Detailed information for compound 1435609

Basic information

Technical information
  • TDR Targets ID: 1435609
  • Name: 8-[4-[di(phenyl)methyl]piperazin-1-yl]-3,7-di methylpurine-2,6-dione
  • MW: 430.502 | Formula: C24H26N6O2
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(nc2c1c(=O)[nH]c(=O)n2C)N1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C24H26N6O2/c1-27-20-21(28(2)24(32)26-22(20)31)25-23(27)30-15-13-29(14-16-30)19(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19H,13-16H2,1-2H3,(H,26,31,32)
  • InChiKey: LDNGXOJWSVZYJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[4-[di(phenyl)methyl]piperazin-1-yl]-3,7-dimethyl-purine-2,6-dione
  • 8-[4-[di(phenyl)methyl]-1-piperazinyl]-3,7-dimethylpurine-2,6-dione
  • 8-[4-[di(phenyl)methyl]piperazin-1-yl]-3,7-dimethyl-xanthine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0644 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0184 0.0367
Brugia malayi Animal haem peroxidase family protein 0.0237 0.2384 0.7719
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.012 0.0213
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0184 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Mycobacterium tuberculosis Conserved protein 0.0037 0.033 0.1347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0184 0.0367
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0062 0.0048
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0182 0.2803
Schistosoma mansoni thyroid hormone receptor 0.0151 0.1503 0.2993
Brugia malayi nuclear receptor RXR 0.0011 0.0062 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0037 0.033 0.5276
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.0239
Onchocerca volvulus 0.0237 0.2384 0.7719
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0055
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0062 0.0096
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.2384 0.7267
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0075 0.0149
Brugia malayi nuclear receptor RXR 0.0012 0.0075 0.02
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Onchocerca volvulus 0.0035 0.0309 0.0961
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0062 0.0148
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0062 0.0157
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0182 1
Mycobacterium ulcerans sulfatase 0.0009 0.0043 0.0922
Brugia malayi hypothetical protein 0.0012 0.0075 0.02
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Echinococcus granulosus protein cereblon 0.0305 0.3085 0.6133
Schistosoma mansoni nuclear receptor 0.0011 0.0062 0.0123
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0184 0.0555
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0188
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0062 0.0157
Schistosoma mansoni DNA helicase recq1 0.0009 0.0045 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Loa Loa (eye worm) hypothetical protein 0.0324 0.3276 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0184 0.0555
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0014 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.033 0.5016
Schistosoma mansoni DNA helicase recq5 0.0009 0.0045 0.009
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0062 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.033 0.1347
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0062 0.0123
Onchocerca volvulus Protein cereblon homolog 0.0305 0.3085 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Schistosoma mansoni hypothetical protein 0.0173 0.1728 0.3441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0149 0.2262
Schistosoma mansoni hypothetical protein 0.0035 0.0314 0.0626
Schistosoma mansoni peroxidasin 0.0237 0.2384 0.4749
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0041 0.0055
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0043 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0043 0.0922
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0006 0.0014 0.0044
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0045 0.0063
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Brugia malayi hypothetical protein 0.0012 0.0075 0.02
Echinococcus granulosus bloom syndrome protein 0.0022 0.0176 0.0325
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0034 0.0628
Brugia malayi beta-lactamase 0.0037 0.033 0.103
Brugia malayi Blistered cuticle protein 3 0.0237 0.2384 0.7719
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0182 0.0547
Loa Loa (eye worm) hypothetical protein 0.0035 0.0314 0.0921
Echinococcus multilocularis geminin 0.0173 0.1728 0.1716
Brugia malayi nuclear hormone receptor 0.0011 0.0062 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.033 0.1347
Toxoplasma gondii thioredoxin reductase 0.0064 0.0613 0.978
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0184 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0184 0.0555
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0045 0.0097
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0644 0.2054
Brugia malayi nuclear receptor NHR-67 0.0011 0.0062 0.0157
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0062 0.0148
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0184 0.0367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0184 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0004 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.033 0.103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0184 0.0555
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0182 0.0336
Brugia malayi steroid hormone receptor 0.0023 0.0184 0.0555
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0182 0.2665
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0309 0.0905
Brugia malayi Thioredoxin reductase 0.0064 0.0613 0.1953
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0708 0.141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.033 0.1347
Mycobacterium tuberculosis Conserved protein 0.0037 0.033 0.1347
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0045 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 1
Onchocerca volvulus Peroxidasin homolog 0.0237 0.2384 0.7719
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0182 0.2665
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0182 0.5313
Brugia malayi hypothetical protein 0.0237 0.2384 0.7719
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.012 0.0107
