Detailed information for compound 1417077

Basic information

Technical information
  • TDR Targets ID: 1417077
  • Name: 5-bromo-N-[2-(4-methylpiperidin-1-yl)phenyl]f uran-2-carboxamide
  • MW: 363.249 | Formula: C17H19BrN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)c1ccccc1NC(=O)c1ccc(o1)Br
  • InChi: 1S/C17H19BrN2O2/c1-12-8-10-20(11-9-12)14-5-3-2-4-13(14)19-17(21)15-6-7-16(18)22-15/h2-7,12H,8-11H2,1H3,(H,19,21)
  • InChiKey: PGQUAIGZSLCGHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-N-[2-(4-methyl-1-piperidyl)phenyl]furan-2-carboxamide
  • 5-bromo-N-[2-(4-methyl-1-piperidinyl)phenyl]-2-furancarboxamide
  • 5-bromo-N-[2-(4-methyl-1-piperidyl)phenyl]-2-furamide
  • ZINC02850520
  • STK254438

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0032 0.0493 0.0692
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0119 0.0159
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3296 0.3675
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0612 0.0637
Plasmodium falciparum importin beta, putative 0.0032 0.0493 0.055
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0119 0.0159
Brugia malayi Cathepsin L-like precursor 0.0012 0.0057 0.0066
Brugia malayi jmjC domain containing protein 0.0019 0.0213 0.0243
Schistosoma mansoni hypothetical protein 0.0102 0.1967 0.2762
Echinococcus multilocularis snurportin 1 0.0347 0.7119 1
Brugia malayi jmjC domain containing protein 0.0019 0.0213 0.0243
Echinococcus granulosus GPCR family 2 0.0038 0.0612 0.0859
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0456 0.064
Entamoeba histolytica cysteine protease, putative 0.0018 0.0181 0.2584
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0213 0.0299
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0112 0.0149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1217 0.1332
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0119 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.029 0.0407
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0213 0.0299
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0181 0.0206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0612 0.0637
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0112 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0855 0.1201
Onchocerca volvulus 0.0014 0.0112 0.0054
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7502 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0213 0.0299
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0428 0.0601
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0363 0.0363
Loa Loa (eye worm) glutathione reductase 0.0043 0.0707 0.0746
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Trypanosoma brucei glucose transporter 2A 0.0032 0.0478 0.0637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0181 0.0141
Brugia malayi jmjC domain containing protein 0.0019 0.0213 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.1326 0.1863
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0312 0.2109
Onchocerca volvulus 0.0014 0.0112 0.0054
Mycobacterium ulcerans sugar transporter 0.0014 0.0112 0.0196
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0119 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1217 0.1332
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1217 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0478 0.0478
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1326 0.1863
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0181 0.2584
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0699 0.0779
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1227 0.1636
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3449 0.4598
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0456 0.064
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.1063 0.1641
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3296 0.3675
Brugia malayi Sugar transporter family protein 0.0102 0.1967 0.2244
Leishmania major protein kinase, putative 0.0031 0.0469 0.0484
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0469 0.0523
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0112 0.0157
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1967 0.2762
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1127 0.1502
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0612 0.0698
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.029 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0213 0.0179
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0213 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0469 0.0617
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0218 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1217 0.171
Echinococcus multilocularis solute carrier family 22 0.0014 0.0112 0.0157
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0181 0.0124
Onchocerca volvulus 0.0061 0.1093 0.1041
Loa Loa (eye worm) fibroinase 0.0018 0.0181 0.0141
Echinococcus multilocularis solute carrier family 22 0.0014 0.0112 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0699 0.0699
Echinococcus multilocularis cysteine protease 0.0018 0.0181 0.0254
Loa Loa (eye worm) hypothetical protein 0.0061 0.1093 0.1189
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0181 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0074 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0855 0.1201
Echinococcus granulosus cathepsin l1 0.0018 0.0181 0.0254
Leishmania major glucose transporter, lmgt2 0.0032 0.0478 0.0495
Brugia malayi jmjC domain containing protein 0.0019 0.0213 0.0243
Brugia malayi jmjC domain containing protein 0.0195 0.3917 0.4469
Toxoplasma gondii hypothetical protein 0.0059 0.1049 0.1617
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0469 0.0535
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3296 0.5495
Echinococcus multilocularis General substrate transporter 0.0088 0.1663 0.2336
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0699 0.0931
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3449 0.4516
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0855 0.0976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0312 0.0346
Entamoeba histolytica hypothetical protein 0.0042 0.0699 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0478 0.0637
Loa Loa (eye worm) ctsf protein 0.0018 0.0181 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2289 0.2564
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 0.897 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0265 0.0373
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0168
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0057 0.0057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0312 0.0348
Echinococcus granulosus solute carrier family 22 0.0014 0.0112 0.0157
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Echinococcus granulosus solute carrier family 22 0.0014 0.0112 0.0157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Trypanosoma brucei trypanothione reductase 0.0043 0.0707 0.0942
