Detailed information for compound 1410623

Basic information

Technical information
  • TDR Targets ID: 1410623
  • Name: [2-oxo-2-[(4-phenyl-1,3-thiazol-2-yl)amino]et hyl] 2-chloropyridine-3-carboxylate
  • MW: 373.813 | Formula: C17H12ClN3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1scc(n1)c1ccccc1)COC(=O)c1cccnc1Cl
  • InChi: 1S/C17H12ClN3O3S/c18-15-12(7-4-8-19-15)16(23)24-9-14(22)21-17-20-13(10-25-17)11-5-2-1-3-6-11/h1-8,10H,9H2,(H,20,21,22)
  • InChiKey: PZYCVTQMWKZRSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-oxo-2-[(4-phenylthiazol-2-yl)amino]ethyl] 2-chloropyridine-3-carboxylate
  • 2-chloro-3-pyridinecarboxylic acid [2-oxo-2-[(4-phenyl-2-thiazolyl)amino]ethyl] ester
  • 2-chloronicotinic acid [2-keto-2-[(4-phenylthiazol-2-yl)amino]ethyl] ester
  • Oprea1_443659
  • Oprea1_342219
  • ZINC03244452
  • MLS000392707
  • SMR000261657
  • T0512-6362

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0048 0.0069 0.0259
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0058 0.0219
Echinococcus multilocularis serotonin receptor 0.0205 0.0447 0.1687
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Loa Loa (eye worm) glutathione reductase 0.0037 0.0042 0.0042
Echinococcus multilocularis G-protein coupled receptor, putative 0.0083 0.0154 0.0581
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0096
Leishmania major C-14 sterol reductase, putative 0.0092 0.0174 0.0133
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0617 0.1443 1
Loa Loa (eye worm) TYRA-2 protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus orexin receptor type 2 0.0083 0.0154 0.0581
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0138 0.0287 0.0246
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.011 0.0218 0.0822
Brugia malayi Cation transporter family protein 0.011 0.0218 0.0218
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.011 0.0218 0.0822
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Mycobacterium ulcerans dehydrogenase 0.0043 0.0058 0.0393
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0112 0.0223 0.1666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0369 1
Brugia malayi hypothetical protein 0.0043 0.0058 0.0058
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.011 0.0218 0.0218
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0058 0.0058
Brugia malayi RE15519p 0.0083 0.0154 0.0154
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0083 0.0154 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0154 0.0154
Schistosoma mansoni acetylcholine receptor-related 0.0046 0.0064 0.0242
Echinococcus granulosus g protein coupled receptor 0.0083 0.0154 0.0581
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0223 0.0182
Brugia malayi ORL1-like opioid receptor 0.0083 0.0154 0.0154
Echinococcus multilocularis nAChR subunit 0.0064 0.0107 0.0404
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Onchocerca volvulus 0.0083 0.0154 0.0581
Schistosoma mansoni lipoxygenase 0.0116 0.0234 0.0882
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0097 0.0367
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.011 0.0218 0.0218
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0083 0.0154 0.0581
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0083 0.0154 0.0581
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.002 0.0076
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0043 0.0163
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0058 1
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0154 0.0581
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0194 0.0194
Echinococcus multilocularis tumor protein p63 0.0408 0.0938 0.3538
Echinococcus multilocularis cpg binding protein 0.003 0.0025 0.0096
Echinococcus granulosus geminin 0.0501 0.1164 0.4389
Brugia malayi follicle stimulating hormone receptor 0.031 0.0701 0.0701
Schistosoma mansoni neuropeptide receptor 0.0083 0.0154 0.0581
Brugia malayi hypothetical protein 0.0235 0.0519 0.0519
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Mycobacterium tuberculosis Probable reductase 0.0084 0.0156 0.1158
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Trypanosoma brucei C-8 sterol isomerase, putative 0.4161 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0154 0.0581
Brugia malayi Cation transporter family protein 0.0181 0.0389 0.0389
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0155 0.0585
Brugia malayi G-protein coupled receptor 0.0083 0.0154 0.0154
Brugia malayi larval opioid receptor 0.0083 0.0154 0.0154
Schistosoma mansoni histamine h1 receptor 0.0083 0.0154 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Brugia malayi Cation transporter family protein 0.011 0.0218 0.0218
Brugia malayi Dopamine receptor protein 2 0.0083 0.0154 0.0154
Echinococcus granulosus neuropeptide receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0042 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.017 0.0642
Schistosoma mansoni biogenic amine (5HT) receptor 0.0205 0.0447 0.1687
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.011 0.0218 0.0822
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.0111
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0064 0.0242
Schistosoma mansoni hypothetical protein 0.0083 0.0154 0.0581
Echinococcus multilocularis glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Echinococcus granulosus neuropeptide s receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.011 0.0218 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0118 0.0118