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Plasmodium falciparum thioredoxin reductase 0.0022 0.0182 0.2803
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0104 0.1507
Brugia malayi nuclear receptor NHR-88 0.0023 0.0184 0.0555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0184 0.0522
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0184 0.0367
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0176 0.053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0062 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0176 0.0163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.033 0.097
Trichomonas vaginalis helicase, putative 0.0008 0.0034 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0184 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0184 0.034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0064 0.0613 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0099
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0182 0.2899
Entamoeba histolytica disulphide oxidoreductase, putative 0.0006 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0097
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0182 0.5313
Brugia malayi hypothetical protein 0.0011 0.0062 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.033 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0075 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus multilocularis cpg binding protein 0.0037 0.0329 0.0316
Onchocerca volvulus Peroxidase homolog 0.0237 0.2384 0.7719
Mycobacterium leprae conserved hypothetical protein 0.0037 0.033 1
Trypanosoma brucei trypanothione reductase 0.0064 0.0613 0.9507
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0644 0.0632
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0184 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0188
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0627 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0062 0.0096
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0182 0.5313
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0006 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0045 0.0721
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0062 0.0096
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2379 0.7702
Plasmodium vivax thioredoxin reductase, putative 0.0064 0.0613 1
Brugia malayi beta-lactamase family protein 0.0037 0.033 0.103
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0176 0.5145
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0184 0.0555
Onchocerca volvulus 0.0011 0.0062 0.0157
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0182 0.2665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.033 0.0657
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2379 0.7251
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0188
Trichomonas vaginalis esterase, putative 0.0037 0.033 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0043 0.0095
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0062 0.0048
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0045 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0184 0.0522
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Onchocerca volvulus Peroxidasin homolog 0.0237 0.2384 0.7719
Loa Loa (eye worm) thioredoxin reductase 0.0064 0.0613 0.1838
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0014 0.0219
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0613 0.9507
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0188
Echinococcus granulosus GPCR family 2 0.0016 0.012 0.0213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.012 0.0347
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0182 1
Echinococcus granulosus geminin 0.0173 0.1728 0.3423
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.033 0.1347
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.033 1
Schistosoma mansoni hypothetical protein 0.0129 0.1272 0.2533
Brugia malayi nuclear hormone receptor 0.0023 0.0184 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0028
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0072 0.093
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0043 0.0922
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0043 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0184 0.034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0184 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0045 0.0103
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.0239
Brugia malayi CXXC zinc finger family protein 0.0035 0.0309 0.0961
Brugia malayi ecdysone receptor 0.0011 0.0062 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0237 0.2384 0.7719
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0353 0.034
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0184 0.0171
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0072 0.0235
Giardia lamblia Hypothetical protein 0.0009 0.0043 0.1735
Mycobacterium leprae Probable lipase LipE 0.0037 0.033 1
Schistosoma mansoni cpg binding protein 0.0035 0.0309 0.0615
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0043 0.0922
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0062 0.0048
Brugia malayi ecdysteroid receptor 0.0023 0.0184 0.0555
Treponema pallidum oxidoreductase 0.0006 0.0014 0.0754
Entamoeba histolytica hypothetical protein, conserved 0.0305 0.3085 1
Leishmania major trypanothione reductase 0.0064 0.0613 0.9507
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0089
Loa Loa (eye worm) DR-78 0.0011 0.0062 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0062 0.0123
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0184 0.0522
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0045 0.0526
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0182 0.0716
Treponema pallidum NADH oxidase 0.0022 0.0182 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.033 0.0657
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0063 0.0151
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0045 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0041 0.0028
Plasmodium falciparum glutathione reductase 0.0022 0.0182 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0014 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0184 0.034
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0184 0.034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.033 0.1347
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0075 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0062 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0184 0.0367
