Detailed information for compound 1437144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 538.577 | Formula: C28H22N6O4S
  • H donors: 3 H acceptors: 6 LogP: 3.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)[N-]c1nc2ccccc2nc1[n+]1ccc(cc1)NC(=O)c1ccccc1
  • InChi: 1S/C28H22N6O4S/c1-19(35)29-21-11-13-23(14-12-21)39(37,38)33-26-27(32-25-10-6-5-9-24(25)31-26)34-17-15-22(16-18-34)30-28(36)20-7-3-2-4-8-20/h2-18H,1H3,(H2,29,31,33,35)
  • InChiKey: ZGNRMHBJPFEFGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0066 0.0079
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.023 0.2599
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.1144 0.1789
Onchocerca volvulus 0.0008 0.0022 0.0034
Schistosoma mansoni hypothetical protein 0.0164 0.3515 0.5383
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.012 0.0163
Onchocerca volvulus 0.0008 0.0022 0.0034
Brugia malayi Globin family protein 0.0008 0.0022 0.0022
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0066 0.0079
Schistosoma mansoni hypothetical protein 0.0164 0.3515 0.5383
Trichomonas vaginalis ran, putative 0.0021 0.0299 0.2648
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0188 0.0188
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0107 0.1205
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0201 0.1794
Brugia malayi hypothetical protein 0.0036 0.0636 0.0636
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0299 0.3367
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2497 0.9131
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0984 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0062 0.0062
Echinococcus granulosus muscleblind protein 0.018 0.3889 0.5959
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0052 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Schistosoma mansoni intermediate filament proteins 0.0026 0.0423 0.0628
Loa Loa (eye worm) hypothetical protein 0.0146 0.3115 0.3115
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Loa Loa (eye worm) hypothetical protein 0.0292 0.6395 0.6395
Schistosoma mansoni ran 0.0021 0.0299 0.0437
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0345 0.315
Mycobacterium tuberculosis Possible toxin MazF4 0.0129 0.2733 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0887 0.1341
Loa Loa (eye worm) hypothetical protein 0.018 0.3889 0.3889
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor 0.001 0.0062 0.0073
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0201 0.2272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0299 0.2956
Mycobacterium ulcerans hypothetical protein 0.0129 0.2733 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0062 0.0097
Brugia malayi Fli-1 protein 0.0212 0.4608 0.4608
Onchocerca volvulus Globin homolog 0.0008 0.0022 0.0034
Brugia malayi glutathione reductase 0.0047 0.0887 0.0887
Trypanosoma cruzi metacaspase, putative 0.0017 0.023 0.2141
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.023 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0062 0.0062
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0105 0.0105
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.023 0.0332
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0062 0.0062
Brugia malayi DKFZp564C0469 protein 0.001 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0853 0.1289
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0887 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0723 0.1089
Onchocerca volvulus Huntingtin homolog 0.0121 0.2555 0.3995
Brugia malayi Ets-domain containing protein 0.007 0.1409 0.1409
Schistosoma mansoni hypothetical protein 0.0036 0.0636 0.0956
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0062 0.0073
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0107 0.0107
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0066 0.0079
Echinococcus multilocularis caspase 2 0.0058 0.1144 0.1737
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1243 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0062 0.0062
Brugia malayi hypothetical protein 0.0041 0.0752 0.0752
Plasmodium vivax hypothetical protein, conserved 0.0017 0.023 0.2599
Echinococcus multilocularis caspase 0.0017 0.023 0.0332
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0188 0.0267
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0984 0.1491
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0062 0.0073
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0066 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0853 0.1289
Echinococcus multilocularis caspase 8 0.0017 0.023 0.0332
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0062 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0062 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0062 0.0073
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0299 0.0437
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0723 0.2733
Toxoplasma gondii thioredoxin reductase 0.0047 0.0887 1
Schistosoma mansoni ets-related 0.0212 0.4608 0.7065
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0887 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2497 0.9131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0062 0.0062
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.023 0.2599
Echinococcus granulosus caspase 2 0.0058 0.1144 0.1737
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0107 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0062 0.0062
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0066 0.0066
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0052 0.011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0186 0.1607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0853 0.1289
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0201 0.1794
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0066 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0201 0.1794
