Detailed information for compound 1435749

Basic information

Technical information
  • TDR Targets ID: 1435749
  • Name: 2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]- N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamid e
  • MW: 367.465 | Formula: C20H21N3O2S
  • H donors: 2 H acceptors: 2 LogP: 3.93 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)nc([nH]2)SCC(=O)NC1CCCc2c1cccc2
  • InChi: 1S/C20H21N3O2S/c1-25-14-9-10-17-18(11-14)23-20(22-17)26-12-19(24)21-16-8-4-6-13-5-2-3-7-15(13)16/h2-3,5,7,9-11,16H,4,6,8,12H2,1H3,(H,21,24)(H,22,23)
  • InChiKey: YBUXXBLQMZRFFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-tetralin-1-yl-acetamide
  • 2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-(1-tetralinyl)acetamide
  • 2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-tetralin-1-yl-acetamide
  • 2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)ethanamide
  • MLS000334011
  • SMR000248769
  • T5239050

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.002 0.0213 0.0216
Toxoplasma gondii prolyl endopeptidase 0.0128 0.3473 0.8792
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.1079 0.1138
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0213 0.0216
Leishmania major cathepsin L-like protease 0.0077 0.1924 0.5527
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0077 0.0404
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0914 0.0776
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0914 0.0962
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0099 0.0256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.2754 0.2921
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Loa Loa (eye worm) animal heme peroxidase 0.0252 0.7207 0.7204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Onchocerca volvulus Cathepsin L homolog 0.002 0.0213 0.0216
Leishmania major cathepsin L-like protease 0.002 0.0213 0.0587
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0213 0.0587
Brugia malayi glutathione reductase 0.0069 0.167 0.1768
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0099 0.0916
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trypanosoma brucei poly(adp-ribose) polymerase 0.0076 0.1901 0.5462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0213 0.1977
Mycobacterium ulcerans beta-lactamase 0.0043 0.0914 0.7214
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1768 0.5075
Mycobacterium tuberculosis Conserved protein 0.0043 0.0914 0.0776
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0376 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0914 0.0776
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0376 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0777 0.7204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0914 0.0962
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0914 0.2609
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0076 0.1901 0.2014
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0006
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.001 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0777 0.7204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.1079 0.1138
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.1079 0.3086
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0012 0.0002
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Mycobacterium tuberculosis Probable peptidase 0.0051 0.1143 0.1075
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.032 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0777 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Toxoplasma gondii ABC1 family protein 0.0043 0.0914 0.2294
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0601 0.0629
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0914 0.0962
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.015 0.0405
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0139 0.3785 0.402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.1079 0.1138
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0213 0.1224
Brugia malayi Cathepsin L-like precursor 0.0014 0.0012 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.167 0.4794
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trypanosoma brucei prolyl endopeptidase 0.0128 0.3473 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.3473 0.3687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Plasmodium falciparum thioredoxin reductase 0.0024 0.032 0.1868
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0477 0.4418
Echinococcus multilocularis ferritin 0.0026 0.0376 0.0389
Brugia malayi WGR domain containing protein 0.0076 0.1901 0.2014
Echinococcus granulosus poly (ADP ribose) polymerase 0.0043 0.0903 0.0951
Trypanosoma brucei trypanothione reductase 0.0069 0.167 0.4794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0099 0.0916
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0914 0.7214
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0254 0.0259
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.032 0.0896
Schistosoma mansoni ferritin 0.0026 0.0376 0.0389
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.167 0.1768
Brugia malayi Animal haem peroxidase family protein 0.0252 0.7207 0.7663
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.2754 0.2921
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.032 0.0896
Brugia malayi beta-lactamase family protein 0.0043 0.0914 0.0962
Onchocerca volvulus 0.0252 0.7207 0.7663
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7969 1
Leishmania major hypothetical protein, conserved 0.003 0.0521 0.1475
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0521 0.1475
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0099 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Toxoplasma gondii cathepsin CPL 0.002 0.0213 0.0516
Onchocerca volvulus 0.0252 0.7207 0.7663
Brugia malayi beta-lactamase family protein 0.0043 0.0914 0.0962
Entamoeba histolytica hypothetical protein, conserved 0.0325 0.9402 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.1079 0.1138
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0914 0.5442
Onchocerca volvulus Peroxidase homolog 0.0252 0.7207 0.7663
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0213 0.0216
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.167 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1768 0.5075
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0213 0.0216
Mycobacterium ulcerans hypothetical protein 0.0043 0.0914 0.7214
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0094
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.3473 1
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0857 0.0901
Schistosoma mansoni hypothetical protein 0.0033 0.0601 0.0629
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0213 0.0216
