Detailed information for compound 1436751

Basic information

Technical information
  • TDR Targets ID: 1436751
  • Name: methyl 1-[2-[(4-tert-butylphenyl)methyl-methy lamino]acetyl]piperidine-4-carboxylate
  • MW: 360.49 | Formula: C21H32N2O3
  • H donors: 0 H acceptors: 2 LogP: 3.3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1CCN(CC1)C(=O)CN(Cc1ccc(cc1)C(C)(C)C)C
  • InChi: 1S/C21H32N2O3/c1-21(2,3)18-8-6-16(7-9-18)14-22(4)15-19(24)23-12-10-17(11-13-23)20(25)26-5/h6-9,17H,10-15H2,1-5H3
  • InChiKey: QVIVLWZKBNHFJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 1-[2-[(4-tert-butylphenyl)methyl-methyl-amino]acetyl]piperidine-4-carboxylate
  • 1-[2-[(4-tert-butylphenyl)methyl-methylamino]-1-oxoethyl]-4-piperidinecarboxylic acid methyl ester
  • 1-[2-[(4-tert-butylbenzyl)-methyl-amino]acetyl]isonipecotic acid methyl ester
  • methyl 1-[2-[(4-tert-butylphenyl)methyl-methyl-amino]ethanoyl]piperidine-4-carboxylate
  • T5530176

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni disulfide oxidoreductase 0.0018 0.0083 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0751 0.1286
Toxoplasma gondii ABC1 family protein 0.0077 0.1317 0.3467
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0992 0.1447
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0018 0.0083 0.0002
Schistosoma mansoni ferritin 0.0018 0.0082 0.012
Loa Loa (eye worm) hypothetical protein 0.0155 0.2943 0.406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0663 0.0968
Loa Loa (eye worm) hypothetical protein 0.034 0.6815 0.9402
Trypanosoma cruzi oligopeptidase b 0.0053 0.082 0.2157
Loa Loa (eye worm) hypothetical protein 0.0134 0.2507 0.3458
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0751 0.1975
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.1276 0.1862
Echinococcus multilocularis expressed protein 0.0018 0.0082 0.012
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0615 0.0897
Schistosoma mansoni apoferritin-2 0.0018 0.0082 0.012
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.1276 0.1862
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.1125 0.296
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0018 0.0083 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1317 0.4717
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.1125 0.296
Brugia malayi beta-lactamase family protein 0.0077 0.1317 0.1923
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0992 0.1447
Schistosoma mansoni ferritin 0.0018 0.0082 0.012
Brugia malayi hypothetical protein 0.0139 0.26 0.3795
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0088 0.0151
Brugia malayi hypothetical protein 0.0016 0.0037 0.0053
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0068 0.1125 0.8583
Entamoeba histolytica hypothetical protein 0.0022 0.0165 0.0243
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1317 0.1923
Trichomonas vaginalis ferritin, putative 0.0018 0.0082 0.0141
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0214 0.0312
Trypanosoma brucei poly(adp-ribose) polymerase 0.0078 0.133 0.35
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0057 0.0083
Mycobacterium tuberculosis Conserved protein 0.0077 0.1317 0.1245
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Entamoeba histolytica hypothetical protein, conserved 0.034 0.6815 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0018 0.0083 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.033 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0269 0.0462
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0018 0.0083 0.0001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0083 0.0121
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Schistosoma mansoni hypothetical protein 0.0049 0.073 0.1066
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0057 0.0083
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 0.2111
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0218 0.0573
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0214 0.0366
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0018 0.0083 0.0121
Schistosoma mansoni hypothetical protein 0.0143 0.2699 0.394
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1317 0.1923
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1276 0.3357
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0018 0.0083 0.0218
Schistosoma mansoni ferritin light chain 0.0018 0.0082 0.012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1297 0.3413
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0088 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1317 0.3467
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0483 0.1271
Onchocerca volvulus Peroxidasin homolog 0.0342 0.6852 1
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0092 0.0243
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.2699 0.394
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0068 0.1125 0.3982
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0663 0.0968
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.1125 0.296
Schistosoma mansoni transcription factor LCR-F1 0.007 0.1168 0.1705
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.1125 0.3982
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1317 0.1245
Trypanosoma brucei trypanothione reductase 0.0196 0.3801 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0018 0.0083 0.0001
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0018 0.0083 0.0218
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.1125 0.296
Leishmania major hypothetical protein, conserved 0.0018 0.0092 0.0243
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0153
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0018 0.0083 0.0122
Brugia malayi follicle stimulating hormone receptor 0.0264 0.5213 0.7608
Mycobacterium ulcerans lipase LipD 0.0077 0.1317 0.4717
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0018 0.0083 0.0218
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0092 0.0243
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1317 0.1817