Entamoeba histolytica hypothetical protein 0.0036 0.0636 0.2378
Loa Loa (eye worm) hypothetical protein 0.0026 0.0423 0.0423
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0201 0.2076
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0201 0.0287
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0052 0.0583
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.1409 0.1409
Trypanosoma brucei metacaspase 0.0017 0.023 0.2141
Loa Loa (eye worm) hypothetical protein 0.0062 0.1242 0.1242
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.023 0.2141
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0062 0.0073
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0723 0.1089
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0201 0.0201
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0062 0.0073
Brugia malayi intermediate filament protein 0.0026 0.0423 0.0423
Schistosoma mansoni thyroid hormone receptor 0.001 0.0062 0.0073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.041 0.4625
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0723 0.0723
Brugia malayi topoisomerase 0.001 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0267
Echinococcus granulosus caspase 8 0.0017 0.023 0.0332
Brugia malayi nuclear receptor NHR-88 0.001 0.0062 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0008 0.0022 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0062 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0062 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0186 0.1607
Loa Loa (eye worm) hypothetical protein 0.0058 0.1144 0.1144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0121 0.2555 0.2555
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0944 0.0944
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0201 0.1794
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0062 0.0073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0723 0.8039
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0119 0.2508 0.2508
Brugia malayi Ets-domain containing protein 0.007 0.1409 0.1409
Trypanosoma brucei Metacaspase-4 0.0017 0.023 0.2141
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0062 0.0062
Brugia malayi hypothetical protein 0.0008 0.0022 0.0022
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0201 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.023 0.0332
Schistosoma mansoni coup transcription factor 0.001 0.0062 0.0073
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0723 0.1089
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0052 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0188 0.0188
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0062 0.0073
Echinococcus granulosus expressed conserved protein 0.0112 0.2346 0.3586
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Brugia malayi hypothetical protein 0.0008 0.0022 0.0022
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0752 0.1134
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0066 0.0066
Onchocerca volvulus 0.0026 0.0423 0.0662
Schistosoma mansoni lamin 0.0026 0.0423 0.0628
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0201 0.2272
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0944 0.0944
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0984 0.1491
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0594 0.0594
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0345 0.315
Echinococcus granulosus intermediate filament protein 0.0026 0.0423 0.0628
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.023 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0062 0.0062
Onchocerca volvulus 0.0026 0.0423 0.0662
Echinococcus multilocularis musashi 0.0026 0.0423 0.0628
Echinococcus multilocularis GPCR, family 2 0.0016 0.0188 0.0267
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.223 0.8147
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0066 0.0079
Trypanosoma brucei metacaspase MCA2 0.0017 0.023 0.2141
Plasmodium falciparum glutathione reductase 0.0016 0.0201 0.2272
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0201 0.2272
Schistosoma mansoni hypothetical protein 0.0049 0.0943 0.1427
Trypanosoma cruzi metacaspase, putative 0.0017 0.023 0.2141
Brugia malayi RNA binding protein 0.0063 0.1243 0.1243
Echinococcus granulosus GPCR family 2 0.0016 0.0188 0.0267
Plasmodium vivax glutathione reductase, putative 0.0047 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0723 0.0723
Echinococcus multilocularis protein dispatched 1 0.0058 0.1146 0.174
Schistosoma mansoni hypothetical protein 0.001 0.0066 0.0079
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.255 0.3899
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0188 0.0267
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0066 0.0079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.2076
Entamoeba histolytica hypothetical protein 0.0036 0.0636 0.2378
Echinococcus granulosus replication factor c subunit 1 0.001 0.0052 0.0057
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0052 0.0583
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.2508 0.3835
Echinococcus granulosus tar DNA binding protein 0.0063 0.1243 0.1889
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0062 0.0073
Schistosoma mansoni ets-related 0.001 0.0066 0.0079
Plasmodium falciparum thioredoxin reductase 0.0047 0.0887 1
Echinococcus multilocularis protein patched 0.0051 0.0984 0.1491
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.012 0.0163
Schistosoma mansoni hypothetical protein 0.0034 0.0594 0.0891
Entamoeba histolytica Ran family GTPase 0.0021 0.0299 0.1005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0201 0.0662
Onchocerca volvulus 0.0008 0.0022 0.0034
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0201 0.2231