Toxoplasma gondii thioredoxin reductase 0.0069 0.167 0.4215
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.1143 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Leishmania major cathepsin L-like protease 0.002 0.0213 0.0587
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.032 0.0896
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0914 0.2609
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0601 0.0591
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0376 0.0675
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0076 0.1901 0.2014
Echinococcus multilocularis peroxidasin 0.0252 0.7207 0.7663
Leishmania major trypanothione reductase 0.0069 0.167 0.4794
Echinococcus granulosus GPCR family 2 0.0033 0.0601 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.032 0.1868
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0213 0.1977
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Brugia malayi Peroxidasin 0.0252 0.7207 0.7663
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.373 0.396
Mycobacterium leprae Probable lipase LipE 0.0043 0.0914 0.7214
Schistosoma mansoni hypothetical protein 0.0071 0.1757 0.186
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0076 0.1901 0.5462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.1143 0.3271
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1924 0.5527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0099 0.0256
Onchocerca volvulus 0.0014 0.0012 0.0002
Entamoeba histolytica cysteine protease, putative 0.002 0.0213 0.0216
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.032 0.033
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0012 0.0002
Schistosoma mansoni hypothetical protein 0.0137 0.373 0.396
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0213 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Trichomonas vaginalis esterase, putative 0.0043 0.0914 0.847
Onchocerca volvulus 0.002 0.0213 0.0216
Onchocerca volvulus 0.002 0.0213 0.0216
Brugia malayi cathepsin L-like precursor 0.0014 0.0012 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0399 0.3702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0914 0.0962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.032 0.0896
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0914 0.7214
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0914 0.847
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0219 0.1256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0012 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0002
Loa Loa (eye worm) cysteine protease 0.002 0.0213 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1924 0.5527
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0213 0.0216
Brugia malayi WGR domain containing protein 0.0139 0.3785 0.402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0485 0.4499
Schistosoma mansoni ferritin light chain 0.0026 0.0376 0.0389
Echinococcus granulosus protein cereblon 0.0325 0.9402 1
Onchocerca volvulus 0.0043 0.0914 0.0962
Brugia malayi hypothetical protein 0.0252 0.7207 0.7663
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0304 0.0312
Brugia malayi hypothetical protein 0.002 0.0196 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0485 0.4499
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0376 1
Onchocerca volvulus 0.002 0.0213 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0863 0.8002
Schistosoma mansoni ferritin 0.0026 0.0376 0.0389
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Leishmania major cysteine peptidase A (CPA) 0.002 0.0213 0.0587
Echinococcus granulosus peroxidasin 0.0252 0.7207 0.7663
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0521 0.1475
Onchocerca volvulus Peroxidasin homolog 0.0252 0.7207 0.7663
Schistosoma mansoni hypothetical protein 0.0033 0.0601 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Plasmodium falciparum glutathione reductase 0.0069 0.167 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.032 0.5
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0099 0.0094
Schistosoma mansoni peroxidasin 0.0252 0.7207 0.7663
Schistosoma mansoni hypothetical protein 0.0184 0.5157 0.548
Schistosoma mansoni thyroid hormone receptor 0.0148 0.4061 0.4313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0213 0.1224
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0521 0.3077
Brugia malayi follicle stimulating hormone receptor 0.0252 0.7194 0.7649
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0076 0.1901 0.5462
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1768 0.1871
Onchocerca volvulus 0.002 0.0213 0.0216
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0304 0.2815
Echinococcus granulosus poly ADP ribose polymerase 1 0.0139 0.3785 0.402
Echinococcus granulosus ferritin 0.0026 0.0376 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Giardia lamblia GTOR 0.0049 0.1079 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.015 0.0405
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1768 0.1871
Loa Loa (eye worm) glutathione reductase 0.0069 0.167 0.1662
Echinococcus multilocularis protein cereblon 0.0325 0.9402 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0213 0.0216
Onchocerca volvulus Peroxidasin homolog 0.0252 0.7207 0.7663
Loa Loa (eye worm) beta-lactamase 0.0043 0.0914 0.0904
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0914 0.0776
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0213 0.0216
Loa Loa (eye worm) hypothetical protein 0.0128 0.3473 0.3467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0485 0.4499
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.3473 0.3687
Echinococcus multilocularis expressed protein 0.0026 0.0376 0.0389
Schistosoma mansoni hypothetical protein 0.0033 0.0601 0.0629
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0778 0.2218
Onchocerca volvulus Chorion peroxidase homolog 0.0252 0.7207 0.7663
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0213 0.1224
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0914 0.7214
Mycobacterium tuberculosis Conserved protein 0.0043 0.0914 0.0776
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.1079 0.3086
Schistosoma mansoni ferritin light chain 0.0026 0.0376 0.0389
Trichomonas vaginalis ferritin, putative 0.0026 0.0376 0.3484
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0213 0.0203
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0213 0.0203
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1924 0.5527
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0857 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.032 0.2969
Onchocerca volvulus Protein cereblon homolog 0.0325 0.9402 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0254 0.0259
Echinococcus granulosus cathepsin l1 0.002 0.0213 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0099 0.0916