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0182 0.2899
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0182 0.2803
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0072 0.093
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0184 0.0555
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0182 0.2665
Toxoplasma gondii ABC1 family protein 0.0037 0.033 0.5264
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0121 0.035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.033 0.0317
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0184 0.0171
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0102 0.1631
Onchocerca volvulus 0.0237 0.2384 0.7719
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.033 0.5016
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0072 0.093
Echinococcus multilocularis peroxidasin 0.0237 0.2384 0.2374
Brugia malayi hypothetical protein 0.0305 0.3085 1
Plasmodium falciparum glutathione reductase 0.0064 0.0613 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0184 0.0555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0034 0.0628
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0182 0.0168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0062 0.0148
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0043 0.0922
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0184 0.0171
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0043 0.0124
Brugia malayi Animal haem peroxidase family protein 0.0237 0.2384 0.7719
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5021 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0184 0.034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0184 0.0555
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0006 0.0014 0.0219
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0644 0.126
Onchocerca volvulus 0.0037 0.033 0.103
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0045 0.0103
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.033 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0184 0.0555
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.033 0.1347
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0062 0.0156
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0022 0.0182 0.5313
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0182 0.2665
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0062 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.033 0.5016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0075 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0184 0.0555
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0182 0.2665
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.033 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0129 0.0258
Schistosoma mansoni cpg binding protein 0.0037 0.0329 0.0655
Leishmania major hypothetical protein, conserved 0.0037 0.033 0.5016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0182 1
Echinococcus granulosus peroxidasin 0.0237 0.2384 0.4734
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0006 0.0014 0.0044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0064 0.0613 0.2553
Mycobacterium ulcerans hydrolase 0.0009 0.0043 0.0922
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0045 0.0721
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0184 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0353 0.0678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0184 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0184 0.0367
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0481 0.1523
Echinococcus granulosus thioredoxin glutathione reductase 0.0064 0.0613 0.1198
Onchocerca volvulus Chorion peroxidase homolog 0.0237 0.2384 0.7719
Schistosoma mansoni hypothetical protein 0.0305 0.3085 0.6144
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0034 0.0628
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.2384 0.7267
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.033 0.0632
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0062 0.0048
Brugia malayi hypothetical protein 0.0011 0.0062 0.0157
Brugia malayi Sulfatase family protein 0.0009 0.0043 0.0095
Onchocerca volvulus 0.0037 0.033 0.103
Giardia lamblia Hypothetical protein 0.0009 0.0043 0.1735
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0062 0.0157
Mycobacterium ulcerans hypothetical protein 0.0037 0.033 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0184 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0184 0.0522
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.012 0.0213
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.2384 0.7267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0184 0.0555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0062 0.0123
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0184 0.0522
Brugia malayi Latrophilin receptor protein 2 0.0016 0.012 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0089
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0006 0.0014 0.0219
Loa Loa (eye worm) RecQ helicase 0.0022 0.0176 0.0499
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0006 0.0014 0.0219
Schistosoma mansoni glutamate synthase 0.0006 0.0014 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0184 0.034
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0182 0.2803
Brugia malayi conserved hypotetical protein 0.0011 0.0062 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0184 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0184 0.0171
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0182 0.5313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0182 0.0716
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0314 0.0979
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0072 0.1854
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0481 0.1434
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1272 0.2512
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0184 0.034
Schistosoma mansoni disulfide oxidoreductase 0.0006 0.0014 0.0027
Schistosoma mansoni nuclear receptor 0.0011 0.0062 0.0123
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0184 0.0367
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0182 0.2665
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0184 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Onchocerca volvulus Peroxidase homolog 0.0237 0.2384 0.7719