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0018 0.0083 0.0121
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0018 0.0083 0.0002
Brugia malayi beta-lactamase family protein 0.0077 0.1317 0.1923
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0751 0.1975
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0083 0.0218
Brugia malayi WGR domain containing protein 0.0141 0.2662 0.3885
Toxoplasma gondii prolyl endopeptidase 0.0134 0.2507 0.6595
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.5836 1
Brugia malayi Probable ClpP-like protease 0.0076 0.1297 0.1893
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.033 0.0566
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0083 0.0142
Mycobacterium ulcerans beta-lactamase 0.0077 0.1317 0.4717
Trypanosoma brucei oligopeptidase b 0.0053 0.082 0.2157
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0018 0.0083 0.0002
Schistosoma mansoni hypothetical protein 0.0049 0.073 0.1066
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0537 0.092
Onchocerca volvulus Dual oxidase homolog 0.0342 0.6852 1
Mycobacterium ulcerans NADH dehydrogenase 0.0018 0.0083 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.1125 0.1928
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2718 0.3749
Toxoplasma gondii selenide, water dikinase 0.0018 0.0083 0.0218
Treponema pallidum oxidoreductase 0.0018 0.0083 0.0001
Loa Loa (eye worm) hypothetical protein 0.0076 0.1297 0.1789
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1276 0.3357
Mycobacterium tuberculosis Probable peptidase 0.0053 0.082 0.0744
Schistosoma mansoni ap endonuclease 0.0018 0.0088 0.0128
Plasmodium falciparum glutathione reductase 0.0196 0.3801 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.014 0.0369
Mycobacterium tuberculosis Probable reductase 0.0018 0.0083 0.0001
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0018 0.0083 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.073 0.1008
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0018 0.0083 0.0218
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0254 0.0669
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0088 0.0232
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.2701 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.1168 0.1705
Echinococcus granulosus geminin 0.0205 0.3981 0.5809
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0092 0.0243
Echinococcus granulosus GPCR family 2 0.0049 0.073 0.1066
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0083 0.0218
Trichomonas vaginalis esterase, putative 0.0077 0.1317 0.2257
Schistosoma mansoni apoferritin-2 0.0018 0.0082 0.012
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.1168 0.1705
Schistosoma mansoni peroxidasin 0.0342 0.6852 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0893 0.1304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0056 0.0871 0.1202
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0992 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0751 0.1286
Plasmodium falciparum thioredoxin reductase 0.0068 0.1125 0.296
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0751 0.1975
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.1125 0.1642
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0537 0.092
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2718 0.3749
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0152 0.04
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0018 0.0083 0.0121
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0018 0.0083 0.0142
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.2701 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0088 0.0128
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0088 0.0128
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Loa Loa (eye worm) programmed cell death 8 0.0018 0.0083 0.0114
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0018 0.0083 0.0122
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0018 0.0083 0.0218
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0749 0.1093
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0615 0.0897
Onchocerca volvulus Peroxidasin homolog 0.0342 0.6852 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0751 0.1096
Leishmania major hypothetical protein, conserved 0.0024 0.0218 0.0573
Echinococcus granulosus poly (ADP ribose) polymerase 0.0044 0.0624 0.0911
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.1125 0.296
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 0.3413
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1317 0.1245
Onchocerca volvulus 0.0077 0.1317 0.1923
Entamoeba histolytica hypothetical protein 0.007 0.1168 0.1714
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0088 0.0006
Entamoeba histolytica hypothetical protein 0.007 0.1168 0.1714
Onchocerca volvulus Prolyl endopeptidase homolog 0.0134 0.2507 0.3658
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0018 0.0083 0.0218
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0018 0.0083 0.0142
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0045 0.0119
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Onchocerca volvulus 0.0077 0.1317 0.1923
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0893 0.3097
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0018 0.0083 0.0004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0088 0.0129
Schistosoma mansoni glutamate synthase 0.0018 0.0083 0.0121
Plasmodium falciparum ferrodoxin reductase-like protein 0.0018 0.0083 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0537 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0269 0.0462
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0748 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0057 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0663 0.0968
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0537 0.092
Mycobacterium leprae Probable lipase LipE 0.0077 0.1317 0.4717
Schistosoma mansoni peroxidasin 0.0342 0.6852 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0018 0.0083 0.0004