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0002
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0066 0.1591 0.1684
Brugia malayi Animal haem peroxidase family protein 0.0252 0.7207 0.7663
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0601 0.0629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0099 0.0094
Loa Loa (eye worm) animal heme peroxidase 0.0252 0.7207 0.7204
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.032 0.033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.4061 0.4313
Onchocerca volvulus 0.002 0.0213 0.0216
Echinococcus multilocularis geminin 0.0184 0.5157 0.548
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.1143 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0521 0.1475
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1924 0.5527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0012 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trypanosoma cruzi oligopeptidase b 0.0051 0.1143 0.3271
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.013 0.0128
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.1079 0.1138
Leishmania major cathepsin L-like protease 0.002 0.0213 0.0587
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Loa Loa (eye worm) hypothetical protein 0.003 0.0521 0.0511
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.3473 0.3687
Onchocerca volvulus Cathepsin F homolog 0.002 0.0213 0.0216
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.032 0.0787
Echinococcus granulosus WGR domain containing protein 0.0043 0.0903 0.0951
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0914 0.847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0562 0.5205
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0055 0.1252 0.1243
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0914 0.847
Loa Loa (eye worm) hypothetical protein 0.0033 0.0601 0.0591
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0914 0.847
Onchocerca volvulus 0.0252 0.7207 0.7663
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.1143 0.3271
Brugia malayi MH2 domain containing protein 0.0115 0.3078 0.3266
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.373 0.396
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0099 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0099 0.0916
Plasmodium falciparum thioredoxin reductase 0.0069 0.167 1
Trypanosoma cruzi oligopeptidase b 0.0051 0.1143 0.3271
Brugia malayi Animal haem peroxidase family protein 0.0252 0.7207 0.7663
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0701 0.1754
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0521 0.3077
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.3473 0.3687
Schistosoma mansoni ferritin 0.0026 0.0376 0.0389
Brugia malayi Blistered cuticle protein 3 0.0252 0.7207 0.7663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0401 0.3713
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0914 0.847
Brugia malayi Animal haem peroxidase family protein 0.0252 0.7207 0.7663
Echinococcus granulosus poly adp ribose polymerase 2 0.0076 0.1901 0.2014
Schistosoma mansoni apoferritin-2 0.0026 0.0376 0.0389
Loa Loa (eye worm) hypothetical protein 0.0076 0.1901 0.1893
Brugia malayi hypothetical protein 0.0132 0.3593 0.3815
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0072 0.0156
Loa Loa (eye worm) blistered cuticle protein 3 0.0252 0.7207 0.7204
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.1079 0.3086
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0069 0.167 0.1765
Onchocerca volvulus 0.0043 0.0914 0.0962
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0099 0.0094
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0139 0.3785 0.402
Onchocerca volvulus Cathepsin L homolog 0.002 0.0213 0.0216
Schistosoma mansoni hypothetical protein 0.0033 0.0601 0.0629
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0213 0.0216
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Leishmania major cathepsin L-like protease 0.0077 0.1924 0.5527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0399 0.3702
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.032 0.2969
Loa Loa (eye worm) hypothetical protein 0.0018 0.015 0.014
Loa Loa (eye worm) animal heme peroxidase 0.0252 0.7207 0.7204
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0304 0.2815
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.032 0.0896
Loa Loa (eye worm) RecQ helicase 0.0023 0.0304 0.0294
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0601 0.0629
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0914 0.0776
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.1143 0.3271
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.032 0.1868
Onchocerca volvulus 0.002 0.0213 0.0216
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0304 0.0312
Echinococcus multilocularis cysteine protease 0.002 0.0213 0.0216
Schistosoma mansoni apoferritin-2 0.0026 0.0376 0.0389
Loa Loa (eye worm) ctsf protein 0.002 0.0213 0.0203
Loa Loa (eye worm) hypothetical protein 0.0043 0.0914 0.0904
Loa Loa (eye worm) hypothetical protein 0.0325 0.9402 0.9401
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0099 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0162 0.0152
Schistosoma mansoni hypothetical protein 0.0325 0.9402 1
Brugia malayi beta-lactamase 0.0043 0.0914 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.167 0.1768
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.032 0.1868
Entamoeba histolytica hypothetical protein 0.0022 0.0254 0.0259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.7194 0.7191
Plasmodium vivax thioredoxin reductase, putative 0.0069 0.167 1
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.015 0.0405
Loa Loa (eye worm) fibroinase 0.002 0.0213 0.0203
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.032 0.0787
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1768 0.1871
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0144 0.3949 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0099 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0477 0.4418
Leishmania major oligopeptidase b 0.0051 0.1143 0.3271
Leishmania major hypothetical protein, conserved 0.0018 0.015 0.0405
Onchocerca volvulus Peroxidase homolog 0.0252 0.7207 0.7663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Plasmodium vivax vivapain-2 0.002 0.0213 0.1224
Schistosoma mansoni thyroid hormone receptor 0.0148 0.4061 0.4313
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1428 0.4094
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0139 0.3785 0.402
Leishmania major cathepsin L-like protease 0.0077 0.1924 0.5527
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.1079 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0099 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Echinococcus multilocularis cysteine protease 0.002 0.0213 0.0216
