TDR Targets

Basic information

Technical information

TDR Targets ID: 1425927
Name: 4-ethoxy-N-[[1-[(3-methylphenyl)methyl]pyrrol -2-yl]methyl]benzenesulfonamide
MW: 384.492 | Formula: C21H24N2O3S
H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)S(=O)(=O)NCc1cccn1Cc1cccc(c1)C
InChi: 1S/C21H24N2O3S/c1-3-26-20-9-11-21(12-10-20)27(24,25)22-15-19-8-5-13-23(19)16-18-7-4-6-17(2)14-18/h4-14,22H,3,15-16H2,1-2H3
InChiKey: GUAUXWPEARRFKG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-ethoxy-N-[[1-[(3-methylphenyl)methyl]-2-pyrrolyl]methyl]benzenesulfonamide
4-ethoxy-N-[[1-(3-methylbenzyl)pyrrol-2-yl]methyl]benzenesulfonamide
G529-0322
NCGC00131601-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0223	0.0804
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.0585	0.069
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0011	0.0039
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0424	0.1532
Loa Loa (eye worm)	hypothetical protein	0.007	0.0678	0.2448
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1445	0.1705
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0024	0.0092	0.0108
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0024	0.0092	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0045	0.037	0.1335
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0275	0.0275
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0024	0.0092	0.0331
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.1445	0.1445
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0026	0.0116	0.0136
Brugia malayi	PHD-finger family protein	0.0028	0.0146	0.0529
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0011	0.0039
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.1358	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0829	0.2995
Echinococcus multilocularis	neuropeptide s receptor	0.0455	0.5611	0.5611
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0172	0.0623
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0172	0.0623
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0222	0.2625	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0172	0.0203
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.1358	0.1601
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0172	0.0623
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0172	0.0203
Entamoeba histolytica	hypothetical protein	0.0038	0.0275	0.9422
Leishmania major	hypothetical protein, conserved	0.0222	0.2625	1
Echinococcus granulosus	Chromo domain	0.0024	0.0092	0.0108
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.024	0.024
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0283	0.1021
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0829	0.4746
Entamoeba histolytica	hypothetical protein	0.0038	0.0275	0.9422
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0172	0.0623
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0105	0.3671
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0062	0.0585	0.0585
Brugia malayi	TAR-binding protein	0.0129	0.1445	0.5219
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0002	0.0007
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.0769	0.0769
Schistosoma mansoni	hypothetical protein	0.0034	0.0223	0.0263
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0172	0.0203
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0275	0.0325
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Loa Loa (eye worm)	CHromoDomain protein family member	0.0026	0.0116	0.0418
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0024	0.0092	0.0108
Brugia malayi	jmjC domain containing protein	0.0062	0.0585	0.2112
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0609	0.0718
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0105	0.0775
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0627	0.2264
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0172	0.0203
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0283	0.1077
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0172	0.0203
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0585	0.0689
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.0609	0.2199
Schistosoma mansoni	hypothetical protein	0.0038	0.0275	0.0325
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0204	0.0241
Schistosoma mansoni	gabp alpha	0.0077	0.0769	0.0908
Brugia malayi	Heterochromatin protein 1	0.0145	0.1647	0.5946
Brugia malayi	jmjC domain containing protein	0.0064	0.0609	0.2199
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0172	0.0623
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0123	0.1358	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0283	0.1077
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0362	0.2664
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0047	0.017
Schistosoma mansoni	chromobox protein	0.0145	0.1647	0.1942
Brugia malayi	hypothetical protein	0.0024	0.0092	0.0331
Brugia malayi	CHD4 protein	0.0026	0.0116	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0197	0.071
Echinococcus multilocularis	lysine specific demethylase 5A	0.0062	0.0585	0.0585
Echinococcus multilocularis	musashi	0.0033	0.0204	0.0204
Brugia malayi	Ets-domain containing protein	0.0077	0.0769	0.2779
Brugia malayi	Protein cec-1.	0.0024	0.0092	0.0331
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0024	0.0092	0.0675
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.0092	0.2532
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0024	0.0092	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0172	0.0623
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0055	0.0199
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0024	0.0092	0.0675
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0283	0.1229
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0283	0.9802
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0172	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0172	0.0623
Echinococcus multilocularis	chromobox protein 2	0.0024	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0105	0.2908
Echinococcus multilocularis	geminin	0.0346	0.422	0.422
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0424	0.1532
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0105	0.0401
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0105	0.3671
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0286	1
Schistosoma mansoni	hypothetical protein	0.002	0.0047	0.0056
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0024	0.0092	0.0108
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0222	0.2625	1