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0165 0.0241
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0088 0.0232
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1317 0.1245
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0992 0.1368
Loa Loa (eye worm) RNA binding protein 0.0062 0.0992 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Plasmodium vivax glutathione reductase, putative 0.0196 0.3801 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.1125 0.3982
Loa Loa (eye worm) RecQ helicase 0.0024 0.0214 0.0295
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0018 0.0083 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0992 0.1447
Mycobacterium tuberculosis Conserved protein 0.0077 0.1317 0.1245
Trichomonas vaginalis glutamate synthase, putative 0.0018 0.0083 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1317 0.3467
Onchocerca volvulus Protein cereblon homolog 0.034 0.6815 0.9946
Onchocerca volvulus DNA ligase 3 homolog 0.0018 0.0092 0.0135
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0751 0.1096
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0018 0.0083 0.0218
Mycobacterium ulcerans monoxygenase 0.0018 0.0083 0.0002
Brugia malayi beta-lactamase 0.0077 0.1317 0.1923
Schistosoma mansoni hypothetical protein 0.0205 0.3981 0.5809
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0083 0.0218
Onchocerca volvulus 0.0342 0.6852 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0893 0.1304
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.1125 0.1642
Brugia malayi glutamate synthase 0.0018 0.0083 0.0121
Onchocerca volvulus 0.0077 0.1317 0.1923
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.1125 0.296
Echinococcus multilocularis thioredoxin glutathione reductase 0.0196 0.3801 0.5546
Mycobacterium tuberculosis Probable dehydrogenase 0.0018 0.0083 0.0001
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.02 0.0527
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0057 0.0149
Leishmania major hypothetical protein, conserved 0.0018 0.0083 0.0218
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0018 0.0083 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0598 0.1025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0018 0.0083 0.0001
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.1297 0.1893
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.1276 0.3357
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.1125 0.1928
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0088 0.0232
Loa Loa (eye worm) beta-lactamase 0.0077 0.1317 0.1817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.073 0.1066
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0018 0.0083 0.0002
Brugia malayi RNA binding protein 0.0062 0.0992 0.1447
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0749 0.2546
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0057 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.033 0.0566
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0018 0.0083 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.073 0.1066
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0018 0.0083 0.0001
Plasmodium vivax ferrodoxin reductase, putative 0.0018 0.0083 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.1125 0.1928
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.082 0.2157
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.082 0.2817
Giardia lamblia GTOR 0.005 0.0751 0.1286
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0018 0.0083 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.2943 0.4295
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0218 0.0573
Brugia malayi hypothetical protein 0.0024 0.0218 0.0318
Loa Loa (eye worm) hypothetical protein 0.0108 0.1956 0.2698
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.1125 0.296
Echinococcus granulosus poly ADP ribose polymerase 1 0.0141 0.2662 0.3885
Onchocerca volvulus Peroxidase homolog 0.0342 0.6852 1
Schistosoma mansoni ap endonuclease 0.0018 0.0088 0.0128
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0078 0.133 0.35
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0214 0.0312
Brugia malayi WGR domain containing protein 0.0078 0.133 0.1941
Loa Loa (eye worm) animal heme peroxidase 0.0342 0.6852 0.9453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0018 0.0083 0.0218
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0893 0.235
Leishmania major trypanothione reductase 0.0196 0.3801 1
Brugia malayi Animal haem peroxidase family protein 0.0342 0.6852 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0049 0.013
Mycobacterium ulcerans hypothetical protein 0.0077 0.1317 0.4717
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1317 0.1245
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0018 0.0083 0.0218
Leishmania major oligopeptidase b 0.0053 0.082 0.2157
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0018 0.0083 0.0002
Giardia lamblia Glutamate synthase 0.0018 0.0083 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0663 0.0968
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0083 0.0218
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0078 0.133 0.35
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.1276 0.1872
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.2701 0.264
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0141 0.2662 0.3885
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0083 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0218 0.0573
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0749 0.1093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0218 0.0301
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0218 0.0573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0057 0.0083
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.005 0.0751 0.1102
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.1125 0.296
Schistosoma mansoni hypothetical protein 0.007 0.1168 0.1705
Leishmania major DNA repair protein, putative 0.0018 0.0092 0.0243