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0046 0.0064 0.0064
Loa Loa (eye worm) ACC-1 protein 0.011 0.0218 0.0218
Trypanosoma cruzi C-14 sterol reductase, putative 0.0092 0.0174 0.0133
Brugia malayi Melatonin receptor type 1A 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.011 0.0218 0.0218
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0046 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi hypothetical protein 0.0046 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0135 0.0278 0.0278
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Echinococcus multilocularis sex peptide receptor 0.0083 0.0154 0.0581
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0107 0.0404
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0058 0.0219
Brugia malayi putative neuropeptide receptor NPR1 0.0083 0.0154 0.0154
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0083 0.0154 0.0581
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0112 0.0223 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0062 0.0103 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0083 0.0154 0.0154
Brugia malayi hypothetical protein 0.0046 0.0064 0.0064
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0107 0.0107
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0369 0.2754
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0805 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Brugia malayi excitatory GABA receptor EXP-1A 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi AKH receptor 0.0083 0.0154 0.0154
Echinococcus granulosus glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0029
Onchocerca volvulus 0.0083 0.0154 0.0581
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0029 0.0111
Loa Loa (eye worm) hypothetical protein 0.2127 0.5088 0.5088
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0179 0.3879
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) solute carrier family 6 member 4 0.0062 0.0103 0.0103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0029 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.017 0.0642
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0181 0.0389 0.1468
Onchocerca volvulus 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0501 0.1164 0.4389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus multilocularis potassium voltage gated channel protein 0.0084 0.0155 0.0585
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0626 0.1464 0.552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.017 0.0642
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0179 0.1328
Treponema pallidum sodium- and chloride- dependent transporter 0.0062 0.0103 0.1265
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.002 0.0076
Onchocerca volvulus 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0068 0.0118 0.0444
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0154 0.0581
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.011 0.0218 0.0218
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0064 0.0242
Echinococcus multilocularis orexin receptor type 2 0.0083 0.0154 0.0581
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0083 0.0154 0.0154
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0066 0.0112 0.0422
Echinococcus granulosus g protein coupled receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0046 0.0064 0.0242
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.011 0.0218 0.0822
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0058 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0083 0.0154 0.0154
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.0103 0.0389
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0154 0.0581
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0154 0.0581
Schistosoma mansoni amine GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0058 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0069 0.0259
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.011 0.0218 0.0822
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0083 0.0154 0.0581
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0154 0.0154
Schistosoma mansoni opsin-like receptor 0.0083 0.0154 0.0581
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0138 0.0287 0.0246
Echinococcus multilocularis dro:myosuppressin receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0154 0.0581
Brugia malayi Dopamine receptor 0.0083 0.0154 0.0154
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0064 0.0107 0.0404
Onchocerca volvulus 0.0046 0.0064 0.0242
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0083 0.0154 0.0581
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0058 0.0424
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.011 0.0218 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0205 0.0447 0.1687
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0058 1
Schistosoma mansoni Lamin B receptor (ERG24) 0.0092 0.0174 0.0658
Brugia malayi Serotonin receptor 0.0083 0.0154 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.017 0.0642
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.002 0.0076
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1965 0.7411
Loa Loa (eye worm) hypothetical protein 0.0181 0.0389 0.0389
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0194 0.0194
Echinococcus granulosus nAChR subunit 0.0064 0.0107 0.0404