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Brugia malayi hypothetical protein 0.0014 0.0112 0.0127
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.1227 0.1636
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.2086 0.5267
Entamoeba histolytica hypothetical protein 0.0023 0.029 0.4149
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.089 0.1186
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0469 0.0659
Loa Loa (eye worm) hypothetical protein 0.0233 0.4722 0.5359
Brugia malayi hypothetical protein 0.0014 0.0112 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0119 0.0216
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0112 0.0127
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0493 0.0657
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.029 0.1875
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.029 0.0323
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.1063 0.1492
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0218 0.0291
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.1063 0.1641
Onchocerca volvulus 0.0014 0.0112 0.0054
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0456 0.064
Loa Loa (eye worm) hypothetical protein 0.012 0.2348 0.2631
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0112 0.0112
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0563 0.0751
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0469 0.0523
Onchocerca volvulus 0.0014 0.0112 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0213 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1217 0.171
Echinococcus granulosus General substrate transporter 0.0088 0.1663 0.2336
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.1093 0.1535
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0493 0.0657
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.2086 1
Echinococcus granulosus transcription factor btf3 0.0042 0.0699 0.0982
Trichomonas vaginalis ran, putative 0.0024 0.0312 0.0312
Trypanosoma cruzi hexose transporter 0.0032 0.0478 0.0637
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.2348 0.2631
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0112 0.0112
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.029 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1093 0.1535
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.1104 0.1472
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0119 0.0133
Leishmania major importin beta-1 subunit, putative 0.0026 0.0363 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0102 0.1959 0.2184
Leishmania major glucose transporter, lmgt3 0.0032 0.0478 0.0495
Brugia malayi glutathione reductase 0.0043 0.0707 0.0806
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0456 0.6522
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0159
Onchocerca volvulus 0.0014 0.0112 0.0054
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0112 0.0149
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0119 0.0133
Entamoeba histolytica protein kinase, putative 0.0031 0.0469 0.6713
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0478 0.0478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0719 0.1009
Schistosoma mansoni glucose transport protein 0.0102 0.1967 0.2762
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0037 0.0042
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0217 0.0282
Mycobacterium ulcerans hypothetical protein 0.0192 0.3861 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Brugia malayi jmjC domain containing protein 0.0072 0.1326 0.1514
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.029 0.0407
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0707 0.1587
Onchocerca volvulus 0.0048 0.081 0.0757
Schistosoma mansoni protein kinase 0.0031 0.0469 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0469 0.0523
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0181 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Plasmodium vivax glutathione reductase, putative 0.0043 0.0707 0.0788
Onchocerca volvulus 0.0014 0.0112 0.0054
Plasmodium vivax vivapain-2 0.0018 0.0181 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Loa Loa (eye worm) sugar transporter 0.0014 0.0112 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0478 0.0478
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0493 0.0658
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0363 0.0363
Onchocerca volvulus 0.0018 0.0181 0.0124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0312 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0112 0.0112
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0218 0.0184
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0456 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0612 0.0859
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0563 0.0611
Onchocerca volvulus 0.0014 0.0112 0.0054
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0719 0.1009
Leishmania major glucose transporter, lmgt1 0.0032 0.0478 0.0495
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0312 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0855 0.1201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1858 0.4657
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0469 0.0523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.1326 0.1863
Brugia malayi hypothetical protein 0.0233 0.4722 0.5389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.081 0.0925
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0612 0.0859
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0119 0.0133
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.1063 0.1155
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0312 0.0416
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0216
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0112 0.0149
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1217 0.171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Mycobacterium tuberculosis Probable reductase 0.0097 0.1858 0.4657
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Schistosoma mansoni glucose transport protein 0.0102 0.1967 0.2762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Plasmodium falciparum protein kinase 6 0.0434 0.897 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7502 1
Plasmodium falciparum hexose transporter 0.0102 0.1967 0.2193
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0612 0.0859
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.029 0.0308
Brugia malayi beta-NAC-like protein 0.0042 0.0699 0.0797
Brugia malayi MH2 domain containing protein 0.0118 0.2289 0.2612
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0469 0.0473
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0231 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0855 0.1201
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0478 0.0478
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0563 0.0751
Echinococcus multilocularis solute carrier family 22 0.0014 0.0112 0.0157
