 0.0427
Echinococcus multilocularis phd:f box containing protein 0.0073 0.0588 0.0742
Loa Loa (eye worm) hypothetical protein 0.0054 0.0373 0.0759
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0257 0.0851
Echinococcus granulosus g protein coupled receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0062
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0523 0.5283
Echinococcus multilocularis solute carrier family 22 0.0031 0.0125 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus granulosus solute carrier family 22 0.0031 0.0125 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0317 0.0427
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis somatostatin receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Plasmodium falciparum protein kinase 7 0.0621 0.6585 0.657
Loa Loa (eye worm) hypothetical protein 0.0227 0.227 0.4619
Echinococcus granulosus PHD finger protein rhinoceros 0.0227 0.227 0.2866
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0073 0.0588 0.083
Entamoeba histolytica phosphofructokinase, putative 0.011 0.099 0.3275
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Onchocerca volvulus 0.0048 0.0317 0.0578
Echinococcus multilocularis solute carrier family 22 0.0031 0.0125 0.0157
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0228
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0523 0.0704
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0317 0.0401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0415 0.0566
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Brugia malayi jmjC domain containing protein 0.0073 0.0588 0.0742
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0045 0.0013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0523 0.066
Echinococcus multilocularis serotonin receptor 0.0048 0.0317 0.0401
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0628 0.6341
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0317 0.0401
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0317 0.0401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.017 0.0214
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1368 1
Onchocerca volvulus 0.0048 0.0317 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.022 0.2193 0.7253
Echinococcus granulosus jumonji domain containing protein 0.0316 0.3243 0.4094
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.099 0.7146
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0228
Echinococcus multilocularis zinc finger protein 0.0021 0.0021 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0317 0.0401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0998 0.126
Toxoplasma gondii sugar transporter ST2 0.0031 0.0125 0.0121
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0317 0.0401
Onchocerca volvulus 0.0048 0.0317 0.0578
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.099 0.3275
Echinococcus granulosus serotonin receptor 0.0048 0.0317 0.0401
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0125 0.0911
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0508 0.0684
Loa Loa (eye worm) jmjC domain-containing protein 0.0278 0.2832 0.5762
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0152
Leishmania major glucose transporter, lmgt3 0.0068 0.0533 0.5379
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.0508 0.0642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Plasmodium vivax hypothetical protein, conserved 0.0227 0.227 0.2235
Echinococcus multilocularis PHD finger protein rhinoceros 0.0227 0.227 0.2866
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0317 0.0401
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0112 0.0101
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0743 0.792 1
Toxoplasma gondii protein kinase, putative 0.0621 0.6585 1
Plasmodium falciparum phd finger protein, putative 0.0227 0.227 0.2235
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0045 0.0457
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0112 0.2489
Echinococcus granulosus 6 phosphofructokinase 0.011 0.099 0.125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0317 0.0427
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Onchocerca volvulus 0.0031 0.0125 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Plasmodium vivax proline--tRNA ligase, putative 0.0077 0.0628 0.0585
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni amine GPCR 0.0048 0.0317 0.0427
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0317 0.0401
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0317 0.0427
Brugia malayi metabotropic glutamate receptor type 2 0.0079 0.0653 0.0824
Schistosoma mansoni protein kinase 0.0067 0.0523 0.0704
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.022 0.2193 0.2768
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0533 0.5379
Brugia malayi G protein-coupled receptor 0.0048 0.0317 0.0401
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Loa Loa (eye worm) hypothetical protein 0.0045 0.0277 0.0563
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0074 0.0598 0.6039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0099
Schistosoma mansoni amine GPCR 0.0048 0.0317 0.0427
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0242 0.0305
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Toxoplasma gondii facilitative glucose transporter GT1 0.022 0.2193 0.3284
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Brugia malayi AF-10 protein 0.0074 0.0598 0.0755
Entamoeba histolytica protein kinase, putative 0.0067 0.0523 0.173
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Brugia malayi putative neuropeptide receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.02 0.1975 0.4018
Schistosoma mansoni amine GPCR 0.0048 0.0317 0.0427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0317 0.0427
Schistosoma mansoni sugar transporter 0.0031 0.0125 0.0168
Brugia malayi Melatonin receptor type 1A 0.0048 0.0317 0.0401
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0317 0.0401
Schistosoma mansoni sugar transporter 0.0031 0.0125 0.0168
Loa Loa (eye worm) runx1 0.0056 0.0402 0.0817
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0588 0.5937
Echinococcus granulosus lysine specific demethylase 6a 0.0073 0.0588 0.0742
Brugia malayi major facilitator superfamily protein 0.0031 0.0125 0.0157
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0317 0.0401
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0524 0.048