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Echinococcus multilocularis glycine receptor subunit beta 0.011 0.0218 0.0822
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0083 0.0154 0.0581
Leishmania major UDP-galactopyranose mutase 0.0043 0.0058 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0234 0.0882
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0574 0.1338 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Echinococcus granulosus glycine receptor subunit beta 0.011 0.0218 0.0822
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0046 0.0064 0.0242
Loa Loa (eye worm) serotonin transporter b 0.0062 0.0103 0.0103
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0083 0.0154 0.0154
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi glutathione reductase 0.0037 0.0042 0.0042
Echinococcus granulosus cpg binding protein 0.003 0.0025 0.0096
Echinococcus granulosus 7tm_1 domain containing protein 0.0083 0.0154 0.0581
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0154 0.0581
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0519 0.1959
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi CXXC zinc finger family protein 0.0028 0.0021 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0083 0.2234
Loa Loa (eye worm) follicle stimulating hormone receptor 0.031 0.0701 0.0701
Schistosoma mansoni hypothetical protein 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni amine oxidase 0.0043 0.0058 0.0219
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0084 0.0155 0.0155
Plasmodium falciparum glutathione reductase 0.0037 0.0042 0.7258
Echinococcus granulosus neuropeptide FF receptor 2 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.4161 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) inositol-1 0.0112 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Onchocerca volvulus 0.0181 0.0389 0.1468
Echinococcus granulosus tumor protein p63 0.0408 0.0938 0.3538
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Onchocerca volvulus 0.0062 0.0103 0.0389
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Echinococcus multilocularis 0.0043 0.0058 0.0219
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0083 0.0154 0.0581
Schistosoma mansoni hypothetical protein 0.0501 0.1164 0.4389
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0083 0.0154 0.0581
Brugia malayi putative neuropeptide receptor 0.0083 0.0154 0.0154
Loa Loa (eye worm) GABA receptor subunit 0.0064 0.0107 0.0107
Onchocerca volvulus 0.011 0.0218 0.0822
Schistosoma mansoni vesicular acetylcholine transporter 0.1118 0.2652 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) ACC-1 protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0235 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus synaptic vesicular amine transporter 0.0185 0.0399 0.1504
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0185 0.0399 0.0399
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis neuropeptide s receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0046 0.0064 0.0242
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0058 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.0111
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0156 0.1158
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0154 0.0581
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.0111
Brugia malayi neuropeptide F receptor 0.0083 0.0154 0.0154
Echinococcus granulosus 7TM GPCR rhodopsin 0.0083 0.0154 0.0581
Echinococcus granulosus glycine receptor subunit beta 0.011 0.0218 0.0822
Echinococcus granulosus dro:myosuppressin receptor 0.0083 0.0154 0.0581
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.006 0.0097 0.0097
Echinococcus granulosus potassium voltage gated channel protein 0.0084 0.0155 0.0585
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0046 0.0064 0.0242
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.011 0.0218 0.0822
Echinococcus granulosus inositol monophosphatase 1 0.0112 0.0223 0.0842
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0154 0.0581
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.011 0.0218 0.0218
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0154 0.0581
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0058 0.0219
Mycobacterium ulcerans oxidoreductase 0.0043 0.0058 0.0393
Schistosoma mansoni neuropeptide receptor 0.0083 0.0154 0.0581
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0058 1
Echinococcus granulosus g-protein coupled receptor 0.0083 0.0154 0.0581
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0069 0.0069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0234 0.0882
Schistosoma mansoni growth hormone secretagogue receptor 0.0083 0.0154 0.0581
Echinococcus granulosus GPCR family 2 0.0032 0.0029 0.0111
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1965 0.7411
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0154 0.0581
Schistosoma mansoni amine GPCR 0.0083 0.0154 0.0581
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0064 0.0064
Brugia malayi hypothetical protein 0.0046 0.0064 0.0064
Onchocerca volvulus 0.011 0.0218 0.0822
Brugia malayi G protein-coupled receptor 0.0083 0.0154 0.0154
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0156 0.3151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0156 0.1158
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) acetylcholine receptor protein 0.0046 0.0064 0.0064