Schistosoma mansoni	lamin	0.0033	0.0204	0.0241
Echinococcus multilocularis	neuropeptide receptor A26	0.0455	0.5611	0.5611
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0984	0.116
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0024	0.0092	0.3197
Schistosoma mansoni	microtubule-associated protein tau	0.0679	0.8478	1
Brugia malayi	hypothetical protein	0.0025	0.0105	0.038
Schistosoma mansoni	hypothetical protein	0.0346	0.422	0.4977
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.0092	0.2532
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0172	0.0203
Echinococcus multilocularis	chromobox protein 1	0.0145	0.1647	0.1647
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0204	0.0738
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.1445	0.5219
Schistosoma mansoni	chromobox protein	0.0145	0.1647	0.1942
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1445	0.1705
Echinococcus granulosus	microtubule associated protein 2	0.0679	0.8478	1
Onchocerca volvulus		0.0064	0.0604	0.6276
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.1445	0.5219
Echinococcus granulosus	neuropeptide s receptor	0.0455	0.5611	0.6618
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.1445	0.5219
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0172	0.0203
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0525	0.2789
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0172	0.0203
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0172	0.0623
Trichomonas vaginalis	chromobox protein, putative	0.0145	0.1647	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Loa Loa (eye worm)	hypothetical protein	0.005	0.0424	0.1532
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0024	0.0092	0.3197
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1445	0.1705
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0172	0.0203
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0105	0.0401
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0283	0.0283
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0984	0.3553
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0984	0.3553
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0984	0.0984
Echinococcus granulosus	neuropeptide receptor A26	0.0455	0.5611	0.6618
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0172	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0271	0.0977
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0026	0.0116	0.0136
Schistosoma mansoni	chromobox protein	0.0024	0.0092	0.0108
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0984	0.116
Entamoeba histolytica	hypothetical protein	0.0038	0.0275	0.9422
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.1669	0.1969
Brugia malayi	RNA binding protein	0.0129	0.1445	0.5219
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0172	0.0623
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0024	0.0028
Trichomonas vaginalis	chromobox protein, putative	0.0088	0.0909	0.5254
Loa Loa (eye worm)	RNA binding protein	0.0129	0.1445	0.5219
Trichomonas vaginalis	chromobox protein, putative	0.0088	0.0909	0.5254
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0172	0.0623
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0204	0.0738
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.1669	0.6027
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1358	1
Echinococcus multilocularis	Chromo domain	0.0024	0.0092	0.0092
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0172	0.0989
Schistosoma mansoni	lamin	0.0033	0.0204	0.0241
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0172	0.0172
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.0769	0.2779
Entamoeba histolytica	hypothetical protein	0.0038	0.0275	0.9422
Schistosoma mansoni	bromodomain containing protein	0.0066	0.063	0.0743
Brugia malayi	nuclear hormone receptor	0.003	0.0172	0.0623
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0172	0.0623
Onchocerca volvulus		0.0033	0.0204	0.1381
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0172	0.0203
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0172	0.0203
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.1358	0.1601
Brugia malayi	SET domain containing protein	0.0024	0.0092	0.0331
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0454	0.1638
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0454	0.1638
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0172	0.0203
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.024	0.0283
Brugia malayi	Bromodomain containing protein	0.0041	0.0315	0.1138
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.1358	0.1358
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0172	0.0623
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0172	0.0989
Loa Loa (eye worm)	heterochromatin protein 1	0.0145	0.1647	0.5946
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0362	0.1737
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1358	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0081	0.0829	0.9031
Leishmania major	hypothetical protein, conserved	0.0025	0.0105	0.0401
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0038	0.0275	0.0994
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0362	0.2664
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0105	0.038
Brugia malayi	Bromodomain containing protein	0.0077	0.0777	0.2807
Brugia malayi	nuclear receptor NHR-88	0.003	0.0172	0.0623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0172	0.0623
Brugia malayi	intermediate filament protein	0.0033	0.0204	0.0738
Brugia malayi	Valyl-tRNA synthetase	0.0024	0.0092	0.0331
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0105	0.0401
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0071	0.0084
Schistosoma mansoni	hypothetical protein	0.0024	0.0092	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0984	0.0984
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0172	0.0623
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0172	0.0203
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0362	1
Schistosoma mansoni	zinc finger protein	0.0023	0.0079	0.0093
Schistosoma mansoni	ets-related	0.0233	0.2769	0.3266
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0172	0.0172
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0172	0.0172
Brugia malayi	M-phase phosphoprotein, mpp8	0.0024	0.0092	0.0331
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0984	0.116
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0362	0.0427
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.1587	0.1872