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0136 0.1275 0.161
Echinococcus granulosus cpg binding protein 0.0033 0.0144 0.0181
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0049 0.0062
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.0242 0.1773
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0073 0.0588 0.5937
Onchocerca volvulus 0.0048 0.0317 0.0578
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0075 0.0094
Onchocerca volvulus Huntingtin homolog 0.0124 0.1143 0.2357
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0041 0.0302
Trypanosoma cruzi hexose transporter 0.0068 0.0533 0.5379
Schistosoma mansoni sugar transporter 0.0031 0.0125 0.0168
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0125 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0588 0.1196
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0524 0.048
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0075 0.0056
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0317 0.0401
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0077 0.0627 0.0792
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Toxoplasma gondii PHD-finger domain-containing protein 0.0227 0.227 0.3401
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0125 0.1259
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0073 0.0588 0.0791
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0533 0.1762
Onchocerca volvulus 0.0031 0.0125 0.0163
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0533 0.1762
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0617 0.0575
Leishmania major hypothetical protein, conserved 0.0031 0.0125 0.1259
Loa Loa (eye worm) hypothetical protein 0.0084 0.0707 0.1439
Echinococcus granulosus g protein coupled receptor 0.0048 0.0317 0.0401
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.002
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0317 0.0645
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0524 0.048
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0317 0.0401
Brugia malayi Sugar transporter family protein 0.0031 0.0125 0.0157
Brugia malayi Cam kinase protein 1 0.0067 0.0523 0.066
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.0508 0.1681
Brugia malayi Dopamine receptor 0.0048 0.0317 0.0401
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0533 0.5379
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.3023 1
Schistosoma mansoni cpg binding protein 0.0033 0.0144 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0523 0.066
Onchocerca volvulus 0.0448 0.4692 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0323 0.0658
Schistosoma mansoni phosphatidylserine receptor 0.0073 0.0588 0.0791
Entamoeba histolytica hypothetical protein 0.0024 0.0045 0.015
Brugia malayi jmjC domain containing protein 0.0743 0.792 1
Schistosoma mansoni biogenic amine receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Onchocerca volvulus 0.0031 0.0125 0.0163
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4317 0.545
Onchocerca volvulus 0.0048 0.0317 0.0578
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0073 0.0588 0.5937
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0075 0.0094
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0317 0.0427
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0523 0.173
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0112 0.0067
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0049 0.0162
Echinococcus multilocularis metabotropic glutamate receptor 5 0.02 0.1975 0.2493
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0125 0.0911
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0125 0.0254
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0323 0.2365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0112 0.0369
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0125 0.0412
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0077 0.0627 0.0792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0524 0.0731
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0317 0.0401
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0524 0.0731
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus phd:f box containing protein 0.0073 0.0588 0.0742
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0049 0.0357
Echinococcus granulosus metabotropic glutamate receptor 5 0.02 0.1975 0.2493
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.0323 0.0408
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0317 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.0323 0.0425
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0125 0.008
Onchocerca volvulus Putative transporter 0.0031 0.0125 0.0163
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0317 0.0401
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0317 0.0401
Schistosoma mansoni glucose transporter 0.0031 0.0125 0.0168
Loa Loa (eye worm) PHD-finger family protein 0.0227 0.227 0.4619
Echinococcus granulosus allatostatin A receptor 0.0048 0.0317 0.0401
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.7429 1
Schistosoma mansoni neuropeptide receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0588 0.1196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0049 0.0357
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Echinococcus multilocularis sex peptide receptor 0.0048 0.0317 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.0508 0.0642
Mycobacterium ulcerans sugar transporter 0.0031 0.0125 0.0911
Plasmodium falciparum proline--tRNA ligase 0.0077 0.0628 0.0585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.3023 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0466 0.0588
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0184 0.0233
Toxoplasma gondii sugar transporter ST1 0.0031 0.0125 0.0121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0073 0.0588 0.1196
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0112 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0588 0.1196
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0317 0.0401
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0317 0.0401
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.017 0.0214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0278 0.2832 0.3811
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Loa Loa (eye worm) sugar transporter 0.022 0.2193 0.4462
Schistosoma mansoni neuropeptide receptor 0.0048 0.0317 0.0427
Entamoeba histolytica phosphofructokinase, putative 0.011 0.099 0.3275