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0805 0.5
Schistosoma mansoni opsin-like receptor 0.0083 0.0154 0.0581
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0058 0.0393
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0062 0.1107
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0083 0.0154 0.0581
Leishmania major sterol C-24 reductase, putative 0.0048 0.0068 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Onchocerca volvulus 0.0181 0.0389 0.1468
Echinococcus multilocularis allatostatin A receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Brugia malayi SWIRM domain containing protein 0.0043 0.0058 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0154 0.0581
Echinococcus granulosus serotonin receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0223 0.0182
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.01 0.0195 0.4401
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.011 0.0218 0.0822
Brugia malayi Cytochrome P450 family protein 0.0033 0.0033 0.0033
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0058 0.0877
Echinococcus multilocularis glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Echinococcus multilocularis nAChR subunit 0.011 0.0218 0.0822
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0369 0.2553
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0083 0.0154 0.0581
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.011 0.0218 0.0822
Onchocerca volvulus 0.0083 0.0154 0.0581
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0156 0.1158
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0068 0.0026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0083 0.0154 0.0581
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0068 0.0026
Trypanosoma brucei Emopamil binding protein, putative 0.0138 0.0287 0.0246
Schistosoma mansoni acetylcholine receptor subunit beta 0.0046 0.0064 0.0242
Schistosoma mansoni amine GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0046 0.0064 0.0064
Schistosoma mansoni inositol monophosphatase 0.0112 0.0223 0.0842
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0058 0.0219
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis g-protein coupled receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0043 0.0058 0.0219
Echinococcus multilocularis serotonin transporter 0.0062 0.0103 0.0389
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0519 0.1959
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0083 0.0154 0.0154
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0181 0.0389 0.0389
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0154 0.0581
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Onchocerca volvulus 0.0083 0.0154 0.0581
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0223 0.0182
Echinococcus granulosus dnaJ subfamily B 0.0403 0.0927 0.3494
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.0111
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) LGC-31 protein 0.011 0.0218 0.0218
Schistosoma mansoni neuropeptide f receptor 76f 0.0083 0.0154 0.0581
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Onchocerca volvulus 0.0083 0.0154 0.0581
Schistosoma mansoni nAChR subunit 0.0046 0.0064 0.0242
Schistosoma mansoni alpha-1 adrenergic receptor 0.0083 0.0154 0.0581
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0156 0.1158
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.011 0.0218 0.0822
Schistosoma mansoni hypothetical protein 0.0083 0.0154 0.0581
Schistosoma mansoni opsin-like receptor 0.0083 0.0154 0.0581
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0107 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Brugia malayi neuropeptide F receptor 0.0083 0.0154 0.0154
Schistosoma mansoni adenoreceptor 0.0083 0.0154 0.0581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Leishmania major C-8 sterol isomerase-like protein 0.4161 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0154 0.0581
Echinococcus granulosus sex peptide receptor 0.0083 0.0154 0.0581
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.0103 0.0389
Onchocerca volvulus 0.0138 0.0287 0.1083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0058 0.0424
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus multilocularis inositol monophosphatase 1 0.0112 0.0223 0.0842
Echinococcus granulosus neuropeptide receptor A26 0.0083 0.0154 0.0581
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0154 0.0581
Echinococcus granulosus glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Brugia malayi sulfakinin receptor protein 0.0083 0.0154 0.0154
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0046 0.0064 0.0242
Echinococcus granulosus nAChR subunit 0.011 0.0218 0.0822
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0179 0.1328
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0058 0.0393
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0029 0.0111
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Echinococcus granulosus fmrfamide receptor 0.0083 0.0154 0.0581
Trypanosoma brucei C-14 sterol reductase, putative 0.0092 0.0174 0.0133
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0223 0.0182
Echinococcus granulosus glutamate NMDA receptor subunit 0.0066 0.0112 0.0422
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.011 0.0218 0.0218
Echinococcus granulosus tm gpcr rhodopsin 0.0626 0.1464 0.552
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0617 0.1443 1
