Detailed information for compound 1427573

Basic information

Technical information
  • TDR Targets ID: 1427573
  • Name: 6-hydrazinyl-N,N-di(propan-2-yl)pyridine-3-su lfonamide
  • MW: 272.367 | Formula: C11H20N4O2S
  • H donors: 2 H acceptors: 3 LogP: 1.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNc1ccc(cn1)S(=O)(=O)N(C(C)C)C(C)C
  • InChi: 1S/C11H20N4O2S/c1-8(2)15(9(3)4)18(16,17)10-5-6-11(14-12)13-7-10/h5-9H,12H2,1-4H3,(H,13,14)
  • InChiKey: JMGXAWUTRFIGLY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-hydrazino-N,N-diisopropyl-pyridine-3-sulfonamide
  • 6-hydrazino-N,N-diisopropyl-3-pyridinesulfonamide
  • ZINC06122026
  • MLS000761312
  • SMR000369623

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0422 0.3882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1393 0.1641
Loa Loa (eye worm) hypothetical protein 0.0459 0.4623 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0943 1
Brugia malayi steroid hormone receptor 0.002 0.0079 0.0051
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.1888 0.2223
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0192 0.0192
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1029 0.2131
Onchocerca volvulus 0.0246 0.2412 0.5135
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.1393 0.2929
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8491 1
Loa Loa (eye worm) hypothetical protein 0.0459 0.4623 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0056 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8491 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0079 0.0093
Brugia malayi hypothetical protein 0.0313 0.3113 0.6695
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.002 0.0079 0.0093
Onchocerca volvulus 0.0313 0.3113 0.6678
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0079 0.0051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0257 0.0257
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0192 0.1282
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0291 0.2886 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0079 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0091 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0079 0.0093
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Schistosoma mansoni Smad4 0.0018 0.0056 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0079 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0079 0.0093
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0379 0.3381
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0383 0.0383
Brugia malayi hypothetical protein 0.0028 0.0158 0.0224
Onchocerca volvulus 0.0031 0.0192 0.0248
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0422 0.0422
Loa Loa (eye worm) MBCTL1 0.0056 0.0454 0.0872
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0079 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2104 0.4485
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0079 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0079 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0192 0.0226
Schistosoma mansoni hypothetical protein 0.0076 0.0663 0.0781
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0079 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0271 0.2674 0.5733
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0158 0.0788
Schistosoma mansoni smad1 5 8 and 0.0018 0.0056 0.0066
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.0943 0.111
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.0943 0.0943
Echinococcus granulosus smad 0.0018 0.0056 0.0066
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0229 0.1622
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0079 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1393 0.1641
Loa Loa (eye worm) MH2 domain-containing protein 0.0261 0.2576 0.5518
Loa Loa (eye worm) hypothetical protein 0.0072 0.0617 0.123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.1393 0.1393
Onchocerca volvulus 0.0459 0.4623 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0079 0.0051
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0257 0.0303
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0079 0.0051
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.038 0.3397
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0663 0.1329
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0079 0.0093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0079 0.0051
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0422 0.0801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0079 0.0051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.1393 0.2929
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0079 0.0093
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.1888 0.1888
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.011 0.0949
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0422 0.3882
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0422 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.1393 0.1393
Brugia malayi mbt repeat family protein 0.0049 0.0383 0.0717
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.0617 0.0617
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0091 0.074
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0229 0.2697
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0079 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.0398
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.1956
Treponema pallidum hypothetical protein 0.0291 0.2886 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Brugia malayi hypothetical protein 0.0459 0.4623 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0079 0.0051
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0079 0.0079
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0291 0.2886 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0079 0.0079
Trypanosoma brucei unspecified product 0.0021 0.0091 0.074
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.0943 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0404 0.1351
Schistosoma mansoni hypothetical protein 0.0037 0.0257 0.0303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0079 0.0051
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0079 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0194 0.1883 0.1883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0079 0.0051
Schistosoma mansoni tsg101-related 0.006 0.0493 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.1393 0.1641
Brugia malayi nuclear hormone receptor 0.002 0.0079 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0238 0.0398
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0422 0.0496
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0454 0.0454
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0422 0.3882
Echinococcus granulosus dna polymerase kappa 0.0021 0.0091 0.0107
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0383 0.0451
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0422 0.1425
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.028
Trichomonas vaginalis hypothetical protein 0.0035 0.0235 0.062
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0454 0.0535
Brugia malayi N-terminal motif family protein 0.0218 0.2126 0.4534
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0422 0.3882
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0422 0.3882
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0422 0.1425
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0079 0.0093
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0383 0.0451
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0422 0.4334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0079 0.0051
Schistosoma mansoni kinase 0.0053 0.0418 0.0493
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0454 0.0535
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0079 0.0079
Echinococcus granulosus GPCR family 2 0.0035 0.0238 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0079 0.0051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0079 0.0093
Schistosoma mansoni lozenge 0.0058 0.0468 0.0551
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.028
Giardia lamblia Kinase, PLK 0.0104 0.0943 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0422 0.0496
