Detailed information for compound 1407971

Basic information

Technical information
  • TDR Targets ID: 1407971
  • Name: 3-(3-nitrophenyl)-5-(phenylmethyl)-N-(2-thiop hen-2-ylethyl)-4,6-dihydro-3aH-pyrrolo[4,3-d] [1,2]oxazole-6a-carboxamide
  • MW: 476.547 | Formula: C25H24N4O4S
  • H donors: 1 H acceptors: 3 LogP: 3.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C12ON=C(C2CN(C1)Cc1ccccc1)c1cccc(c1)[N+](=O)[O-])NCCc1cccs1
  • InChi: 1S/C25H24N4O4S/c30-24(26-12-11-21-10-5-13-34-21)25-17-28(15-18-6-2-1-3-7-18)16-22(25)23(27-33-25)19-8-4-9-20(14-19)29(31)32/h1-10,13-14,22H,11-12,15-17H2,(H,26,30)
  • InChiKey: KMSALHUCZNBRKQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(3-nitrophenyl)-5-(phenylmethyl)-N-[2-(2-thienyl)ethyl]-4,6-dihydro-3aH-pyrrolo[4,3-d]isoxazole-6a-carboxamide
  • 5-(benzyl)-3-(3-nitrophenyl)-N-[2-(2-thienyl)ethyl]-4,6-dihydro-3aH-pyrrolo[4,3-d]isoxazole-6a-carboxamide
  • MLS000561435
  • SMR000156020