Schistosoma mansoni myosin xvIII 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Abnormal catecholamine distribution protein 1 0.0185 0.0399 0.0399
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.011 0.0218 0.0822
Schistosoma mansoni biogenic amine receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0062 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0083 0.0154 0.0581
Schistosoma mansoni glutamate receptor NMDA 0.0066 0.0112 0.0422
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.0195 0.1449
Echinococcus granulosus hypothetical protein 0.0083 0.0154 0.0581
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.008 0.0146 0.0552
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0112 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0194 0.0194
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0181 0.0389 0.1468
Echinococcus granulosus peptide allatostatin:somatostatin 0.0083 0.0154 0.0581
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Brugia malayi hypothetical protein 0.0046 0.0064 0.0064
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0083 0.0154 0.0581
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0205 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Onchocerca volvulus 0.0083 0.0154 0.0581
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0805 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0205 0.0447 0.0447
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.011 0.0218 0.0822
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Echinococcus granulosus serotonin transporter 0.0062 0.0103 0.0389
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0046 0.0064 0.0242
Schistosoma mansoni hypothetical protein 0.0403 0.0927 0.3494
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Brugia malayi Inositol-1 0.0112 0.0223 0.0223
Onchocerca volvulus 0.0028 0.0021 0.0081
Schistosoma mansoni lipoxygenase 0.0081 0.0149 0.0563
Onchocerca volvulus 0.0064 0.0107 0.0404
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.011 0.0218 0.0822
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0058 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1965 0.7411
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Onchocerca volvulus 0.0064 0.0107 0.0404
Onchocerca volvulus 0.0083 0.0154 0.0581
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.017 0.0642
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.0154 0.0581
Trypanosoma cruzi Emopamil binding protein, putative 0.0138 0.0287 0.0246
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Brugia malayi GnHR receptor homolog 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.011 0.0218 0.0822
Echinococcus granulosus lamin b receptor 0.0092 0.0174 0.0658
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Echinococcus multilocularis glycine receptor subunit beta 0.011 0.0218 0.0822
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0112 0.0223 0.154
Echinococcus granulosus allatostatin A receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Echinococcus multilocularis G protein coupled receptor 139 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Tachykinin-like peptides receptor 99D 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Plasmodium vivax glutathione reductase, putative 0.0037 0.0042 0.7258
Schistosoma mansoni nAChR subunit 0.0046 0.0064 0.0242
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni inositol monophosphatase 0.0112 0.0223 0.0842
Brugia malayi hypothetical protein 0.0046 0.0064 0.0064
Echinococcus granulosus g protein coupled receptor 0.0083 0.0154 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Schistosoma mansoni neuropeptide receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.011 0.0218 0.0822
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0084 0.0155 0.0585
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.0107 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0098 0.037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.011 0.0218 0.0822
Echinococcus granulosus vesicular acetylcholine transporter 0.1118 0.2652 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0083 0.0154 0.0581
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0046 0.0064 0.0064
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0156 0.1158
Schistosoma mansoni amine GPCR 0.0083 0.0154 0.0581
Loa Loa (eye worm) norepinephrine transporter 0.0062 0.0103 0.0103
Echinococcus multilocularis neuropeptide receptor A26 0.0083 0.0154 0.0581
Echinococcus multilocularis synaptic vesicular amine transporter 0.0185 0.0399 0.1504
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.0927 0.3494
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0058 0.0219
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0042 0.7258
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1118 0.2652 0.2652
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Echinococcus multilocularis lamin b receptor 0.0092 0.0174 0.0658
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Leishmania major hypothetical protein, conserved 0.0138 0.0287 0.0246
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Plasmodium falciparum thioredoxin reductase 0.0037 0.0042 0.7258
Loa Loa (eye worm) hypothetical protein 0.0062 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Schistosoma mansoni cpg binding protein 0.0028 0.0021 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0043 0.0163