Plasmodium falciparum glutathione reductase 0.0024 0.032 0.1868
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.1079 0.3086
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.1079 0.3086
Echinococcus granulosus expressed protein 0.0026 0.0376 0.0389
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.013 0.0128
Leishmania major cathepsin L-like protease 0.002 0.0213 0.0587
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.1143 0.3271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0914 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.032 0.2902
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.1143 0.1075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.032 0.033
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0217 0.0597
Loa Loa (eye worm) hypothetical protein 0.0071 0.1757 0.1749
Mycobacterium tuberculosis Conserved protein 0.0043 0.0914 0.0776
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0016 0.0006
Onchocerca volvulus 0.0043 0.0914 0.0962
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.032 0.1868
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1768 0.1871
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0601 0.0629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Brugia malayi hypothetical protein 0.003 0.0521 0.0544
Brugia malayi hypothetical protein 0.0325 0.9402 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.032 0.0896
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.3078 0.3071
Leishmania major DNA repair protein, putative 0.0018 0.015 0.0405
Onchocerca volvulus DNA ligase 3 homolog 0.0018 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0203
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Leishmania major cathepsin L-like protease 0.002 0.0213 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1079 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.1079 0.1138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0016 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0777 0.7204
Loa Loa (eye worm) animal heme peroxidase 0.0252 0.7207 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0401 0.3713
Brugia malayi Thioredoxin reductase 0.0069 0.167 0.1768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0914 0.0904
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.032 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0778 0.2218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0777 0.7204
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0399 0.3702
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0914 0.0776
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0376 0.0073
Trypanosoma brucei oligopeptidase b 0.0051 0.1143 0.3271
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0914 0.0776
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0099 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0914 0.2609
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0032 0.0564 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0701 0.6498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0914 0.0776
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1079 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Brugia malayi Cathepsin L-like precursor 0.0014 0.0012 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0213 0.1977
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0213 0.0216
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.3078 0.3071
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.1079 0.3086
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0601 0.0629
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0099 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0302 0.0842
Plasmodium vivax vivapain-2 0.002 0.0213 0.1224
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.032 0.0896
Plasmodium vivax glutathione reductase, putative 0.0069 0.167 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0601 0.0629
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1768 0.1871
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.032 0.0896
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1723 0.4946
Brugia malayi Animal haem peroxidase family protein 0.0252 0.7207 0.7663
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.3067 0.3591
Mycobacterium ulcerans lipase LipD 0.0043 0.0914 0.7214
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1768 0.5075
Schistosoma mansoni ferritin 0.0026 0.0376 0.0389
Echinococcus granulosus prolyl endopeptidase 0.0128 0.3473 0.3687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1924 0.5527
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.3473 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.3473 0.3687
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0254 0.0259
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1757 0.186
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0213 0.0216
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0521 0.1297
Loa Loa (eye worm) hypothetical protein 0.0252 0.7207 0.7204
Schistosoma mansoni hypothetical protein 0.0184 0.5157 0.548
Echinococcus granulosus bloom syndrome protein 0.0023 0.0304 0.0312
Onchocerca volvulus Dual oxidase homolog 0.0252 0.7207 0.7663
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0521 0.3077
Echinococcus granulosus cathepsin l1 0.0014 0.0012 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1079 1
Trypanosoma brucei DNA repair protein, putative 0.0018 0.015 0.0405
Loa Loa (eye worm) hypothetical protein 0.0105 0.2754 0.2747
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.1143 0.3271
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0601 0.0629
Echinococcus granulosus geminin 0.0184 0.5157 0.548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0401 0.3713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0593 0.5501
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1768 0.5075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0213 0.1977
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.032 0.0896
Leishmania major hypothetical protein, conserved 0.0043 0.0914 0.2609
Brugia malayi Cathepsin L-like precursor 0.002 0.0213 0.0216
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1768 0.1759
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0376 0.0675
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0376 0.0073
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0778 0.2218
Loa Loa (eye worm) hypothetical protein 0.0106 0.2787 0.278
Schistosoma mansoni peroxidasin 0.0252 0.7207 0.7663
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0013 0.001 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0401 0.3713
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.2754 0.2747

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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