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0267
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0887 0.319
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0723 0.8039
Schistosoma mansoni DNA helicase recq1 0.0012 0.0107 0.0142
Schistosoma mansoni hypothetical protein 0.0049 0.0943 0.1427
Echinococcus granulosus nibrin 0.001 0.0052 0.0057
Echinococcus granulosus protein C ets 2 0.001 0.0066 0.0079
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0066 0.0079
Plasmodium falciparum importin beta, putative 0.0028 0.0464 0.5229
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1243 0.1243
Onchocerca volvulus 0.0008 0.0022 0.0034
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0188 0.0188
Echinococcus multilocularis nibrin 0.001 0.0052 0.0057
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.223 0.8147
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0052 0.0583
Brugia malayi MH1 domain containing protein 0.0008 0.0015 0.0015
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0299 0.3367
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.023 0.023
Echinococcus multilocularis muscleblind protein 1 0.018 0.3889 0.5959
Trypanosoma cruzi metacaspase, putative 0.0017 0.023 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0121 0.2555 0.2555
Echinococcus multilocularis snurportin 1 0.0297 0.6517 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0723 0.1089
Schistosoma mansoni myoglobin 1 0.0008 0.0022 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0062 0.0073
Plasmodium falciparum metacaspase-like protein 0.0017 0.023 0.2599
Echinococcus multilocularis ets variant gene 4 0.001 0.0066 0.0079
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0201 0.0662
Brugia malayi Globin family protein 0.0008 0.0022 0.0022
Brugia malayi hypothetical protein 0.0292 0.6395 0.6395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0062 0.0062
Schistosoma mansoni topbp1 0.001 0.0052 0.0057
Plasmodium falciparum metacaspase 1 0.0017 0.023 0.2599
Echinococcus granulosus FTZ F1 alpha 0.001 0.0062 0.0073
Brugia malayi MH2 domain containing protein 0.0008 0.0015 0.0015
Brugia malayi Globin family protein 0.0008 0.0022 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.023 0.2599
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0299 0.2956
Schistosoma mansoni topbp1 0.001 0.0052 0.0057
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0107 0.1205
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0201 0.1794
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0062 0.0062
Loa Loa (eye worm) globin family protein 0.0008 0.0022 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0062 0.0062
Trypanosoma cruzi metacaspase, putative 0.0017 0.023 0.2141
Loa Loa (eye worm) Smad1 0.0008 0.0015 0.0015
Mycobacterium tuberculosis Probable reductase 0.0107 0.223 0.8147
Echinococcus granulosus geminin 0.0164 0.3515 0.5383
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0723 0.8107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0853 0.1289
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0299 0.3367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0944 0.0944
Brugia malayi MH1 domain containing protein 0.0008 0.0015 0.0015
Mycobacterium tuberculosis Toxin MazF9 0.0129 0.2733 1
Onchocerca volvulus 0.0292 0.6395 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0107
Echinococcus multilocularis lamin 0.0026 0.0423 0.0628
Loa Loa (eye worm) hypothetical protein 0.0041 0.0752 0.0752
Treponema pallidum NADH oxidase 0.0016 0.0201 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0066 0.0079
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.2508 0.2508
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0278 0.3139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0062 0.0062
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0489 0.4692
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2497 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.018 0.3889 0.3889
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0152 0.0152
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0186 0.144
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0267
Loa Loa (eye worm) glutathione reductase 0.0047 0.0887 0.0887
Onchocerca volvulus 0.001 0.0062 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0723 0.7201
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0345 0.315
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0201 0.1794
Loa Loa (eye worm) hypothetical protein 0.0028 0.0464 0.0464
Echinococcus granulosus GA binding protein alpha chain 0.007 0.1409 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0062 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.223 0.8147
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0062 0.0073
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0201 0.1607
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0062 0.0073
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0299 0.3677
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0723 0.1089
Brugia malayi Importin beta-1 subunit 0.0028 0.0464 0.0464
Schistosoma mansoni hypothetical protein 0.0041 0.0752 0.1134
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0066 0.0079
Brugia malayi MH2 domain containing protein 0.0008 0.0015 0.0015
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0066 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0887 0.1341
Leishmania major metacaspase, putative 0.0017 0.023 0.2411
Mycobacterium tuberculosis Possible toxin MazF5 0.0129 0.2733 1
Mycobacterium tuberculosis Possible toxin MazF7 0.0129 0.2733 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0015 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0062 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Brugia malayi CHE-14 protein 0.0051 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0016 0.0188 0.0188