Brugia malayi beta-lactamase family protein 0.0037 0.033 0.103
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0644 0.1283
Schistosoma mansoni sulfide quinone reductase 0.0006 0.0014 0.0027
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0182 0.2803
Onchocerca volvulus Dual oxidase homolog 0.0237 0.2384 0.7719
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0182 0.2665
Mycobacterium ulcerans lipase LipD 0.0037 0.033 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0075 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Onchocerca volvulus 0.0037 0.033 0.103
Onchocerca volvulus 0.0011 0.0062 0.0157
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0182 0.5313
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2362 1
Entamoeba histolytica thioredoxin reductase, putative 0.0006 0.0014 0.0044
Schistosoma mansoni hypothetical protein 0.0173 0.1728 0.3441
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0184 0.0555
Schistosoma mansoni cpg binding protein 0.0037 0.0329 0.0655
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.2384 0.7267
Loa Loa (eye worm) hypothetical protein 0.0037 0.033 0.097
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0062 0.0123
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0062 0.0157
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.0239
Schistosoma mansoni coup transcription factor 0.0023 0.0184 0.0367
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0062 0.0157
Schistosoma mansoni thyroid hormone receptor 0.0151 0.1503 0.2993
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.033 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.033 0.1347
Loa Loa (eye worm) beta-lactamase 0.0037 0.033 0.097
Brugia malayi nuclear receptor NHR-88 0.0011 0.0062 0.0157
Loa Loa (eye worm) hypothetical protein 0.0237 0.2384 0.7267
Schistosoma mansoni hypothetical protein 0.0494 0.5021 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0644 0.2089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0184 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Schistosoma mansoni hypothetical protein 0.0006 0.0014 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0184 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0644 0.1933
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.012 0.0326
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0182 0.0716
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0184 0.0367
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Schistosoma mansoni zinc finger protein 0.0011 0.0062 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0184 0.0555
Echinococcus multilocularis GPCR, family 2 0.0016 0.012 0.0107
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0182 0.0716
Schistosoma mansoni peroxidasin 0.0237 0.2384 0.4749
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.012 0.0107
Brugia malayi glutathione reductase 0.0064 0.0613 0.1953
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0176 0.5145
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0045 0.1875
Loa Loa (eye worm) hypothetical protein 0.0305 0.3085 0.9414
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Echinococcus multilocularis protein cereblon 0.0305 0.3085 0.3075
Brugia malayi Animal haem peroxidase family protein 0.0237 0.2384 0.7719
Brugia malayi Peroxidasin 0.0237 0.2384 0.7719
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0062 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Brugia malayi hypothetical protein 0.0124 0.1228 0.3954
Loa Loa (eye worm) hypothetical protein 0.0023 0.0184 0.0522
Echinococcus granulosus cpg binding protein 0.0037 0.0329 0.063
Loa Loa (eye worm) glutathione reductase 0.0064 0.0613 0.1838
Mycobacterium tuberculosis Conserved protein 0.0037 0.033 0.1347
Mycobacterium ulcerans beta-lactamase 0.0037 0.033 1
Plasmodium vivax glutathione reductase, putative 0.0064 0.0613 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1272 0.126
Schistosoma mansoni glutamate synthase 0.0006 0.0014 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Schistosoma mansoni glutamate synthase 0.0006 0.0014 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0034 0.0628
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0041 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0062 0.0048
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0062 0.0157
Loa Loa (eye worm) hypothetical protein 0.0052 0.0481 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0184 0.0555
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0043 0.0124
Treponema pallidum thioredoxin reductase (trxB) 0.0006 0.0014 0.0754
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0043 0.0922
Onchocerca volvulus 0.0023 0.0184 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0326
Plasmodium falciparum thioredoxin reductase 0.0064 0.0613 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0184 0.0367
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0075 0.02
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0184 0.0555
Toxoplasma gondii selenide, water dikinase 0.0006 0.0014 0.0219
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0006 0.0014 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0043 0.0922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0481 0.1523
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.1503 0.1491
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0121 0.035
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0182 0.2665
Brugia malayi hypothetical protein 0.0009 0.0043 0.0095
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0182 0.0362
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0062 0.0157
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5021 0.5014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0184 0.0367
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0062 0.0096
Brugia malayi Animal haem peroxidase family protein 0.0237 0.2384 0.7719
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0182 0.2665
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0075 0.0061
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0043 0.0124
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.036
Onchocerca volvulus 0.0237 0.2384 0.7719
Brugia malayi tailless protein 0.0011 0.0062 0.0157
Loa Loa (eye worm) blistered cuticle protein 3 0.0237 0.2384 0.7267

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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