Schistosoma mansoni hypothetical protein 0.0049 0.073 0.1066
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.1297 0.1893
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0018 0.0083 0.0218
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0663 0.0915
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1919 0.28
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0992 0.1368
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0165 0.0241
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0057 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0663 0.0968
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0057 0.0149
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.1297 0.3413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1317 0.1923
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1317 0.4717
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0018 0.0083 0.0001
Echinococcus granulosus expressed protein 0.0018 0.0082 0.012
Loa Loa (eye worm) animal heme peroxidase 0.0342 0.6852 0.9453
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0018 0.0083 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0751 0.1036
Onchocerca volvulus Peroxidase homolog 0.0342 0.6852 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0018 0.0083 0.0002
Brugia malayi TAR-binding protein 0.0062 0.0992 0.1447
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.1125 0.3982
Brugia malayi Peroxidasin 0.0342 0.6852 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.1276 0.1862
Trichomonas vaginalis glutamate synthase, putative 0.0018 0.0083 0.0142
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.1125 0.1642
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0893 0.3097
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.1125 0.296
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0088 0.0232
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0018 0.0083 0.0001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0751 0.1096
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.1125 0.296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.027 0.0463
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1317 0.1923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.027 0.0463
Loa Loa (eye worm) animal heme peroxidase 0.0342 0.6852 0.9453
Leishmania major NADH dehydrogenase, putative 0.0018 0.0083 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0057 0.0097
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.1125 0.8583
Trypanosoma brucei prolyl endopeptidase 0.0134 0.2507 0.6595
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0893 0.0818
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Schistosoma mansoni hypothetical protein 0.034 0.6815 0.9946
Echinococcus multilocularis ferritin 0.0018 0.0082 0.012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1297 0.3413
Brugia malayi glutathione reductase 0.0196 0.3801 0.5546
Leishmania major hypothetical protein, conserved 0.0018 0.0083 0.0218
Loa Loa (eye worm) hypothetical protein 0.0361 0.7249 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0018 0.0083 0.0218
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0218 0.0573
Loa Loa (eye worm) hypothetical protein 0.0049 0.073 0.1008
Toxoplasma gondii hypothetical protein 0.0026 0.0254 0.0669
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Echinococcus multilocularis prolyl endopeptidase 0.0134 0.2507 0.3658
Trypanosoma brucei NADH dehydrogenase 0.0018 0.0083 0.0218
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 1
Trypanosoma cruzi oligopeptidase b 0.0053 0.082 0.2157
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.1125 0.296
Loa Loa (eye worm) animal heme peroxidase 0.0342 0.6852 0.9453
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.082 0.2157
Treponema pallidum NADH oxidase 0.0068 0.1125 0.1812
Trichomonas vaginalis apoptosis inducing factor, putative 0.0018 0.0083 0.0142
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0078 0.133 0.1941
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1317 0.3467
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0057 0.0149
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.3801 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.294 0.429
Onchocerca volvulus 0.0342 0.6852 1
Brugia malayi Animal haem peroxidase family protein 0.0342 0.6852 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.2699 0.394
Trypanosoma cruzi NADH dehydrogenase, putative 0.0018 0.0083 0.0218
Entamoeba histolytica hypothetical protein 0.007 0.1168 0.1714
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Schistosoma mansoni hypothetical protein 0.0205 0.3981 0.5809
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1317 0.2257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0751 0.1096
Echinococcus granulosus thioredoxin glutathione reductase 0.0196 0.3801 0.5546
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.1297 0.4639
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0088 0.001
Trypanosoma cruzi prolyl endopeptidase 0.0134 0.2507 0.6595
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0018 0.0083 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.1125 0.296
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1317 0.1245
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.082 0.0744
Brugia malayi Latrophilin receptor protein 2 0.0049 0.073 0.1066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0384 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0663 0.0968
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0078 0.133 0.1941
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0141 0.2662 0.3885
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0083 0.0121
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0018 0.0083 0.0121
Echinococcus granulosus peroxidasin 0.0342 0.6852 1
Schistosoma mansoni ferritin light chain 0.0018 0.0082 0.012
Echinococcus multilocularis protein cereblon 0.034 0.6815 0.9946
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.1125 0.296