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Loa Loa (eye worm) jmjC domain-containing protein 0.0468 0.4914 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0125 0.1259
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0112 0.2489
Echinococcus granulosus jumonji domain containing 1A 0.0073 0.0588 0.0742
Echinococcus multilocularis lysine specific demethylase 6a 0.0073 0.0588 0.0742
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0112 0.0369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0998 0.126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus microtubule associated protein 2 0.0698 0.7429 0.938
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0317 0.0401
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.017 0.0214
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0317 0.0401
Leishmania major glucose transporter/membrane transporter D2, putative 0.0068 0.0533 0.5379
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0317 0.0401
Brugia malayi RE15519p 0.0048 0.0317 0.0401
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0317 0.0401
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Onchocerca volvulus 0.0084 0.0707 0.1418
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Plasmodium vivax hexose transporter 0.022 0.2193 0.2157
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Onchocerca volvulus 0.0031 0.0125 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) sugar transporter 0.0031 0.0125 0.0254
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0317 0.0401
Schistosoma mansoni cpg binding protein 0.0033 0.0144 0.0193
Brugia malayi hypothetical protein 0.0031 0.0125 0.0157
Schistosoma mansoni biogenic amine receptor 0.0048 0.0317 0.0427
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0049 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0147 0.1397 0.1764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0042 0.0242 0.0492
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Brugia malayi Bromodomain containing protein 0.0077 0.0635 0.0802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0317 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0317 0.0401
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.099 0.3275
Brugia malayi PHD-finger family protein 0.0078 0.0637 0.0805
Echinococcus granulosus sex peptide receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0184 0.0233
Schistosoma mansoni opsin-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Brugia malayi CXXC zinc finger family protein 0.0029 0.0104 0.0132
Brugia malayi 6-phosphofructokinase 0.011 0.099 0.125
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0628 0.6341
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0317 0.0427
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.099 0.3182
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0628 0.6341
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.017 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0998 0.203
Onchocerca volvulus 0.0031 0.0125 0.0163
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0076 0.0617 0.0575
Schistosoma mansoni hypothetical protein 0.0076 0.0614 0.0827
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Loa Loa (eye worm) hypothetical protein 0.0072 0.057 0.1159
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Echinococcus granulosus g protein coupled receptor 0.0048 0.0317 0.0401
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0112 0.0236
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0317 0.0645
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.099 0.125
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0099
Onchocerca volvulus 0.0029 0.0104 0.012
Echinococcus granulosus neuropeptide receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0242 0.0492
Brugia malayi Bromodomain containing protein 0.0039 0.021 0.0266
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0112 0.0369
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1368 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0523 0.066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0254
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0317 0.0401
Brugia malayi Bromodomain containing protein 0.0229 0.2296 0.2899
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0317 0.0401
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0317 0.0645
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Brugia malayi ORL1-like opioid receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Schistosoma mansoni amine GPCR 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Onchocerca volvulus 0.0031 0.0125 0.0163
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0317 0.0401
Schistosoma mansoni biogenic amine receptor 0.0048 0.0317 0.0427
Brugia malayi Sugar transporter family protein 0.0031 0.0125 0.0157
Onchocerca volvulus 0.0031 0.0125 0.0163
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.0323 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0461 0.062
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0317 0.0401
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0524 0.0731
Echinococcus multilocularis calcium dependent protein kinase 0.0063 0.0478 0.0603
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0194 0.1961
Brugia malayi Serotonin receptor 0.0048 0.0317 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Echinococcus multilocularis GPCR, family 2 0.0035 0.017 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Schistosoma mansoni amine GPCR 0.0048 0.0317 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0323 0.0435
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.099 0.2015
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0533 0.1762
Brugia malayi larval opioid receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0533 0.1762
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.022 0.2193 0.2768
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0045 0.0331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0637 0.1297
Loa Loa (eye worm) hypothetical protein 0.0076 0.0614 0.125
Schistosoma mansoni myosin xvIII 0.0048 0.0317 0.0427
Schistosoma mansoni cpg binding protein 0.0029 0.0104 0.014
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Onchocerca volvulus 0.0048 0.0317 0.0578
Leishmania major ATP-dependent phosphofructokinase 0.011 0.099 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0112 0.0067