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0525	0.2789
Echinococcus granulosus	chromobox protein 1	0.0145	0.1647	0.1942
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0071	0.0084
Loa Loa (eye worm)	fli-1 protein	0.0233	0.2769	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0062	0.0585	0.069
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0172	0.0172
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0024	0.0024
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0283	0.9866
Brugia malayi	Fli-1 protein	0.0233	0.2769	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0172	0.0172
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1445	0.1705
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.1248
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1445	0.1705
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0362	0.1737
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0283	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0204	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0223	0.0804
Echinococcus multilocularis	zinc finger protein	0.0023	0.0079	0.0079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0172	0.0623
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0286	1
Echinococcus granulosus	lamin	0.0033	0.0204	0.0241
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0026	0.0116	0.0116
Echinococcus granulosus	Chromobox protein 3	0.0024	0.0092	0.0108
Schistosoma mansoni	hypothetical protein	0.0346	0.422	0.4977
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0283	0.0333
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0172	0.0203
Echinococcus granulosus	geminin	0.0346	0.422	0.4977
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0172	0.0623
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0275	0.0325
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.1669	0.1669
Loa Loa (eye worm)	acetyltransferase	0.0147	0.1669	0.6027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0283	0.7815
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.1358	0.5171
Brugia malayi	ecdysteroid receptor	0.003	0.0172	0.0623
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0172	0.0623
Loa Loa (eye worm)	hypothetical protein	0.003	0.0172	0.0623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0172	0.0623
Echinococcus multilocularis	chromobox protein 1	0.0145	0.1647	0.1647
Echinococcus granulosus	lamin dm0	0.0033	0.0204	0.0241
Echinococcus granulosus	intermediate filament protein	0.0033	0.0204	0.0241
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1358	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0172	0.0623
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0585	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0283	0.1021
Loa Loa (eye worm)	helicase	0.0024	0.0092	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0172	0.0623
Schistosoma mansoni	chromobox protein	0.0024	0.0092	0.0108
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0172	0.0203
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0002	0.0002
Onchocerca volvulus		0.003	0.0172	0.0989
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0024	0.0092	0.0675
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0283	0.1077
Echinococcus multilocularis	lamin dm0	0.0033	0.0204	0.0204
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.0609	0.0718
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0172	0.0989
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0984	0.116
Echinococcus multilocularis	Chromobox protein 3	0.0024	0.0092	0.0092
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.0609	0.0718
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0984	0.116
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0424	0.1532
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0172	0.0623
Echinococcus granulosus	tar DNA binding protein	0.0129	0.1445	0.1705
Echinococcus granulosus	zinc finger protein	0.0023	0.0079	0.0093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0172	0.0623
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0071	0.0071
Brugia malayi	Ets-domain containing protein	0.0077	0.0769	0.2779
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0172	0.0203
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0286	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0604	0.2182
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0283	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0283	0.1229
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0024	0.0092	0.0108
Echinococcus multilocularis	lamin	0.0033	0.0204	0.0204
Schistosoma mansoni	ap endonuclease	0.0039	0.0283	0.0333
Schistosoma mansoni	coup transcription factor	0.003	0.0172	0.0203
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.0769	0.0908
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0829	0.4746
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0172	0.0203
Schistosoma mansoni	ap endonuclease	0.0039	0.0283	0.0333
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0172	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0172	0.0623
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0002	0.0002
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0088	0.0909	1
Brugia malayi	steroid hormone receptor	0.003	0.0172	0.0623
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0283	0.1077
Toxoplasma gondii	exonuclease III APE	0.0039	0.0283	0.2082
Brugia malayi	Associated with TFs and helicases family protein	0.0024	0.0092	0.0331
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0172	0.0172
Plasmodium vivax	heterochromatin protein 1, putative	0.0024	0.0092	0.2532
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0204	0.0738
Echinococcus multilocularis	microtubule associated protein 2	0.0679	0.8478	0.8478
Onchocerca volvulus		0.0033	0.0204	0.1381
Plasmodium falciparum	heterochromatin protein 1	0.0024	0.0092	0.3197
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0002	0.0002
Echinococcus granulosus	chromobox protein 1	0.0145	0.1647	0.1942
Echinococcus granulosus	chromobox protein 2	0.0024	0.0092	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0172	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0331
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0172	0.0203
Trichomonas vaginalis	chromobox protein, putative	0.0145	0.1647	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.1358	1
Brugia malayi	chromobox protein homolog 3	0.0081	0.0829	0.2995

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1558377

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1425927