Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Inositol-1 | 0.0045 | 0.3332 | 0.3332 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.2654 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.2583 | 0.7752 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3583 | 0.3873 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.2654 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.3332 | 0.4552 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.3332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4333 | 0.4683 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.3332 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1225 | 0.1225 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0811 | 0.1107 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3156 | 0.4312 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.3332 | 0.4552 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.2583 | 0.2792 |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.2583 | 0.7752 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.2583 | 0.2792 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0291 | 0.0397 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.732 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.2583 | 0.7752 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.3332 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.3332 | 0.3602 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.3332 | 0.4193 |
Brugia malayi | Cytochrome P450 family protein | 0.008 | 0.8461 | 0.8461 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.008 | 0.8461 | 0.9147 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.3332 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3156 | 0.4312 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.3332 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0476 | 0.0515 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.2583 | 0.2583 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0811 | 0.1107 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0291 | 0.0366 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3571 | 0.3571 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.2583 | 0.7752 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0476 | 0.0599 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.3332 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.2583 | 0.7752 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0291 | 0.0397 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.3332 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.3332 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.3332 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.3332 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0811 | 0.102 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.3332 | 0.4193 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7947 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.2583 | 0.2583 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3998 | 0.4322 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.2583 | 0.2792 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.3332 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.