Schistosoma mansoni hypothetical protein 0.0227 0.227 0.3055
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0073 0.0588 0.083
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0242 0.1491
Echinococcus multilocularis peregrin 0.0229 0.2296 0.2899
Trypanosoma brucei glucose transporter, putative 0.0068 0.0533 0.5379
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.0323 0.107
Schistosoma mansoni opsin-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0125 0.0157
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0125 0.0412
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0357
Brugia malayi neuropeptide F receptor 0.0048 0.0317 0.0401
Onchocerca volvulus 0.0031 0.0125 0.0163
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.0508 0.1681
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0317 0.0427
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0508 0.0684
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0081 0.0677 0.0911
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.0323 0.0408
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0125 0.1259
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0588 0.0791
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0317 0.0401
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.0508 0.0642
Brugia malayi hypothetical protein 0.0048 0.0317 0.0401
Loa Loa (eye worm) phosphofructokinase 0.011 0.099 0.2015
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.0323 0.3266
Echinococcus multilocularis jumonji domain containing protein 0.0316 0.3243 0.4094
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0355 0.3675 0.3646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0125 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0317 0.0401
Schistosoma mansoni 6-phosphofructokinase 0.011 0.099 0.1333
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0112 0.0067
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0317 0.0401
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.099 0.2015
Echinococcus multilocularis jumonji domain containing 1A 0.0073 0.0588 0.0742
Schistosoma mansoni hypothetical protein 0.0048 0.0317 0.0427
Brugia malayi lysyl-tRNA synthetase 0.0049 0.0323 0.0408
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0533 0.5379
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0317 0.0401
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0045 0.0331
Onchocerca volvulus Huntingtin homolog 0.0124 0.1143 0.2357
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0317 0.0401
Echinococcus multilocularis solute carrier family 22 0.0031 0.0125 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0317 0.0645
Brugia malayi major facilitator superfamily protein 0.0031 0.0125 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.099 0.3275
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0317 0.0401
Echinococcus multilocularis General substrate transporter 0.0189 0.1854 0.2341
Schistosoma mansoni 6-phosphofructokinase 0.011 0.099 0.1333
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0317 0.0427
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni glucose transport protein 0.022 0.2193 0.2951
Echinococcus multilocularis lysine specific demethylase 5A 0.0274 0.2792 0.3526
Onchocerca volvulus 0.0048 0.0317 0.0578
Schistosoma mansoni jumonji domain containing protein 0.059 0.6249 0.8411
Plasmodium falciparum mitogen-activated protein kinase 2 0.0355 0.3675 0.3646
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0317 0.0401
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0317 0.0645
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0317 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0533 0.1762
Loa Loa (eye worm) hypothetical protein 0.0448 0.4692 0.9548
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0242 0.1773
Schistosoma mansoni hypothetical protein 0.0026 0.0075 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0357
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0317 0.0645
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0524 0.048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0317 0.0401
Echinococcus granulosus solute carrier family 22 0.0031 0.0125 0.0157
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0524 0.048
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.0323 0.0279
Loa Loa (eye worm) hypothetical protein 0.0039 0.0211 0.043
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0317 0.0401
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0317 0.0401
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.3023 1
Loa Loa (eye worm) glutamate receptor 0.0064 0.0486 0.0988
Echinococcus multilocularis solute carrier family 22 0.0031 0.0125 0.0157
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0317 0.0401
Brugia malayi jmjC domain containing protein 0.0073 0.0588 0.0742
Schistosoma mansoni opsin-like receptor 0.0048 0.0317 0.0427
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0628 0.6341
Schistosoma mansoni hypothetical protein 0.0414 0.4317 0.581
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0317 0.0401
Schistosoma mansoni bromodomain containing protein 0.0066 0.0505 0.068
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Loa Loa (eye worm) hypothetical protein 0.0111 0.0998 0.203
Echinococcus granulosus hypothetical protein 0.0048 0.0317 0.0401
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0317 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0645
Schistosoma mansoni hypothetical protein 0.022 0.2193 0.2951
Onchocerca volvulus 0.0048 0.0317 0.0578
Echinococcus granulosus solute carrier family 22 0.0031 0.0125 0.0157
Echinococcus granulosus somatostatin receptor 0.0048 0.0317 0.0401
Brugia malayi hypothetical protein 0.0448 0.4692 0.5924
Brugia malayi Sugar transporter family protein 0.022 0.2193 0.2768
Brugia malayi 6-phosphofructokinase 0.011 0.099 0.125
Onchocerca volvulus 0.0031 0.0125 0.0163
Leishmania major protein kinase, putative 0.0067 0.0523 0.5283
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0074 0.0598 0.6039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0237 0.0483
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0317 0.0401
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0323 0.0435
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0125 0.0412

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 354.8134 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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