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.2507 0.3658
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0018 0.0083 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0992 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0751 0.1286
Treponema pallidum thioredoxin reductase (trxB) 0.0018 0.0083 0.0001
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0018 0.0083 0.0218
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.1125 0.296
Brugia malayi Animal haem peroxidase family protein 0.0342 0.6852 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 0.4639
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0537 0.092
Mycobacterium ulcerans ferredoxin reductase 0.0018 0.0083 0.0002
Leishmania major hypothetical protein, conserved 0.0018 0.0083 0.0218
Echinococcus multilocularis glutamate synthase 0.0018 0.0083 0.0121
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.3801 0.5243
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0032 0.0384 0.0561
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.1125 0.8583
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0893 0.1304
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0018 0.0083 0.0121
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0214 0.0366
Echinococcus multilocularis geminin 0.0205 0.3981 0.5809
Echinococcus granulosus bloom syndrome protein 0.0024 0.0214 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0324 0.0555
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0018 0.0083 0.0218
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0088 0.0232
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.1125 0.296
Echinococcus granulosus protein cereblon 0.034 0.6815 0.9946
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.073 0.1066
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0083 0.0121
Onchocerca volvulus 0.0342 0.6852 1
Echinococcus granulosus prolyl endopeptidase 0.0134 0.2507 0.3658
Brugia malayi MH2 domain containing protein 0.0144 0.2718 0.3966
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0147 0.2777 0.7308
Echinococcus granulosus poly adp ribose polymerase 2 0.0078 0.133 0.1941
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0663 0.0968
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0538 0.1415
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0254 0.0669
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0813 0.1122
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0893 0.1304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.027 0.0463
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0218 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0057 0.0097
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0057 0.0149
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.1276 0.1862
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.082 0.2157
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0018 0.0083 0.0121
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.1125 0.1642
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0088 0.0151
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0018 0.0083 0.0121
Schistosoma mansoni ferritin 0.0018 0.0082 0.012
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0018 0.0083 0.0002
Giardia lamblia Thioredoxin reductase 0.0018 0.0083 0.0142
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0018 0.0083 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0057 0.0097
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0751 0.1975
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0018 0.0083 0.0004
Echinococcus granulosus glutamate synthase 0.0018 0.0083 0.0121
Echinococcus granulosus WGR domain containing protein 0.0044 0.0624 0.0911
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0538 0.1415
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0057 0.0083
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.2507 0.3658
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.082 0.2157
Onchocerca volvulus Chorion peroxidase homolog 0.0342 0.6852 1
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.3801 1
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.0092 0.0243
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0749 0.0672
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0141 0.2662 0.3906
Schistosoma mansoni hypothetical protein 0.0018 0.0083 0.0121
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.5836 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0254 0.0657
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0018 0.0083 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Schistosoma mansoni hypothetical protein 0.0049 0.073 0.1066
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.2213 0.2148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5836 1
Mycobacterium ulcerans dehydrogenase 0.0018 0.0083 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0088 0.0232
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0018 0.0083 0.0002
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0018 0.0083 0.0121
Mycobacterium ulcerans hypothetical protein 0.0018 0.0083 0.0002
Plasmodium falciparum glutathione reductase 0.0068 0.1125 0.296
Echinococcus multilocularis peroxidasin 0.0342 0.6852 1
Entamoeba histolytica thioredoxin reductase, putative 0.0018 0.0083 0.0122
Brugia malayi Animal haem peroxidase family protein 0.0342 0.6852 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1317 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.027 0.0463
Brugia malayi hypothetical protein 0.007 0.1168 0.1705
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.2943 0.406
Trypanosoma cruzi NADH dehydrogenase, putative 0.0018 0.0083 0.0218
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0018 0.0083 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1317 0.2257
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0068 0.1125 0.1051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.073 0.1066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.1276 0.3357