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0723 0.8039
Loa Loa (eye worm) fli-1 protein 0.0212 0.4608 0.4608
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0489 0.4692
Schistosoma mansoni DNA ligase IV 0.001 0.0052 0.0057
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0036 0.0636 0.2378
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0201 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0036 0.0636 0.2378
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.1409 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0062 0.0062
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0201 0.2076
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0052 0.0583
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0062 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.2508 0.3835
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.2508 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0853 0.0853
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0423 0.0423
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0201 0.2272
Echinococcus multilocularis lamin dm0 0.0026 0.0423 0.0628
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0062 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0066
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0984 0.1491
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0066 0.0079
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0201 1
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.1144 0.1737
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Leishmania major trypanothione reductase 0.0047 0.0887 1
Onchocerca volvulus 0.0008 0.0022 0.0034
Brugia malayi Cell death protein 3 precursor 0.0058 0.1144 0.1144
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0066 0.0079
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.2076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0062 0.0062
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0489 0.0489
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0723 0.1089
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0062 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0062 0.0097
Echinococcus granulosus snurportin 1 0.0297 0.6517 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0345 0.3517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.001 0.0066 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.223 0.8147
Plasmodium falciparum glutathione reductase 0.0047 0.0887 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0423 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0723 0.7201
Brugia malayi transcription factor E74 isoform 0.001 0.0066 0.0066
Trypanosoma brucei metacaspase 5, putative 0.0017 0.023 0.2141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0062 0.0073
Loa Loa (eye worm) globin family protein 0.0008 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1243 0.1889
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0062 0.0073
Mycobacterium tuberculosis Toxin MazF3 0.0129 0.2733 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1181 0.1181
Schistosoma mansoni importin beta-1 0.0028 0.0464 0.0691
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0201 0.0662
Schistosoma mansoni globin X 0.0008 0.0022 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1243 0.1889
Plasmodium falciparum thioredoxin reductase 0.0016 0.0201 0.2272
Mycobacterium tuberculosis Toxin MazF2 0.0129 0.2733 1
Echinococcus granulosus lamin dm0 0.0026 0.0423 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0297 0.6517 1
Brugia malayi ecdysteroid receptor 0.001 0.0062 0.0062
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0201 1
Onchocerca volvulus 0.001 0.0052 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0201 0.2272
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0299 0.2956
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0186 0.0546
Echinococcus multilocularis muscleblind protein 0.018 0.3889 0.5959
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0636 0.0956
Brugia malayi Muscleblind-like protein 0.018 0.3889 0.3889
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0464 0.4934
Mycobacterium tuberculosis Conserved protein 0.0129 0.2733 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.1243 0.1243
Brugia malayi TAR-binding protein 0.0063 0.1243 0.1243
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0201 0.0287
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.3654 0.5597
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0423 0.0423
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0201 0.0662
Echinococcus granulosus caspase 0.0017 0.023 0.0332
Brugia malayi steroid hormone receptor 0.001 0.0062 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Loa Loa (eye worm) hypothetical protein 0.0012 0.011 0.011
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0052 0.0057
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0464 0.0691
Onchocerca volvulus Huntingtin homolog 0.0121 0.2555 0.3995
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0489 0.073
Entamoeba histolytica hypothetical protein 0.0023 0.0345 0.1196
Brugia malayi Ets-domain containing protein 0.001 0.0066 0.0066
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.023 0.0332
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0186 0.1896
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0944 0.0944
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0107 0.0142
Brugia malayi RNA, U transporter 1 0.0079 0.1617 0.1617
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0062 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1243 0.1889
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0273 0.308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0853 0.1289