Echinococcus multilocularis GPCR, family 2 0.0032 0.0029 0.0111
Echinococcus granulosus neuropeptide receptor 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0181 0.0389 0.1468
Echinococcus granulosus glycine receptor subunit alpha 1 0.011 0.0218 0.0822
Schistosoma mansoni amine oxidase 0.0043 0.0058 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Schistosoma mansoni vesicular amine transporter 0.0185 0.0399 0.1504
Onchocerca volvulus 0.011 0.0218 0.0822
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0058
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.011 0.0218 0.0218
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.011 0.0218 0.0822
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0107 0.0404
Brugia malayi Serotonin receptor 0.1007 0.2384 0.2384
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0155 0.0585
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0029 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0154 0.0581
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0154 0.0581
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0083 0.0154 0.0154
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0064 0.0107 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0029 0.0111
Echinococcus multilocularis geminin 0.0501 0.1164 0.4389
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0154 0.0154
Echinococcus multilocularis neuropeptide FF receptor 2 0.0083 0.0154 0.0581
Schistosoma mansoni nAChR subunit 0.011 0.0218 0.0822
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0058 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0103 0.0103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis vesicular acetylcholine transporter 0.1118 0.2652 1
Echinococcus multilocularis serotonin receptor 0.0205 0.0447 0.1687
Schistosoma mansoni biogenic amine receptor 0.0083 0.0154 0.0581
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0805 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0064 0.0064
Onchocerca volvulus 0.0083 0.0154 0.0581
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Onchocerca volvulus 0.006 0.0097 0.0367
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.011 0.0218 0.0822
Brugia malayi vesicular acetylcholine transporter unc-17 0.1118 0.2652 0.2652
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Onchocerca volvulus 0.0083 0.0154 0.0581
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0083 0.0154 0.0581
Echinococcus multilocularis somatostatin receptor 0.0083 0.0154 0.0581
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0154 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0805 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0107
Loa Loa (eye worm) melatonin receptor type 1A 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1118 0.2652 1
Schistosoma mansoni hypothetical protein 0.0048 0.0069 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0154 0.0581
Trypanosoma cruzi C-14 sterol reductase, putative 0.0092 0.0174 0.0133
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.011 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.011 0.0218 0.0218
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0084 0.0155 0.0155
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0046 0.0064 0.0064
Onchocerca volvulus 0.0083 0.0154 0.0581
Schistosoma mansoni amine GPCR 0.0083 0.0154 0.0581
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0046 0.0064 0.0242
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0138 0.0287 0.0246
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4161 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Echinococcus granulosus G protein coupled receptor 139 0.0083 0.0154 0.0581
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0083 0.0154 0.0581
Schistosoma mansoni neuropeptide receptor 0.0083 0.0154 0.0581
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Brugia malayi Dopamine receptor protein 1 0.0083 0.0154 0.0154
Brugia malayi hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0154 0.0154
Brugia malayi Thioredoxin reductase 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Trypanosoma cruzi Emopamil binding protein, putative 0.0138 0.0287 0.0246
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0179 0.1328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.017 0.0642
Loa Loa (eye worm) hypothetical protein 0.0046 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0194 0.0194
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0083 0.0154 0.0581
Loa Loa (eye worm) hypothetical protein 0.0083 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.011 0.0218 0.0218
Onchocerca volvulus Putative nachr subunit 0.011 0.0218 0.0822
Echinococcus granulosus somatostatin receptor 0.0083 0.0154 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.017 0.0642
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0154 0.0581
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0058 0.0219
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0033 0.0033
Brugia malayi G-protein coupled receptor 0.0083 0.0154 0.0154
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0083 0.0154 0.0154
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0058 0.0016
Schistosoma mansoni biogenic amine receptor 0.0083 0.0154 0.0581

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 9.9763 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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