Loa Loa (eye worm) hypothetical protein 0.0082 0.1544 0.1708
Plasmodium falciparum thioredoxin reductase 0.0015 0.0119 0.0133
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus granulosus jumonji domain containing protein 0.0083 0.1554 0.2182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0855 0.1201
Leishmania major cathepsin L-like protease 0.0018 0.0181 0.0093
Brugia malayi Bromodomain containing protein 0.0059 0.1063 0.1213
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0011
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1858 0.4657
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0699 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0119 0.0014
Onchocerca volvulus 0.0018 0.0181 0.0124
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0174 0.0232
Onchocerca volvulus 0.0014 0.0112 0.0054
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0181 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0478 0.0478
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0469 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0699 0.0699
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1967 0.3201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0855 0.0916
Plasmodium vivax SET domain protein, putative 0.0061 0.1093 0.1218
Leishmania major GTP-binding protein, putative 0.0024 0.0312 0.0271
Entamoeba histolytica hypothetical protein 0.0026 0.0363 0.5202
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0112 0.0196
Schistosoma mansoni sugar transporter 0.0014 0.0112 0.0157
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0312 0.0438
Plasmodium falciparum glutathione reductase 0.0015 0.0119 0.0133
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0119 0.0216
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0218 0.0291
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0213 0.0299
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0057 0.0822
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0037 0.0042
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.7502 1
Loa Loa (eye worm) sugar transporter 0.0102 0.1967 0.2193
Loa Loa (eye worm) hypothetical protein 0.0032 0.0493 0.05
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Leishmania major cathepsin L-like protease 0.0018 0.0181 0.0093
Loa Loa (eye worm) hypothetical protein 0.0025 0.0334 0.0318
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1858 0.8776
Schistosoma mansoni jumonji domain containing protein 0.0155 0.3072 0.4315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1093 0.1535
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Plasmodium vivax JmjC domain containing protein 0.0019 0.0213 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Brugia malayi cathepsin L-like precursor 0.0012 0.0057 0.0066
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.029 0.0407
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1227 0.1636
Brugia malayi RNA, U transporter 1 0.0092 0.1756 0.2004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0312 0.0416
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3861 1
Schistosoma mansoni importin beta-1 0.0032 0.0493 0.0692
Brugia malayi PHD-finger family protein 0.0059 0.1063 0.1213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.0185
Echinococcus multilocularis cysteine protease 0.0018 0.0181 0.0254
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.2398 0.2689
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0478 0.0478
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0181 0.0254
Schistosoma mansoni hypothetical protein 0.0347 0.7119 1
Schistosoma mansoni protein kinase 0.0031 0.0469 0.0659
Leishmania major trypanothione reductase 0.0043 0.0707 0.0805
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0119 0.0159
Trichomonas vaginalis set domain proteins, putative 0.0483 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0612 0.0859
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0112 0.0157
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3449 0.4598
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.029 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0493 0.055
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0112 0.0127
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0478 0.0637
Loa Loa (eye worm) hypothetical protein 0.0019 0.0213 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Schistosoma mansoni protein kinase 0.0031 0.0469 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1093 0.1535
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0478 0.0637
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0213 0.0299
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0181 0.0241
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0312 0.0438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0855 0.1201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Echinococcus multilocularis peregrin 0.0059 0.1063 0.1492
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0181 0.0254
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.1326 0.1863
Entamoeba histolytica protein kinase, putative 0.0031 0.0469 0.6713
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0265 0.0303
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.4722 0.6633
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0312 0.0356
Schistosoma mansoni transcription factor btf3 0.0042 0.0699 0.0982
Onchocerca volvulus 0.0014 0.0112 0.0054
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0119 0.0133
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0563 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Schistosoma mansoni sugar transporter 0.0014 0.0112 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1217 0.1389
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0707 0.0746
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0112 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0456 0.0457
Echinococcus granulosus cathepsin l1 0.0012 0.0057 0.0081
Loa Loa (eye worm) hypothetical protein 0.0031 0.0456 0.0457
Plasmodium falciparum thioredoxin reductase 0.0043 0.0707 0.0788
Brugia malayi Sugar transporter family protein 0.0014 0.0112 0.0127
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0699 0.0931
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0217 0.0282
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0563 0.0628
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0181 0.0201
Onchocerca volvulus 0.0018 0.0181 0.0124
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0707 0.0942
Plasmodium vivax hexose transporter 0.0102 0.1967 0.2193
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0699 0.0737
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0213 0.0284
Brugia malayi hypothetical protein 0.0014 0.0112 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0699 0.0699
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0924 0.1231
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Entamoeba histolytica Ran family GTPase 0.0024 0.0312 0.4468