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0107 0.0107
Schistosoma mansoni lamin 0.0026 0.0423 0.0628
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0066 0.0066
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0636 0.0956
Leishmania major importin beta-1 subunit, putative 0.0023 0.0345 0.374
Schistosoma mansoni hypothetical protein 0.0049 0.0943 0.1427
Loa Loa (eye worm) RecQ helicase 0.0029 0.0489 0.0489
Echinococcus granulosus importin subunit beta 1 0.0028 0.0464 0.0691
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.023 0.2141
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2497 0.9131
Schistosoma mansoni hypothetical protein 0.0049 0.0943 0.1427
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0052 0.0052
Brugia malayi hypothetical protein 0.0008 0.0022 0.0022
Brugia malayi hypothetical protein 0.0008 0.0022 0.0022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0299 0.0437
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0299 0.0299
Schistosoma mansoni ets 0.001 0.0066 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.223 0.8147
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0887 0.0887
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0107 0.0142
Trypanosoma brucei metacaspase MCA3 0.0017 0.023 0.2141
Brugia malayi hypothetical protein 0.0121 0.2555 0.2555
Brugia malayi MH2 domain containing protein 0.0115 0.2428 0.2428
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0464 0.5229
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1243 0.1889
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0201 0.1794
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0201 0.2272
Echinococcus granulosus lamin 0.0026 0.0423 0.0628
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1243 0.1889
Plasmodium vivax importin-beta 2, putative 0.0028 0.0464 0.5229
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0152 0.0152
Schistosoma mansoni gabp alpha 0.007 0.1409 0.2145
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0984 0.0984
Schistosoma mansoni patched 1 0.0051 0.0984 0.1491
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1243 0.1889
Echinococcus multilocularis expressed conserved protein 0.0112 0.2346 0.3586
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0594 0.0594
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.223 0.8908
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0853 0.0853
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0723 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.6517 0.6517
Brugia malayi nuclear hormone receptor 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0016 0.0188 0.0267
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0723 0.1089
Loa Loa (eye worm) hypothetical protein 0.0013 0.012 0.012
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0107 0.0822
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0723 0.7201
Echinococcus multilocularis geminin 0.0164 0.3515 0.5383
Loa Loa (eye worm) hypothetical protein 0.0051 0.0984 0.0984
Brugia malayi Thioredoxin reductase 0.0047 0.0887 0.0887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0853 0.1289
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2428 0.2428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0062 0.0062
Echinococcus multilocularis protein C ets 2 0.001 0.0066 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0188 0.0267
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0464 0.4934
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.023 0.1918
Mycobacterium tuberculosis Toxin MazF6 0.0129 0.2733 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0853 0.1289
Trypanosoma brucei trypanothione reductase 0.0047 0.0887 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0723 0.1089
Schistosoma mansoni DNA helicase recq5 0.0012 0.0107 0.0142
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0201 0.1794
Leishmania major GTP-binding protein, putative 0.0021 0.0299 0.3198
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0062 0.0097
Schistosoma mansoni elf1 0.001 0.0066 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.011 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0188 0.0267
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1243 0.1243
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0052
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.0008 0.0022 0.0022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0299 0.0299
Brugia malayi Smad1 0.0008 0.0015 0.0015
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0352 0.0519
Mycobacterium tuberculosis Possible toxin MazF1 0.0129 0.2733 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0636 0.0956
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0201 0.1607
Schistosoma mansoni ran 0.0021 0.0299 0.0437
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0066
Plasmodium vivax metacaspase 1, putative 0.0017 0.023 0.2599
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0107 0.1205
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.3654 0.5597
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0452 1 1
Echinococcus granulosus bloom syndrome protein 0.0029 0.0489 0.073
Brugia malayi hypothetical protein 0.001 0.0052 0.0052
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0752 0.1134
Onchocerca volvulus 0.0041 0.0752 0.1175
Schistosoma mansoni thyroid hormone receptor 0.001 0.0062 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.023 0.1918
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0107 0.0142
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0062 0.0062

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) 69.541 uM PubChem BioAssay. Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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