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0018 0.0083 0.0121
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0088 0.0046
Toxoplasma gondii exonuclease III APE 0.0018 0.0088 0.0232
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0018 0.0083 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0324 0.0555
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.5836 0.8564
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0992 0.1447
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0165 0.0241
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0088 0.0128
Entamoeba histolytica disulphide oxidoreductase, putative 0.0018 0.0083 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1317 0.2257
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.082 0.2157
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.082 0.2817
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Brugia malayi Thioredoxin reductase 0.0196 0.3801 0.5546
Brugia malayi Animal haem peroxidase family protein 0.0342 0.6852 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0018 0.0083 0.0142
Entamoeba histolytica hypothetical protein 0.007 0.1168 0.1714
Schistosoma mansoni sulfide quinone reductase 0.0018 0.0083 0.0121
Schistosoma mansoni glutamate synthase 0.0018 0.0083 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1317 0.3467
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.3801 0.3749
Echinococcus granulosus tar DNA binding protein 0.0062 0.0992 0.1447
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.2507 0.3658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0057 0.0097
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0018 0.0083 0.0122
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0751 0.1975
Loa Loa (eye worm) hypothetical protein 0.0078 0.133 0.1835
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0134 0.2507 0.6595
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.073 0.1066
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0068 0.1125 0.1051
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.1125 0.1051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1297 0.4639
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0751 0.1975
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1317 0.2257
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.1297 0.1893
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0088 0.0151
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0748 0.1092
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.1125 0.296
Schistosoma mansoni hypothetical protein 0.0106 0.1919 0.28
Mycobacterium ulcerans glutamate synthase subunit beta 0.0018 0.0083 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1317 0.1923
Leishmania major hypothetical protein, conserved 0.0077 0.1317 0.3467
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.2943 0.4295
Schistosoma mansoni thyroid hormone receptor 0.0155 0.294 0.429
Brugia malayi hypothetical protein 0.034 0.6815 0.9946
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.073 0.1066
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.1276 0.176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0407 0.0697
Loa Loa (eye worm) hypothetical protein 0.0106 0.1919 0.2647
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.005 0.0751 0.1102
Loa Loa (eye worm) glutathione reductase 0.0196 0.3801 0.5243
Loa Loa (eye worm) hypothetical protein 0.0342 0.6852 0.9453
Schistosoma mansoni thyroid hormone receptor 0.0155 0.294 0.429
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0992 0.1447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0663 0.0968
Brugia malayi hypothetical protein 0.0342 0.6852 1
Plasmodium falciparum thioredoxin reductase 0.0196 0.3801 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0538 0.1415
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0107 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0483 0.0828
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1317 0.4717
Schistosoma mansoni glutamate synthase 0.0018 0.0083 0.0121
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0254 0.0299
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0018 0.0083 0.0142
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1317 0.1245
Schistosoma mansoni ferritin 0.0018 0.0082 0.012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0749 0.0672
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.5213 0.7191
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.5836 0.8564
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1317 0.2257
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0088 0.0121
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0018 0.0083 0.0142
Loa Loa (eye worm) hypothetical protein 0.0077 0.1317 0.1817
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0083 0.0218
Schistosoma mansoni sulfide quinone reductase 0.0018 0.0083 0.0121
Brugia malayi Blistered cuticle protein 3 0.0342 0.6852 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.1317 0.1245
Echinococcus granulosus ferritin 0.0018 0.0082 0.012
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0018 0.0083 0.0002
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0067 0.1111 0.1621
Loa Loa (eye worm) blistered cuticle protein 3 0.0342 0.6852 0.9453
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0018 0.0083 0.0002
Toxoplasma gondii thioredoxin reductase 0.0196 0.3801 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0018 0.0083 0.0122
Onchocerca volvulus 0.0018 0.0083 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0218 0.0573
Mycobacterium tuberculosis Probable oxidoreductase 0.0068 0.1125 0.1051
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0018 0.0083 0.0002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0057 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0269 0.0462

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0065 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1995 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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