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0181 0.0141
Echinococcus granulosus peregrin 0.0059 0.1063 0.1492
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0181 0.0093
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1858 0.4657
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0478 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Toxoplasma gondii thioredoxin reductase 0.0043 0.0707 0.1027
Echinococcus multilocularis GPCR, family 2 0.0038 0.0612 0.0859
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0213 0.0299
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0428 0.0601
Onchocerca volvulus Alhambra homolog 0.0059 0.1063 0.1011
Onchocerca volvulus 0.0018 0.0181 0.0124
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Echinococcus granulosus solute carrier family 22 0.0014 0.0112 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0213 0.0175
Schistosoma mansoni hypothetical protein 0.0038 0.0612 0.0859
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0213 0.0284
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0112 0.0157
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0218 0.0184
Leishmania major basic transcription factor 3a, putative 0.0042 0.0699 0.0795
Brugia malayi RNA binding protein 0.0067 0.1217 0.1389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.8763 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0456 0.064
Echinococcus granulosus snurportin 1 0.0347 0.7119 1
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0048 0.081 0.1138
Echinococcus multilocularis solute carrier family 22 0.0014 0.0112 0.0157
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0119 0.0159
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.1045 0.1468
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0119 0.0011
Leishmania major cathepsin L-like protease 0.0018 0.0181 0.0093
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0057 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0181 0.0181
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.029 0.0662
Loa Loa (eye worm) RNA binding protein 0.0067 0.1217 0.1332
Loa Loa (eye worm) hypothetical protein 0.0023 0.029 0.0267
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0112 0.0157
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0082 0.1544 0.2169
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.029 0.0407
Brugia malayi major facilitator superfamily protein 0.0014 0.0112 0.0127
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0213 0.0299
Brugia malayi Thioredoxin reductase 0.0043 0.0707 0.0806
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0119 0.3264
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.1554 0.2182
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0218 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Brugia malayi Importin beta-1 subunit 0.0032 0.0493 0.0563
Brugia malayi major facilitator superfamily protein 0.0014 0.0112 0.0127
Schistosoma mansoni hypothetical protein 0.0059 0.1063 0.1492
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0563 0.0779
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Brugia malayi Pre-SET motif family protein 0.0424 0.8763 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.029 0.0323
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0057 0.0081
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0112 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0213 0.0179
Onchocerca volvulus 0.0014 0.0112 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.1544 0.1762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0469 0.0523
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0181 0.0254
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0119 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1093 0.1535
Onchocerca volvulus 0.0018 0.0181 0.0124
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2289 0.2564
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Schistosoma mansoni survival motor neuron protein 0.0048 0.081 0.1138
Plasmodium falciparum glutathione reductase 0.0043 0.0707 0.0788
Leishmania major hypothetical protein, conserved 0.0019 0.0213 0.0137
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.2348 0.2679
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0469 0.0617
Plasmodium vivax sugar transporter, putative 0.0014 0.0112 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0213 0.0179
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0112 0.0127
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0612 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1967 0.1967
Leishmania major cathepsin L-like protease 0.0018 0.0181 0.0093
Echinococcus granulosus phd:f box containing protein 0.0019 0.0213 0.0299
Schistosoma mansoni glucose transporter 0.0014 0.0112 0.0157
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0168
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0469 0.0523
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.1093 0.1535
Schistosoma mansoni hypothetical protein 0.0038 0.0612 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0112 0.0112
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0478 0.0495
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0469 0.0617
Schistosoma mansoni sugar transporter 0.0014 0.0112 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0159
Brugia malayi Cathepsin L-like precursor 0.0012 0.0057 0.0066
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0469 0.0523
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0469 0.0625
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0213 0.0299
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0469 0.0659
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0119 0.0011
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0493 0.0692
Plasmodium falciparum phd finger protein, putative 0.0059 0.1063 0.1185
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0469 0.0473
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0563 0.0611
Brugia malayi Cam kinase protein 1 0.0031 0.0469 0.0535
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0181 0.2584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Brugia malayi Sugar transporter family protein 0.0014 0.0112 0.0127
Echinococcus granulosus solute carrier family 22 0.0014 0.0112 0.0157
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0363 0.0485
Leishmania major cathepsin L-like protease 0.0067 0.1227 0.151
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0699 0.0931
Onchocerca volvulus 0.0014 0.0112 0.0054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.2086 0.5267
Plasmodium vivax hypothetical protein, conserved 0.0059 0.1063 0.1185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.089 0.1186
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0181 0.0254
Schistosoma mansoni hypothetical protein 0.0038 0.0612 0.0859
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0213 0.0299