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0021 0.0017 0.003
Leishmania major cathepsin L-like protease 0.002 0.0012 0.0114
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0028 0.0096 0.1439
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0042 0.0042
Brugia malayi PHD-finger family protein 0.0035 0.0168 0.0611
Onchocerca volvulus 0.0021 0.0017 0.0309
Leishmania major cathepsin L-like protease 0.0077 0.0604 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0005 0.0017
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0168 0.0298
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0565 0.1002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0739
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0021 0.0017 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0168 0.2822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0021 0.0017 0.0017
Onchocerca volvulus Fxna peptidase homolog 0.0021 0.0017 0.0309
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0565 0.2052
Loa Loa (eye worm) hypothetical protein 0.029 0.2819 0.9055
Echinococcus multilocularis transfer RNA-Gly 0.0023 0.0042 0.0042
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0042 0.0042
Echinococcus multilocularis geminin 0.0205 0.1933 0.1933
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0604 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0005 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Loa Loa (eye worm) CYP4Cod1 0.002 0.0005 0.0017
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0021 0.0017 0.0062
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0271 0.2626 0.2626
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0042 0.0074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0565 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.023 0.0836
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0012 0.0044
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0534 0.8837
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0021 0.0017 0.003
Leishmania major cathepsin L-like protease 0.002 0.0012 0.0114
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Onchocerca volvulus Glutaminyl cyclase homolog 0.0021 0.0017 0.0309
Echinococcus multilocularis peregrin 0.0035 0.0168 0.0168
Brugia malayi FXNA 0.0021 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni hypothetical protein 0.0041 0.023 0.0836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0012 0.5
Echinococcus multilocularis cysteine protease 0.002 0.0012 0.0012
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0028 0.0096 0.1617
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0432 0.7131
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0012 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0035 0.0168 0.0611
Brugia malayi Cytochrome P450 family protein 0.002 0.0005 0.002
Loa Loa (eye worm) ctsf protein 0.002 0.0012 0.0039
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0021 0.0017 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0429 0.1377
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0042 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0284 0.2755 1
Echinococcus granulosus peregrin 0.0035 0.0168 0.0298
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0168 0.0611
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0012 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0042 0.0042
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0021 0.0017 0.0017
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0604 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0284 0.2755 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0023 0.0042 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Leishmania major cathepsin L-like protease 0.0077 0.0604 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0023 0.0042 0.0074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0012 0.0039
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0012 0.0022
Echinococcus multilocularis potassium voltage gated channel protein 0.0284 0.2755 0.2755
Brugia malayi Peptidase family M28 containing protein 0.0021 0.0017 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0012 0.0044
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0168 0.2822
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0042 0.0152
Plasmodium falciparum phd finger protein, putative 0.0035 0.0168 1
Trypanosoma brucei glutaminyl cyclase, putative 0.0021 0.0017 0.0195
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0604 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0168 0.054
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0565 0.0565
Schistosoma mansoni nicalin (M28 family) 0.0021 0.0017 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0023 0.0042 0.0152
Toxoplasma gondii hypothetical protein 0.0021 0.0017 0.0087
Leishmania major hypothetical protein, conserved 0.0021 0.0017 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 1
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0021 0.0017 0.0017
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0042 0.0042
Trypanosoma cruzi glutaminyl cyclase, putative 0.0021 0.0017 0.0195
Echinococcus granulosus potassium voltage gated channel protein 0.0284 0.2755 0.4883
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Echinococcus granulosus shaker cognate 0.0023 0.0042 0.0074
Schistosoma mansoni hypothetical protein 0.0205 0.1933 0.7015
Echinococcus multilocularis cysteine protease 0.002 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0604 1
Schistosoma mansoni voltage-gated potassium channel 0.0284 0.2755 1
Schistosoma mansoni Fxna peptidase (M28 family) 0.0021 0.0017 0.0062
Trypanosoma cruzi glutaminyl cyclase, putative 0.0021 0.0017 0.0195
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0565 1
Schistosoma mansoni hypothetical protein 0.0035 0.0168 0.0611
Schistosoma mansoni hypothetical protein 0.0205 0.1933 0.7015
Brugia malayi Cytochrome P450 family protein 0.003 0.0114 0.0413
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Loa Loa (eye worm) leucyl aminopeptidase 0.0021 0.0017 0.0055
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0012 0.0044
Schistosoma mansoni vesicular amine transporter 0.0023 0.0042 0.0152
Echinococcus granulosus cathepsin l1 0.002 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0135
Loa Loa (eye worm) fibroinase 0.002 0.0012 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0756 0.2743
Leishmania major cathepsin L-like protease 0.002 0.0012 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0012 0.0114
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0565 0.2052
Leishmania major cysteine peptidase A (CPA) 0.002 0.0012 0.0114
Loa Loa (eye worm) hypothetical protein 0.0211 0.1999 0.6421
Echinococcus multilocularis shaker cognate 0.0023 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0284 0.2755 0.8848
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0023 0.0042 0.0074
Mycobacterium ulcerans hypothetical protein 0.0021 0.0017 0.0208
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0042 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 1
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0312 0.0312
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0012 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0561 0.5642 1
Echinococcus multilocularis neuropeptide receptor A26 0.0561 0.5642 0.5642
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0284 0.2755 0.4883
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0565 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1003 0.1777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0114 0.0366
Echinococcus granulosus neuropeptide receptor A26 0.0561 0.5642 1
Onchocerca volvulus Alhambra homolog 0.0035 0.0168 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0012 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0429 0.1556
Leishmania major cathepsin L-like protease 0.002 0.0012 0.0114
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0312 0.0553
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0023 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0168 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.3114 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0005 0.002
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0168 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0042 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Giardia lamblia PHD finger protein 15 0.0035 0.0168 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0042 0.0074
Entamoeba histolytica cysteine protease, putative 0.002 0.0012 0.5
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0023 0.0042 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0042 0.0074
Brugia malayi leucyl aminopeptidase 0.0021 0.0017 0.0062
Leishmania major cathepsin L-like protease 0.002 0.0012 0.0114
Toxoplasma gondii peptidase, M28 family protein 0.0021 0.0017 0.0087
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0168 0.0168
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.006 0.043 0.1382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0429 0.1556
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0245 0.0788
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0245 0.0891
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0039
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0021 0.0017 0.0062
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0012 0.0012
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.031 0.3035 0.3035
Brugia malayi nicalin 0.0021 0.0017 0.0062
Onchocerca volvulus Fxna peptidase homolog 0.0021 0.0017 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0604 1
Onchocerca volvulus Fxna peptidase homolog 0.0021 0.0017 0.0309
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0203 0.192 0.697
Brugia malayi jmjC domain containing protein 0.0115 0.1003 0.3639
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0245 0.0891
Leishmania major cathepsin L-like protease 0.0077 0.0604 1
Echinococcus multilocularis neuropeptide s receptor 0.0561 0.5642 0.5642
Brugia malayi Cathepsin L-like precursor 0.002 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.006 0.0429 0.1377
Echinococcus granulosus geminin 0.0205 0.1933 0.3426
Leishmania major glutaminyl cyclase, putative 0.0021 0.0017 0.0195
Loa Loa (eye worm) cysteine protease 0.002 0.0012 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0559 0.1794
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0565 0.9354
Brugia malayi jmjC domain containing protein 0.0043 0.0245 0.0891
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1003 0.1003
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0245 0.0435

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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