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0091 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0422 0.1425
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0158 0.0788
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.0943 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0079 0.0093
Trypanosoma brucei protein kinase, putative 0.0053 0.0422 0.4334
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0079 0.0093
Brugia malayi Pre-SET motif family protein 0.0031 0.0192 0.0298
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0383 0.0451
Echinococcus multilocularis GPCR, family 2 0.0035 0.0238 0.0238
Echinococcus multilocularis dna polymerase eta 0.0049 0.038 0.038
Echinococcus granulosus Smad4 0.0018 0.0056 0.0066
Schistosoma mansoni thyroid hormone receptor 0.002 0.0079 0.0093
Schistosoma mansoni smad 0.0018 0.0056 0.0066
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2126 0.4506
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0091 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0192 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0192 0.0226
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0079 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0056 0.0066
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0422 0.0496
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0091 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0079 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Loa Loa (eye worm) transcription factor SMAD2 0.0261 0.2576 0.5518
Echinococcus multilocularis smad 0.0018 0.0056 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0257 0.0303
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.0943 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0079 0.0051
Loa Loa (eye worm) hypothetical protein 0.0313 0.3113 0.6695
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0079 0.0093
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.1956
Loa Loa (eye worm) hypothetical protein 0.0271 0.2674 0.5733
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0056 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0079 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2412 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.0617 0.0727
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8491 0.8491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0192 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0079 0.0051
Brugia malayi MH2 domain containing protein 0.0261 0.2576 0.5518
Schistosoma mansoni smad1 5 8 and 0.0018 0.0056 0.0066
Echinococcus granulosus FTZ F1 alpha 0.002 0.0079 0.0093
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0383 0.0451
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.1956
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0238 0.028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0663 0.1329
Brugia malayi ecdysteroid receptor 0.002 0.0079 0.0051
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0192 0.0226
Schistosoma mansoni DNA polymerase eta 0.0049 0.038 0.0448
Schistosoma mansoni nuclear hormone receptor 0.002 0.0079 0.0093
Brugia malayi hypothetical protein 0.0072 0.0617 0.123
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0454 0.0535
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0383 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0079 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0079 0.0079
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0383 0.0383
Schistosoma mansoni smad1 5 8 and 0.0018 0.0056 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0079 0.0093
Brugia malayi mbt repeat family protein 0.0049 0.0383 0.0717
Loa Loa (eye worm) hypothetical protein 0.0056 0.0454 0.0872
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.038 0.071
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1029 0.2131
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0091 0.074
Loa Loa (eye worm) runx1 0.0058 0.0468 0.0902
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0192 0.0298
Loa Loa (eye worm) hypothetical protein 0.0028 0.0158 0.0224
Brugia malayi hypothetical protein 0.0037 0.0257 0.0442
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0404 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0079 0.0051
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0454 0.0454
Schistosoma mansoni coup transcription factor 0.002 0.0079 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0943 0.111
Schistosoma mansoni tsg101-related 0.006 0.0493 0.058
Leishmania major hypothetical protein, conserved 0.0028 0.0158 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0079 0.0051
Echinococcus granulosus dna polymerase eta 0.0049 0.038 0.0448
Trypanosoma brucei polo-like protein kinase 0.0104 0.0943 1
Brugia malayi Pre-SET motif family protein 0.0216 0.2104 0.4485
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0158 0.1469
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0049 0.038 0.071
Brugia malayi hypothetical protein 0.0018 0.0056 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0422 0.1425
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0079 0.0093
Brugia malayi MAP kinase sur-1 0.0053 0.0422 0.0801
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0238 0.0238
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0454 0.0872
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0079 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0079 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0238 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0079 0.0093
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0091 0.0107
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.0943 0.1901
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Echinococcus multilocularis Protein lozenge 0.0058 0.0468 0.0468
Leishmania major DNA polymerase eta, putative 0.0035 0.0229 0.1622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0192 0.0226
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0091 0.074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0383 0.0717
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.028
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Brugia malayi nuclear receptor NHR-88 0.002 0.0079 0.0051
Schistosoma mansoni hypothetical protein 0.0301 0.2982 0.3512
Entamoeba histolytica hypothetical protein 0.0037 0.0257 0.1956
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0383 0.0717
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.1393 0.1641
Leishmania major DNA polymerase eta, putative 0.0049 0.038 0.3397
Plasmodium vivax SET domain protein, putative 0.0031 0.0192 0.0124
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0238 0.0398
Echinococcus multilocularis Smad4 0.0018 0.0056 0.0056
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0383 0.0669
Leishmania major hypothetical protein, conserved 0.0023 0.011 0.0226
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0291 0.2886 0.5
Schistosoma mansoni tsg101-related 0.0049 0.0379 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.1393 0.1641
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.018 0.0212
Onchocerca volvulus 0.0049 0.0383 0.0669
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0194 0.1883 0.2217
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0422 0.3882
Loa Loa (eye worm) hypothetical protein 0.0218 0.2126 0.4534
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0291 0.2886 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0422 0.3882
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0291 0.2886 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.011 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0079 0.0051
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.0943 0.1943
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.038 0.3885
Loa Loa (eye worm) hypothetical protein 0.002 0.0079 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0943 0.367
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0091 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0091 0.074
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0079 0.0051

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.3981 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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