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Plasmodium vivax vivapain-2 0.0018 0.0181 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Treponema pallidum NADH oxidase 0.0015 0.0119 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.1063 0.1492
Leishmania major cathepsin L-like protease 0.0067 0.1227 0.151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.1063 0.1492
Giardia lamblia PHD finger protein 15 0.0059 0.1063 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1093 0.1693
Onchocerca volvulus 0.0018 0.0181 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0181 0.0254
Schistosoma mansoni ran 0.0024 0.0312 0.0438
Loa Loa (eye worm) cysteine protease 0.0018 0.0181 0.0141
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Onchocerca volvulus 0.0014 0.0112 0.0054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0119 0.0136
Leishmania major cathepsin L-like protease 0.0018 0.0181 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0213 0.0237
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0119 0.0168
Schistosoma mansoni glucose transport protein 0.0102 0.1967 0.2762
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.029 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0112 0.0112
Onchocerca volvulus Putative transporter 0.0014 0.0112 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.1227 0.1636
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0478 0.0637
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0119 0.0021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.089 0.1186
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.089 0.1186
Trypanosoma brucei glucose transporter 1E 0.0032 0.0478 0.0637
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0181 0.0181
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0699 0.1013
Onchocerca volvulus 0.0018 0.0181 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0469 0.0659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0456 0.3619
Trypanosoma brucei sugar transporter, putative 0.0014 0.0112 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0181 0.0254
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.2348 0.2679
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0213 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0057 0.0057
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0456 0.1276
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0181 0.0254
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0699 0.0779
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0119 0.0011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.7119 0.8112
Onchocerca volvulus 0.0014 0.0112 0.0054
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0213 0.0299
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0478 0.0637
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0181 0.0254
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0181 0.0124
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.029 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0038 0.0612 0.0859
Schistosoma mansoni ran 0.0024 0.0312 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0181 0.0181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0363 0.0363
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1858 0.4657
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.2086 0.5267
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.7502 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.3917 0.5501
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.029 0.029
Brugia malayi Pre-SET motif family protein 0.0061 0.1093 0.1247
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Trypanosoma brucei glucose transporter, putative 0.0032 0.0478 0.0637
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0855 0.1201
Schistosoma mansoni sugar transporter 0.0014 0.0112 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0031 0.0469 0.0473
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0312 0.0348
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0112 0.0124
Plasmodium falciparum protein kinase 7 0.0289 0.5907 0.6585
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1858 0.4657
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0213 0.0299
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0478 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.1227 0.1636
Onchocerca volvulus 0.0014 0.0112 0.0054
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1967 0.2762
Brugia malayi PHD-finger family protein 0.0019 0.0218 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0019 0.0218 0.0306
Loa Loa (eye worm) hypothetical protein 0.0059 0.1063 0.1155
Toxoplasma gondii protein kinase, putative 0.0289 0.5907 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0213 0.0299
Brugia malayi lysyl-tRNA synthetase 0.0023 0.029 0.0331
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0213 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1093 0.1535
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1217 0.171
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0112 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0469 0.0469
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.3917 0.5501
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.4722 0.6633
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0456 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0112 0.0112
Leishmania major cathepsin L-like protease 0.0067 0.1227 0.151
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0469 0.0523
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0707 0.0788
Brugia malayi Cathepsin L-like precursor 0.0018 0.0181 0.0206
Onchocerca volvulus 0.0014 0.0112 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1326 0.1458
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1217 0.171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0062
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0112 0.0062
Echinococcus granulosus tar DNA binding protein 0.0067 0.1217 0.171
Brugia malayi TAR-binding protein 0.0067 0.1217 0.1389
Toxoplasma gondii cathepsin CPL 0.0018 0.0181 0.0119
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0213 0.0299
Onchocerca volvulus 0.0014 0.0112 0.0054
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0112 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0181 0.0141
Brugia malayi AF-10 protein 0.0019 0.0218 0.0249
Echinococcus multilocularis transcription factor btf3 0.0042 0.0699 0.0982
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0119 0.0159
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0456 0.052
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0563 0.0751
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.029 0.0241

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.288 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 43.571 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 446.6836 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.